Abstract: An implantable drug deliver depot comprising a hydrophilic poly(glutamic acid-co-ethyl glutamate) structure having one or more substances, e.g., drugs and/or diagnostic agents physically contained therein. The drug or diagnostic agent is released by its permeation of and diffusion through the copolymer structure. The depot may be designed to release the substance or substances at predetermined rates and in predetermined sequence. The copolymer structure ultimately biodegrades to glutamic acid. Among the preferred configurations for the depots are rods and closed-end capsules.

Abstract: A device for the controlled release of an active material into a liquid medium comprises a liquid soluble body having an array of cavities therein containing the active material. The body may be enclosed in a casing of a material having a relatively low dissolution rate and provided with means, e.g. an aperture whereby a portion of the body can be exposed to dissolving attack by the liquid medium. The body is so constructed that the cavity contents are released sequentially and at a predetermined rate.

Abstract: An osmotic device is disclosed for delivering two beneficial drugs to an environment of use. The device comprises a wall surrounding a lumen divided into a first compartment containing a drug that is separated by a hydrogel partition from a second compartment containing a different drug. An orifice through the wall communicates with the first compartment for delivering drug formulation from the first compartment, and another orifice through the wall communicates with the second compartment for delivering drug formulation from the second compartment.

Abstract: A breath actuated device for the oral inhalation of medicaments in finely divided powder form, comprising a chamber (72) having one or more inlet ports for the entry of air and an outlet in direct communication with a mouthpiece (66) and positioned within the chamber, means for separating the lid and base components (62A, 62B) of a capsule (as defined herein) containing the medicament while holding the capsule substantially vertically to expose an aperture in the base component facilitating access to the powdered medicament and means for supporting the base component of the capsule containing the powdered medicament in a substantially vertical position, the inlet ports, outlet port and means for supporting the base component of the capsule being arranged such that when the device is operated by suction at the mouthpiece an air flow is established from the entry ports to the outlet port directly across the aperture in the base component of the capsule causing the particles of powdered medicament in the base co

Abstract: Drilling fluid additives are prepared by oxidation of sulfonated lignin-containing materials with manganese dioxide under highly acidic conditions to make manganese lignosulfonates. Additional improvements in the rheological properties of the additives may be obtained by complexing the manganese lignosulfonate so obtained with a heavy metal cation (preferably iron or copper), by, for example, addition of ferrous sulfate or ferric sulfate to the manganese lignosulfonate. These products show the requisite combination of rheological properties for a satisfactory drilling fluid additive or conditioner.

Abstract: A method for hot-consolidating powder of metallic and nonmetallic composition and combinations thereof to form a densified compact at a predetermined temperature and pressure at which the powder is transformed into a compact comprises the steps of filling the cavity of a container with a powder, such as a superalloy, to be compacted and hermetically sealing the container. The method is characterized by the steps of heating the container within an autoclave having an inert gas therein, such as argon, to an intermediate temperature, then pressurizing the autoclave to an intermediate temperature and thereafter raising the temperature to thereby increase the pressure and, consequently, reach the temperature and pressure to effect compaction or densification of the compact or article.

Abstract: A device for inserting a sterile tampon comprising an outer tube, an insertion tube which slides telescopically inside the outer tube, and a sterile tampon releasably attached to the forward end of the insertion tube and pressed against the inside of the closed forward end of the outer tube, the outer tube being weakened at its forward end so as to rupture when manual pressure is applied to the insertion tube to permit ejection of the tampon into the vagina, the outer tube having two spaced laterally outwardly projecting members, one located adjacent the rearward end of the outer tube and the other located in the central portion between the forward end and the rearward end of the outer tube to position the forward end of the outer tube at a desired depth, the member at the rearward end of the outer tube serving as a finger grip, the insertion tube having at its forward end a means for releasably gripping the string end of the tampon and at its rearward end a laterally outwardly projecting member to prevent sl

Abstract: Disclosed is a technique for screening populations to detect potential bladder cancer patients. The screening test is based on a discovered correlation between the respective ratios of C-reactive protein to total protein in urine and serum and the incidence of bladder cancer.

Abstract: A process for recovering one or more nonradioactive transition metal compounds from an ore containing one or more compounds of said transition metal or metals and further containing at least one complex of a member selected from the group consisting of uranium, thorium, radium, titanium, and rare earth metals, which comprises decomposing said ore in crushed condition by means of an acid so that a portion of the ore is brought into solution in a liquid phase and another portion of the ore remains in a solid phase, said compound or compounds of the transition metal or metals to be recovered passing into only the liquid or into only the solid phase, the uranium in the crushed ore being treated so as to cause substantially all of said uranium to be present in an oxidation state in which it cannot, during the decomposition step, pass into the phase containing the transition metal compound or compounds.

Abstract: A prostate antigen distinct from prostatic acid phosphatase has been detected in normal, benign hypertrophic and malignant prostatic tissues, but not in other human tissues. The prostate antigen was purified to homogeneity from prostatic tissues by ammonium sulfate precipitation, DEAE-BioGel A anion exchange chromatography, molecular sievings on Sephadex G-100 and Sephadex G-75, and preparative polyacrylamide gel electrophoresis. The purified prostate antigen shows a single protein band on analytical polyacrylamide gel electrophoresis and isoelectric focusing. The molecular weight of purified antigen was estimated by Sephadex G-75 gel filtration to be 33,000 and by sodium dodecyl sulfate polyacrylamide gel electrophoresis to be 34,000 with no subunit. The prostate antigen had an isoelectric point of 6.9.

