Patents Examined by Benjamin R. Padgett
  • Patent number: 4618485
    Abstract: An improved radioimmunoassay test method and device based upon competitive binding test methods wherein immunoreactions are halted at a time when the rate of change of the quantity of bound radiolabeled analyte of interest is inversely proportional to the concentration of analyte of interest in an unknown sera. Based thereon, a test device is created having a single calibration curve 36 which is accurate throughout the shelf life of the device.
    Type: Grant
    Filed: March 12, 1982
    Date of Patent: October 21, 1986
    Assignee: International Immunoassay Laboratories, Inc.
    Inventors: Yuh-Geng Tsay, Vipin D. Shah
  • Patent number: 4569787
    Abstract: A radioactive waste is treated by supplying a liquid concentrate of at least one of a radioactive liquid waste and a radioactive waste slurry to a centrifugal film dryer, thereby drying and pulverizing insoluble and soluble solid matters contained in the concentrate, washing the centrifugal film drier with hot water after the drying and pulverization, settling the effluent washing water together with a condensate containing solid matters generated in the drying and pulverization, and supplying a slurry of insoluble solid matters separated by the settling to the centrifugal film drier, thereby drying and pulverizing the solid matters. The dried powder from the centrifugal film drier can be pelletized in a pelletizer, and effluent washing water generated by washing the pelletizer with hot water after the pelletization can be subjected to the settling together with the effluent washing water and the condensate from the centrifugal film drier.
    Type: Grant
    Filed: June 23, 1982
    Date of Patent: February 11, 1986
    Assignee: Hitachi, Ltd.
    Inventors: Susumu Horiuchi, Mikio Hirano, Toru Saito
  • Patent number: 4532220
    Abstract: There is provided an assay for the determination of the carcinogenicity of chemical and physical agents, by exposing a selected line of tumor virus transformed cells to the agent to be tested and determining whether such exposure induces endogenous viral DNA replication in such cells, which induction is indicative of the carcinogenicity of the tested agent by in situ hybridization. There is provided a kit for carrying out such assay.
    Type: Grant
    Filed: March 23, 1982
    Date of Patent: July 30, 1985
    Assignee: Yeda Research and Development Company Ltd.
    Inventor: Sara Lavi
  • Patent number: 4530908
    Abstract: Antibodies and antigens are disclosed which provide a method of detecting and a method of combating flukes. A diagnostic method for the determination of an active fluke infection in a warm-blooded animal is provided which comprises the testing of body serum or body fluids for the presence of fluke spine glycoprotein or anti-spine antibodies. Fused cell hybrids ATCC HB-8086, ATCC HB-8087 and ATCC HB-8088, as well as the antibodies produced by the fused cell hybrids, are also provided.
    Type: Grant
    Filed: April 27, 1983
    Date of Patent: July 23, 1985
    Assignee: The Johns Hopkins University
    Inventor: Mette Strand
  • Patent number: 4528134
    Abstract: Method of separating A.sub.14 -.sup.125 I-insulin from heterogeneously labeled insulin molecules for biological studies which involves iodating insulin in a controlled manner, selectively absorbing the insulin from the iodination procedure in a tightly packed bed of octadecylsilane bonded to silica employing reverse phase liquid chromatography principles, thereafter eluting large and small radioactive and nonradioactive materials such as damaged insulin, various contaminants and polar materials from the bed with dilute trifluoroacetic acid, thereafter eluting the intact .sup.125 I-insulin from the bed with a mixture of acetonitrile and dilute trifluoroacetic acid and then separating the A.sub.14 -insulin by high performance liquid chromatography or ion exchange chromatography.
    Type: Grant
    Filed: December 27, 1982
    Date of Patent: July 9, 1985
    Assignee: University of TN Research Corporation
    Inventors: Frankie B. Stentz, Reba K. Wright, Abbas E. Kitabchi
  • Patent number: 4528130
    Abstract: Method for dissolving hard-to-dissolve thorium and/or plutonium oxides, especially dioxides such as ThO.sub.2, PuO.sub.2 or (U/Pu)O.sub.2 mixed oxides by heating the oxides in a hermetically sealed vessel in fluoride-free nitric acid. The use of a gas atmosphere containing oxygen in the sealed vessel is advantageous.
