Patents Examined by Brown, Johnnie R.
  • Patent number: 5210264
    Abstract: The compound S-(2,4-dichlorobenzyl)-.beta.-cyanoethyl phosphorothioate diester is disclosed as useful in the synthesis of phosphorothioate oligonucleotides. In certain embodiments of the invention, this reagent is used to prepare 3'-S-(alkaryl) phosphorothioates. The .beta.-cyanoethyl blocking group can be removed and the resulting diester reacted with a nucleotide having a free 5'-hydroxyl group to yield compounds of the structure: ##STR1## where X is H, a first blocking group, a nucleoside, a nucleotide or an oligonucleotide; Y is H, a second blocking group, a nucleotide or an oligonucleotide; R is an alkaryl or aryl group; n is an integer greater than 0; and Bx is a heterocyclic base. Deblocking of the S-alkaryl or S-aryl moiety yields a phosphorothioate oligonucleotide.
    Type: Grant
    Filed: January 10, 1992
    Date of Patent: May 11, 1993
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventor: Eric K. Yau
  • Patent number: 4568741
    Abstract: An improved process for preparing 7-halo-7-deoxylincomycins and analogs thereof. The compounds prepared have anti-bacterial activity.
    Type: Grant
    Filed: May 15, 1984
    Date of Patent: February 4, 1986
    Assignee: The Upjohn Company
    Inventor: Douglas A. Livingston
  • Patent number: 4335114
    Abstract: The invention relates to sisomicin derivatives defined below in Formula (I) and a process for the preparation of said derivatives. Also included in the invention are compositions containing said derivatives and methods for using said derivatives and compositions.
    Type: Grant
    Filed: June 20, 1980
    Date of Patent: June 15, 1982
    Assignee: Bayer Aktiengesellschaft
    Inventors: Eckart Voss, Karl G. Metzger, Hans-Joachim Zeiler, Uwe Petersen, Peter Stadler