Abstract: The present disclosure relates to systems, methods, and computer-readable storage media for radiotherapy. Embodiments of the present disclosure may receive a plurality of training data and determine one or more predictive models based on the training data. The one or more predictive models may be determined based on at least one of a conditional probability density associated with a selected output characteristic given one or more selected input variables or a joint probability density. Embodiments of the present disclosure may also receive patient specific testing data. In addition, embodiments of the present disclosure may predict a probability density associated with a characteristic output based on the one or more predictive models and the patient specific testing data. Moreover, embodiments of the present disclosure may generate a new treatment plan based on the prediction and may use the new treatment plan to validate a previous treatment plan.

Abstract: Described are implants, tools, and methods useful for treating pelvic conditions such as prolapse, by placing an implant to support pelvic tissue, the implants, tools, and methods involving one or more of adjusting engagements, specific implants and pieces of implants, placement of implants at locations within the pelvic region, and insertion, adjusting, and grommet management tools.

Abstract: The invention relates to a system (102) for providing biofeedback to a person (104). The system (102) comprises a source (106) for generating a source signal (108) and a transducer (110) for generating a measurement signal (112) in response to a physiological parameter (114) indicative for mental relaxation of the person (104). The system (102) furthermore comprises a filter (116) for variably filtering the source signal via modifying a cut-off frequency in response to the measurement signal (112) and an interface (118) for providing a biofeedback signal (119) to the person on the basis of the source signal as variably filtered by the filter (116).

Abstract: Device and method for generating brief strong current pulses in a coil for generating magnetic field pulses which according to the electromagnetic induction principle induce stimulation currents in the body tissue triggering an action potential of the nerve and/or muscle cells, where the coil is positionable close to the body tissue to be stimulated so that its magnetic field passes through the body tissue, and where the device comprises a power generating unit that can generate a freely selectable temporal course of the current through the coil during the current pulse.

Abstract: The present invention relates to methods and compositions of treating patients suffering from, or at risk for, DNA damage and to increase life span, i.e., prevent or slow the aging process in all species. The treatment includes administering to the patient a pharmaceutical composition that includes carbon monoxide.

Abstract: A sub-cranial vibratory stimulator that at least partially bypasses a recipient's skull bone and delivers vibration to fluid within a recipient's skull bone. The sub-cranial vibratory stimulator comprises an actuator that is configured to be implanted beneath a recipient's skull bone. The actuator transfers vibration to the fluid within the recipient's skull without first passing through the skull bone. The actuator is also substantially mechanically decoupled (isolated) from the recipient's skull bone.

Abstract: An incubator comprises an incubator chamber defined by a bottom part and a top casing covering a bed area of the bottom part. The incubator comprises an air treatment and circulation device for treating air and circulating it through the chamber, said air treatment and circulation device including a ventilator. The air treatment and circulation device is connected to chamber inlet openings which are arranged along one or more sides of said bed area, allowing treated air to flow from the treatment and circulation device into the chamber. The air treatment and circulation device furthermore is connected to at least one chamber outlet opening allowing air to flow out from the chamber to the treatment and circulation device. The air flows in the incubator are routed such that noise is reduced and no high air flow speeds occur near the infant in the incubator.

Abstract: A puncture device and method are disclosed, the puncture device includes a puncture member having a puncture needle for puncturing a biological tissue, a shaft portion, and a connection portion for connecting the puncture needle and the shaft portion to each other. The puncture needle includes a needle main body for puncturing the biological tissue, and an extension needle provided for movement relative to the needle main body along a longitudinal direction of the needle main body and configured to puncture the biological tissue. The puncture device includes, as extension means for moving the extension needle in a direction toward the distal end of the needle main body with respect to the needle main body to extend the puncture needle, and/or a pusher for pushing the extension needle to move in the direction toward the distal end of the needle main body.

Abstract: There is provided a method for controlling a flow of eggs in a uterine tube formed by a uterine tube wall of a patient. The method comprises gently constricting (i.e., without substantially hampering the blood circulation in the uterine tube wall) at least one portion of the uterine tube wall to influence the flow of eggs in the uterine tube, and stimulating the constricted wall portion to cause contraction of the uterine tube wall portion to further influence the flow of eggs in the uterine tube. The method can be used for restricting or stopping the flow of eggs in the uterine tube, or for actively moving the fluid in the uterine tube, with a low risk of injuring the uterine tube.

