Patents Examined by Ana Z Muresan
  • Patent number: 10428014
    Abstract: The present invention relates to a compound represented by the general formula (A), a base generator comprising the compound, a base-reactive composition which comprises the base generator and a base-reactive compound, as well as a method for generating a base, etc.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: October 1, 2019
    Assignees: FUJIFILM Wako Pure Chemical Corporation, Tokyo University of Science Foundation
    Inventors: Nobuhiko Sakai, Kosuke Yanaba, Koji Arimitsu
  • Patent number: 10428003
    Abstract: It is intended to provide an acetic acid production method capable of industrially advantageously separating and removing a by-product acetaldehyde in the separation step of separating a process stream into aqueous and organic phases. In the present invention, the separation step satisfies, for example, the following conditions (vi) to (viii), and at least a portion of the aqueous phase is treated in the acetaldehyde separation and removal step: (vi) acetaldehyde concentrations in the aqueous and/or organic phases are not more than 28.1 mass % and not more than 24.8 mass %, respectively; (vii) a separation temperature is not more than 70° C.; and (viii) methyl acetate concentrations in the aqueous and/or organic phases are not more than 12.0 mass % and not more than 47.6 mass %, respectively, and/or the sum of the methyl acetate concentrations in the aqueous and organic phases is not more than 59.6 mass %.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: October 1, 2019
    Assignee: DAICEL CORPORATION
    Inventors: Masahiko Shimizu, Susumu Goda, Hiroyuki Miura
  • Patent number: 10428005
    Abstract: It is intended to provide a method capable of industrially and efficiently producing acetic acid having a good potassium permanganate test value without a large cost. The method includes a step of distilling an aqueous phase and/or an organic phase of a column top condensate of a lower boiling point component removal column by a crotonaldehyde removal column; and the reflux ratio of the lower boiling point component removal column is not less than 2 (when the aqueous phase is refluxed), and the crotonaldehyde removal column is operated such that at least one of the following conditions (i) to (iii) is satisfied: (i) the reflux ratio of the distillation column is not less than 0.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: October 1, 2019
    Assignee: DAICEL CORPORATION
    Inventor: Masahiko Shimizu
  • Patent number: 10428004
    Abstract: It is intended to provide a method capable of suppressing distillation apparatus corrosion as a method for producing acetic acid, comprising the step of distilling a crude acetic acid solution containing acetic acid and an impurity having a higher boiling point than that of acetic acid to purify the acetic acid. The method for producing acetic acid of the present invention comprises the step described above, wherein the distillation of the crude acetic acid solution is performed under a condition involving a distillation column bottom temperature of not more than 165° C. An acetic acid concentration in the crude acetic acid solution to be subjected to the distillation is preferably not less than 90 mass %. Examples of the impurity having a higher boiling point than that of acetic acid include acetate salts, acetic anhydride, and propionic acid. A column bottom pressure of the distillation column is preferably less than 0.255 MPaG.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: October 1, 2019
    Assignee: DAICEL CORPORATION
    Inventors: Masahiko Shimizu, Yoshihisa Mizutani
  • Patent number: 10421708
    Abstract: The present disclosure provides a sensitizer for UV-LED photocuring, having a chemical structure as represented by formula (I). This sensitizer has a very good adaptability to existing photoinitiators, can significantly improve the curing efficiency under the irradiation of a UV-LED light source when used in a photocurable composition, and has excellent application properties.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: September 24, 2019
    Assignee: Changzhou Tronly New Electronic Materials Co., Ltd.
    Inventor: Xiaochun Qian
  • Patent number: 10421715
    Abstract: A pleuromutilin derivative having a 2-amino phenyl mercaptan side chain as well as a preparation method and application thereof are provided. The derivative has a structure represented by formula 2 or formula 3, wherein, R1, R2 and R3 are each independently selected from a hydrogen atom, hydroxyl, amino, sulfydryl, hydroxymethyl, amine methyl, nitro, halogen, trihalogenated methyl, methyl, natural amino acid acylamino and C1-6 alkoxy. The plueuromutilin derivative in the disclosure has good activity of inhibiting drug-resistant Staphylococcus aureus and mycoplasma, and is especially suitable for preventing and treating infectious diseases caused by human or animal mycoplasma or drug-resistant Staphylococcus aureus or multidrug resistant bacteria as a novel antibacterial drug.
