Patents Examined by C. Joseph Faraci
  • Patent number: 4656024
    Abstract: A new galenic form with delayed release of METROCLOPRAMIDE, useful for gastric treatment, is formed by microgranules comprising a neutral core formed by a grain of an inert excipient comprising at least two components of the type belonging to the class formed by saccharose, starch, talc, desiccating silica, lactose and stearic acid, this neutral grain being provided with a first layer comprising METOCLOPRAMIDE, then a second outer layer formed by a microporous envelope comprising at least one natural and/or synthetic polymer belonging to the class formed by shellac, gum arabic, ethyl cellulose, cellulose acetophtalate, cellulose triacetate, polyoxyethyleneglycol, the methacrylates, styrene-acrylonitrile copolymer and polyvinylpyrrolidone in successive envelopes.
    Type: Grant
    Filed: May 3, 1984
    Date of Patent: April 7, 1987
    Inventor: Claude Laruelle
  • Patent number: 4650666
    Abstract: Novel sugar-coated pharmaceutical composition such as tablets, pills, granules or the like, which contains pullulan in the sugar layer for the purpose of preventing brownish color change of the composition with lapse of time, and a method for preparing the composition.
    Type: Grant
    Filed: November 20, 1984
    Date of Patent: March 17, 1987
    Assignee: Dainippon Pharmaceutical Co., Ltd.
    Inventors: Yasuo Izutsu, Kiyomi Sogo, Shizuo Okamoto, Terukazu Tanaka
  • Patent number: 4642340
    Abstract: The compound consists of a mixed salt of glucosamine sulphate and sodium chloride corresponding to the formula: ##STR1## and is in the form of a crystalline powder with a melting point above C. The salt is stable at ambient temperatures and humidities and has pharmacological properties practically identical to those of glucosamine sulphate.
    Type: Grant
    Filed: April 30, 1982
    Date of Patent: February 10, 1987
    Assignee: Rotta Research Laboratorium S.p.A.
    Inventors: Paolo Senin, Francesco Makovec, Luigi Rovati
  • Patent number: 4636381
    Abstract: A coated ubidecarenone-containing liposome which comprises the ubidecarenone-containing liposome and a polysaccharide fatty acid ester applied on the surface of the membrane of said liposome, whereby the ubidecarenone can be selectively transferred in high concentrations to the lungs, spleen and kidneys.
    Type: Grant
    Filed: May 19, 1983
    Date of Patent: January 13, 1987
    Assignee: Eisai Co., Ltd.
    Inventors: Masahiro Takada, Teruaki Yuzuriha, Kouichi Katayama, Junzo Sunamoto
  • Patent number: 4622219
    Abstract: Local anesthesia is induced using microdroplets of a general anesthetic in liquid form. As an example, microdroplets of the general anesthetic methoxyfluorane coated by a unimolecular layer of dimysistoyl phosphatidylcholine are prepared by sonication. The microdroplets so prepared remain stable in physiologically-compatible solution, and are suitable for injection, typically intradermally or intraveneously, into a patient for inducing local anesthesia. These methoxyflurane-containing microdroplets have been demonstrated to cause long-term local anesthesia when injected intradermally, giving duration of anesthesia 28 times longer than with other anesthetics, such as lidocaine and 11 times longer than with bupivacaine.
    Type: Grant
    Filed: June 17, 1983
    Date of Patent: November 11, 1986
    Inventor: Duncan H. Haynes
  • Patent number: 4613496
    Abstract: Solid pharmaceutical preparations containing Rifampicin, crystalline cellulose, sodium lauryl sulfate and a lubricant have improved elution properties.
    Type: Grant
    Filed: February 27, 1984
    Date of Patent: September 23, 1986
    Assignee: Ciba-Geigy Corporation
    Inventors: Helmut Kopf, Christian Bucher
  • Patent number: 4612187
    Abstract: A soft capsule containing as active ingredient .gamma.-oryzanol alone or oryzanol in combination with riboflavin butyrate is described. The shelf life of this composition is increased without precipitation of the ingredients thereof.
    Type: Grant
    Filed: November 6, 1984
    Date of Patent: September 16, 1986
    Assignee: Nisshin Chemicals Co., Ltd.
