Patents Examined by Anna Falkowitz
  • Patent number: 9932446
    Abstract: To provide a method for manufacturing a purified product of an alkyl-modified polydimethylsiloxane that is practically odorless and compatible with other cosmetic raw materials. The manufacturing method comprises the steps of: [A] synthesizing an alkyl-modified polydimethylsiloxane by subjecting a hydrosilyl-containing polydimethylsiloxane and an C2-C30 ?-olefin to a hydrosilation reaction, and [B] subjecting the crude alkyl-modified polydimethylsiloxane obtained in Step [A] to a treatment of rendering it odorless by a hydrogenation reaction in the presence of a hydrogenation catalyst in an organic solvent (c) that is essentially free of active hydrogen atoms and has a boiling point equal to or greater than 70° C.
    Type: Grant
    Filed: September 8, 2010
    Date of Patent: April 3, 2018
    Assignee: DOW CORNING TORAY CO., LTD.
    Inventors: Yasuo Nomura, Keisuke Nishino, Yasue Kanzaki
  • Patent number: 9931411
    Abstract: Disclosed are microparticles containing physiologically active peptides, a method for preparing the same, and a pharmaceutical composition comprising the same.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: April 3, 2018
    Assignee: SAMYANG BIOPHARMACEUTICALS CORPORATION
    Inventors: Hye Jeong Yoon, Min Hyo Seo, Yil Woong Yi, Bong Oh Kim
  • Patent number: 9925293
    Abstract: A solution for treating contact lens is provided. The solution includes about 0.01-1.0 parts by weight (pbw) of a polymer having phosphorylcholine groups, about 0.01-1 pbw of an inorganic salt, and about 100 pbw of water. The polymer has a number-average molecular weight of about 4,000 to about 1,000,000 daltons and has a structure of formula (I): wherein, in formula (I), m is a positive integer, n is zero or a positive integer, and R is C2-C12 alkyl group or C2-C12 hydroxyalkyl group. When n is a positive integer, m/n is greater than 1.
    Type: Grant
    Filed: September 5, 2016
    Date of Patent: March 27, 2018
    Assignee: PEGAVISION CORPORATION
    Inventors: Han-Yi Chang, Ya-Hsuan Liao, Shu-Chen Lu, Ya-Hui Chang, Yu-Chin Lai
  • Patent number: 9925270
    Abstract: A heparin mimicking polymer, its conjugate with bFGF, and method of making and using the same are disclosed. In particular, described herein are conjugates of biologic agents (e.g., bFGF) and heparin mimicking polymers having superior stability while retaining full native activity after a variety of stressors.
    Type: Grant
    Filed: November 28, 2012
    Date of Patent: March 27, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Heather D. Maynard, Thi Nguyen
  • Patent number: 9919052
    Abstract: Polyurethane microparticles are derived from structural units comprising poly(alkylene oxide) moieties, caprolactone moieties and urethane moieties. The microparticles may include an active agent and have a particle size from 0.1 to 100 microns. Microparticles for injection have a particle size of 15 to 80 microns; for use as a aerosol 1 to 3 microns; and for intraocular use 0.02 to 2 microns. Dispersivity is in the range 1 to 3.
    Type: Grant
    Filed: June 20, 2012
    Date of Patent: March 20, 2018
    Assignee: Ferring B.V.
    Inventors: Alistair Ross, Jennifer S. Law, Fiona E. McInnes
  • Patent number: 9913926
    Abstract: Described herein is the synthesis of adhesive complex coacervates and their use thereof. The adhesive complex coacervates are composed of a mixture of one or more polycations and one or more polyanions. The polycations and polyanions in the adhesive complex coacervate are crosslinked with one another by covalent bonds upon curing. The adhesive complex coacervates have several desirable features when compared to conventional bioadhesives, which are effective in water-based applications. The adhesive complex coacervates described herein exhibit good interfacial tension in water when applied to a substrate (i.e., they spread over the interface rather than being beaded up). Additionally, the ability of the complex coacervate to crosslink intermolecularly increases the cohesive strength of the adhesive complex coacervate.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: March 13, 2018
    Assignee: University of Utah Research Foundation
    Inventors: Russell J. Stewart, Hui Shao
  • Patent number: 9849309
    Abstract: Aminofunctional silicone compositions are disclosed comprising: an organopolysiloxane having an average formula of (CH3)3SiO[(CH3)2SiO]x [(CH3)RNSiO]ySi(CH3)3 with less than 1 weight % of nitrogen in its formula, where RN is an aminofunctional group, x is ?100, y is ?1 with the proviso the sum of x+y is from 250 to 350; wherein the viscosity of the silicone composition ranges from 1000 to 2500 cP at 25° C. and is measured by a Brookfield RV DV viscometer equipped with Pro CP 52 spindle at 20 RPM; and the aminofunctional silicone composition contains less than 0.1 weight % of D4 and less than 0.1 weight % D5 cyclic siloxanes.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: December 26, 2017
