Patents Examined by Blaine Lankford
  • Patent number: 10070653
    Abstract: The invention relates to the method for producing the fungus Paecilomyces spp., and to the uses, methods and nematicide compositions for the prevention and/or control and/or eradication of nematodes that form cysts developing in solanaceae cultures. Said invention includes a system for the application of the fungus combined with the rotation of cultures for effectively and efficiently reducing the viability of the cysts of nematodes in solanaceae cultures.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: September 11, 2018
    Assignee: Instituto de Ecologia, A.C.
    Inventors: Gloria Luz Laura Carrion Villarnovo, Tania Isadora Hernandez Leal, Jose Daniel Lopez Lima, Angel Enrique Nunez Sanchez
  • Patent number: 10066210
    Abstract: The present invention provides methods to promote differentiation of pancreatic endoderm cells to pancreatic endocrine rich clusters and to enhance insulin expression in hormone-expressing cells.
    Type: Grant
    Filed: June 6, 2013
    Date of Patent: September 4, 2018
    Assignee: Janssen Biotech, Inc.
    Inventor: Alireza Rezania
  • Patent number: 10053718
    Abstract: The present invention provides a novel and potent cellulose producing bacterial species, Gluconacetobacter oboediens which was isolated from mixed fruit residue deposited at MTCC, IMTECH, Chandigarh under the deposition number MTCC 5610. The process for the production of microbial cellulose by this bacterium was optimized and thus, an efficient and economic process for producing high titers of microbial cellulose was developed. Further, a novel and improved method for drying of microbial cellulose has been developed wherein the microbial cellulose mats were dried using a wooden plank and porous fabric as a base at room temperature. The microbial cellulose production was successfully scaled up to 5 liters volume of production medium in trays. The present invention also recites the production and optimization of microbial cellulose in different shapes and sizes (gloves and vessels) which will be of great help for burn and injured persons/patients.
    Type: Grant
    Filed: August 15, 2013
    Date of Patent: August 21, 2018
    Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Rajendra Kumar Saxena, Firdaus Jahan
  • Patent number: 10047345
    Abstract: Methods of culturing mesenchymal stem cells are provided. The methods comprise culturing MSCs in a medium comprising nicotinamide and fibroblast growth factor 4 (FGF4). Populations of mesenchymal stem cells generated using the methods described herein and uses thereof are also provided.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: August 14, 2018
    Assignee: Gamida-Cell Ltd.
    Inventors: Tony Peled, Yair Steinhardt
  • Patent number: 10018635
    Abstract: The present invention relates to methods for continuous or near-continuous separation and purification of samples, particularly biological samples, to reduce the number or volume of non-targeted analytes in those samples to enable improved mass spectrometric analysis of analytes of interest, and apparatuses for conducting those methods, utilizing a transport agent with a core domain and a binding domain, the transport agent exceeding 200 kiloDaltons or 10 nm, and the binding domain targeted to the analytes of interest, in conjunction with size-exclusion based chromatography to separate the transport agent-analyte of interest complex from non-targeted analytes that are not bound, or are only non-specifically bound, to the transport agent.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: July 10, 2018
    Inventors: Fred Regnier, JinHee Kim
  • Patent number: 10016463
    Abstract: The current application is directed to a method for treating pulmonary arterial hypertension (PAH), comprising: providing isolated endothelial progenitor cells (EPCs); treating the EPCs with prostacyclin, wherein the treated EPCs exhibit a hyperproliferative phenotype with enhanced angiogenic property; and administering a composition comprising the treated EPCs into a subject suffering from PAH.
