Patents Examined by Ana Z Muresan
  • Patent number: 10995053
    Abstract: A compound having the formula (I): is disclosed. Methods of preparing the compound of formula (I) are also disclosed. The compound of formula (I) can be prepared by reacting a compound of formula (II) with a compound of formula (III) in an organic solvent with EDC (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide). The compound of formula (I) can also be prepared by reacting the compound of formula (II) with the compound of formula (III) in 1-ethyl-3-methylimidazolium hexafluorophosphate as a solvent with silicomolybdic acid as a catalyst.
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: May 4, 2021
    Assignee: SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Han Li, Nan Hui, Bin Tian, Xingke Ju, Yuzhi Liu, Dan Yang, Jingwen Xu, Liang Qi, Qianqian Zhao, Yongbo Wang
  • Patent number: 10995060
    Abstract: The present invention provides for crystalline Form B1 of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenyl-methyl)-4-amino-2R-methyl butanoic acid ethyl ester sodium salt, crystalline Form B2 of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-2R-methyl butanoic acid ethyl ester sodium salt, a novel process for the preparation of crystalline Form B of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-2R-methyl butanoic acid ethyl ester sodium salt.
    Type: Grant
    Filed: October 28, 2017
    Date of Patent: May 4, 2021
    Assignee: BIOCON LIMITED
    Inventors: Palle Venkata Raghavendra Charyulu, Pratik Rameshchandra Patel, Thirunelimada Devaiah Venu, Reddy Avathu Vidyasagar, Rajmahendra Shanmughasamy
  • Patent number: 10954186
    Abstract: The invention relates to a process for the production of urea ammonium nitrate, a system and a method of modifying a plant. The process comprises subjecting ammonia-containing off-gas resulting from the production of ammonium nitrate (AN off-gas) to condensation under acidic conditions so as to form an acidic condensate, and using at least part of the acidic condensate as an acidic scrubbing liquid in a finishing treatment section having a gas inlet in fluid communication with a gas outlet of a finishing section of a urea production unit, wherein the finishing section is adapted to solidify urea liquid, and wherein said finishing treatment section is adapted to subject ammonia-containing off-gas of the finishing section to treatment with an acidic scrubbing liquid.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: March 23, 2021
    Assignee: Stamicarbon B.V.
    Inventors: Giusy Elisa Puci, Joey Dobree
  • Patent number: 10941307
    Abstract: A photopolymerization initiator which is a compound having a structure in which one or more carbonyl groups that link to a carbon atom are further directly bonded to an aromatic ring of an aromatic acyl group that bonds to a phosphorus atom in an acylphosphine oxide structure. A producing method of a photopolymerization initiator produces the photopolymerization initiator. In a polymerizable composition and an ink jet recording method, the photopolymerization initiator is used. Furthermore, an acylphosphine oxide compound has a partial structure represented by Formula 1 or Formula 2.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: March 9, 2021
    Assignee: FUJIFILM CORPORATION
    Inventors: Hiroaki Tsuyama, Kazuhiro Yokoi, Kouki Nakamura, Kenjiro Araki
  • Patent number: 10941168
    Abstract: The present invention relates to a compound comprising at least one phosphepine ring and having the phosphorus atom of the phosphepine ring substituted with at least one monovalent substituent R, a semiconducting material comprising the compound, and electronic device comprising the semiconducting material.
    Type: Grant
    Filed: June 21, 2017
    Date of Patent: March 9, 2021
    Assignee: Novaled GmbH
    Inventor: Julien Frey
  • Patent number: 10941124
    Abstract: The present invention provides methods for the preparation of compounds useful in in vivo therapeutic and diagnostic applications. In particular, the present invention provides a method for the synthesis of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and also methods for the preparation of metal chelates of DOTA.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: March 9, 2021
    Assignee: GE HEALTHCARE AS
    Inventors: Andreas Richard Meijer, Arne Wang Aabye, Khalid Hussain, Sondre Nilsen, Mikkel Jacob Thaning, Jarle Andre Haugan, Ingvil Gausemel, Nikolai Enes, Silalahi Sumihar
  • Patent number: 10933044
    Abstract: Using the cobblestone area (CA) formation inhibitory activity of human leukemic stem cell-like cells as an indicator, a fraction having the activity has been extracted from the fat-soluble fraction of Porifera, then, a compound having the activity has been isolated and purified from the aforementioned fraction, and then, the structure thereof has been determined, so that a Stelliferin compound comprising a novel compound has been identified. Moreover, it has been found that the isolated and purified Stelliferin compound significantly suppresses the niche formation of leukemic stem cell-like cells derived from human chronic myelogenous leukemia (CML) having resistance to existing antitumor agents and enhances the effects of antitumor agents on the cells.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: March 2, 2021
    Assignees: WASEDA UNIVERSITY, KABUSHIKI KAISHA YAKULT HONSHA
    Inventors: Yoichi Nakao, Shigetaka Asano, Daisuke Arai, Yukari Kase, Teppei Shimomoto
  • Patent number: 10927139
    Abstract: Disclosed is the use of the reactive components of the inverse electron-demand Diels Alder reaction for chemical masking and unmasking in vitro. This can be applied in complex chemical reactions and, particularly in the synthesis of biomolecules, e.g. on solid supports. The reactive components are a dienophile, particularly a trans-cyclooctene, and a diene, particularly a tetrazine.