    Assignee: Dow Corning Corporation
    Inventors: Sylvie Bouzeloc, Severine Cauvin, Cindy Delvalle, Tatiana Dimitrova, Sophie Hanssens, Lok Ming Eva Li, Elodie Raynaud, Houria Seghir, Avril E. Surgenor, Blondine Donatienne Van Roy
  • Patent number: 9808556
    Abstract: The present invention provides a biocompatible and biodegradable elastomer, comprising a hard segment and a soft segment. The hard segment is formed by reacting diisocyanate and a chain extender; and the soft segment is comprising a biodegradable oligomer diol, wherein the biodegradable oligomer diol is selected from the group consisting of polycaprolactone diol, polyethylene butylene adipate diol (PEBA diol), poly-L-lactic acid diol (PLLA diol), polylactic acid diol and any combination thereof. The biocompatible and biodegradable elastomer of present invention can be used to produce vascular graft, cell carrier, drug carrier or gene carrier.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: November 7, 2017
    Assignee: National Taiwan University
    Inventors: Shan-hui Hsu, Kun-Che Hung
  • Patent number: 9795462
    Abstract: The invention consists of a rapidly crosslinkable, two-component silicone elastomer together with a specially designed tray that serves as a form for the silicone resin and forms an integral portion of a dental appliance.
    Type: Grant
    Filed: April 28, 2014
    Date of Patent: October 24, 2017
    Assignee: EZ Tray LLC
    Inventors: James V. Crivello, Lewis R Morrison
  • Patent number: 9789186
    Abstract: Materials capable of delivering stabilized free radicals to targeted treatment sites. The materials comprise semi-crystalline, hydrolytically degradable polymers that are subjected to ionizing radiation to create stabilized free radicals therein. Upon exposure to oxygen containing aqueous media, the materials generate reactive oxidative species which are useful in biological processes.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: October 17, 2017
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Tiffany J. Brown, Adam S. Lafleur, Kenneth Mazich, Jeffrey C. Towler, Ji Zhang
  • Patent number: 9775901
    Abstract: Materials capable of delivering stabilized free radicals to targeted treatment sites. The materials comprise semi-crystalline, hydrolytically degradable polymers that are subjected to ionizing radiation to create stabilized free radicals therein. Upon exposure to oxygen containing aqueous media, the materials generate reactive oxidative species which are useful in biological processes.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: October 3, 2017
    Assignee: W.L. Gore & Associates, Inc.
    Inventors: Tiffany J. Brown, Adam S. Lafleur, Kenneth Mazich, Jeffrey C. Towler, Ji Zhang
  • Patent number: 9775729
    Abstract: Provided herein is a drug delivery system comprising: a. substrate; b. a plurality of components combined with the substrate to form the drug delivery system; wherein at least one components comprises a bioabsorbable polymer and at least one other component comprises one or more active agents; wherein at least part of the active agent is in crystalline form.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: October 3, 2017
    Assignee: Micell Technologies, Inc.
    Inventors: James B. McClain, Charles Douglas Taylor
  • Patent number: 9777160
    Abstract: The invention relates to copper-containing metal pigments, wherein the copper-containing metal pigments have an elemental copper content of at least 50 wt.-%, relative to the total weight of the uncoated copper-containing metal pigment, wherein the copper-containing metal pigments have at least one enveloping metal oxide layer and at least one enveloping chemically non-reactive plastic layer, wherein the sum of the amounts of the at least one chemically non-reactive plastic layer and of the at least one metal oxide layer lies in a range of from 10 to 50 wt.-%, relative to the weight of the uncoated metal pigment, and the weight ratio of the at least one metal oxide layer to the at least one chemically non-reactive plastic layer lies in a range of from 1:2 to 1:20. The invention furthermore relates to a method for producing these pigments and the use thereof.
    Type: Grant
    Filed: March 21, 2012
    Date of Patent: October 3, 2017
    Assignee: ECKART GMBH
    Inventors: Oliver Struck, Phu Qui Nguyen, Dirk Schumacher, Sebastian Hoefener
  • Patent number: 9770418
    Abstract: The present invention provides a sonochemical irradiation-based method for the preparation of polydopamine (PDA) nanocapsules having reduced wall thickness and uniform size distribution, which may further comprise at least one payload; nanocapsules obtained by this method; and compositions thereof. Such compositions may be formulated for different purposes, e.g., as pharmaceutical compositions for various therapeutic or diagnostic purposes.
