Abstract: A method for selecting cancer patient for treatment with Seneca Valley Virus (SVV) by determining expression of ANTXR1 in a cancerous tissue in a cancer patient; and designating the cancer patient as a candidate for treatment with SVV if normal levels or elevated levels of ANTXR1 expression is detected in the cancerous tissue. Also a method for treating a cancer patient with SVV is disclosed.
Type:
Grant
Filed:
August 19, 2021
Date of Patent:
August 29, 2023
Assignee:
Memorial Sloan-Kettering Cancer Center
Inventors:
Linde Miles, John Poirier, Charles Rudin
Abstract: The invention relates to a pharmaceutical combination and related methods for reducing tumor volume and/or increasing the survival of a cancer patient. The combination comprises an intravenous administration of a recombinant MVA encoding a tumor-associated antigen and an administration of an antibody to a cancer patient.
Type:
Grant
Filed:
March 14, 2022
Date of Patent:
August 15, 2023
Assignee:
Bavarian Nordic A/S
Inventors:
Hubertus Hochrein, Henning Lauterbach, José Medina Echeverz, Matthias Habjan
Abstract: Provided herein are nucleic acid constructs, host insect cells, and methods for producing recombinant AAV capsids with high potency at high yield.
Type:
Grant
Filed:
February 14, 2020
Date of Patent:
August 8, 2023
Assignee:
Sangamo Therapeutics, Inc.
Inventors:
Andrea J. Kang, Richard T. Surosky, Alex Michael Ward
Abstract: This disclosure relates to antibodies and antigen binding fragments that specifically bind Ebola virus particles. In certain embodiments, the antibodies and fragments are capable of treating or preventing an Ebola viral infection. In certain embodiments, the antibodies and antigen binding fragments are also contemplated for diagnostic methods and compositions related thereto.
Type:
Grant
Filed:
March 9, 2021
Date of Patent:
August 1, 2023
Assignees:
Emory University, The Scripps Research Institute
Inventors:
Rafi Ahmed, Carl Davis, Erica Ollmann Saphire
Abstract: A mucosal adjuvant may have high mucosal immunogenicity and high safety and be useful in the preparation of mucosal vaccines, and a mucosal vaccine composition may include the same. Such mucosal adjuvant may include TGDK. A method for preparing the mucosal vaccine composition may include mixing TGDK with an immunogen.
Type:
Grant
Filed:
September 26, 2019
Date of Patent:
July 25, 2023
Assignees:
DENKA COMPANY LIMITED, NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY
Abstract: An immunogenic composition comprising: (i) a non-virion influenza virus antigen, prepared from a virus grown in cell culture; and (ii) an adjuvant. Preferred adjuvants comprise oil-in-water emulsions.
Type:
Grant
Filed:
October 16, 2020
Date of Patent:
July 25, 2023
Assignee:
Seqirus UK Limited
Inventors:
Rino Rappuoli, Derek O'Hagan, Giuseppe Del Giudice
Abstract: The present invention relates to the production of plasmids which are useful in the production of Adeno-Associated Virus (AAV) particles. In particular, the invention provides nucleic acid molecules comprising capgenes and repgenes, wherein the capand repgenes are both operably-associated with the same promoter. The invention also provides host cells comprising nucleic acid molecules of the invention and methods for their use.
Type:
Grant
Filed:
January 18, 2019
Date of Patent:
July 11, 2023
Assignee:
Oxford Genetics Limited
Inventors:
Ryan Cawood, Alissa Sarah Bray, Thomas Augustus Payne
Abstract: The present disclosure provides a replication-competent, recombinant oncolytic vaccinia virus, compositions comprising the vaccinia virus, and use of the vaccinia virus or composition for inducing oncolysis in an individual having a tumor.
Type:
Grant
Filed:
February 10, 2020
Date of Patent:
June 27, 2023
Assignee:
Ignite Immunotherapy, Inc.
Inventors:
David H. Kirn, Liliana Maruri Avidal, Prajit Limsirichai
Abstract: The present disclosure relates to methods and compositions, e.g., kits, for quantitatively detecting an antibody of a subject to an infectious organism. In some embodiments, the present disclosure provides for methods and compositions, e.g., kits, for quantitatively detecting a human antibody to SARS-CoV-2 polypeptide or S (spike) polypeptide. Certain applications and uses of the present methods and compositions, e.g., kits, are also provided.
Type:
Grant
Filed:
April 28, 2021
Date of Patent:
June 27, 2023
Assignee:
Quanterix Corporation
Inventors:
Andrew Ball, Lei Chang, Syrena Fernandes, Joe Johnson, Jeremy Lambert, Dawn Mattoon, Tatiana Plavina, David Wilson
Abstract: Provided herein are universal prophylactic compositions for preventing infection with influenza viruses by directing the immune response to highly conserved regions of the virus. Also provided are universal therapeutic compositions for treating influenza infection by targeting the highly conserved regions. Methods for using the prophylactic and therapeutic compositions are also provided.
