Patents Examined by Ana Z Muresan
  • Patent number: 12221409
    Abstract: Provided in the present invention is a method for preparing chiral alkyl compounds by the asymmetric hydrogenation reaction of iron complex catalysts catalysing olefins: using the disubstituted olefin shown in formula I as a raw material, atmospheric hydrogen as a hydrogen source, FeX2-8-OIQ complex as a catalyst, and a silane compound and acetonitrile as cocatalysts, and reacting for 12-24 hours under the action of a reducing agent to prepare the chiral alkyl compound shown in formula II. The method of the present invention has mild reaction conditions, simple operation, and high atom economy. In addition, the reaction does not require the addition of any other toxic transition metal (such as ruthenium, rhodium, and palladium), and has great practical application value in the synthesis of drugs and materials. The conversion rate of the reaction is also good, generally reaching >99%, and the enantioselectivity is also high, generally 70-99%.
    Type: Grant
    Filed: June 16, 2023
    Date of Patent: February 11, 2025
    Assignee: Zhejiang University
    Inventors: Zhan Lu, Peng Lu, Xiang Ren
  • Patent number: 12215105
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.
    Type: Grant
    Filed: September 11, 2020
    Date of Patent: February 4, 2025
    Assignee: Nimbus Saturn, Inc.
    Inventors: Neelu Kaila, Ian Linney, Stuart Ward, Grant Wishart, Ben Whittaker, Alexandre Cote, Jeremy Robert Greenwood, Abba Leffler, Steven K. Albanese, Daniel L. Severance, Robert Griffiths
  • Patent number: 12208377
    Abstract: A solution consisting of: a poly(a-olefin) (PAO) selected from the group consisting of PAO283, PAO432, and PAO687; and a reactive organometallic reagent selected from the group consisting of n-butyllithium, sec-butyllithium, tert-butyllithium, n-butyllithium in hexane, sec-butyllithium in cyclohexane, and tert-butyllithium in pentane.
    Type: Grant
    Filed: July 30, 2019
    Date of Patent: January 28, 2025
    Assignee: The Texas A&M University System
    Inventors: David E. Bergbreiter, Thomas J. Malinski
  • Patent number: 12202796
    Abstract: A method of preparing 3(4),8(9)-bisformyltricyclo[5.2.1.02,6]decane is provided. According to the present invention, 3(4),8(9)-bisformyltricyclo[5.2.1.02,6]decane (TCDDA) may be prepared with a high conversion rate and purity without a separate catalyst recovery process.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: January 21, 2025
    Assignee: SK Chemicals Co., Ltd.
    Inventors: Hee Il Chae, Jeong Ho Park, Kyung Sil Yoon, Ju-Sik Kang, Yu Mi Chang, Nam-Choul Yang, Jae Kyun Park, Song Lee
  • Patent number: 12187668
    Abstract: Compounds, pharmaceutical compositions, methods and kits are described for treating or preventing neurodegenerative diseases such as Alzheimer's disease.
    Type: Grant
    Filed: February 16, 2022
    Date of Patent: January 7, 2025
    Assignee: Alzheon, Inc.
    Inventors: Petr Kocis, Martin Tolar, John Hey
  • Patent number: 12187670
    Abstract: Oxidizing a first aromatic compound in the presence of a metal salt to yield a second aromatic compound includes combining the first aromatic compound, the metal salt, and water to yield an aqueous mixture, and heating the aqueous mixture at a temperature exceeding 200° C. to yield a reaction product that includes the second aromatic compound.
    Type: Grant
    Filed: January 25, 2021
    Date of Patent: January 7, 2025
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Grant Loescher, Everett Shock, Ian Gould, Hilairy Hartnett, Lynda B. Williams
  • Patent number: 12186284
    Abstract: There is provided a composition comprising an organic material and at least a first surfactant which following addition of an aqueous solution to the composition can form a biphasic system, wherein the biphasic system is useful for the treatment of or prevention of hoof infections. Also provided is a biphasic system useful for the treatment of or prevention of hoof infections, wherein the biphasic system comprises the composition and an aqueous phase wherein the composition is dispersed as droplets within the aqueous phase.
