Patents Examined by Blaine Lankford
  • Patent number: 10265344
    Abstract: Provided herein is a placental product comprising an immunocompatible chorionic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: April 23, 2019
    Assignee: Osiris Therapeutics, Inc.
    Inventors: Samson Tom, Alla Danilkovitch, Dana Yoo, Timothy Jansen, Jin-Qiang Kuang, Jennifer Michelle Marconi
  • Patent number: 10258628
    Abstract: Methods and compositions for producing mature myotubes are provided herein. In some instances, the method involves contacting a myoblast in an in vitro culture with a compound, wherein the contacting the myoblast in the in vitro culture with the compound results in generation of mature myotubes or myotube-like cells. In some cases, methods of treatment are provided involving treating a subject with a compound such as a Chk1 inhibitor in order to treat muscle deficiency. The compound may be administered as a stand-alone therapy or in combination with a cell therapy, such as introduction of muscle precursor cells such as satellite cells or myoblasts. Methods for identifying compounds that induce formation of mature myotubes or myotube-like cells from myoblasts are also provided herein, as well as methods of using the identified compounds to treat subjects.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: April 16, 2019
    Assignee: GENEA BIOCELLS USA (HOLDINGS), INC.
    Inventors: Uli Schmidt, Anabel De La Garza, Alexander Kiselyov
  • Patent number: 10258650
    Abstract: Provided herein is a placental product comprising an immunocompatible chorionic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: April 16, 2019
    Assignee: Osiris Therapeutics, Inc.
    Inventors: Samson Tom, Alla Danilkovitch, Dana Yoo, Timothy Jansen, Jin-Qiang Kuang, Jennifer Michelle Marconi
  • Patent number: 10260043
    Abstract: The present invention provides a human cell population that can self-renew extensively and yet retain the capacity to differentiate into red blood cells (RBCs). These cells are referred to as extensively self-renewing erythroblasts (ESREs). The cells of the invention serve among other things as a renewable source of transfusable RBCs.
    Type: Grant
    Filed: May 15, 2014
    Date of Patent: April 16, 2019
    Assignee: UNIVERSITY OF ROCHESTER
    Inventors: James Palis, Samantha England, Ah Ram Kim
  • Patent number: 10253348
    Abstract: Provided is a method for capture and release of microorganisms using microstructures. The method includes providing microstructures coated with a protein for attachment/detachment of microorganisms, mixing the microstructures with a solution containing substances assisting in attachment of microorganisms in a solution containing microorganisms to prepare a mixed solution, stirring the mixed solution to attach the microorganisms to the microstructures, separating the microorganism-attached microstructures from the mixed solution; and exposing the microstructures to an environment where the substances assisting in attachment of the microorganisms are present at a low concentration to detach the microorganisms from the microstructures.
    Type: Grant
    Filed: July 4, 2013
    Date of Patent: April 9, 2019
    Assignee: QUANTAMATRIX INC.
    Inventor: Yong Gyun Jung
  • Patent number: 10226485
    Abstract: The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.
    Type: Grant
    Filed: March 21, 2005
    Date of Patent: March 12, 2019
    Assignees: ABT Holding Company, Regents of the University of Minnesota
    Inventors: Leo T. Furcht, Catherine M. Verfaillie, Morayma Reyes
  • Patent number: 10213579
    Abstract: A catheter has a proximal portion of relatively larger central lumen diameter and outer diameter, and a distal portion of relatively smaller central lumen diameter and outer diameter, the two portions being integral with one another so that cells delivered into the central lumen of the proximal portion will flow through and exit the central lumen of the distal portion, encountering a constriction at the junction of the two portions, for infusion into body tissue at a predetermined target site when the catheter is inserted into a designated natural body vessel or duct leading to the target site. The cells are delivered in a fluid under pressure through a central lumen of the catheter to exit distally from the lumen at the target site, and meander of exiting fluid pressure from a predetermined value is minimized by adjusting the fluid pressure at the point of entry into the catheter's central lumen accordingly.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: February 26, 2019
    Assignee: SciCoTec GmbH
    Inventor: Eckhard U. Alt
  • Patent number: 10208345
    Abstract: Isolated non-naturally occurring populations of spermatozoa (15) having high purity and technologies to differentiate spermatozoa (28) based on characteristics such as mass, volume, orientation, or emitted light including methods of analysis and apparatus such as beam shaping optics (30) and detectors (32).