    Type: Grant
    Filed: October 13, 1981
    Date of Patent: July 9, 1985
    Assignee: ALKEM GmbH
    Inventors: Friedrich-Wilhelm Ledebrink, Wolfgang Rosenkranz, Wolfgang Stoll
  • Patent number: 4526747
    Abstract: The disclosure relates to a method of manufacturing a turbine wheel using an elastomeric mold for the acceptance of powdered metal. The powdered metal is cold isostatically pressed and thereafter heated to effect metallurgical bonding thereof.
    Type: Grant
    Filed: March 18, 1982
    Date of Patent: July 2, 1985
    Assignee: Williams International Corporation
    Inventors: William P. Schimmel, Clifford S. Barker, Dana P. Jones
  • Patent number: 4522731
    Abstract: A high strength propping agent for use in hydraulic fracturing of subterranean formations comprising solid, spherical particles having an alumina content of between 40 and 60%, a density of less than 3.0 gm/cc and an ambient temperature permeability of 100,000 or more millidarcies at 10,000 psi.
    Type: Grant
    Filed: October 28, 1982
    Date of Patent: June 11, 1985
    Assignee: Dresser Industries, Inc.
    Inventor: Eugene P. Lunghofer
  • Patent number: 4521496
    Abstract: Metal/ceramic abradable seals of the type used in jet aircraft are improved by using a substrate which is able to deform during cooling from the brazing temperature and then rendering the substrate rigid after the cool down.
    Type: Grant
    Filed: April 7, 1983
    Date of Patent: June 4, 1985
    Inventor: Raymond V. Sara
  • Patent number: 4514506
    Abstract: The invention comprises a method for the purification of a human lung tumor-associated antigen (hLTAA) specific to human lung tumors of diverse histological characteristics; serum levels of hLTAA correlate with lung tumor incidence, and appear to usefully discriminate between various stages of the malignancies. The invention further comprises an immunoassay predicated on purified hLTAA for the detection and quantitative determination of hLTAA in biological fluids, particularly blood serum, and diagnostic systems for clinical immunoassay procedures.
    Type: Grant
    Filed: January 28, 1983
    Date of Patent: April 30, 1985
    Assignee: The Government of the United States as represented by the Secretary of the Department of Health and Human Services
    Inventors: James A. Braatz, Kenneth R. McIntire, Gerald L. Princler
  • Patent number: 4514507
    Abstract: An assay for interferon comprises two antibodies to interferon, one labelled and at least one being a monoclonal antibody. The non-labelled antibody is suitably attached to a solid support such as polystyrene beads and the labelled antibody is suitably a radiolabelled monoclonal antibody, e.g. 125 I-NK2.
    Type: Grant
    Filed: June 28, 1982
    Date of Patent: April 30, 1985
    Inventor: David S. Secher
  • Patent number: 4514469
    Abstract: Disclosed are coatings which are improved by a special peening process. Uniform sized spherical steel shot, in the range 1-2.5 mm is impacted at uniform low velocities onto a coated workpiece. Peening intensities are in the range 0.30-0.60 mm N. MCrAlY high temperature coatings are particularly improved, with densities of the order of 99 percent. Physical vapor desposited coatings have surface finishes of the order of 30.times.10.sup.-6 inch AA (Arithmetic Average) and plasma sprayed coatings have finishes of the order of 100.times.10.sup.-6 inch AA compared to unpeened finishes of 50-60.times.10.sup.-6 inch AA and 200-300.times.10.sup.-6 AA respectively.
    Type: Grant
    Filed: September 10, 1981
    Date of Patent: April 30, 1985
    Assignee: United Technologies Corporation
    Inventors: Joseph F. Loersch, James W. Neal
  • Patent number: 4514505
    Abstract: Mixtures of monoclonal antibodies which contain effective assaying amounts of each of at least two monoclonal antibodies that bind to different antigenic sites on the antigen and are capable under appropriate conditions of binding simultaneously to an antigen are useful in enhanced sensitivity assays for the antigen. By utilizing such mixtures in diagnostic assays for important antigens such as the polypeptide human chorionic gonadotropin enhanced sensitivity can be achieved as compared with assays employing individual monoclonal antibodies.