    Type: Grant
    Filed: April 26, 2022
    Date of Patent: January 7, 2025
    Assignee: Provita Eurotech Ltd.
    Inventors: Michael Kerr, Teresa Allen
  • Patent number: 12180221
    Abstract: The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.
    Type: Grant
    Filed: September 22, 2020
    Date of Patent: December 31, 2024
    Assignee: JANSSEN PHARMACEUTICA NV
    Inventors: Bertrand Le Bourdonnec, Matthew Lucas, Kerem Ozboya, Bhaumik Pandya, Parcharee Tivitmahaisoon, Iwona Wrona
  • Patent number: 12180151
    Abstract: This invention provides compounds of Formulae (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (IJ), (IK), (IL), (II), (III), (IIIA), and (IIIB); pharmaceutically acceptable salts and solvates thereof; and compositions thereof.
    Type: Grant
    Filed: June 1, 2023
    Date of Patent: December 31, 2024
    Assignee: Espervita Therapeutics, Inc.
    Inventor: Daniela Carmen Oniciu
  • Patent number: 12098122
    Abstract: A system and method for producing acetic acid, including dry reforming methane with carbon dioxide to give syngas, cryogenically separating carbon monoxide from the syngas giving a first stream including primarily carbon monoxide and a second stream including carbon monoxide and hydrogen. The method includes synthesizing methanol from the second stream via hydrogenation of carbon monoxide in the second stream, synthesizing dimethyl ether from the methanol, and generating acetic acid from the dimethyl ether and first-stream carbon monoxide.
    Type: Grant
    Filed: March 19, 2021
    Date of Patent: September 24, 2024
    Assignee: Saudi Arabian Oil Company
    Inventors: Ali Shakir Al Hunaidy, Hasan Imran, Hyungmuk Lim, Kosan Roh, Jay H. Lee
  • Patent number: 12090473
    Abstract: The present invention relates to catalyst compositions for hydroformylation processes and to hydroformylation processes utilizing certain catalysts. In one aspect, a catalyst composition for a hydroformylation process comprises (a) a transition metal; (b) a monophosphine; and (c) a tetraphosphine having the structure described herein, and wherein the composition comprises at least 40 moles of monophosphine per mole of transition metal.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: September 17, 2024
    Assignee: Dow Technology Investments LLC
    Inventor: Michael A. Brammer
  • Patent number: 12091378
    Abstract: The invention provides novel compounds, pharmaceutical compositions and methods of preparation and use thereof for treating disease affecting the central nervous system such as multiple sclerosis.
    Type: Grant
    Filed: May 23, 2022
    Date of Patent: September 17, 2024
    Assignees: GLOBE BIOMEDICAL CO., LTD., GLOBE HEALTH INSTITUTE LLC
    Inventors: Chiang J. Li, Suzhen Chen, Jifeng Liu
  • Patent number: 12083118
    Abstract: The present invention includes substituted 3,3?bis(phenoxymethyl)-1,1?-biphenyl compounds, analogues thereof, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a patient.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: September 10, 2024
    Assignee: Arbutus Biopharma Corporation
    Inventors: Yingzhi Bi, Bruce D. Dorsey, Yi Fan, Christopher Brooks Moore, Duyan Nguyen
  • Patent number: 12064513
    Abstract: The invention provides a cationic lipid, a lipid membrane structure containing same, and use thereof. The cationic lipid is represented by the formula (1) wherein R1a, R1b, R2a, R2b, R3a, R3b, Xa, Xb, Ya, Yb, Za, and Zb are as defined in the specification.
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: August 20, 2024
    Assignees: NOF CORPORATION, NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
    Inventors: Yuta Nakai, Kota Tange, Hiroki Yoshioka, Shinya Tamagawa, Hidetaka Akita, Hiroki Tanaka, Nae Takata, Manami Konishi, Tatsunari Takahashi
  • Patent number: 12065442
    Abstract: Bivalent compounds, compositions comprising one or more of the bivalent compounds, and methods of use the bivalent compounds for the treatment of certain disease in a subject in need thereof are provided. Methods for identifying such bivalent compounds are provided, either.