    Type: Grant
    Filed: January 28, 2013
    Date of Patent: February 19, 2019
    Assignee: XY, LLC
    Inventors: Kenneth M. Evans, Erik B. van Munster
  • Patent number: 10208288
    Abstract: The present invention provides methods to promote differentiation of pancreatic endoderm cells to pancreatic endocrine rich clusters and to enhance insulin expression in hormone-expressing cells.
    Type: Grant
    Filed: November 1, 2016
    Date of Patent: February 19, 2019
    Assignee: Janssen Biotech, Inc.
    Inventor: Alireza Rezania
  • Patent number: 10196665
    Abstract: This invention relates to a novel cell culture medium and methods to enhance recombinant antibody purity using the cell culture medium disclosed herein. The novel cell culture medium is a self-made feeding medium, which comprises from about 90 nM to about 500 mM cysteine, from about 50 mM to about 500 mM tyrosine, and from about 50 mM to about 300 tryptophan. This invention also relates to a method of growing cell culture using the cell culture medium disclosed herein By controlling the concentration of cysteine in the self-made feed medium as well as the amount and time of adding this feed medium into the cell culture, the purity of antibodies is significantly improved while glycosylation profile and antibody expression level are consistently maintained to guarantee the efficacy of antibodies.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: February 5, 2019
    Assignee: SUNSHINE LAKE PHARMA CO., LTD.
    Inventors: Xiwen Cheng, Chengwei Yan, Bin Yang, Wen-Chen Suen, Yuancan Weng, Chongfei Deng
  • Patent number: 10188114
    Abstract: It can be useful to regulate the growth of microbial cells. Some embodiments herein provide genetically engineered microbial cells that can produce bacteriocins to control the growth of microbial cells. In some embodiments, microbial cells are contained within a desired environment. In some embodiments, contaminating microbial cells are neutralized. In some embodiments, a first microbial cell type regulates the growth of a second microbial cell type so as to maintain a desired ratio of the two cell types.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: January 29, 2019
    Assignee: SYNGULON SA
    Inventor: Philippe Gabant
  • Patent number: 10175219
    Abstract: A method of sensing radionuclides in cells is provided that includes exposing a cell of interest to a radiolabeled molecule, encapsulating the cell of interest with a chemical sensor in an encapsulant to hold the cell of interest and the chemical sensor in proximity, where the radiolabeled molecule decays to emit an energetic particle, and detecting a fluorescence or optical absorption signal in the chemical sensor induced by the radio molecule decay, using an illumination source and a detector, where single-cell analysis with the radiolabeled molecule is performed.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: January 8, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Guillem Pratx, Silvan Tuerkcan
  • Patent number: 10167449
    Abstract: An isolated human brown adipose tissue stem cell line. In one embodiment, the isolated human brown adipose tissue stem cell line expresses the markers CD9, SSEA4, CD44, CD90, CD166, CD73, but not CD14, CD34, CD45 or STRO-1. In another embodiment, the isolated human brown adipose tissue stem cell line expresses the genes UCP1, PPARGC1A, NRF1, FOXC2, CREB1, SIRT3, and WNT5A (REFX). In still another embodiment, the isolated human brown adipose tissue stem cell line is capable of differentiating into osteoblasts, chondrocytes, and adipocytes.
    Type: Grant
    Filed: April 17, 2014
    Date of Patent: January 1, 2019
    Assignee: BIORESTORATIVE THERAPIES, INC.