Abstract: The present disclosure provides, among other things, a pharmaceutical composition that includes a lipid nanoparticle adjuvant and an anti-human papillomavirus (HPV) comprising HPV virus-like particles (VLPs) of at least one type of human papillomavirus (HPV) selected from the group consisting of HPV types: 6, 11, 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 55, 56, 58, 59, 66, 68, 73, and 82.
Type:
Grant
Filed:
February 9, 2021
Date of Patent:
May 2, 2023
Assignee:
Merck Sharp & Dohme LLC
Inventors:
Andrew J. Bett, John P. Bilello, Amy S. Espeseth, Tong-Ming Fu, Marian E. Gindy
Abstract: An immunogenic composition comprising at least one Norovirus antigen and at least one adjuvant which is at least one B subunit of an AB5 toxin such as cholera toxin subunit B (CTB) or the B subunit of heat-labile E. coli exotoxin LT (LTB).
Type:
Grant
Filed:
February 14, 2019
Date of Patent:
April 25, 2023
Assignee:
Icon Genetics GmbH
Inventors:
Vesna Blazevic, Maria Malm, Frank Thieme, Franziska Jarczowski, Andre Diessner, Victor Klimyuk
Abstract: The invention provides broadly neutralizing antibodies directed to epitopes of Human Immunodeficiency Virus, or HIV. The invention further provides compositions containing HIV antibodies used for prophylaxis, and methods for diagnosis and treatment of HIV infection.
Type:
Grant
Filed:
January 11, 2021
Date of Patent:
April 25, 2023
Assignees:
The Rockefeller University, California Institute of Technology
Inventors:
Johannes Scheid, Michel Nussenzweig, Pamela J. Bjorkman, Ron Diskin
Abstract: The present invention relates to adeno-associated viral vector useful for transducing adipose tissue. The invention also relates to polynucleotides, plasmids, vectors and methods for the production of such adeno-associated viral vector. The invention also relates to gene therapy methods useful for the treatment of a disease that requires the regulation of the expression levels of a gene.
Abstract: Modified E1a regulatory sequences are provided, wherein at least one Pea3 binding site, or a functional portion thereof, is deleted. Also provided are modified E1a sequences that selectively express particular isoforms. Also provided is an E1b-19K clone insertion site. These modified sequences can be used individually, or in combination with one another, to provide tumor-selective expression of proteins.
Type:
Grant
Filed:
November 20, 2020
Date of Patent:
April 4, 2023
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventors:
Tony Reid, Farah Hedjran, Shantanu Kumar
Abstract: Methods are provided for targeting cells for depletion, including without limitation tumor cells, in a regimen comprising contacting the targeted cells with a combination of agents that modulate immunoregulatory signaling. Immunoregulatory modulating agents include (i) an agent that blockades CD47 activity; and (ii) an agent that agonizes an immune costimulatory molecule, e.g. CD137. The regimen may further comprise an agent that specifically binds to the target cell, e.g. an antibody or biologically active fragment or derivative thereof. The level of depletion of the targeted cell is enhanced relative to a regimen in which a single immunoregulatory modulating agent is used; and the effect may be synergistic relative to a regimen in which a single immunoregulatory modulating agent is used.
Type:
Grant
Filed:
December 11, 2020
Date of Patent:
March 21, 2023
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Peter J. Schnorr, Akanksha Chhabra, Judith A. Shizuru, Irving L. Weissman, Kipp Andrew Weiskopf
Abstract: Disclosed herein are methods and compositions related to therapy for cancer. More specifically, the disclosed methods and compositions are related to the use of smallpox vaccine to induce an effective anti-tumor immune response.
Abstract: The present disclosure provides a method of dispersing agglomerated material in a preparation comprising influenza proteins. The method comprises subjecting the preparation to sonication.
Type:
Grant
Filed:
July 10, 2019
Date of Patent:
March 7, 2023
Assignee:
Seqirus Pty Ltd
Inventors:
Steven Rockman, Jesse Bodle, Nancy Guzzo-Pernell
Abstract: The present invention discloses novel recombinant multivalent non-pathogenic Marek's Disease virus constructs that encode and express both Infectious Laryngotracheitis Virus protein antigens and an Infectious Bursal Disease virus protein antigen, and methods of their use in poultry vaccines.
Type:
Grant
Filed:
June 15, 2017
Date of Patent:
March 7, 2023
Assignee:
Intervet Inc.
Inventors:
Stephanie Cook, Mohamad Morsey, Ian Tarpey, Iwan Verstegen, Paulus Jacobus Antonius Sondermeijer, Paul Vermeij