    Type: Grant
    Filed: July 30, 2013
    Date of Patent: July 10, 2018
    Assignee: United Therapeutics Corporation
    Inventors: Roger Jeffs, Thomas Petersen, Roger M. Ilagan, Michael Wade
  • Patent number: 10017740
    Abstract: The present invention relates to brown adipose tissue (BAT) cells derived from adult stern or progenitor cells, derived from adult white fat tissue (WAT), as well as to methods for deriving such cells.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: July 10, 2018
    Assignee: Plasticell Limited
    Inventors: Marina Tarunina, Yen Choo, Mylvaganam Jeyakumar, Thomas Watson, Meritxell Rosell, Lilian Hook, Diana Hernandez
  • Patent number: 10004236
    Abstract: The invention provides isolated Brevibacillius laterosporus strains with insecticidal activity against at least one Lepidopteraspecies and at least one Dipteraspecies. In particular the invention provides the isolated B. laterosporus strains NMI No. V12/001946, NMI No. V12/001945 and NMI No. V12/001944. The invention provides compositions comprising one or more strain of the invention. The invention also provides methods of use of one or more strains or compositions of the inventions to control pests, particularly insect pests.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: June 26, 2018
    Assignee: Lincoln University
    Inventors: Travis Robert Glare, John Graham Hampton, Murray Paul Cox, Damian Alexander Bienkowski
  • Patent number: 10006003
    Abstract: The present technology provides methods for preparing a flowable amniotic composition derived from amniotic membrane of humans. Various embodiments of the method for preparing the amniotic composition may comprise mincing the amniotic membrane in a cryopreservation solution, cryopreservation, homogenization, filtration, centrifugation, and resuspension of a pellet in a cell solution to produce the flowable amniotic composition. The amniotic composition may comprise approximately 2.7 million viable cells per milliliter. The viability of the cells may be substantially stable for at least six months at ?18° C. Some preparations of the amniotic composition may have a flowability that may be at least partially characterized by a viscosity suitable for delivery to the target site through at least a 22 gauge needle.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: June 26, 2018
    Assignee: Surgenex, LLC
    Inventors: Eliott Spencer, Doug Schmid, Abel Bullock
  • Patent number: 10006005
    Abstract: Provided are a method of inducing differentiation of pluripotent stem cells, such as induced pluripotent stem cells (hereinafter abbreviated as iPS cells), to hepatocytes in a short period of time, and a substance to be used in the method. Specifically, provided are a method of producing a cell culture formed substantially of hepatoblasts, the method including culturing pluripotent stem cells, such as iPS cells, in a culture medium having a composition shown in Table 1 below, and a culture medium for inducing differentiation of pluripotent stem cells into hepatoblasts, which has a composition shown in Table 1 below.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: June 26, 2018
    Assignee: National University Corporation Chiba University
    Inventor: Minoru Tomizawa
  • Patent number: 9994814
    Abstract: A method comprising obtaining a donor composition from a donor subject wherein the donor composition comprises a plurality of adult stem cell types; obtaining a receiver composition from a receiver subject wherein the receiver composition comprises a plurality of adult stem cell types; and co-culturing the donor composition and receiver composition wherein co-culturing comprises contacting the receiver composition a cell-free portion of the donor composition to produce a restored composition. Pharmaceutical compositions comprising a restored composition.
    Type: Grant
    Filed: April 9, 2014
    Date of Patent: June 12, 2018
    Assignee: Advanced Regen Medical Technologies, LLC
    Inventor: Vincent C. Giampapa
  • Patent number: 9993525
    Abstract: A method for making a biomaterial comprising providing at least one polypeptide fraction chymotryptically isolated and extracted from fibroin, and adding the at least one extracted polypeptide fraction to a hydrogel precursor before gelling, wherein the at least one isolated and extracted polypeptide fraction is selected from a soluble fraction Cs, and a precipitated fraction Cp. A biomaterial comprising at least one of the isolated and extracted polypeptide fractions incorporated in a hydrogel or a hydrogel precursor. Use of the biomaterial for constructing, regenerating, repairing, replacing or augmenting soft or hard tissue; as an in vitro or in vivo construct; as a coating material; or as a cell, molecule or particle delivery medium. Use of the isolated and extracted polypeptide fraction Cs for promoting osteoinduction, osteoconduction or osteogenesis. Use of the isolated and extracted polypeptide fraction Cp for enhancing a mechanical compressive modulus of a material into which it is incorporated.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: June 12, 2018
    Assignees: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING, MCGILL UNIVERSITY
    Inventors: Showan N. Nazhat, Benedetto Marelli, Giuliano Freddi, Antonio Alessandrino, Jake E. Barralet
  • Patent number: 9988601
    Abstract: The present invention relates to a method for retrieving more numerous, viable and efficient stem cells from the blood of a patient. The method comprises a preliminary step of pre-treating blood cells using an oxygen-ozone mixture and a subsequent step of separating the stem cells from said pre-treated blood cells.
    Type: Grant
    Filed: October 6, 2014
    Date of Patent: June 5, 2018
    Assignee: PAOLO GOBBI FRATTINI S.R.L.