    Inventor: Francisco Javier Silva
  • Patent number: 10150950
    Abstract: A method for culturing mesenchymal stem cells. The method includes isolating mesenchymal stem cells having a size of 8 ?m or less and culturing the mesenchymal stem cells in a medium containing calcium and magnesium and under a low oxygen condition. The method can significantly improve the proliferative capacity and differentiation potential of the mesenchymal stem cells.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: December 11, 2018
    Assignee: MEDIPOST CO., LTD
    Inventors: Yoon-Sun Yang, Won Il Oh, Hye Jin Jin, Soon-Jae Kwon, Miyeon Kim
  • Patent number: 10119113
    Abstract: Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
    Type: Grant
    Filed: October 12, 2015
    Date of Patent: November 6, 2018
    Assignee: CYTORI THERAPEUTICS, INC.
    Inventors: Marc H. Hedrick, John K. Fraser, Michael J. Schulzki, Bobby Byrnes, Grace Carlson, Ronda Elizabeth Schreiber, Isabella Wulur
  • Patent number: 10111907
    Abstract: The invention provides compositions comprising stem and/or progenitor cells that have been treated to enhance the therapeutic properties of the cells for treating ischemia. In particular, the present invention relates to the use of stem and/or progenitor cells having enhanced therapeutic properties to treat an ischemic tissue, a tissue damaged by ischemia, or at least one symptom associated with an ischemic tissue or a tissue damaged by ischemia.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: October 30, 2018
    Assignee: Fate Therapeutics, Inc.
    Inventors: Dan Shoemaker, Pratik S. Multani, John D. Mendlein, David Robbins
  • Patent number: 10091984
    Abstract: Methods and compositions for stabilizing a biological sample for analysis, comprising the steps of obtaining in a sample collection device a biological sample from a subject, the biological sample including at least one circulating tumor cell from the subject. The methods may include a step of contacting the biological sample with a protective agent composition that includes a preservative agent, an optional anticoagulant, and a quenching agent to form a mixture that includes the protective agent composition and the sample.
    Type: Grant
    Filed: July 22, 2014
    Date of Patent: October 9, 2018
    Assignee: STRECK, INC.
    Inventors: Rohan M. Fernando, Wayne L. Ryan, Brad Hunsley
  • Patent number: 10093897
    Abstract: The invention relates to in vitro methods for differentiating mammalian pluripotent stem cells into cells displaying a neuronal phenotype, more particularly into cortical-type neurons including inter alia pyramidal neurons and cortical inhibitory interneurons. The invention further encompasses so-obtained neuronal cells and cell population, compositions comprising such, and further uses of said neuronal cells and cell population.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: October 9, 2018
    Assignee: Université Libre de Bruxelles
    Inventors: Pierre Vanderhaeghen, Nicolas Gaspard, Gilles Naeije, Jelle Van Den Ameele, Fabienne Devreker, Yvon Englert
  • Patent number: 10080810
    Abstract: A method for testing, treating, and preventing delayed food allergies includes: receiving detailed symptom, medical, and dietary histories from a patient; formulating a combination of one or more food extracts at selected concentrations for sublingual administration over a trial period; determining whether the patient's symptoms have improved, worsened, or had no change, in response to the administration of the combination; and altering the combination in response to whether the patient's symptoms have improved, worsened, or not changed, so as to induce immune system food tolerance.
    Type: Grant
    Filed: August 12, 2014
    Date of Patent: September 25, 2018
    Inventor: John Shea
  • Patent number: 10081823
    Abstract: Disclosed is a treatment method of biomass to maximize sugar yield, which uses a specific additive which can effectively adsorb lignin-derived compounds and various inhibitors of the enzymatic activity to promote saccharification of cellulose catalyzed by cellulose hydrolases, and thus can maximize sugar yield from pretreated biomass.
    Type: Grant
    Filed: December 23, 2011
    Date of Patent: September 25, 2018
    Assignee: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
    Inventors: Ju Hyun Yu, Chan Duck Jung, In Yong Eom, Kyung Sik Hong, Bong Keun Song