Patents Examined by Anish Gupta
  • Single branch heparin-binding growth factor analogs
    Patent number: 8101570
    Abstract: A heparin-binding growth factor (HBGF) analog having two substantially similar sequences (homodimeric sequences) branched from a single amino acid residue, where the sequences are analogs of a particular HBGF that binds to a heparin-binding growth factor receptor (HBGFR), or alternatively that bind to a HBGFR without being an analog of any particular HBGF. The homodimeric sequences may be derived from any portion of a HBGF. The synthetic HBGF analog may be an analog of a hormone, a cytokine, a lymphokine, a chemokine or an interleukin, and may bind to any HBGFR. Further provided are preparations for medical devices, pharmaceutical compositions and methods of using the same.
    Type: Grant
    Filed: May 24, 2010
    Date of Patent: January 24, 2012
    Assignee: BioSurface Engineering Technologies, Inc.
    Inventors: Kazuyuki Takahashi, Paul O. Zamora, Louis A. Pena, Xinhua Lin
  • Cyclic sulfones with aminobenzyl substitution useful as BACE inhibitors
    Patent number: 8093406
    Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
    Type: Grant
    Filed: July 9, 2009
    Date of Patent: January 10, 2012
    Assignee: Novartis AG
    Inventors: Emmanuelle Briard, Rainer Martin Lueoend, Rainer Machauer, Henrik Moebitz, Olivier Rogel, Jean-Michel Rondeau, Heinrich Rueeger, Marina Tintelnot-Blomley, Siem Jacob Veenstra
  • Polyethlene glycol modifications of thymosin alpha-1
    Patent number: 8080522
    Abstract: Polyethylene glycol modifications of thymosin alpha 1 (T&agr; 1-PEGs), their preparation process, the medicine composition containing them, and their application in the medicine for preventing and treating diseases related with immune deficiency and hypoimmunity, including hepatitis B, hepatitis C, hepatoma, malignant melanoma, non-small cell lung cancer, SARS, and AIDS etc.
    Type: Grant
    Filed: November 11, 2006
    Date of Patent: December 20, 2011
    Assignee: Institute of Pharmacology and Toxicology Academy of Military Mecical Sciences, P.L.A., China
    Inventors: Keliang Liu, Jiankun Qie, Jinbo Ma, Jianquan Zheng, Sijian Dong, Wenxia Zhou, Chunhui Qi
  • Treatment for obesity
    Patent number: 8076291
    Abstract: The present invention provides peptides and pharmaceutical compositions thereof for appetite suppression and weight control. Preferred peptides are calcitonin analogs, preferably with specific amino acid changes to make the peptide more amylin-like.
    Type: Grant
    Filed: January 22, 2010
    Date of Patent: December 13, 2011
    Assignee: Unigene Laboratories Inc.
    Inventors: Nozer M. Mehta, Amy Sturmer, William Stern, James P. Gilligan
  • Use of the neurotoxic component of a botulinum toxin for treating arthritis
    Patent number: 8052980
    Abstract: A method for treating a patient suffering from arthritis and associated pain include the administration to the patient of a therapeutically effective amount of a neurotoxic component of neurotoxin selected from a group consisting of Botulinum toxin types A, B, C, D, E, F and G.
    Type: Grant
    Filed: August 28, 2009
    Date of Patent: November 8, 2011
    Assignee: Allergan, Inc.
    Inventors: K. Roger Aoki, Michael W. Grayston, Steven R. Carlson, Judith M. Leon
  • Reagents and methods for smooth muscle therapies
    Patent number: 8044018
    Abstract: The present invention provides novel polypeptides comprising heat shock protein 20 (HSP20)-derived polypeptides to treat or inhibit smooth muscle vasospasm, as well to treat and inhibit smooth muscle cell proliferation and migration.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: October 25, 2011
    Assignee: Arizona Board of Regents
    Inventors: Colleen Brophy, Alyssa Panitch, Padmini Komalavilas, Brandon Seal, Lokesh Joshi
  • Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders
    Patent number: 8044103
    Abstract: The present invention provides 4-substituted-2-azetidinone compounds, bicyclic 2-5-diketopiperazine compounds, and pharmaceutical compositions thereof that are potent, safe and effective neuroprotective agents. Due to their strong central nervous system (CNS) activity, the compounds can be used to enhance memory and to treat a variety of neurological disorders. The compounds are particularly useful for treating neurological disorders caused by, or associated with, CNS trauma.
    Type: Grant
    Filed: February 22, 2007
    Date of Patent: October 25, 2011
    Assignee: Georgetown University
    Inventors: Alan P. Kozikowski, Alan I. Faden, Gian Luca Araldi
  • Melanocortin receptor ligands
    Patent number: 8039435
    Abstract: The present invention is directed to compounds according to formula, (R2R3)-A1-c(A2-A3-A4-A5-A6-A7-A8-A9)-A10-R1, and pharmaceutically-acceptable salts thereof that act as ligands for one or more of the melanocortin receptors, to methods of using such compounds to treat mammals and to pharmaceutical compositions comprising said compounds.