    Type: Grant
    Filed: December 29, 2018
    Date of Patent: September 24, 2019
    Assignee: SOUTH CHINA AGRICULTURAL UNIVERSITY
    Inventors: Youzhi Tang, Yahong Liu, Zhaosheng Zhang
  • Patent number: 10399936
    Abstract: The present invention relates to an industrial process for the preparation of (5S,10S)-10-benzyl-16-methyl-11,14,18-trioxo-15,17,19-trioxa-2,7,8-trithia-12-azahenicosan-5-aminium (E)-3-carboxyacrylate salt of following formula (I): wherein X is fumarate. This process comprises the following successive key steps: a kinetic resolution, formation of disulfide compound, peptide coupling, and anion exchange reaction to obtain the desired product of formula (I).
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: September 3, 2019
    Assignee: PHARMALEADS
    Inventors: Herve Poras, Loic Lefebvre, Xinjun Zhao, Luca Gamberoni, Sabrina De Rosa, Rosario Velardi
  • Patent number: 10392317
    Abstract: The present disclosure provides methods to produce para-xylene, toluene, and other compounds from renewable sources (e.g., cellulose, hemicellulose, starch, sugar) and ethylene in the presence of a catalyst. For example, cellulose and/or hemicellulose may be converted into 2,5-dimethylfuran (DMF), which may be converted into para-xylene by cycloaddition of ethylene to DMF. Para-xylene can then be oxidized to form terephthalic acid.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: August 27, 2019
    Assignee: MICROMIDAS, INC.
    Inventors: Makoto N. Masuno, Ryan L. Smith, John Bissell, II, Patrick B. Smith, Dennis A. Hucul, Edmund J. Stark, Daniel R. Henton, Adina Dumitrascu, Katherine Brune, Dimitri A. Hirsch-Weil
  • Patent number: 10385011
    Abstract: Disclosed are a novel benzoic acid amide derivative compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof, or a solvate thereof. The novel compound and the like inhibit melanin production, prevent tyrosinase activity, and have an excellent skin whitening effect.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: August 20, 2019
    Assignee: AMOREPACIFIC CORPORATION
    Inventors: Yung Hyup Joo, Soo Jeong Choi, Heung Soo Baek, Chang Seok Lee, Jeong Hwan Kim, Yongjin Kim, Hong-Ju Shin, Ho Sik Rho, Song Seok Shin, Jon Hwan Lee
  • Patent number: 10384996
    Abstract: A fluorene-containing compound having a formula (I) where X and R are as defined in as defined in the specification.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: August 20, 2019
    Assignee: National Kaohsiung University of Applied Sciences
    Inventors: Fu-San Yen, Chi-Han Hsieh
  • Patent number: 10385016
    Abstract: The invention relates to a compound of the general formula (I) N3O2S—Ar-L-Ar?—SO2N3, wherein: —Ar and Ar? are aromatic building blocks; and —L is a linking group comprising at least one heteroatom as well as an organic chain denoted as Sp? and having at least two carbon atoms. The invention also relates to a compound of the general formula (II) wherein: —Ar and Ar? are aromatic building blocks; —L is a covalent bond or a linking group; —m and n are both 0 or 1, at least one of m and n being 1; —Sp and Sp? are organic chains having at least two carbon atoms. The invention also relates to the use of these compounds as cross linking agents in the manufacture of polymers.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: August 20, 2019
    Assignee: DYNAMIT NOBEL GMBH EXPLOSIVSTOFF-UND SYSTEMTECHNIK
    Inventors: Jan Haller, Thierry Durand
  • Patent number: 10377697
    Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: August 13, 2019
    Assignee: Novartis AG
    Inventors: Florian Karl Kleinbeck-Riniker, Benjamin Martin, Gerhard Penn, Francesco Venturoni, Thierry Schlama, Thomas Ruch, Thomas Allmendinger, Bernhard Wietfeld, Paolo Filipponi
  • Patent number: 10370326
    Abstract: The invention relates to a process for the production of urea ammonium nitrate, a system and a method of modifying a plant. The process comprises subjecting ammonia-containing off-gas resulting from the production of ammonium nitrate (AN off-gas) to condensation under acidic conditions so as to form an acidic a acidic scrubbing liquid in a finishing treatment section having a gas inlet in fluid communication with a gas outlet of a finishing section of a urea production unit, wherein the finishing section is adapted to solidify urea liquid, and wherein said finishing treatment section is adapted to subject ammonia-containing off-gas of the finishing section to treatment with an acidic scrubbing liquid.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: August 6, 2019
    Assignee: Stamicarbon B.V.