    Type: Grant
    Filed: January 7, 2014
    Date of Patent: September 26, 2017
    Assignee: BAR-ILAN UNIVERSITY
    Inventors: Shai Rahimipour, Gil Yeroslavsky, Michal Richman
  • Patent number: 9770420
    Abstract: A method for producing a polyglycerol nanogel is disclosed, the method comprising the following steps: Mixing an aqueous solution of first polyglycerol macromonomers, which are modified with a first reactive group, with an aqueous solution of second polyglycerol macromonomers, which are modified with a second reactive group, wherein the first reactive group and the second reactive group can react with each other forming a chemical bond; transferring the mixture into an organic non-solvent; and precipitation of a polyglycerol nanogel consisting of first polyglycerol macromonomers and second polyglycerol macromonomers which are covalently bound to each other. According to an aspect of the invention, the method is characterized in that the organic non-solvent is miscible with water and in that the method is carried out without adding surface-active substances.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: September 26, 2017
    Assignee: FREIE UNIVERSITÄT BERLIN
    Inventors: Rainer Haag, Dirk Steinhilber, Wolfgang Friess, Sarah Küchler, Madeleine Witting
  • Patent number: 9757492
    Abstract: The present invention relates to a process for producing a hydroxy amino polymer comprising the steps: a) Reaction of an H functional starter compound bearing at least one Zerewitinoff active H atom with an unsaturated, cyclical carboxylic acid anhydride and at least one alkylene oxide compound for obtaining a prepolymer bearing hydroxyl groups, b) Addition of a primary amine and/or of ammonia to the double bond(s) of the prepolymer bearing hydroxyl groups obtained according to step a) for obtaining the hydroxy amino polymer, wherein the ratio of added amino groups to hydroxyl groups in a hydroxy amino polymer is at least 0.6. Furthermore, the invention relates to a hydroxy amino polymer, which can be achieved according to this process as well as a polyurea/polyurethane system, which contains such a hydroxy amino polymer.
    Type: Grant
    Filed: January 10, 2017
    Date of Patent: September 12, 2017
    Assignee: Adhesys Medical GmbH
    Inventors: Heike Heckroth, Christoph Eggert, Jörg Hofmann, Klaus Lorenz, Edward Browne, Hartmut Nefzger
  • Patent number: 9750803
    Abstract: The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles comprise terminal-cysteine-bearing antigens or cysteine-modified antigens, at their surface and/or internally.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: September 5, 2017
    Assignee: Massachusetts Institute of Technology
    Inventors: Darrell J. Irvine, Jaehyun Moon
  • Patent number: 9750765
    Abstract: Materials capable of delivering stabilized free radicals to targeted treatment sites. The materials comprise semi-crystalline, hydrolytically degradable polymers that are subjected to ionizing radiation to create stabilized free radicals therein. Upon exposure to oxygen containing aqueous media, the materials generate reactive oxidative species which are useful in biological processes.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: September 5, 2017
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Tiffany J. Brown, Adam S. Lafleur, Kenneth Mazich, Jeffrey C. Towler, Ji Zhang
  • Patent number: 9750841
    Abstract: A medical adhesive with good biodegradable performance capable of undergoing crosslinking copolymerization, comprising a mono-alpha-cyanoacrylate and a bis-alpha-cyanoacrylic acid diol ester monomer molecule. The olefinic bonds in the mono-alpha-cyanoacrylate structure are polymerized in the presence of infinitesimal anions to form a solid 3D high polymer; the 3D high polymer is provided with degradation sites on the web-like backbone chain, with clear degradation path and absorbable degradation products. The medical adhesive can be used for wound adhesive, large area wound hemostasia, and visceral and soft tissue wound closure.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: September 5, 2017
    Assignees: INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A., CHENGDU YIPING MEDICAL SCIENCE & TECHNOLOGY CO. LTD
    Inventors: Keliang Liu, Liang Xu, Qingsong Zhang, Dazhen Cai, Qingbin Meng
  • Patent number: 9750598
    Abstract: The present invention provides a biocompatible and biodegradable elastomer, comprising a hard segment and a soft segment. The hard segment is formed by reacting diisocyanate and a chain extender; and the soft segment is comprising a biodegradable oligomer diol, wherein the biodegradable oligomer diol is selected from the group consisting of polycaprolactone diol, polyethylene butylene adipate diol (PEBA diol), poly-L-lactic acid diol (PLLA diol), polylactic acid diol and any combination thereof. The biocompatible and biodegradable elastomer of present invention can be used to produce vascular graft, cell carrier, drug carrier or gene carrier.
    Type: Grant
    Filed: December 31, 2013
    Date of Patent: September 5, 2017
    Assignee: National Taiwan University
    Inventors: Shan-hui Hsu, Kun-Che Hung, Shenghong A. Dai, Chun-Yi Lu