Patents Examined by Anton H. Sutto
  • Patent number: 4920108
    Abstract: Bisthiophosphates of the general formula ##STR1## where R.sup.1 is ethyl or isopropyl and R.sup.2 is branched or straight-chain C.sub.1 -C.sub.4 -alkyl, and their use for combating pests.
    Type: Grant
    Filed: January 27, 1988
    Date of Patent: April 24, 1990
    Assignee: BASF Aktiengesellschaft
    Inventors: Rainer Burstinghaus, Peter Hofmeister
  • Patent number: 4920226
    Abstract: There is provided novel (2-imidazolin-2-yl)thieno and furo compounds, and intermediate compounds for the preparation thereof, and a method for controlling a wide variety of annual and perennial plant species therewith.
    Type: Grant
    Filed: May 30, 1989
    Date of Patent: April 24, 1990
    Assignee: American Cyanamid
    Inventors: Marinus Los, David W. Ladner, Barrington Cross
  • Patent number: 4920221
    Abstract: 1,2,3,4,4a,4b,5,6,7,8,8a,12b-Dodecahydro-7-(oxo, hydroxy or amino)-9-hydroxy-11-(alkyl, alkoxy or alkoxyalkyl)triphenylenes, 2,3,3a,3b,4,5,6,7,7a,11b-decahydro-6-(oxo, hydroxy or amino)-8-hydroxy-10-(alkyl, alkoxy or alkoxyalkyl)-1H-cyclopenta[1]-phenanthrenes, 2,3,4,4a,4b,5,6,7,8,8a-decahydro-7-(oxo, hydroxy or amino)-9-hydroxy-11-(alkyl, alkoxy, alkoxyalkyl, aralkyl, aralkoxy, aryloxyalkyl or aralkoxyalkyl)-1H-pyrido[1,2-f]phenanthridines, and 1,2,3,3a,3b,4,5,6,7,7a-decahydro-6-(oxo, hydroxy or amino)-8-hydroxy-10-(alkyl, alkoxy or alkoxyalkyl)-pyrrolo[1,2-f]phenanthridines and derivatives are valuable as central nervous system active agents or as intermediates to compounds having such activity.
    Type: Grant
    Filed: October 16, 1986
    Date of Patent: April 24, 1990
    Assignee: Pfizer Inc.
    Inventors: James F. Eggler, Michael R. Johnson, Lawrence S. Melvin, Jr.
  • Patent number: 4918212
    Abstract: Phosphonic acid, phosphinic acid and phosphine oxide derivatives of the general formula ##STR1## where A, B and R.sup.1 to R.sup.5 have the meanings stated in the description, processes for their preparation, pharmaceutical agents containing them, and their use for the treatment of acne and psoriasis are described .
    Type: Grant
    Filed: August 12, 1988
    Date of Patent: April 17, 1990
    Assignee: BASF Aktiengesellschaft
    Inventors: Hans-Heiner Wuest, Bernd Janssen
  • Patent number: 4918074
    Abstract: A polyazaheterocycle compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof, wherein each symbol is as defined in the specification.Said compounds exhibit calcium antagonistic and/or calcium agonistic activities.
    Type: Grant
    Filed: February 10, 1988
    Date of Patent: April 17, 1990
    Assignee: Yoshitomi Pharmaceutical Industries, Ltd.
    Inventors: Yoshinao Tsuda, Tadashi Mishina, Minoru Obata, Kazuhiko Araki, Jun Inui, Tadao Nakamura
  • Patent number: 4918064
    Abstract: A class of phenyl glycine compounds is described for treatment to reduce neurotoxic injury associated with anoxia or ischemia which typically follows stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of a phenyl glycine compound alone or in a composition in an amount effective as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites.
    Type: Grant
    Filed: October 21, 1987
    Date of Patent: April 17, 1990
    Assignee: G. D. Searle & Co.
    Inventors: Alex A. Cordi, Michael L. Vazquez
  • Patent number: 4916250
    Abstract: Novel phosphonate compounds of the formula ##STR1## are disclosed and claimed, as well as methods for manufacturing the phosphonates from C-14 through C-16 aldehydes. The phosphonate compounds of the present invention can be employed to form 13-cis retinoic acid, retin-A and beta-carotene.
    Type: Grant
    Filed: October 31, 1988
    Date of Patent: April 10, 1990
    Assignee: Loyola University of Chicago
    Inventor: James H. Babler
  • Patent number: 4916249
    Abstract: The invention relates to novel glycero-3(2)phospho-L-serine derivatives of the general formula ##STR1## in which A represents unsubstituted or substituted (C5-C30) alkoxy, or unsubstituted or substituted (C5-C30) alkenoxy, whereby a double bond of the alkenoxy residue does not originate at the C atom bound to oxygen, or halogen, or a group of the general formula--O--(CH.sub.2).sub.n --CF.sub.3 II,wherein n is 0 or an integer 1, 2 or 3, one of the two residues B and C, which is identical to or different from A, has one of the definitions given for A or represents hydrogen, and the respective other residue represents the phosphatidyl-Lserine group of the formula ##STR2## with the proviso that at least one residue A, B or C represents (C5-C30) alkoxy or (C5-C30) alkenoxy; and the pharmaceutically acceptable salts of compounds of general formula I with bases, a process for the preparation thereof, pharmaceutical preparations containing the said compounds, and their use in drugs with cytostatic activity.
