Abstract: Methods, systems, and apparatuses are disclosed for radiation treatment of tumors based at least in part on patient-specific imaging information. The methods, systems and apparatuses include computer programs encoded on computer-readable media. The methods include acquiring imaging information relating to a target to be treated. The imaging information is non-anatomic imaging information relating to the target acquired from at least one imaging marker that reflects at least one of the metabolic, physiological and histological features of the target. The methods further include computing a radiation dose based at least on the imaging information.

Abstract: A vaginal speculum includes a spreading element and at least two electromyographic sensors. At least one of the electromyographic sensors is mounted in or on the spreading element. The electromyographic sensors generate signals indicative of electromyographic activity in a vagina, cervix, or uterus.

Abstract: Systems and methods for anatomical alignment are disclosed herein. In some embodiments, the systems and methods can provide accurate and continuous intraoperative validation of anatomical alignment, e.g., of the spine, hips, pelvis, and/or shoulders. An exemplary system can include a sensor and marker arrangement for measuring coronal imbalance. Another exemplary system can include a sensor and marker arrangement for shoulder or pelvic leveling. Yet another exemplary system can include a mechanical frame for establishing a simulated ground plane and projecting a plumb line from the simulated ground plane.

Abstract: A needle assembly comprising a housing, a first needle hub provided by the housing, a first hollow needle portion mounted to the first needle hub and extending from the first needle hub in a distal direction. A second needle hub is provided by the housing. A second hollow needle portion is mounted to the second needle hub and extends from the second needle hub in a proximal direction, opposite to the distal direction, wherein a hollow flashback chamber is arranged within the housing between the first needle portion and the second needle portion. The flashback chamber communicates with the inner lumen provided within the first and second hollow needle portion and is connected to the atmosphere by a passage and wherein a filter is provided within the passage, which is designed such that it is permeable for air to pour out of the flashback chamber into the atmosphere.

Abstract: A biopsy device includes a cannula that defines a tissue chamber configured to receive a tissue sample from a patient. A pressure chamber includes a body having a distal end and a proximal end. The proximal end has an inlet coupled in fluid communication with the cannula. The body has a first recessed area proximate the proximal end, wherein the first recessed area is configured to release positive pressure within the pressure chamber. The body has a second recessed area proximate the distal end, wherein the second recessed area is configured to release negative pressure within the pressure chamber. A piston is movably received in the body and configured to move over the first recessed area to release the positive pressure and configured to move over the second recessed area to release the negative pressure.

Abstract: Provided herein are devices and methods for securing surgical guide wires. In particular, provided herein are devices for securing radiologically located guide wires prior to surgery (e.g., lumpectomy).

Abstract: Embodiments of the present invention may provide a limb motion sensor system (100) used to objectively assist detection of equine lameness and even monitor change in gait quality over time. Biosensors (102) may be attached to the pair of front and/or hind limbs. Each conformally shaped biosensor device may be placed lateral to the metacarpal/metatarsal bone (e.g., attached to the lower limb). Inertial data may be collected by the set of sensor devices and may be wirelessly transferred to a portable, perhaps wearable, mobile controller and analytics unit (104) (e.g., smart phone, tablet, or the like). A signal processor application (108) may automatically segment each stride into phases and perform analyses to quantify limb motion metrics and uniformity over time for a single limb (unilateral consistency) or between the contralateral limbs (bilateral symmetry). Three-dimensional motion metrics may be processed, displayed, stored on, and even transmitted from the mobile information system.

Abstract: A sensor system is for determining a breathing type of a subject. It has first and second electromagnetic radiation (e.g. optical) sensors, for example PPG sensors. The sensors are for application to the skin of the subject at different sensor locations. The signals from the first and second sensors are analyzed to determine if there is predominantly a first breathing type (e.g. chest breathing) or predominantly a second breathing type (e.g. belly breathing), or a mixture of the first and second breathing types.

Abstract: In one embodiment, a system for detecting tremors includes a contactless tremor detector, the detector including an oscillator circuit having a sensing coil, an oscillator configured to generate alternating electromagnetic fields, and a frequency counter configured to sense the resonant frequency of the oscillator circuit as the resonant frequency changes in response to movement of a body part of an individual adjacent to the sensing coil, wherein the system is configured to determine a frequency of movement of the body part from the sensed resonant frequency for the purpose of determining if the individual is experiencing tremors.