    Inventors: Giusy Elisa Puci, Joey Dobree
  • Patent number: 10370393
    Abstract: The present disclosure provides tri-orthoalkylphenyl phosphine catalysts of formula I wherein A is CH2, C?O, or NRA; R1 is aryl, heteroaryl, isopropyl, tert-butyl, cycloalkyl, or heterocycloalkyl, wherein aryl, heteroaryl, cycloalkyl and heterocycloalkyl are optionally substituted; R2 is H, (C1-C8)alkyl, (C1-C8)alkoxy, N(RA)2, or an electron withdrawing group; and each RA is independently H or (C1-C8)alkyl; that are tuned electrically and sterically.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: August 6, 2019
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Martin D. Burke, Ian Crouch, Jonathan Lehmann, Andrea Palazzolo, Claire Simons
  • Patent number: 10370318
    Abstract: The present invention provides a method for preparing acetic acid by carbonylation of methanol, which comprises: passing a raw material containing methanol, carbon monoxide and water through a reaction region loaded with a catalyst containing an acidic molecular sieve with an adsorbed organic amine, and carrying out a reaction under the following conditions to prepare acetic acid. The method in the present invention offers high acetic acid selectivity and good catalyst stability. The catalyst in the present invention does not contain noble metals such as rhodium or iridium, and does not need additional agent containing iodine, and thus does not generate a strong corrosive hydroiodic acid and the like.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: August 6, 2019
    Assignee: Dalian Institute of Chemical Physics, Chinese Academy of Sciences
    Inventors: Youming Ni, Wenliang Zhu, Lei Shi, Hongchao Liu, Yong Liu, Zhongmin Liu
  • Patent number: 10363230
    Abstract: Derivatives of 6-shogaol are described herein. Also described herein are methods of preparing the derivatives, as well as methods of using the derivatives to activate Nrf2 and to treat diseases associated with inflammation and/or oxidative stress.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: July 30, 2019
    Assignee: North Carolina Agricultural and Technical State University
    Inventors: Shengmin Sang, Yingdong Zhu
  • Patent number: 10358404
    Abstract: This invention relates to an improved continuous process for the production of low molecular weight polyoxyalkylene polyether polyols. These polyoxyalkylene polyether polyols have a hydroxyl content of from about 3.4 to about 12.1% by weight, and may also be characterized as having an OH number of from about 112 to about 400. The process comprises establishing oxyalkylation conditions in a continuous reactor in the presence of a DMC catalyst; continuously introducing alkylene oxide and a low molecular weight starter into the continuous reactor; recovering a partially oxyalkylated polyether polyol from the reactor; and allowing the recovered partially oxyalkylated polyether polyol to further reactor until the unreacted alkylene oxide content of the mixture is reduced to 0.001% or less by weight.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: July 23, 2019
    Assignee: Covestro LLC
    Inventor: Jack R. Reese
  • Patent number: 10351513
    Abstract: Provided are: a compound, a thickening/stabilizing agent including the compound, a thickened/stabilized composition including the thickening/stabilizing agent and a fluid organic substance, and a method for producing the thickened/stabilized composition, where the compound effectively thickens the fluid organic substance to a desired viscosity and effectively uniformly stabilizes the formulation of the composition containing the fluid organic substance via thickening of the fluid organic substance. The thickening/stabilizing agent according to the present invention includes a compound represented by Formula (1): (R2—HNOC)4-n—R1—(CONH—R3)n??(1) where R1 is a group resulting from removing four hydrogen atoms from the structural formula of butane; R2 and R3 are different from each other and are aliphatic hydrocarbon groups each containing 4 or more carbon atoms; and n is an integer of 1 to 3.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: July 16, 2019
    Assignees: DAICEL CORPORATION, YAMAGUCHI UNIVERSITY
    Inventors: Yuichi Sakanishi, Takashi Saeki, Mami Itoh
  • Patent number: 10343983
    Abstract: A polycarbamate comprising having less than 5 wt % total of biuret, cyanuric acid, and polyallophanate; and has a Gardner level of equal or greater than 3 is provided. A coating comprising the polycarbamate is also provided.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: July 9, 2019
    Assignee: Dow Global Technologies LLC
    Inventors: Xinrui Yu, Yiyong He, John W. Hull, Jr., Daryoosh Beigzadeh, Duane R. Romer, Thomas P. Clark, Peter Margl, Congcong Lu
  • Patent number: 10343973
    Abstract: A method for producing a bifunctional compound of formula (3) wherein R2 represents H, CH3 or C2H5, the method comprising reducing a bifunctional compound of formula (1): wherein R1 represents COOCH3, COOC2H5, COOC3H7, COOC4H9, or CHO; and R2 represents H, CH3 or C2H5, provided that when R1 represents CHO, R2 represents C2H5, in the presence of a catalyst having hydrogenation activity and hydrogen.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: July 9, 2019
    Assignee: MITSUBISHI GAS CHEMICAL COMPANY, INC.
    Inventors: Takashi Motoi, Mitsuharu Kitamura, Manabu Hirakawa