Abstract: Scanning mechanisms that have application in confocal imaging use electromagnetic actuation to move elements in an optical system. An objective lens mounted to a flexure comprising a magnetic material is actuated in the axial direction by an electromagnet coil. An optical path may pass through the coil. Scanning in transverse directions may be provided using magnetically actuated flexible beams which move the tip of an optical fiber or other pinhole in one or more transverse directions. Actuators may be actuated using driving currents that include an AC component and a DC bias component. The scanning mechanisms may be miniaturized and may be constructed to provide real-time imaging.

Abstract: Methods for assessing spinal health and treatment effectiveness for spinal conditions in a patient via use of an ultrasonagraphic system are shown and described. The ultrasonagraphic system includes optical targets, a transducer probe, an optical tracker unit, an image processing system, a 3D ultrasound processor, and a display. The methods include attaching optical targets to the patient's body; detecting locations of the optical targets on the patient; detecting a location of the transducer probe; moving the transducer probe over at least a portion of the patient's body to collect spinal image data; generating 3D image data; sending 3D image data to the image processing system; processing 3D image data; displaying a real-time 3D image of the one or more vertebrae on the display to allow a healthcare provider to assess spinal health and treatment effectiveness based on the displayed real-time 3D image.

Abstract: A method and system for anatomical object detection using marginal space deep neural networks is disclosed. The pose parameter space for an anatomical object is divided into a series of marginal search spaces with increasing dimensionality. A respective deep neural network is trained for each of the marginal search spaces, resulting in a series of trained deep neural networks. Each of the trained deep neural networks can evaluate hypotheses in a current parameter space using discriminative classification or a regression function. An anatomical object is detected in a medical image by sequentially applying the series of trained deep neural networks to the medical image.

Abstract: An ultrasound observation apparatus for generating an ultrasound image based on an ultrasound signal obtained by an ultrasound probe having an ultrasound transducer for transmitting an ultrasound wave to an observation target and receiving the ultrasound wave reflected from the observation target. The ultrasound observation apparatus includes: a frequency analysis unit that analyzes a frequency of the ultrasound signal to calculate frequency spectra depending on a reception depth and a reception direction of the ultrasound signal; a frequency band setting unit that sets a frequency band used for calculating a feature of each of the frequency spectra by use of parameters associated with a frequency spectrum in each of candidate bands having different bandwidths; a feature calculation unit that calculates the feature of each of the frequency spectra based on the frequency band; and a feature image data generation unit that generates feature image data based on the feature.

Abstract: Systems and method for producing functional brain organization maps are provided. The method includes providing functional connectivity magnetic resonance image (fcMRI) data, a population atlas, a variation map indicative of inter-subject variability in the atlas. The method also includes initializing a subject map using the atlas, determining a reference signal for each functional connectivity network in the subject map using signals derived from the fcMRI data, computing correlations between the signals and reference signal of each functional connectivity network, and iteratively updating the subject map by reassigning locations in the subject brain when correlating with a functional connectivity network, updating at each iteration the reference signal using the subject map, the population atlas, the variation map, and the set of fcMRI data. The method further includes generating a report indicative of a functional brain organization for the brain of the subject using the subject map.

Abstract: The invention provides for a medical instrument (200, 300, 400, 500, 502, 600, 700, 702, 800, 802) comprising a LINAC guided by a magnetic resonance imaging system (204). Execution of the instructions by processor to controlling the medical instrument cause the processor to: receive (100) a treatment plan (260) for irradiating the target zone; modify (102) the treatment plan in accordance with an X-ray transmission model of an accessory; acquire (104) magnetic resonance data using the magnetic resonance imaging system; reconstruct (106) a magnetic resonance image (268) from the magnetic resonance data; register (108) a location (272) of the target zone in the magnetic resonance image; generate (110) control signals (274) in accordance with the location of the target zone and the X-ray transmission model; and control (112) the LINAC to irradiate the target zone using the control signals.

Abstract: An animal handling system (AMS), for positioning an immobilized animal in a predefined configuration therein, comprising an automated tuning unit, including: a proximal portion, held outside a medical device including: at least one inner shaft, and at least one outer shaft, the at least one inner is telescopically maneuverable within the at least one outer shaft providing a variable telescopic mechanism; and a distal portion including: a configurable encapsuable life support system (ELSS), the ELSS is rotatable about a longitudinal axis of the at least outer shaft and the at least inner shaft and translationally moveable parallel to the longitudinal axis by means of the maneuverable telescopic mechanism.

Abstract: Disclosed is an ultrasound diagnostic imaging apparatus including an ultrasound probe which outputs transmission ultrasound toward a subject due to a pulse signal being input and which outputs a received signal by receiving reflected ultrasound from the subject and a transmission unit which makes the ultrasound probe generate the transmission ultrasound by outputting a pulse signal whose drive waveform is formed of rectangular waves. The transmission unit outputs pulse signals whose drive waveforms are asymmetric to each other on a same scanning line for a plurality of times with a time interval therebetween. The ultrasound diagnostic imaging apparatus further includes an image generation unit which combines received signals each of which obtained from the reflected ultrasound of the transmission ultrasound generated by each output of pulse signal and generates ultrasound image data on a basis of a composite received signal.