    Type: Grant
    Filed: July 7, 1989
    Date of Patent: April 10, 1990
    Inventors: Hans Brachwitz, Peter Langen, Christine Lehmann, Eckart Matthes, Jurgen Schildt, Iduna Fichtner, Albin Hermetter, Friedrich Paltauf
  • Patent number: 4915876
    Abstract: Disclosed are novel deodorization processes to realize highly polyunsaturated oils of enhanced stability. The novel deodorization has particular suitability for processing fish oils and soybean oil. The process involves use of mild solutions of acids and/or bases in sequential distillations to manipulate the volatility of undesirable aroma compounds to effect removal of offending compounds and precursors therefor. The oils are then polished to remove residual moisture and salts and to acidify the oil.
    Type: Grant
    Filed: July 20, 1987
    Date of Patent: April 10, 1990
    Assignee: General Mills, Inc.
    Inventor: Robert C. Lindsay
  • Patent number: 4914234
    Abstract: Novel 10,10-Dihydro-10-[substituted carbonyl)imino]-10-phenyl-10H-phenoxaphines of the formula: ##STR1## wherein A is selected from the group consisting of hydrogen and COOR.sub.1, where, when A is hydrogen the compound is in the form of a water soluble salt HnX, where n is an integer 1 or 2 and X is selected from the group consisting of sulfate, trefluoroacetate, bromide and chloride and R.sub.1 is selected from the group consisting of straight or branched chain alkyl(C.sub.1 -C.sub.4), alkenyl(C.sub.2 -C.sub.4), alkynyl(C.sub.2 -C.sub.4), cycloalkyl(C.sub.3 -C.sub.6), cycloalkyl(C.sub.3 -C.sub.6)methyl, benzyl, pyridylmethyl and tetrahydro-3-furanyl; methods for using these compounds for effecting diuresis, treating hypertension and edema and lowering plasma renin activity in mammals; pharmaceutical compositions of matter containing these compounds and processes for their preparation.
    Type: Grant
    Filed: August 4, 1988
    Date of Patent: April 3, 1990
    Assignee: American Cyanamid Company
    Inventors: Andrew S. Tomcufcik, Joseph W. Marsico, Nancy H. Eudy, Howard Newman
  • Patent number: 4914104
    Abstract: This invention relates to a novel imidazo[1,5-a]pyrimidine derivatives and process for their preparation.Moreover, it relates to novel imidazo[1,5-a]pyrimidine derivatives and salts thereof having antifungal activities, and process for their preparation.
    Type: Grant
    Filed: January 4, 1989
    Date of Patent: April 3, 1990
    Assignee: Kyorin Pharmaceutical Co., Ltd.
    Inventors: Tsutomu Irikura, Seigo Suzue, Hiroaki Uchida, Hirotaka Shinoda, Satoshi Murayama, Susumu Kinoshita
  • Patent number: 4914210
    Abstract: Oligonucleotide functionalizing reagents are disclosed which are useful in introducing sulfhydryl, amino and additional hydroxyl groups into oligonucleotides. The reagents are substantially linear in structure, at one end provided with a phosphoramidite moiety, at an opposing end provided with a sulfhydryl, amino or hydroxyl moiety, the two ends linked through a hydrophilic spacer chain. Methods of using and synthesizing the novel reagents are disclosed as well.
    Type: Grant
    Filed: October 2, 1987
    Date of Patent: April 3, 1990
    Assignee: Cetus Corporation
    Inventors: Corey Levenson, Chu-An Chang, Fred T. Oakes
  • Patent number: 4912155
    Abstract: Organic materials normally subject to gradual degradation in the presence of oxygen are stabilized by inclusion of an aromatic fluorophosphite having at least one benzene group bonded through oxygen to phosphorus and at least one fluorine atom bonded directly to the same phosphorus. Stabilization is improved by also including a conventional phenolic antioxidant. Many of the aromatic fluorophosphites are new compounds.
    Type: Grant
    Filed: February 27, 1987
    Date of Patent: March 27, 1990
    Assignee: Ethyl Corporation
    Inventor: Lester P. J. Burton
  • Patent number: 4912245
    Abstract: Surfactant compositions in an acidic or neutralized form containing a mixture of at least one polyoxyalkylenated phosphoric acid monoester and at least one polyoxyalkylenated diester and a nonionic polyoxyalkylenated compound wherein the phosphoric acid diester:phosphoric acid monoester molar ratio before neutralization, if carried out, is at least equal to 0.9:1 and the phosphoric acid monoester and phosphoric acid diester content is at least 1 mol %, preferably at least 50 mol % of said composition. The surfactant compositions are prepared by phosphatization of a nonionic polyoxyalkylenated compound at a temperature of from about to about C. followed by maturing at from about to about C., in a stirred turbulent state. The compositions are useful in the formulation of active substances in the form of microgranules and flowables.