    Type: Grant
    Filed: November 22, 2013
    Date of Patent: February 23, 2021
    Assignee: TAGWORKS PHARMACEUTICALS B.V.
    Inventors: Marc Stefan Robillard, Ronny Mathieu Versteegen, Wolter ten Hoeve, Raffaella Rossin
  • Patent number: 10913729
    Abstract: Described are specific mixtures comprising one or more (cannabinoid) compounds of the formula (A) and/or one or more of their salts as well was methods for their production. Further described are a compound of the formula (A), a salt of the formula (A) and a corresponding mixture for use as a medicament or, respectively, for use in a method for therapeutic treatment of the human or animal body. Described are also corresponding pharmaceutical formulations, cosmetic preparations and preparations for pleasure and/or nutrition, suitable for consumption, as well as methods for producing CBDV and THCV.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: February 9, 2021
    Assignee: SYMRISE AG
    Inventors: Oskar Koch, Marcus Rudolf Götz
  • Patent number: 10906019
    Abstract: The present invention relates to a method for producing a modified polymerization initiator, and more particularly, to a method for preparing a modified polymerization initiator, wherein the method includes the steps of: (S1) introducing a first fluid and a second fluid into a reactor, and reacting the compounds included in the fluids, and (S2) obtaining the modified polymerization initiator prepared by the reaction of the step (S1) through an outlet of the reactor, wherein the step (S1) and step (S2) are continuously performed, wherein in the step (S1), the flow amount of the first fluid and the second fluid is maintained constant at the time when the first fluid and the second fluid are mixed, and the flow rate of the first fluid is increased. Also, the present invention provides an apparatus for producing a modified polymerization initiator for performing the same.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: February 2, 2021
    Inventors: Tae Chul Lee, Won Hee Kim, Hae Sung Sohn, No Ma Kim
  • Patent number: 10899701
    Abstract: Provided are a method for producing N-(?-alkoxyethyl)formamide, comprising adding an acid catalyst to the mixed liquid within 3 hours from start of mixing after mixing of N-(?-hydroxyethyl)formamide with an alcohol has been started, by which the N-(?-alkoxyethyl)formamide can be produced at a high yield without additional investment in plant and equipment while suppressing an increase in the temperature of the mixed liquid and preventing corrosion of a pipe; and a method for producing N-(?-alkoxyethyl)formamide, comprising degassing carbon dioxide in the reaction of N-(?-hydroxyethyl)formamide with an alcohol, by which the N-(?-alkoxyethyl)formamide having a decreased carbonate concentration can be produced.
    Type: Grant
    Filed: January 8, 2019
    Date of Patent: January 26, 2021
    Assignee: Mitsubishi Chemical Corporation
    Inventors: Kouji Teramoto, Yasuharu Mori, Hitoshi Nishimura
  • Patent number: 10875824
    Abstract: A nickel diatomaceous earth catalyst having a weight loss rate measured by hydrogen-TG at 400 to 600° C. of 0.05 to 2.0%.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: December 29, 2020
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Kouji Suzuki, Hajime Yamada
  • Patent number: 10870621
    Abstract: The present invention relates to a process for preparing latanoprostene bunod and an intermediate therefor. In accordance with the preparation process of the present invention, latanoprostene bunod can be efficiently and cost-effectively prepared while reducing side reactions.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: December 22, 2020
    Assignee: YONSUNG FINE CHEMICAL CO., LTD.
    Inventors: Eun Jeong Ko, Hyun Ik Shin, Kee Young Lee, Chang Young Oh
  • Patent number: 10851039
    Abstract: The present invention provides a polyhydric phenol compound which has an excellent alkali resistance and which does not cause a deterioration in color even when used as a resin raw material or a color developer. The polyhydric phenol compound includes: a bisphenol compound (A) represented by the following Formula (1) and a trisphenol compound (B) represented by the following Formula (2): [wherein R1 represents a monovalent aliphatic hydrocarbon group having from 6 to 24 carbon atoms; each of R2, R3, R4, R5 and R6 represents a monovalent hydrocarbon group having from 1 to 15 carbon atoms; and each of a, b, c, d and e represents an integer from 0 to 4]; wherein the trisphenol compound (B) is contained in an amount, in terms of absorption intensity ratio at 254 nm, of less than 1.6% by area with respect to the amount of the bisphenol compound (A).