    Type: Grant
    Filed: August 21, 2019
    Date of Patent: August 20, 2024
    Assignee: CULLGEN (SHANGHAI), INC.
    Inventors: Jing Liu, Liqun Chen
  • Patent number: 12054449
    Abstract: The present invention relates to crystalline forms of a phenyl carbamate derivative compound and compositions and uses thereof.
    Type: Grant
    Filed: March 17, 2023
    Date of Patent: August 6, 2024
    Assignee: Bio-Pharm Solutions Co., Ltd.
    Inventor: Yong Moon Choi
  • Patent number: 12049437
    Abstract: The diisocyanate composition according to an embodiment of the present invention comprises, in the composition, a benzyl isocyanate having a methyl group in an amount of 5 ppm to 200 ppm, an aromatic compound having a halogen group in an amount of 5 ppm to 1,000 ppm, a benzyl isocyanate having an ethyl group in an amount of 1 ppm to 1,000 ppm, or a combination thereof. It is possible to improve the optical characteristics by preventing the occurrence of yellowing, striae, and cloudiness and to enhance the mechanical properties such as impact resistance at the same time. Thus, it can be advantageously used to prepare an optical material of high quality.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: July 30, 2024
    Assignees: SK PUCORE CO., LTD., WOORI FINE CHEM CO., LTD.
    Inventors: Jaeyoung Pai, Jeongmoo Kim, Hyuk Hee Han, Jung Hwan Myung, Myung-Ok Kyun, Jooyoung Jung
  • Patent number: 12018303
    Abstract: Described herein is a method for preparing an amino salt compound, the method including: i) providing a carbonyl compound; ii) reacting the carbonyl compound provided according to (i) in the presence of a transaminase with ii-a) at least one primary amine; and ii-b) at least one carboxylic acid; thereby obtaining a mixture including an at least partially crystallized amino salt compound including a cation and a carboxylate anion based on the at least one carboxylic acid added according to (ii-b). Also described herein is an amino salt compound obtained or obtainable by the method and to the amino salt compound, and a composition including a) an amine of general formula (IIa); and b) at least one carboxylic acid of general formula (III).
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: June 25, 2024
    Assignee: Enzymicals AG
    Inventors: Jan Von Langermann, Dennis Hülsewede, Marco Cornelius, Ulf Menyes, Philipp Süss
  • Patent number: 11987548
    Abstract: The invention provides methods of preparing 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid and methods of making a pharmaceutical material comprising a purified amount of 8-hydroxy-2,2,14, 14-tetramethylpentadecanedioic acid. Also provided are compositions and pharmaceutical materials including a purified amount of 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid as well as methods of treating various diseases and conditions using the compositions and pharmaceutical materials.
    Type: Grant
    Filed: July 19, 2022
    Date of Patent: May 21, 2024
    Assignee: Esperion Therapeutics, Inc.
    Inventors: Richard Copp, Mohamed Abdelnasser, Christopher M. Cimarusti, Jonathan Lane, Michael Barkman, Rasidul Amin, Arthur John Cooper, Damodaragounder Gopal, Philipp Selig
  • Patent number: 11964955
    Abstract: Described are specific mixtures comprising one or more (cannabinoid) compounds of the formula (A) and/or one or more of their salts as well was methods for their production. Further described are a compound of the formula (A), a salt of the formula (A) and a corresponding mixture for use as a medicament or, respectively, for use in a method for therapeutic treatment of the human or animal body. Described are also corresponding pharmaceutical formulations, cosmetic preparations and preparations for pleasure and/or nutrition, suitable for consumption, as well as methods for producing CBDV and THCV.
    Type: Grant
    Filed: December 7, 2020
    Date of Patent: April 23, 2024
    Assignee: SYMRISE AG
    Inventors: Oskar Koch, Marcus Rudolf Götz