Abstract: The present disclosure provides collagen bioink compositions and chemically uncrosslinked and crosslinked collagen structures including collagen microparticles and scaffolds. Also provided are methods of their fabrication and use. Applications for using these collagen structures include treatments of damaged tissue, particularly those caused by osteoarthritis.

Abstract: The present invention relates to a pharmaceutical composition for treating and preventing gingivoperiodontitis or peri-implantitis, comprising, as effective components, sodium ethylenediaminetetra acetate, cetylpyridinium chloride, octyl phenol ethoxylate, and sodium bicarbonate. The composition according to the present invention can effectively eliminate bacteria causing gingivoperiodontitis and peri-implantitis, thereby alleviating inflammation, and furthermore, an interdental brush coated with the composition is convenient to apply to gaps between teeth, dental implants, orthodontic appliances, etc. and thus can be used to treat and prevent gingivoperiodontitis and peri-implantitis conveniently at home.

Abstract: Pharmaceutical, odontological, cosmetic and dermatological compositions comprising addition salts of trichloroacetic acid, one or more hydroxyacids and optionally glutamic acid or glutamic acid bioisosteres and phytic acid are useful for the peeling of the gingival collar, skin peeling, for resurfacing, treating skin hyper pigmentation, control sebum production, acne, pore size reduction and reducing the appearance of scars without causing undesirable side effects and contrast in coloration of the treated skin, for stimulation of the fibroblasts, transdermal biorevitalization, stimulation of the production of new collagen, for aesthetic improvement, for skin lightening, skin beautifying, skin firming and skin rejuvenation.

Abstract: A respirable dry powder can include acetylsalicylic acid in particles having a mass median aerodynamic diameter (MMAD) within a range of about 0.5 ?m to about 10 ?m. The respirable dry powder may contain a pharmaceutically acceptable excipient, such as an amino acid (e.g., Leucine), in an amount ranging from about 0.1% (w/w) to about 40% (w/w) of the particles.

Abstract: This disclosure provides an eco-friendly colloidal silver-based composition with the ability to prevent and control infections caused by pathogenic microorganisms in superficial organs of plants. The composition comprises water, colloidal silver, methyl vinyl ether copolymer, African palm vegetable oil, polyoxyethylene octylphenyl ether, triethanolamine, sodium hydroxide, and sodium benzoate. Due to its characteristics and the non-systemic application, the disclosed composition is non-toxic to host plants and other multicellular organisms.

Abstract: Alprazolam formulated as an inhaled condensation aerosol and method for treating epilepsy and/or seizures.

Abstract: A method of delivering a therapeutic agent into the central nervous system through the blood-brain barrier includes implanting an implant within the submucosal space of the olfactory epithelium. The implant can provide sustained drug delivery to the brain. The implant can be placed using a minimally invasive surgical approach.

Abstract: The present disclosure relates generally to an osteo-tissue graft capable of promoting bone tissue growth and regeneration, comprising at least one self-assemble peptide and mesenchymal stem cells (MSCs) in accordance with the present invention and a method of preparing such an osteo-tissue graft. The grafts are suitable for treatment of bone disorder or damages through tissue engineering, cellular replacement therapies as well as other applications.

Abstract: Peptides able to inhibit the muscarinic receptor M3 activity and to products comprising such peptides, in particular pharmaceutical and cosmetic products useful for ameliorating skin conditions mediated by the muscarinic receptor M3 activity, such as excessive perspiration, inflammation, sebum production, and cell adhesion, motility, growth, differentiation and proliferation.

Abstract: Medical articles formed from a polyurethane-based resin including an ionically-charged modifier provide enhanced properties. The polyurethane-based resin is a reaction product of ingredients comprising: a diisocyanate; a diol chain extender; a polyglycol; and an ionically-charged modifier incorporated into a backbone, as a side chain, or both of the polyurethane-based resin. Embodiments include the ionically-charged modifier is a combination of anionic and cationic modifiers. Embodiments include the ionically-charged modifier is zwitterionic. Medical articles herein either have inherent antimicrobial and/or anti-fouling characteristics or can easily bond ionic active agents to provide desirable material properties, including antimicrobial, anti-fouling, and/or radiopacity.