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: December 1, 2020
    Assignee: MITSUBISHI CHEMICAL CORPORATION
    Inventors: Takeshi Nakamura, Yoshie Takami, Tomoko Maeda, Naoko Sumitani, Hiroki Shibata, Toshiki Monden
  • Patent number: 10836693
    Abstract: The present invention provides a process for the preparation of Docosanol (I). The process comprises reducing cis-13-Docosenoic acid (V) to obtain Docosanoic acid (III), which is further reduced to obtain Docosanol (I).
    Type: Grant
    Filed: May 28, 2018
    Date of Patent: November 17, 2020
    Assignee: Aurobindo Pharma Ltd.
    Inventors: Nandi Sukumar, Theriviam Sudalayandi Shanmugam Sundaram Dhanraj, Sreedhar Reddy Dwarakapally, Ravi Kumar Gupta Miriyala, Sivakumaran Meenakshisunderam
  • Patent number: 10836781
    Abstract: The present invention relates to an improved process for the preparation of tetrofosmin or acid addition salt thereof. The present invention also relates to the process for the preparation of tetrofosmin disulfosalicylate salt. Further the present invention also provides the polymorphic form J of disulfosalicylate salt of tetrofosmin.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: November 17, 2020
    Assignee: JUBILANT GENERICS LIMITED
    Inventors: Mokkapati Umamaheshwar Prasad, Anjul Kumar, Shishupal Singh, Dharam Vir
  • Patent number: 10814314
    Abstract: The present invention relates to a catalyst for aminating a polyether polyol and preparation method thereof and a method of preparing a polyetheramine using the catalyst. The catalyst has active components and a carrier. The active components are Ni, Cu, and Pd. The method of preparing the catalyst comprises the following steps: using a metal solution or a metal melt impregnated carrier, obtaining a catalyst precursor; and drying and calcinating the obtained catalyst precursor, so as to obtain a catalyst. By introducing the active component Pd in the catalyst, the present invention clearly improves selectivity of an amination catalyst with respect to a preaminated product, and increases raw material conversion rate.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: October 27, 2020
    Assignee: Wanhua Chemical Group Co., Ltd.
    Inventors: Congying Zhang, Shujie Ren, Xin Li, Zhenguo Liu, Xiaolong Wang, Ningning Wang, Hao Chen, Yuan Li, Xueli Yu, Jinhong Song
  • Patent number: 10807935
    Abstract: A process for producing acetic acid that involves operating the flash vessel and first column at the lowest possible pressure for a given production rate is described. Low pressures are achieved by operating on a back pressure established by a vapor discharge from an absorbing system. This reduces the pressure differential to allow steady and efficient acetic acid production.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: October 20, 2020
    Assignee: CELANESE INTERNATIONAL CORPORATION
    Inventor: Ronald D. Shaver
  • Patent number: 10800737
    Abstract: The present invention relates to a cost-effective and efficient method for preparing treprostinil with high purity, and an intermediate therefor.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: October 13, 2020
    Assignee: YONSUNG FINE CHEMICAL CO., LTD.
    Inventors: Hyun Ik Shin, Hyoseon Lee, Kyung Jin Lee, Kee Young Lee, Changyoung Oh
  • Patent number: 10793512
    Abstract: Disclosed is a preparation method for a racemic adrenaline as represented by formula II. The method comprises the following steps: compound 1 is directly racemized in an acidic solution to produce compound 2, the acid solution comprising neither sodium bisulfite nor salicylic acid; and specifically comprises (a), in the acid solution of which the pH is 0.5-1.5, compound 1 is placed under the protection of nitrogen gas and, with the reaction temperature being controlled at 75-95° C., stirred and reacted for 1-3 hours; (b) the reaction solution is controlled at a temperature of 5-20° C., into which an activated carbon is added, under the protection of nitrogen gas, stirred for 20-40 minutes, and filtered, then a filtrate is collected; the filtrate is controlled at a temperature of 5-20° C., the pH thereof is adjusted using ammonia to 8.5-9.5, and is filtered when the pH is stabilized, and a filter cake is washed and dried to produce a high purity racemic adrenaline white powder.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: October 6, 2020
    Assignee: AMPHASTAR NANJING PHARMACEUTICALS INC.
    Inventors: Yin Wang, Aoxiang Zhang, Yonggang Xu, Song Chen, Haoning Zhang