    Inventor: Paolo Giuseppe Gobbi Frattini
  • Patent number: 9980985
    Abstract: Compositions comprising stem cells delivered into infarcted myocardium by endocardial injection, engraft and differentiate into myocytes, endothelial cells, and vascular smooth muscle, and do so without the requirement for survival enhancing modification. These cells engraft whether injected acutely (days) or late (months) after myocardial infarction, and the efficiency of engraftment correlates with the functional recovery of the heart. The stem cells also recruit endogenous cardiac precursor cells, reconstitute myocardial stem cell niches, and enhance endogenous cell differentiation into myocytes.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: May 29, 2018
    Assignee: Vestion, Inc.
    Inventors: Joshua Hare, Konstantinos Chatzistergos, Alan W. Heldman
  • Patent number: 9968639
    Abstract: Fresh human pancreas tissue can be used as a source of cells when to identify and select a non-stem cell population that is predisposed to be a source for surrogate pancreatic cells that can be used in treating insulin-dependent diabetes. The progenitors of these surrogate pancreatic cells have no reprogramming genes integrated into their genomes, differentiate to the pancreatic lineage pursuant to a protocol that employs only defined reagents, and are substantially unable to differentiate to the mesodermal lineage.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: May 15, 2018
    Assignee: Seraxis, Inc.
    Inventor: William L. Rust
  • Patent number: 9969966
    Abstract: A cell culture system for fermentation or cultivation of at least one of cells, tissues or tissue-like cell cultures, organs or organ-like cell cultures and multicellular organisms comprises: a system vessel (1) in which at least one cavity (6) is formed, the cavity (6) having at least three ports (2, 3, 4); at least one porous substrate (9) installed within the cavity (6) so as to allow fluid flowing from any one to any other of said three ports (2, 3, 4) to pass through said porous substrate (9); and, at least one channel extending from a first one of said ports (3) within the porous substrate (9) towards a central region of said porous substrate (9).
    Type: Grant
    Filed: May 30, 2011
    Date of Patent: May 15, 2018
    Assignee: ATECH PARTNERS LIMITED
    Inventor: Sohéil Asgari
  • Patent number: 9964474
    Abstract: A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration device comprising a sintered porous polymer matrix comprising at least one concentration agent that comprises diatomaceous earth bearing, on at least a portion of its surface, a surface treatment comprising a surface modifier comprising ferric oxide, titanium dioxide, fine-nanoscale gold or platinum, or a combination thereof; (b) providing a sample comprising at least one microorganism strain; and (c) contacting the concentration device with the sample such that at least a portion of the at least one microorganism strain is bound to or captured by the concentration device.
    Type: Grant
    Filed: March 22, 2010
    Date of Patent: May 8, 2018
    Assignee: 3M Innovative Properties Company
    Inventors: Manjiri T. Kshirsagar, Andrew W. Rabins
  • Patent number: 9962409
    Abstract: Compositions comprising stem cells delivered into infarcted myocardium by endocardial injection, engraft and differentiate into myocytes, endothelial cells, and vascular smooth muscle, and do so without the requirement for survival enhancing modification. These cells engraft whether injected acutely (days) or late (months) after myocardial infarction, and the efficiency of engraftment correlates with the functional recovery of the heart. The stem cells also recruit endogenous cardiac precursor cells, reconstitute myocardial stem cell niches, and enhance endogenous cell differentiation into myocytes.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: May 8, 2018
    Assignee: Vestion, Inc.
    Inventors: Joshua Hare, Konstantinos Chatzistergos
  • Patent number: 9958436
    Abstract: Methods for determining cell chirality using micropatterned substrates are disclosed. Also provided are methods for diagnosing diseases such as genetic diseases or cancer by comparing the chirality of sample cells from a subject with normal cells, and determining a difference in chirality between the sample cells and normal cells.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: May 1, 2018
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Gordana Vunjak-Novakovic, Leo Qun Wan
  • Patent number: 9951309
    Abstract: This invention concerns methods of packaging and shipping stem cells. Also disclosed are related package products.
    Type: Grant
    Filed: February 14, 2012
    Date of Patent: April 24, 2018
    Assignee: Stemcyte Inc.
    Inventors: Wise Young, Dongming Sun, Robert Fleischaker, Kam Sze Kent Tsang