Patents Examined by Anthony P. Bottino
  • Synthesis of bisindolylmaleimides
    Patent number: 5559228
    Abstract: The present invention provides an efficient process of reacting a bis-indolyl acid of the Formula (II): ##STR1## wherein R.sup.1 is a hydrogen or C.sub.1 -C.sub.4 alkyl and R, X, and Y are optional substitutions; to produce a bis-indolyloxallic acid of the Formula (III): ##STR2## Compounds of the Formula (III) are readily converted to the bis-indolylmaleimides.
    Type: Grant
    Filed: March 30, 1995
    Date of Patent: September 24, 1996
    Assignee: Eli Lilly and Company
    Inventors: James R. Gillig, Michael R. Jirousek
  • Method for the production of azaphenothiazines
    Patent number: 5539107
    Abstract: A process for the production of azophenothiazine derivatives having either of the following structures: ##STR1## where X and Y include alkyl, alkoxy, halogen, hydrogen, carboxy, or carboxy alkyl substituents. These compounds are precursors to pharmaceutically active compounds such as pipacetate. The process involves the reaction of a 2-chloropyridine with a 2-mercaptoaniline or a dimer of 2-(2-mercaptophenylamino)pyridine in an inert solvent, e.g., .gradient.-methylpyrolidone in the presence of an oxidizing agent, e.g., performic acid.
    Type: Grant
    Filed: April 17, 1995
    Date of Patent: July 23, 1996
    Assignee: ASTA Medica Aktiengesellschaft
    Inventors: Bernhard Kutscher, Hans-Reinhold Dieter
  • Purification of indigo
    Patent number: 5536842
    Abstract: A process for purifying indigo comprises extracting an aqueous leuco indigo alkali metal salt solution with an inert solvent under oxygen-excluding conditions and conventionally regenerating the indigo by oxidation.
    Type: Grant
    Filed: October 21, 1994
    Date of Patent: July 16, 1996
    Assignee: BASF Aktiengesellschaft
    Inventors: Udo Bergmann, Manfred Gang, Reinhold Kohlhaupt