Abstract: Disclosed herein is a hydrogel that eradicates biofilm bacteria from wounds and accelerates diabetic wound healing. Also disclosed herein are methods of manufacture and use of said hydrogel.

Abstract: A nanomedicinal composition comprising a nanocarrier and a pharmaceutical agent mixture comprising an anti-cancer therapeutic and an antioxidant. The nanocarrier comprises a porous silicate matrix and particles of a magnetic ferrite disposed in the pores of the porous silicate matrix. The pharmaceutical agent mixture is disposed in the pores and/or on the surface of the nanocarrier by a solution phase impregnation process. The nanomedicinal composition is used in a method of treating breast cancer.

Abstract: In one aspect, methods of preparing composite nanoparticle compositions are described herein. For example, in some embodiments, a method comprises providing a zein solution stream, an organic fluid stream including at least one additive and at least one buffer fluid stream. The zein solution stream, organic fluid stream and buffer fluid stream are delivered to a chamber for mixing at one or more rates sufficient to flash precipitate composite nanoparticles including the additive encapsulated by a shell comprising the zein.

Abstract: Sustained-release composite particles having improved dispersion stability and improved sustained-release properties, and exhibiting longer-term effects, a method for producing the sustained-release composite particles, a dry powder comprising the sustained-release composite particles, and wallpaper comprising the sustained-release composite particles. The sustained-release composite particles comprise core particles containing at least one type of polymer and at least one type of functional component, and micronized cellulose coating at least a part of the surface of the core particles, the core particles and the micronized cellulose being inseparable from each other.

Abstract: A core-shell microcapsule comprising a core containing a functional ingredient and a shell surrounding or at least partially surrounding said core, the shell comprising a thermosetting resin formed by the reaction of shell-forming monomers comprising a polyamine and a material comprising a plurality of olefinic double bonds capable of reacting with the polyamine.

Abstract: The present disclosure is directed to oral tablet of ribociclib including its salt(s). One embodiment of the present disclosure is directed to tablet of ribociclib with high drug load with an immediate release profile. One embodiment of the present disclosure is directed to coated tablet of ribociclib. Another embodiment of the present disclosure is directed to coated tablet of ribociclib where the coating is an advanced moisture barrier coating (e.g., Opadry® amb II coating where the coating is PVA based).

Abstract: The instant disclosure generally relates to a multicomponent composition for coloring mammalian or synthetic substrate material and textiles, the composition comprising a first and second components and a third component. The first and second components comprise first and second silicone polymers respectively. Any one or more of the first, second and third components may also comprise pigment microparticles. The first, second and third compounds meld together on substrate material and textiles and especially on hair to form a highly remanent colored coating. The multicomponent composition formed and set in situ as a solid linked coating has a substantially permanent pigment lastingness and minimally alters the substrate material and textiles.

Abstract: The invention relates to a functional wound dressing being able to detect and indicate the state of the wound, in particular with regard to infections for example caused by toxins produced by bacteria such Staphylococcus aureus and Pseudomonas aeruginosa. The present wound dressing can be used in moist wound healing and contains a substance being able to absorb wound exudate from the wound and to provide moisture to the wound.

Abstract: The present invention relates to a transdermal therapeutic system for the transdermal administration of guanfacine comprising a guanfacine-containing layer structure, said guanfacine-containing layer structure comprising: A) a backing layer; and B) a guanfacine-containing layer; wherein the transdermal therapeutic system comprises at least one silicone acrylic hybrid polymer.

Abstract: Described herein are oral care compositions comprising a crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide, together with particular co-polymers as additional excipients; including some embodiments which further comprise a calcium abrasive.