Abstract: A new galenic form with delayed release of METROCLOPRAMIDE, useful for gastric treatment, is formed by microgranules comprising a neutral core formed by a grain of an inert excipient comprising at least two components of the type belonging to the class formed by saccharose, starch, talc, desiccating silica, lactose and stearic acid, this neutral grain being provided with a first layer comprising METOCLOPRAMIDE, then a second outer layer formed by a microporous envelope comprising at least one natural and/or synthetic polymer belonging to the class formed by shellac, gum arabic, ethyl cellulose, cellulose acetophtalate, cellulose triacetate, polyoxyethyleneglycol, the methacrylates, styrene-acrylonitrile copolymer and polyvinylpyrrolidone in successive envelopes.
Abstract: Novel sugar-coated pharmaceutical composition such as tablets, pills, granules or the like, which contains pullulan in the sugar layer for the purpose of preventing brownish color change of the composition with lapse of time, and a method for preparing the composition.
Abstract: The compound consists of a mixed salt of glucosamine sulphate and sodium chloride corresponding to the formula: ##STR1## and is in the form of a crystalline powder with a melting point above 300.degree. C. The salt is stable at ambient temperatures and humidities and has pharmacological properties practically identical to those of glucosamine sulphate.
April 30, 1982
Date of Patent:
February 10, 1987
Rotta Research Laboratorium S.p.A.
Paolo Senin, Francesco Makovec, Luigi Rovati
Abstract: A coated ubidecarenone-containing liposome which comprises the ubidecarenone-containing liposome and a polysaccharide fatty acid ester applied on the surface of the membrane of said liposome, whereby the ubidecarenone can be selectively transferred in high concentrations to the lungs, spleen and kidneys.
Abstract: Local anesthesia is induced using microdroplets of a general anesthetic in liquid form. As an example, microdroplets of the general anesthetic methoxyfluorane coated by a unimolecular layer of dimysistoyl phosphatidylcholine are prepared by sonication. The microdroplets so prepared remain stable in physiologically-compatible solution, and are suitable for injection, typically intradermally or intraveneously, into a patient for inducing local anesthesia. These methoxyflurane-containing microdroplets have been demonstrated to cause long-term local anesthesia when injected intradermally, giving duration of anesthesia 28 times longer than with other anesthetics, such as lidocaine and 11 times longer than with bupivacaine.
Abstract: A soft capsule containing as active ingredient .gamma.-oryzanol alone or oryzanol in combination with riboflavin butyrate is described. The shelf life of this composition is increased without precipitation of the ingredients thereof.
Abstract: Transparent and translucent dentifrice compositions improved in cleaning ability, stain removing ability and feeling are disclosed which comprise a mixture of an amorphous silica and an amorphous silicate containing at least 70% by weight of SiO.sub.2 which is partially inter-bonded with 1-10% by weight of an oxide of a metal selected from the group consisting of aluminum, magnesium and calcium and a transparent vehicle having substantially the same refractive index as that of the silica, the ratio of the silica to the silicate being in the range of 4:6 to 6:4 on a weight basis, the content of said mixture being in the range of 1 to 25% by weight of the composition, and the pH of the composition being in the range of 4.5 to 10.
Abstract: New pharmaceutical preparation containing pinacidil (N"-cyano-N-4-pyridyl-N'-1,2,2-trimethylpropylguanidine) in slow-release form, providing more uniform absorption rates and resulting blood levels when administered to the individual patients.
January 23, 1984
Date of Patent:
July 15, 1986
Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselkab)
Abstract: A cosmetic breath freshener composition, in wafer form, having slow release comprising a multiplicity of microencapsulated liquid droplets of flavoring material contained in a base or carrier. The microcapsules are soluble in the saliva in the mouth to release the flavoring material at sustained rate. The base has an adhesive therein so that the formed wafer can be placed on the lower or upper gums of the user, thus being activated by the saliva in the mouth causing the capsules to release the flavoring material at a sustained rate for long periods of time in the mouth to mask bad breath and also offering a cool feel effect in the mouth of the user.