Abstract: The present invention relates to an ophthalmic device with a retinal vascularization monitoring system and associated methods. In some embodiments, the ophthalmic device can be a contact lens with a retinal vascularization monitoring system that can be used to monitor temporal changes of a pulsating vessel forming part of the retinal vascularization. Further, the retinal vascularization monitoring system may include elements for delivering a signal, including an audible and/or visual message, to the user that can be useful for identifying abnormal conditions such as a cardiac failure without delay. The audible and/or visual messages can be signals communicated to the user using one or both of the ophthalmic device and a wireless device in communication with the ophthalmic device.

Abstract: An ultrasound observation apparatus includes: a first generation unit that computes a received signal based on first and second echo signals obtained by transmitting ultrasound signals having different phases along a same line to a specimen and reflection of the ultrasound signals from the specimen, and generates a first ultrasound image having first display mode, using the received signal; an extraction unit that calculates first and second features based on frequency spectra of the first and second echo signals, and extracts a third feature from the first and second features so as to be associated with a pixel position in image; a second generation unit that generates a second ultrasound image having second display mode at a pixel position where the third feature is not less than threshold; and a composition unit that generates a composite image by combining the first and second ultrasound images at the pixel position.

Abstract: A method and system for non-invasive assessment of renal artery stenosis is disclosed. A patient-specific anatomical model of at least a portion of the renal arteries and aorta is generated from medical image data of a patient. Patient-specific boundary conditions of a computational model of blood flow in the portion of the renal arteries and aorta are estimated based on the patient-specific anatomical model. Blood flow and pressure are simulated in the portion of the renal arteries and aorta using the computational model based on the patient-specific boundary conditions. At least one hemodynamic quantity characterizing functional severity of a renal stenosis region is calculated based on the simulated blood flow and pressure in the portion of the renal arteries and aorta.

Abstract: Systems and methods are described herein for tracking, localization or controlling an elongate instrument or other medical instrument in an image or patient.

Abstract: In a method and an apparatus to provide updated images during a robotically-implemented surgical procedure, 3D data are obtained of a volume of a patient, which includes anatomy involved in the procedure. The anatomy is segmented from a reconstructed image of the volume. During the procedure, the surgeon applies forces on the anatomy, causing a geometric change of the anatomy. Force sensors in the surgical robot detect these forces, which are supplied to a processor that controls display of the segmented anatomy at a display screen. From the applied forces and the physical properties of the anatomy, the processor calculates the geometric change of the anatomy that has occurred and modifies the appearance and/or position of the displayed segmented anatomy on the display screen in real time during the procedure, so as to visualize the geometric change.

Abstract: A method for fusing information related to structural features and characteristics of a biological sample. The resulting fused image may be imported into a surgical navigation technology intra-operatively to aid in surgical interventions by co-registering the fused image with the patient's anatomical features.

Abstract: A method for determining a volume of ablated tissue includes the steps of supplying energy to tissue, indicating an axis within the tissue, and simulating slicing of the tissue substantially perpendicular to the axis to obtain a plurality of simulated slices. Each of the plurality of simulated slices has a thickness, a cross-sectional perimeter, and a trajectory point defined by the axis within the tissue. The method further includes the steps of determining a volume of each of the plurality of simulated slices based on the trajectory point, the cross-sectional perimeter, and the thickness of each simulated slice, and summing the volumes from each of the plurality of simulated slices to obtain the volume of the ablated tissue.

Abstract: Hardware and software methodology are described for a non-invasive approach to blood pressure measurement in pulmonary artery and systemic arteries by using wall displacement and blood velocity that are measured using ultrasound, microwave techniques and/or other radiofrequency (RF) techniques.

Abstract: An endovascular device monitoring system is provided that determines, based on movement of the endovascular device past a selected reference location, at least one of a movement rate of a endovascular device and position of a distal end of a endovascular device in a body of a patient.

Abstract: A method of determining fractional flow reserve (FFR) in a blood vessel having stenosis includes injecting fluid into the blood vessel upstream of the stenosis using a power fluid injector, measuring pressure drop across the stenosis, and calculating FFR from measured pressure drop. The injected fluid may comprise a contrast medium. Further action may include placing a pressure sensor proximal of the stenosis, injecting fluid into the blood vessel upstream of the stenosis using the power fluid injector, and measuring pressure in the blood vessel proximal of the stenosis. The pressure sensor may then be repositioned to a position distal of the stenosis, fluid may be reinjected into the blood vessel upstream of the stenosis using the power fluid injector, and pressure may be measured in the blood vessel distal of the stenosis.

Abstract: The present invention provides a method for creating a personalized digital planning file for simulation of dental implant placement. After planning, the digital representation in a plaster model may be used to design and produce dedicated surgical templates to assist the surgeon in transferring the implant plan to a patient during medical intervention.

Abstract: An ultrasonic diagnosis apparatus according to the present invention includes: a storing section storing a plurality of items for inspection including ultrasonic imaging or measurement of an imaged ultrasonogram and an order thereof; a controlling section calculating, regarding an item set for inspection constituted of a next item for inspection which is an item for inspection subsequent to a current item for inspection which is currently being implemented out of the plurality of items for inspection, an implementation frequency at which the item set for inspection is implemented, for each next item for inspection; a displaying section displaying a candidate for the next item for inspection on the basis of the implementation frequency; and an inputting section inputting the next item for inspection from the candidate for the next item for inspection.