    Type: Grant
    Filed: July 10, 2006
    Date of Patent: October 18, 2011
    Assignee: Ipsen Pharma S.A.S.
    Inventors: Zheng Xin Dong, Jacques-Pierre Moreau
  • Methods of collagen imaging
    Patent number: 8034898
    Abstract: Diagnostic compositions and methods for imaging and/or assessing collagen are described. The diagnostic compositions can include collagen binding peptides.
    Type: Grant
    Filed: December 29, 2006
    Date of Patent: October 11, 2011
    Assignee: Collagen Medical, LLC
    Inventors: Peter D. Caravan, Andrew Kolodziej, Zhaoda Zhang, Stephane Dumas, Biplab Kumar Das, Vincent Jacques, Richard Looby, Steffi K. Koerner, Wei-Chuan Sun, David R. Buckler, Aida Abujoub, Aaron K. Sato
  • Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
    Patent number: 8034782
    Abstract: The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cGMP-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. The gastrointestinal disease may be classified as either inflammatory bowel disease or other GI condition including Crohn's disease and ulcerative colitis, and cancer.
    Type: Grant
    Filed: July 16, 2009
    Date of Patent: October 11, 2011
    Assignee: Synergy Pharmaceuticals, Inc.
    Inventor: Kunwar Shailubhai
  • Antimicrobial linear peptides
    Patent number: 8026219
    Abstract: The present invention relates to novel linear peptides with antimicrobial activity. Said peptides are made up of 11 amino acids, and they have the amino group of the amino acid constituting the N-terminal end in a non-derived form or functionalized with an acetyl group, p-toluene sulphonyl, benzyl or benzoyl. The amino acid constituting the C-terminal end of said peptides is in carboxamide form. The invention describes the synthesis and use of said peptides as antimicrobial agents to combat pathogenic bacteria for plants. The invention also relates to compositions containing said peptides and an auxiliary agent, and to a method for preventing and treating infections and diseases of plants caused by pathogenic bacteria.
    Type: Grant
    Filed: April 24, 2007
    Date of Patent: September 27, 2011
    Assignee: Universitat de Girona
    Inventors: Eduard Bardaji Rodriguez, Emili Montesinos Segui, Esther Badosa Romacho, Lidia Feliu Soley, Marta Planas Grabuleda, Rafael Ferre Malagón
  • Use of stabilised synthetic compounds in immunoassay
    Patent number: 8013115
    Abstract: The invention concerns the use of at least a synthetic compound comprising: a carrier molecule having at least a hydrocarbon chain comprising at least 10, advantageously at least 12, preferably at least 14 and not more than 300, advantageously not more than 100, preferably not more than 50, selected'among C, N, O, S, P and Si, and comprising at least two reactive functions, or capable of reacting, for grafting lateral arms on said chain, and at least two different epitopes carried by said lateral arms grafted on said carrier molecule, as standard or control for immunoassay of said biological molecules, in particular of polypeptides or proteins.
    Type: Grant
    Filed: August 14, 2000
    Date of Patent: September 6, 2011
    Assignee: Bio-Rad Pasteur
    Inventors: Isabelle Nathalie Garric, Isabelle Karine Giuliani, Catherine Christiane Marie Larue, François Yves Rieunier, Sylvie Marie-France Trinquier
  • Organic compounds and their uses
    Patent number: 8008263
    Abstract: The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
    Type: Grant
    Filed: October 10, 2008
    Date of Patent: August 30, 2011
    Assignee: Novartis AG
    Inventors: Shawn D. Britt, Lech Andrzej Ciszewski, Jiping Fu, Subramanian Karur, Yugang Liu, Peichao Lu, David Thomas Parker, Mahavir Prashad, Prakash Raman, Pascal Rigollier, Mohindra Seepersaud, Aregahegn Yifru, Rui Zheng
  • CB-1 receptor modulator formulations
    Patent number: 8003672
    Abstract: Described herein are solid, stable pharmaceutical formulations of cannabinoid receptor inverse agonists, such as taranabant, and processes of making such formulations. Additionally, described herein are solid stable pharmaceutical formulations of cannabiniod inverse agonists, such as taranabant, and an additional therapeutic agent, as well as processes for making such pharmaceutical formulations.