    Inventors: Takeo Iijima, Hiroyuki Sano
  • Patent number: 4612189
    Abstract: Transparent and translucent dentifrice compositions improved in cleaning ability, stain removing ability and feeling are disclosed which comprise a mixture of an amorphous silica and an amorphous silicate containing at least 70% by weight of SiO.sub.2 which is partially inter-bonded with 1-10% by weight of an oxide of a metal selected from the group consisting of aluminum, magnesium and calcium and a transparent vehicle having substantially the same refractive index as that of the silica, the ratio of the silica to the silicate being in the range of 4:6 to 6:4 on a weight basis, the content of said mixture being in the range of 1 to 25% by weight of the composition, and the pH of the composition being in the range of 4.5 to 10.
    Type: Grant
    Filed: April 26, 1982
    Date of Patent: September 16, 1986
    Assignee: Lion Corporation
    Inventors: Masaaki Oyobe, Hiromichi Ichikawa, Tsutomu Maeyama
  • Patent number: 4600577
    Abstract: New pharmaceutical preparation containing pinacidil (N"-cyano-N-4-pyridyl-N'-1,2,2-trimethylpropylguanidine) in slow-release form, providing more uniform absorption rates and resulting blood levels when administered to the individual patients.
    Type: Grant
    Filed: January 23, 1984
    Date of Patent: July 15, 1986
    Assignee: Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselkab)
    Inventor: Erik J. Didriksen
  • Patent number: 4597959
    Abstract: A cosmetic breath freshener composition, in wafer form, having slow release comprising a multiplicity of microencapsulated liquid droplets of flavoring material contained in a base or carrier. The microcapsules are soluble in the saliva in the mouth to release the flavoring material at sustained rate. The base has an adhesive therein so that the formed wafer can be placed on the lower or upper gums of the user, thus being activated by the saliva in the mouth causing the capsules to release the flavoring material at a sustained rate for long periods of time in the mouth to mask bad breath and also offering a cool feel effect in the mouth of the user.
    Type: Grant
    Filed: April 30, 1982
    Date of Patent: July 1, 1986
    Inventor: Arthur Barr
  • Patent number: 4595584
    Abstract: Disclosed is a composition adapted for use in coating pellets orally administrable to ruminants which protects the core material in the rumen and releases it in the abomasum comprising a film-forming polymeric material, a hydrophobic material dispersed in said polymeric material, and a physiologically acceptable flake material dispersed in said polymeric material, the flake material having been treated by bringing the particles into rubbing contact with the hydrophobic material so that the surface of the particles of flake material become hydrophobic.
    Type: Grant
    Filed: January 7, 1985
    Date of Patent: June 17, 1986
    Assignee: Eastman Kodak Company
    Inventors: Stephen H. W. Wu, M. Akram Sandhu
  • Patent number: 4594241
    Abstract: Antimony-containing anti-leishmaniasis drugs are encapsulated in a lipid based liposomal formulation having a weight ratio of lipid to encapsulated antimony-containing drug of 1:1.6 to 1:0.25 and a salt concentration in the continuous aqueous phase which is at least isotonic with human blood. Such formulations are found to have a leakage rate of initially encapsulated antimony-containing drug of less than 50% by weight after storage at C. for 6 weeks from encapsulation and hence provide storage stable formulations which can be used effectively after prolonged storage without refrigeration in tropical climates. The anti-parasital activity of the liposomal formulations has been found greater than that of corresponding aqueous formulations.
    Type: Grant
    Filed: November 5, 1984
    Date of Patent: June 10, 1986
    Assignee: Burroughs Wellcome Co.
    Inventor: Leburu S. Rao
  • Patent number: 4587119
    Abstract: Isomaltulose is of use as a whole or partial replacement for sucrose in products for human or animal consumption.
    Type: Grant
    Filed: December 14, 1984
    Date of Patent: May 6, 1986
    Assignee: Tate & Lyle Public Limited Company
    Inventors: Christopher Bucke, Peter S. J. Cheetham
  • Patent number: 4568535
    Abstract: A composition for periodontal administration and a method of periodontal treatment involving a slow release device which can be placed directly into the periodontal pocket where metronidazole, with or without antioxidants, are released over periods of days to weeks at a cidal concentration for anaerobes in the domain of the periodontal pocket.