    Type: Grant
    Filed: May 21, 1982
    Date of Patent: April 30, 1985
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Robert E. Canfield, Paul H. Ehrlich, William R. Moyle
  • Patent number: 4504586
    Abstract: Murine-derived hybridoma tumor cell lines and monoclonal anti-Colony Stimulating Factor Subclass Number 1 antibody substances produced by these cell lines. Use of said monoclonal antibody substances, alone or in combination, in immunological procedures for isolation of natural Colony Stimulating Factor Subclass Number 1 and for quantitative detection of colony Stimulating Factor Subclass Number 1 in fluid samples.
    Type: Grant
    Filed: February 3, 1983
    Date of Patent: March 12, 1985
    Assignee: Amgen
    Inventor: Margery Nicolson
  • Patent number: 4502479
    Abstract: An orthopedic casting material is disclosed having improved strength and porosity characteristics. The casting material comprises a fabric which is made from a high modulus fiber and has a thickness between 0.020 and 0.045 inches and a mesh size of 20 to 200 openings per square inch. The fabric is impregnated with a reactive resin which hardens by wetting with a curing agent.
    Type: Grant
    Filed: September 4, 1979
    Date of Patent: March 5, 1985
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Donald C. Garwood, Shiraz A. Kathiriya
  • Patent number: 4501718
    Abstract: A method of consolidating a metallic or ceramic body is disclosed. The method comprises the steps of forming an article of manufacture from powdered metal or ceramic; sintering the article of manufacture so as to increase the strength thereof; providing a bed of heated, generally spheroidal ceramic particles; and compacting the article of manufacture embedded in the heated bed under pressure to thereby consolidate the article into a dense, desired shape.
    Type: Grant
    Filed: February 23, 1983
    Date of Patent: February 26, 1985
    Assignee: Metal Alloys, Inc.
    Inventor: Richard C. Bradt
  • Patent number: 4499049
    Abstract: A method of consolidating a metallic or ceramic body is disclosed. The method comprises the steps of forming an article of manufacture from powdered metal; sintering the article of manufacture so as to increase the strength thereof; providing a bed of heated, generally spheroidal ceramic particles which have been coated with a thermally stable lubricant; and compacting the article of manufacture embedded in the heated bed under pressure to thereby consolidate the article into a dense, desired shape.
    Type: Grant
    Filed: February 23, 1983
    Date of Patent: February 12, 1985
    Assignee: Metal Alloys, Inc.
    Inventor: Francis G. Hanejko
  • Patent number: 4499048
    Abstract: A method of consolidating a metallic body is disclosed. The method comprises the steps of forming an article of manufacture from powdered metal; sintering the article of manufacture so as to increase the strength thereof; coating the article with a sacrificial layer of ceramic; providing a bed of heated, generally spheroidal ceramic particles; compacting the coated article of manufacture embedded in the heated bed under pressure to thereby consolidate the article into a dense, desired shape; and, removing said sacrificial coating such that the surface of the article remains substantially free of process-related imperfections.
    Type: Grant
    Filed: February 23, 1983
    Date of Patent: February 12, 1985
    Assignee: Metal Alloys, Inc.
    Inventor: Francis G. Hanejko
  • Patent number: RE31846
    Abstract: A material and a process for use in making electrical contacts. The material is produced in powder form suitable for later processing into electrical contacts by standard metallurgical techniques generally involving compacting the powdered material to form a compact that preferably has a backing of metallic silver, sintering the compact to form the contact having a fine sintered silver backing and forming or cutting the contact to make it to the desired shape and size. The material, and in most general applications the contact made from the material, essentially consists of silver, approximately 15% cadmium oxide by weight, and lithium carbonate at a proportion of about 0.005 weight percent of lithium, which is approximately equal to 0.04 molecular percent of lithium carbonate.
    Type: Grant
    Filed: April 22, 1983
    Date of Patent: March 12, 1985
    Assignee: Square D Company
    Inventor: Frank S. Brugner, Jr.
  • Patent number: RE31855
    Abstract: This invention relates to a flexible cannula comprising material which tears readily in a longitudinal direction and can thus be easily removed by pulling tabs on opposite sides of the cannula apart after the catheter or other device has been inserted into the body.
    Type: Grant
    Filed: November 22, 1982
    Date of Patent: March 26, 1985
    Assignee: Cook, Inc.
    Inventor: Thomas A. Osborne