    Type: Grant
    Filed: June 16, 1987
    Date of Patent: March 27, 1990
    Assignee: Rhone-Poulenc Chimie
    Inventors: Yvette Girardeau, Christian Segaud
  • Patent number: 4910324
    Abstract: Phosphorus compounds having at least one chlorine, bromine or iodine bonded directly to phosphorus are transhalogenated with fluorine by reaction with a fluoride salt, e.g., KF, or ammonium fluoride in an inert solvent in the presence of a catalytic amount of a carboxylic acid.
    Type: Grant
    Filed: August 29, 1988
    Date of Patent: March 20, 1990
    Assignee: Ethyl Corporation
    Inventors: Lester P. J. Burton, Vincent J. Gatto
  • Patent number: 4908464
    Abstract: Process for production of derivatives of 1,3,2-oxazaphosphorinane of general formula 1, ##STR1## wherein R.sub.1 and R.sub.2 represent hydrogen atom or 2-halogenoalkyl group, and R.sub.1 and R.sub.2 are not at the same time hydrogen atoms, and X represents halogen atom is based, according to the invention, on the reduction of the respective 3-halogenoacyl derivatives of 1,3,2-oxazaphosphorinane of general formula 2, ##STR2## wherein the substituents have the above given meaning. The reduction is accomplished with the use of sodium borohydride in the presence of boron trifluoride etherate.Derivatives that are prepared by the procedure described here demonstrate antitumor activity.
    Type: Grant
    Filed: June 9, 1988
    Date of Patent: March 13, 1990
    Assignees: Instytut Przemyslu Farmaceutycznego, Centrum Baden Molekularnych i Makromolekularnych -PAN, Instytut Immunologii i Terapii Doswiadczalnej -PAN
    Inventors: Wojciech J. Stec, Czeslaw Radzikowski, Wieslaw Szelejewski, Ryszard Kinas, Konrad Misiura, Grzegorz Grynkiewicz, Jacek Grodner, Halina Kusnierczyk, Andrzej Kutner, Slawomira Pilichowska
  • Patent number: 4906764
    Abstract: A process for producing a phosphinylamino acid derivative of the formula: ##STR1## wherein R.sup.1 is a lower alkyl group, R.sup.2 is a hydrogen atom, a lower alkyl group, a halo-lower alkyl group or a substituted or unsubstituted phenyl group, and R.sup.3 is a substituted or unsubstituted alkyl group or a substituted or unsubstituted phenyl group, which comprises reacting a compound of the formula: ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, and/or a compound of the formula: ##STR3## wherein R.sup.1 and R.sup.2 are as defined above, with a compound of the formula:R.sup.3 CONH.sub.2 (IV)wherein R.sup.3 is as defined above, carbon monoxide and hydrogen in the presence of a catalyst containing a metal of group VIII of the Periodic Table.
    Type: Grant
    Filed: May 13, 1988
    Date of Patent: March 6, 1990
    Assignee: Nissan Chemical Industries Ltd.
    Inventors: Hideki Takamatsu, Hiroyuki Mutoh, Fumio Suzuki, Shinichiro Takigawa
  • Patent number: 4906412
    Abstract: An improved process for the treatment of lauric fats and oils to reduce or prevent both hydrolytic and oxidative rancidity comprising adding to said fat or oil a sequestering amount of citric acid, and with said citric acid lecithin in the amount of at least about 30 ppm (parts per million) based on the weight of the fat or oil.
    Type: Grant
    Filed: March 28, 1988
    Date of Patent: March 6, 1990
    Assignee: Durkee Industrial Foods Corp.
    Inventors: Richard J. Zielinski, Daniel A. Ebner
  • Patent number: 4906777
    Abstract: Ethylidene bis-formamide, a precursor for the monomer N-vinylformamide, is made in high yield by heating together formamide and acetaldehyde in a mol ratio of at least 3:1 and in a reaction mixture which is at least 20 weight percent formic acid. In a preferred procedure the acetaldehyde is added after the formamide has been preheated and formic acid is present. Yields of ethylidene bis-formamide of over 50%, based on the acetaldehyde, are obtained in relatively short reaction times, before loss of substantial amounts of recoverable formamide through hydrolysis.
    Type: Grant
    Filed: October 19, 1988
    Date of Patent: March 6, 1990
    Assignee: Air Products and Chemicals, Inc.
    Inventors: Robert K. Pinschmidt, Jr., Andrew F. Nordquist
  • Patent number: 4904646
    Abstract: Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have the structure ##STR1## including salts thereof, wherein R is OH, lower alkoxy or lower alkyl; R.sup.x is H or alkyl;X is --O-- or --NH--;n is 1 or 2Z is a hydrophobic anchor, such as ##STR2## wherein the dotted lines represent optional double bonds. New intermediates used in preparing the above compounds, pharmaceutical compositions containing such compounds and a method for using such compounds to inhibit cholesterol biosynthesis are also provided.
    Type: Grant
    Filed: April 18, 1988
    Date of Patent: February 27, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Donald S. Karanewsky, Scott A. Biller, Eric M. Gordon