Abstract: Medical devices, perfusion systems, and methods for detecting a pressure within a space in a subject and for perfusion of fluid into a space in a subject. The space may be a fluid-filled space, or a space that is depleted of fluid due to an obstruction to fluid flow into the space. Methods for forming the medical devices.

Abstract: A pressure isolation mechanism including a valve housing which defines a first lumen associated with a pressurizing device, a second lumen associated with an input line which connects a low pressure fluid delivery system to the valve housing, and a pressure isolation port is disclosed. The pressure isolation mechanism further includes a first valve having a normally open position permitting fluid communication between the first lumen and the second lumen and movable to a closed position when fluid pressure in the first lumen reaches a predetermined pressure level, and a second valve disposed within the second lumen and regulating fluid flow through the second lumen, wherein the second valve substantially isolates the input line from a pressure transducer connected to the pressure isolation port. A method for correcting for dampened hemodynamic blood pressure signals in a fluid delivery system which includes the pressure isolation mechanism is also described.

Abstract: Injection devices for delivering pharmaceutical compositions into the eye are described. Some devices include a resistance component for controllably deploying an injection needle through the eye wall. The resistance component may be disposed on a removable injector attachment or on a portion of the injection device housing. Other devices may include a filter for the removal of air, infectious agents, and/or other particulate matter from the composition before the composition is injected into the eye. Related methods and systems comprising the devices are also described.

Abstract: A miniature portable multifunctional infusion device includes a liquid bottle (4) and a film box body (16) secured to a support frame (1). The film box body (16) is respectively provided with a directional input interface (17) and a directional output interface (14) in communication with the liquid bottle (4) and a needle via an infusion pipe. The film box body (16) is installed with an elastic film (27), and a transmission system (31) is arranged at a side of the elastic film (27). The transmission system (31) includes a miniature direct current motor (32) connected to a frequency modulating system (28). The miniature direct current motor (32) is connected to a spiral straightening device (34) via a speed reducer (33), and the spiral straightening device (34) is connected to a reciprocating film propping device (36) via a two-order shaft (43). A truncated cone (39) of the reciprocating film propping device (36) at a front end is in contact with the elastic film (27).

Abstract: A portable insulin pump can utilize readings from a sensor incorporated into an infusion set used with the pump to deliver insulin to a patient to determine if the infusion set is or is likely to become dislodged from the patient. Readings from the sensor that are inconsistent with expected readings or a range of expected readings can indicate that the infusion set has become dislodged from the patient.

Abstract: Disclosed is a system and method for enabling user preview and control of the size and shape of an electromagnetic energy field used in a surgical procedure. The disclosed system includes a selectively activatable source of microwave surgical energy in the range of about 900 mHz to about 5 gHz in operable communication with a graphical user interface and a database. The database is populated with data corresponding to the various surgical probes, such as microwave ablation antenna probes, that may include a probe identifier, the probe diameter, operational frequency of the probe, ablation length of the probe, ablation diameter of the probe, a temporal coefficient, a shape metric, and the like. The probe data is graphically presented on the graphical user interface where the surgeon may interactively view and select an appropriate surgical probe. Three-dimensional views of the probe(s) may be presented allowing the surgeon to interactively rotate the displayed image.

Abstract: The present invention relates to a medicament delivery device (100) having a a drive mechanism arranged to drive a plunger rod (12). A last dose limiting mechanism is arranged to interact with the drive mechanism and limit the distal end position of an actuator (3) when the plunger rod (12) has reached a pre-determined position between its distal end position and its proximal end position.

Abstract: The breakaway assembly includes a first breakaway subassembly and a second breakaway subassembly. The subassemblies are configured to connect, which causes bellows sheaths in each subassembly to compress and open pores, allowing fluid to flow through the subassemblies. The subassemblies can be connected to luer tip. The luer tips can be connected to the an intravenous (IV) fluid line or other types of lines used in the medical field to move fluids. This allows the movement of fluid from a fluid-holding component to a patient. Unless the subassemblies are locked together, the subassemblies will be disconnected under the correct amount of pressure. This disconnection closes the pores on the subassemblies, which keeps fluid from leaking, and prevents the contamination of the IV line. Luer tips may also be connected to the subassemblies. Some of the luer tips allow for the quick connection of the luer tip to the subassembly through a flange being inserted into a notch or flange acceptor.

Abstract: In an elongated casing, an active agent container connected to an injection needle can be shifted axially by a spring force. Auto-injectors which are sold or distributed filled and with the springs tensed have to be provided with a needle protecting cap to ensure the sterility of the injection needle. When such a needle protecting cap is removed as preparation for using the auto-injector, a tensile force can be exerted on the active agent container. Therefore, the active agent container comprising the injection needle must be prevented from being undesirably pulled forwards. At least one latching tongue prevents the active agent container from being prematurely shifted with respect to the casing, by abutting a flange arranged on a sliding sleeve which accommodates the active agent container. When the auto-injector is placed onto a person's skin, a needle protecting tube is shifted into the casing, forcing the latching tongue away from the flange and, thus, freeing the travel path for needle movement.

Abstract: The present invention is directed to a pen-type injector equipped with a cartridge holder for a drug delivery device. The cartridge holder has a longitudinal axis and comprises a body for receiving a cartridge, wherein the body comprises at a proximal end engagement means for releasably coupling the cartridge holder to the drug delivery device, a latch member for releasably engaging a cap of the drug delivery device and an alignment element which is visual from the outer side of the body. The alignment element may be an aperture provided in the body and/or a lug which forms the latch member.