    Type: Grant
    Filed: July 16, 1984
    Date of Patent: February 4, 1986
    Inventor: Walter J. Loesche
  • Patent number: 4548990
    Abstract: A controlled-release, drug-delivery composition which comprises (A) a crosslinked copolymer, capable of swelling in ethanol to give a swollen copolymer containing at least 40% by weight of ethanol, and capable of swelling in water to give a swollen copolymer containing no more than 20% by weight of water, where the swelling ratio (% ethanol: % water) is 2:1 to 22:1, which comprises the copolymerization product of (a) 50 to 99% by weight of said copolymer of a water-insoluble monoolefinic monomer or (a) with 0 to 45% by weight of total monomers of a water-soluble monoolefinic monomer, with (b) 50 to 1% by weight, but not more than 20 mol % of a divinyl or polyvinyl crosslinking agent; and (B) an effective amount of a pharmaceutical medicament is useful for the controlled and prolonged release of drugs when taken orally.
    Type: Grant
    Filed: August 15, 1983
    Date of Patent: October 22, 1985
    Assignee: Ciba-Geigy Corporation
    Inventors: Karl F. Mueller, Sonia J. Heiber
  • Patent number: 4548762
    Abstract: A process for the preparation of vinylphosphonic acid dichloride and 2-chloroethanephosphonic acid dichloride, wherein 2-chloroethanephosphonic acid derivatives containing 2-chloroethyl ester groups, as produced in the Arbusow rearrangement of tris-chloroethyl phosphite, are heated to to C. in a first stage, and, in a second stage, the residual reaction mixture is reacted with phosgene at C., in the presence of basic catalysts or of alkali metal salts as catalysts, and in the presence of phosphonic acid dichlorides.
    Type: Grant
    Filed: February 4, 1983
    Date of Patent: October 22, 1985
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hans-Jerg Kleiner, Walter Dursch
  • Patent number: 4536388
    Abstract: A pest control device, such as an ear tag, for controlling pests such as flies, fleas and ticks on animals such as cattle and other livestock or pet animals which comprises a polymeric resin matrix and the pesticidally active compound .alpha.-cyano-3-phenoxybenzyl 2-(2-chloro-4-trifluoromethylanilino)-3-methylbutanoate.
    Type: Grant
    Filed: July 18, 1983
    Date of Patent: August 20, 1985
    Assignee: Zoecon Corporation
    Inventor: Robert C. Pearce, III
  • Patent number: 4533553
    Abstract: Growth of cattle and swine is promoted and feed utilization efficiency increased by an improved nutrient feed containing the antibiotic of the formula ##STR1##
    Type: Grant
    Filed: November 9, 1983
    Date of Patent: August 6, 1985
    Assignee: Pfizer Inc.
    Inventors: Walter D. Celmer, Walter P. Cullen, Riichiro Shibakawa, Junsuke Tone
  • Patent number: 4510306
    Abstract: The subject invention relates to the removal of residual higher alcohols which are present from the preparation of crude higher-alkyl glycosides. The residual higher alcohols are removed via vacuum distillation with a hydroxyl-containing solvent. The purified higher-alkyl glycosides are biodegradable nonionic surfactants which are soluble and stable in highly alkaline cleaning formulations used for bottle washing, metal cleaning, textile treatment and other applications.
    Type: Grant
    Filed: September 13, 1983
    Date of Patent: April 9, 1985
    Assignee: BASF Wyandotte Corporation
    Inventor: William K. Langdon
  • Patent number: 4508659
    Abstract: Fungicidal compositions comprise a compound of formula I ##STR1## in which R.sup.1 and R.sup.3 are hydrogen, alkyl or alkenyl;R.sup.2 is alkyl optionally substituted by a 5 or 6 membered oxygen containing ring or by phenyl (optionally substituted) and one of R.sup.4 and R.sup.5 is--CN and the other is a carboxylic ester or amide group. Many of the compounds are novel.
    Type: Grant
    Filed: February 28, 1983
    Date of Patent: April 2, 1985
    Assignee: FBC Limited
    Inventors: Graham P. Rowson, Albert Percival, Philip N. Judson