Abstract: A high current density cathode is made by first forming an active porous h purity tungsten pellet by the steps of:(A) mixing tungsten powder with about 1 to 5 percent by weight of the mixture of an activator powder and compacting the powders at a pressure of about 35 tons per square inch to form a pellet,(B) sintering the pellet in a non-oxidizing atmosphere at about 1800 degrees C. for about 11/2 to 31/2 hours to the desired porosity,(C) filling the porous pellet with a filler material,(D) machining to the desired size and shape,(E) removing the filler material, and then forming the cathode by impregnating the pellet with Ba.sub.5 Sr(WO.sub.6).sub.2 at about 1700 degrees C. in an inert atmosphere and subsequently firing for 2 minutes at 1800 degrees C. in dry hydrogen.

Abstract: Chlorine-containing gases which may be formed in containers of solid chloroisocyanurates such as trichloroisocyanuric acid are adsorbed and decomposed by a gas scavenging agent consisting essentially of silica gel, an alkali metal bicarbonate, and carbon. The gas scavenger is preferably enclosed in a gas permeable spun-bonded polyolefin envelope. The scavenging agent adsorbs moisture, absorbs and decomposes nitrogen trichloride, removes chlorine, and neutralizes hydrogen chloride formed. The gas scavenging mixture is physically compatible and readily blended while minimizing dusting during packaging operations.

Abstract: Monoclonal antibodies specific for surface antigens of bacteria which act as adhesins between prokaryotic and eukaryotic cells and, in particular, K-99 pili, and methods for production thereof are described. These monoclonal antibodies may be used for the prophylactic and therapeutic treatment of diseases induced by adhesin-bearing pathogens in animals and humans, and for the diagnostic identification of adhesin-bearing bacteria.

Abstract: A novel casting or splinting package is disclosed wherein a sheet comprising a textile substrate impregnated or coated with a water-curable resin system is non-sealably confined between a sheet of resilient, non-water-absorptive material and a sheet of flexible, non-water-absorptive material. The assembled sheets are enclosed in a porous envelope. In use, the casting or splinting package is immersed in water, squeezed to remove excess water, and then applied to and formed about the body part to be immobilized or supported whereupon the package becomes rigid.

Abstract: Monoclonal antibodies specific to a mature human T cell surface antigen of molecular weight of about 120,000 daltons as determined by electrophoresis, the antigen not being modulated by monoclonal antibodies specific to it and being restricted within the human lymphoid system to the surface of mature T cells, the monoclonal antibodies being capable of selectively binding mature human T cells and rendering them inactive in vivo and failing to induce the proliferation or activation of human lymphocytes.

Abstract: Granular sorbent material comprising a granular high surface area support impregnated with a water soluble, essentially non-volatile primary or secondary amine with equivalent weight less than about 400 and bearing either zero or two carbonyl substituents attached directly to the amino nitrogen atom is disclosed. The resulting material can be used as the filtration media in respirators, powered air purifiers, room air purifiers, ventilation filters, exhaust filters, process gas filters and the like to reduce the formaldehyde content of air.

Abstract: A method is provided for propping a fracture in a subterranean formation which comprises injecting into a subterranean well a suspension in a carrier fluid of a pre-cured proppant charge, the pre-cured proppant charge being pre-cured prior to injection into the well, and comprising prior to injection into the well, resin coated sand particles most of which are composed of a single substrate particle with a thermoset resite coating thereon, the resite coating being one which, when it is the resin coating on sand particles of a proppant charge, produces a charge wherein at least one of: (a) the Conductivity Ratio thereof, throughout a given closure stress range, is greater than that of a charge of the uncoated sand particles having substantially the same particle size distribution; or (b) the Permeability Ratio thereof, throughout the stress range of about 2,000 to about 10,000 p.s.i.

Abstract: Concentrations of non-ionic species in aqueous media are measured as a function of potentiometric or polarographic response, employing a membrane electrode selective for the non-ionic species being measured. The electrode comprises a conductive substrate and a membrane formed as a layer on the conductive substrate and adapted for interfacing with the aqueous medium. The membrane is composed of a polymeric matrix having dispersed or dissolved therein an anion exchange material and a water-insoluble salt of the non-ionic species being measured. The electrode is particularly suitable for use as an implantable glucose sensor for continuous in vivo monitoring of glucose concentration in the blood or interstitial fluid.

Abstract: A hydrocarbonaceous liquid stream is modified to contain a minor amount of the amide reaction product of a polyalkylene polyamine, a neo-acid having 5 to 20 carbon atoms, the neo-acid having three alkyl groups on the carbon atom which is in the alpha position relative to the carboxylic group, and an aliphatic fatty acid having 10 to 30 carbon atoms, whereby corrosion of iron and other metals contacted by said stream is significantly reduced.

Abstract: The present invention provides a process for preparing stable, uniform dispersions of chain extenders in polyurethane-forming polyol. The preferred chain extender is hydroquinone di(.beta.-hydroxyethyl)ether. The process comprises an adiabatic quenching step in combination with an annealing step. The inventive process avoids the need for slow, carefully controlled cooling schemes.