    Type: Grant
    Filed: April 17, 2009
    Date of Patent: August 23, 2011
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Craig McKelvey, Sarah Geers, Justin Moser, Bhagwant Rege, Dina Zhang, Sutthilug Sotthivirat
  • Bis-urea compounds and compositions and method of cosmetic treatment
    Patent number: 8003086
    Abstract: Disclosed herein is a cosmetic and/or pharmaceutical composition comprising, in a physiologically acceptable medium, a fatty phase and at least one compound chosen from compounds of formula (I), salts thereof, and isomers thereof, used to texture the fatty phase. Also disclosed herein is a method for texturing a cosmetic and/or pharmaceutical composition comprising adding to the composition at least one compound of formula (I). Further disclosed herein is a method for the cosmetic treatment of keratin materials comprising applying to the materials at least one composition of the present disclosure.
    Type: Grant
    Filed: May 9, 2007
    Date of Patent: August 23, 2011
    Assignee: L'Oreal S.A.
    Inventor: Sandrine Chodorowski-Kimmes
  • Composite material useful as biomaterial and its preparation
    Patent number: 8003611
    Abstract: The present invention aims at providing a biomaterial composite not having risks of pathogen infection and unfavorable side effects such as rejection response. According to the invention, there is provided a biomaterial composite, which comprises a polypeptide and a calcium phosphate compound, said peptide comprising the units of Formulas (I) to (III): [—(OC—(CH2)m—CO)p-(Pro-Y-Gly)n-]a??(I) [—(OC—(CH2)m—CO)q-(z)r-]b??(II) [—HN—R—NH—]c??(III) wherein m, p, q, Y, n, Z, r, R, a, b and c are as defined in the specification. The composite of the invention is particularly suitable for an artificial bone due to its high biocompatibility, high endurance and mechanical strength. Further, the invention can provide a process of the composite according to the invention can for preparation of the composite having excellent mechanical characteristics by a simple procedure.
    Type: Grant
    Filed: March 14, 2006
    Date of Patent: August 23, 2011
    Assignee: National University Corporation Nara Institute of Science and Technology
    Inventors: Masanobu Kamitakahara, Masao Tanihara, Chikara Ohtsuki, Shinichi Ogata
  • Use of N-(dibenz(b,f)oxepin-10-ylmethyl)-N-methyl-N-prop-2-ynylamine (omigapil) or a pharmaceutically acceptable addition salt thereof for the prophylaxis and/or treatment of muscular dystrophy
    Patent number: 7999002
    Abstract: The invention relates to the use of a compound of the formula (I) or a pharmaceutically acceptable addition salt thereof for the preparation of a medicament for the prophylaxis and/or treatment of muscular dystrophy.
    Type: Grant
    Filed: August 22, 2006
    Date of Patent: August 16, 2011
    Assignee: Santhera Pharmaceuticals (Schweiz) AG
    Inventors: Thomas Meier, Markus A. Ruegg
  • Stable analogs of peptide and polypeptide therapeutics
    Patent number: 7994121
    Abstract: The present invention relates to compositions of peptide and polypeptide analogs that are resistant to proteolysis, pharmaceutical uses thereof, and methods of preparation thereof.
    Type: Grant
    Filed: August 21, 2007
    Date of Patent: August 9, 2011
    Assignee: Trustees of Tufts College
    Inventors: William W. Bachovchin, Hung-Sen Lai, David George Sanford
  • Peptides for preventing or treating liver damage
    Patent number: 7985734
    Abstract: The application of a peptide having sequence of formula I or its derivant in preparing the medicine for preventing or treating liver damage, especially liver damage and hepatitis C is disclosed, Xaa1-Gln-Xaa2-Xaa3-Thr-Ser-Gly-Xaa4 (formula I) wherein, Xaa1 is deletion, Ala, Gly, Val, Leu or Ile, Xaa2 is Thr or Ser, Xaa3 is Tyr, Phe or Trp, and Xaa4 is deletion, Ala, Gly, Val, Leu, Ile or Pro. The composite medicine containing the said peptide, its preparation method, and the polynucleotide for coding the said peptide are also disclosed.
    Type: Grant
    Filed: June 1, 2006
    Date of Patent: July 26, 2011
    Inventors: Yun Cheng, Ruihe Yu, Wan Zhou Zhao, Jun Zhao, Jing Li
  • Juvenile hormone compositions and methods for making same
    Patent number: 7977305
    Abstract: The present invention relates to hormone coating layers having desirable hormone delivery characteristics and product lifetime. In one embodiment, the invention is a hormone composition including a substrate having an external surface, and a coating layer disposed on the external surface. The coating layer preferably includes a polymer web, and from about 1 wppm to about 100,000 wppm of a hormone comprising a terpene dispersed throughout the polymer web. The invention also relates to methods for making hormone coating materials of the present invention. The coating compositions of the present invention preferably are implemented in human and animal food packaging materials in order to safely and efficiently protect the foodstuffs contained therein from insect infestation.
    Type: Grant
    Filed: May 16, 2007
    Date of Patent: July 12, 2011
    Inventors: Timothy Jon Leeper, Joy Michelle Thomas, Amy Marie Nichols