Abstract: A breath sensor includes a base body, a first electrode provided on a part of a surface of the base body, a second electrode provided on a part of the surface of the base body, and a covering layer made of a material that does not pass moisture therethrough, the covering layer covering the second electrode with the base body. The base body is preferably made of a material whose surface potential changes due to attachment of moisture to one of a surface of the first electrode and the surface of the base body. A surface potential on a side of the first electrode of the base body changes when a breath containing moisture touches the surface of the first electrode.

Abstract: A method and a device to determine a hydration condition is disclosed. The wearable device may have a top wall, a bottom wall, and a perimeter wall that form an inner cavity. The external surface of the bottom wall may have a projection and an inner surface of the bottom wall may have a channel. A circuit board may have a first portion in the channel, a second portion that extends through a first side wall of the channel to a first recess in the external surface of the bottom wall, and a third portion that extends through a second side wall of the channel to a second recess in the external surface of the bottom wall. A first impedance pad may be on the second portion in the first recess and a second impedance pad may be on the third portion in the second recess.

Abstract: One aspect of the present disclosure relates a system that can employ micromagnetic stimulation to activate or suppress one or more areas of the central nervous system. A portion of the central nervous system can be exposed. A probe can be configured to be located in proximity to the exposed portion of the nervous system. A microcoil (of a size less than or equal to 10 millimeters) can be coupled to the probe and configured to activate or suppress the portion of the central nervous system via electromagnetic induction.

Abstract: An apparatus includes a substrate and a plurality of biological material stimulators positioned on the substrate. Each biological material stimulator forms a fluctuating magnetic field capable of inducing a current in biological material.

Abstract: A medical device includes an elongate member having a proximal end portion and a distal end portion. The distal end portion is configured to be inserted into a body of a patient. The elongate member is configured to be associated with a bodily implant. The distal end portion of the elongate member is configured to move from a first position to a second position such that distal end potion of the elongate member may be inserted into the body of the patient in its second position and is moved to its first position while disposed within the body of the patient.

Abstract: Devices for containing exposed internal body parts during insertion into the body of a human or veterinary patient are provided. The devices include a surgical pouch for containing the exposed internal body parts. The devices also include one or more sealing elements disposed on the surgical pouch between the proximal end and the distal end of the surgical pouch such that a section of the pouch is closed off when each sealing element is sealed. Also provided are methods for containing exposed internal body parts of a human or veterinary patient during insertion into the body of the patient.

Abstract: The present disclosure relates to systems, methods, and computer-readable storage media for radiotherapy. Embodiments of the present disclosure may receive a plurality of training data and determine one or more predictive models based on the training data. The one or more predictive models may be determined based on at least one of a conditional probability density associated with a selected output characteristic given one or more selected input variables or a joint probability density. Embodiments of the present disclosure may also receive patient specific testing data. In addition, embodiments of the present disclosure may predict a probability density associated with a characteristic output based on the one or more predictive models and the patient specific testing data. Moreover, embodiments of the present disclosure may generate a new treatment plan based on the prediction and may use the new treatment plan to validate a previous treatment plan.

Abstract: Described are implants, tools, and methods useful for treating pelvic conditions such as prolapse, by placing an implant to support pelvic tissue, the implants, tools, and methods involving one or more of adjusting engagements, specific implants and pieces of implants, placement of implants at locations within the pelvic region, and insertion, adjusting, and grommet management tools.

Abstract: The invention relates to a system (102) for providing biofeedback to a person (104). The system (102) comprises a source (106) for generating a source signal (108) and a transducer (110) for generating a measurement signal (112) in response to a physiological parameter (114) indicative for mental relaxation of the person (104). The system (102) furthermore comprises a filter (116) for variably filtering the source signal via modifying a cut-off frequency in response to the measurement signal (112) and an interface (118) for providing a biofeedback signal (119) to the person on the basis of the source signal as variably filtered by the filter (116).

Abstract: Device and method for generating brief strong current pulses in a coil for generating magnetic field pulses which according to the electromagnetic induction principle induce stimulation currents in the body tissue triggering an action potential of the nerve and/or muscle cells, where the coil is positionable close to the body tissue to be stimulated so that its magnetic field passes through the body tissue, and where the device comprises a power generating unit that can generate a freely selectable temporal course of the current through the coil during the current pulse.

Abstract: The present invention relates to methods and compositions of treating patients suffering from, or at risk for, DNA damage and to increase life span, i.e., prevent or slow the aging process in all species. The treatment includes administering to the patient a pharmaceutical composition that includes carbon monoxide.