Abstract: Disclosed is a composition adapted for use in coating pellets orally administrable to ruminants which protects the core material in the rumen and releases it in the abomasum comprising a film-forming polymeric material, a hydrophobic material dispersed in said polymeric material, and a physiologically acceptable flake material dispersed in said polymeric material, the flake material having been treated by bringing the particles into rubbing contact with the hydrophobic material so that the surface of the particles of flake material become hydrophobic.
Abstract: Antimony-containing anti-leishmaniasis drugs are encapsulated in a lipid based liposomal formulation having a weight ratio of lipid to encapsulated antimony-containing drug of 1:1.6 to 1:0.25 and a salt concentration in the continuous aqueous phase which is at least isotonic with human blood. Such formulations are found to have a leakage rate of initially encapsulated antimony-containing drug of less than 50% by weight after storage at 25.degree. C. for 6 weeks from encapsulation and hence provide storage stable formulations which can be used effectively after prolonged storage without refrigeration in tropical climates. The anti-parasital activity of the liposomal formulations has been found greater than that of corresponding aqueous formulations.
Abstract: A composition for periodontal administration and a method of periodontal treatment involving a slow release device which can be placed directly into the periodontal pocket where metronidazole, with or without antioxidants, are released over periods of days to weeks at a cidal concentration for anaerobes in the domain of the periodontal pocket.
Abstract: A controlled-release, drug-delivery composition which comprises (A) a crosslinked copolymer, capable of swelling in ethanol to give a swollen copolymer containing at least 40% by weight of ethanol, and capable of swelling in water to give a swollen copolymer containing no more than 20% by weight of water, where the swelling ratio (% ethanol: % water) is 2:1 to 22:1, which comprises the copolymerization product of (a) 50 to 99% by weight of said copolymer of a water-insoluble monoolefinic monomer or (a) with 0 to 45% by weight of total monomers of a water-soluble monoolefinic monomer, with (b) 50 to 1% by weight, but not more than 20 mol % of a divinyl or polyvinyl crosslinking agent; and (B) an effective amount of a pharmaceutical medicament is useful for the controlled and prolonged release of drugs when taken orally.
Abstract: A process for the preparation of vinylphosphonic acid dichloride and 2-chloroethanephosphonic acid dichloride, wherein 2-chloroethanephosphonic acid derivatives containing 2-chloroethyl ester groups, as produced in the Arbusow rearrangement of tris-chloroethyl phosphite, are heated to 150.degree. to 230.degree. C. in a first stage, and, in a second stage, the residual reaction mixture is reacted with phosgene at 90.degree.-200.degree. C., in the presence of basic catalysts or of alkali metal salts as catalysts, and in the presence of phosphonic acid dichlorides.
Abstract: A pest control device, such as an ear tag, for controlling pests such as flies, fleas and ticks on animals such as cattle and other livestock or pet animals which comprises a polymeric resin matrix and the pesticidally active compound .alpha.-cyano-3-phenoxybenzyl 2-(2-chloro-4-trifluoromethylanilino)-3-methylbutanoate.
Abstract: The subject invention relates to the removal of residual higher alcohols which are present from the preparation of crude higher-alkyl glycosides. The residual higher alcohols are removed via vacuum distillation with a hydroxyl-containing solvent. The purified higher-alkyl glycosides are biodegradable nonionic surfactants which are soluble and stable in highly alkaline cleaning formulations used for bottle washing, metal cleaning, textile treatment and other applications.
Abstract: Fungicidal compositions comprise a compound of formula I ##STR1## in which R.sup.1 and R.sup.3 are hydrogen, alkyl or alkenyl;R.sup.2 is alkyl optionally substituted by a 5 or 6 membered oxygen containing ring or by phenyl (optionally substituted) and one of R.sup.4 and R.sup.5 is--CN and the other is a carboxylic ester or amide group. Many of the compounds are novel.
February 28, 1983
Date of Patent:
April 2, 1985
Graham P. Rowson, Albert Percival, Philip N. Judson