Abstract: Some embodiments an infusion pump system can be configured to modify alarm limit parameters as the user's insulin load increases or decreases. Moreover, in particular embodiments, the infusion pump system can be configured to provide a “missed bolus” or “missed meal” alarm in response to the user's blood glucose characteristics, the user's insulin load information, or the like.

Abstract: It is an object of the present invention to provide a syringe which is capable of preventing an accident such that a patient inadvertently sticks her/his hand with an injection needle when improperly performing a needle retracting operation. A sleeve (10) is fitted around a syringe barrel (2) so as to be axially movable from an administration position such that the injection needle (5) projects to a distill side to an accommodation position such that the injection needle (5) is accommodated. A coil spring (16) for biasing the sleeve (10) toward the accommodation position is provided between the sleeve (10) and the syringe barrel (2), and is held in a compressed state in a spring holder (17). The spring holder (17) is disposed in association with the syringe barrel (2) so as to release the coil spring by further pushing the syringe barrel (2) to the distal side after completion of the administration of a liquid drug.

Abstract: A drive mechanism suitable for use in drug delivery devices is disclosed. The drive mechanism may be used with injector-type drug delivery devices, such as those permitting a user to set the delivery dose. The drive mechanism may include a housing, a dose dial sleeve, and a drive sleeve. A clutch is configured to permit rotation of the drive sleeve and the dose dial sleeve with respect to the housing when the dose dial sleeve and drive sleeve are coupled through the clutch. Conversely, when the dose dial sleeve and drive sleeve are in a de-coupled state, rotation of the dose dial sleeve with respect to the housing is permitted and rotation of the drive sleeve with respect to the housing is prevented. In the de-coupled state, axial movement of the drive sleeve transfers force in a longitudinal direction for actuation of a drug delivery device.

Abstract: A nitric oxide gas-releasing conduit configured for surgical implantation through a patient's tympanic membrane. The nitric oxide gas-releasing conduit comprises a gas-permeable cured resin material configured for releasably sequestering therein gas. The gas-permeable cured resin material is charged with nitric oxide gas. The nitric oxide gas-releasing conduit may be optionally coated with an antimicrobial gas-releasing composition. The gas-releasing coating composition may be configured to release nitric oxide.

Abstract: An autoinjector includes a housing for receiving in use in a generally longitudinal loading direction a syringe assembly including a syringe carrier and a syringe, the syringe including a syringe body having a slideable internal piston for expressing a dose contained in the body through a needle at a forward end thereof; a drive mechanism for providing drive for operation of the autoinjector and being disposed generally within the housing and including a mechanical energy source and a winder element for being rotated to charge the energy source, and an input transmission train operational between the syringe assembly and the winder element in use, whereby loading of the syringe assembly into the housing rotates the winder element to charge the energy source.

Abstract: A rapid exchange catheter comprises a guide wire lumen including a substantially sealed portion in which a lumen wall extends around an entire periphery thereof and a channel portion including a channel opening the lumen to an exterior of the catheter, wherein a width of the channel is less than a maximum width of the channel portion. A guide wire ramp extends into the channel portion, with the ramp extending further into the lumen of the channel portion as a distal end of the ramp is approached.

Abstract: An enhanced medicine cup for use with a medicine bottle is disclosed, the medicine cup having a sipping straw running along a sidewall of the cup, the straw enabling a person to easily sip medicine from the bottom of the cup. The sipping straw extends upward beyond the sidewall, having a first opening at it's top end, and extends downward along the sidewall, being sealed at it's bottom end, and having instead a second opening near its bottom end in its sidewall that is in fluid communication with the inside of the cup via a corresponding opening near the bottom of the cup. Retaining protrusions are provided around the inner surface of the sidewall of the cup that engage with a cooperative ridge on the outer surface of a cap or a neck of a medicine bottle so as to removably retain the enhanced medicine cup on the medicine bottle.

Abstract: A method for discharging fluid from a syringe and for mitigating occlusion conditions includes actuating the plunger of a syringe into a barrel. The method monitors fluid pressure within the barrel of the syringe and determines that an occlusion exists when the fluid pressure exceeds a predetermined threshold. The method actuates the plunger out of the barrel by a predetermined amount in response to the detected occlusion and actuates the plunger of the syringe into the barrel until a measured fluid pressure within the barrel of the syringe exceeds another predetermined threshold.

Abstract: A transdermal device (1) comprising at least one substrate (2) arranged to be applied against the dermal surface or the mucous membrane. The at least one active ingredient is grafted to the substrate (2) by at least one photolabile ligand, and at least one light source (11) operated by a control mechanism arranged to generate light pulses, of a predetermined wavelength, intended to break covalent bonds between the active ingredient and the ligand in order to release the active ingredient from the substrate (2). The substrate (2) comprises at least one porous matrix (6) with a three-dimensional structure comprising a plurality of pits (7) organized in a sponge-like fashion and constructed of a polymer chosen between chitin and chitosan, and the matrix (6) defines at least one three-dimensional tank (8). The active ingredient is contained and grafted by the ligand.

Abstract: A catheter insertable into a urethra to drain urine from a bladder includes a tubular portion, a sleeve disposed relative to the tubular portion, with the tubular portion having a bendable zone that is configured to allow the catheter to fold to a compact length. The catheter has a total catheter length measured between an end of a connector that is attachable to a drainage bag and an insertion end of the tubular portion that is insertable into the bladder. The compact length is less than the total catheter length, and the sleeve is operable to support the tubular portion by removing the bend in the bendable zone to thus align the connector axially with the insertion end of the tubular portion.