Abstract: A kit having instructions for use for performing uterine lavage in a female patient includes a uterine lavage catheter configured for insertion into a woman's uterus to remove viable blastocysts from the uterus, and one or more first containers having a sufficient dosage amount of a GnRH antagonist to cause desynchronization of the endometrium of the patient prior to, during and/or following recovery of viable blastocysts from the uterus.

Abstract: A platform for creating an artificial blood brain barrier including a functional, perfused artificial vessel lined with endothelial cells embedded in a physiologically relevant three-dimensional extracellular matrix is described.

Abstract: Devices and methods for directing a magnetic field into a body party of a subject are provided. The devices include at least one electromagnetic coil, a magnetic core or yoke, and a pair of flux concentrators. The flux concentrators are separated by a gap into which the body part fits and through which the flux concentrators focus the magnetic field. The devices allow magnetic fields to be transmitted through the gap with higher intensity at greater distances from the device than possible with previous designs. The methods of using such devices allow the delivery of magnetic fields with higher intensity to the interior of a body part without exposing interposed proximal regions to magnetic fields of unduly high intensity. The devices and methods are useful for deep transcranial magnetic stimulation of the brain to treat various medical conditions.

Abstract: Veins and other blood vessels may be reshaped by introducing an implant through the vessel walls with anchors positioned on opposite sides of the wall. The anchors typically include an elongate body having coils or other anchors formed therein. The implants may be delivered percutaneously using a cannula which can hold the anchor externally or internally. The methods and devices are useful in treating a dorsal vein to reduce blood flow in patients suffering from erectile dysfunction.

Abstract: An endoluminal prosthesis including a radially expandable support member having interior and exterior surfaces and a wall with openings, a first covering member including a biocompatible polymer material at least partially positioned against the interior surface, and a second covering member including a biocompatible polymer material at least partially positioned against the exterior surface. The first covering member attaches to the second covering member at predetermined bonding locations within less than all of the openings thereby leaving unbonded regions.

Abstract: The invention relates to a sampling needle, in particular to a needle suitable for oocyte retrieval from a human or animal subject, said needle comprising a first tubular region in fluid communication with a second tubular region, the first tubular region comprising a leading end for insertion into a subject and the second tubular region comprising a trailing end for fluid communication with a means for receiving a fluid, in which the first tubular region has an outer diameter which is less than the outer diameter of the second tubular region and the first tubular region has an inner diameter which is less than the inner diameter of the second tubular region. The invention also relates to a method of retrieving a sample, in particular an oocyte, from a human or animal subject.

Abstract: A sound enrichment system for provision of tinnitus relief, the sound enrichment system includes a noise generator, at least one signal modulator for random or pseudo-random modulation of a noise signal that is obtained using the noise generator, and an output transducer for conversion of the modulated noise signal to an acoustic signal for presentation to a user. A method of providing a noise enriched sound signal for provision of relief of tinnitus includes generating a randomly or pseudo-randomly modulated noise signal, generating an acoustic noise signal using the modulated noise signal, and presenting the acoustic noise signal to a tinnitus suffering person.

Abstract: An embryo transfer syringe has a roller (30) coupled with the rear end of its plunger (15). The roller (30) is displaceable along an elongate housing (20) extending from the rear of the barrel (10) of the syringe. The roller (30) can be manually engaged through a slot (23) along the housing (20) to rotate it and roll it along the housing thereby smoothly and controllably displacing the plunger (15).

Abstract: An applicator device is provided including a connecting unit. The connecting unit includes a first connector coupled to a first colpostat and a second connector coupled to a second colpostat. The first connector includes a first contact portion and a body portion, the first contact portion being immovably fixed to the body portion. The second connector includes a second contact portion and a third contact portion, the second contact portion being configured to contact and pivotally engage the first contact portion. The first connector further includes a fourth contact portion configured to contact the third contact portion. The second contact portion and the third contact portion are disposed between the first contact portion and the fourth contact portion, and the first contact portion are disposed in closer proximity to a point of delivery of a radiation source than the second, third, or fourth contact portions.

Abstract: An electrical connection system that can feed power, signal, data, and communication lines into a rotating or static patient support system in an infant warming device.

Abstract: The invention discloses an implant. The implant may include a first flap and a second flap. The first flap may further include a first portion, a second portion and a transition region. The first portion may be configured to be attached proximate a sacrum. The second portion may be configured to be attached to an anterior vaginal wall. The transition region lies between the first portion and the second portion. The second flap may be fabricated such that a portion of the second flap is configured to be attached to a posterior vaginal wall. The implant may be configured such that a value corresponding to a biomechanical parameter defining a biomechanical attribute of the portion of the first flap attaching to the anterior wall is different from a value of the biomechanical parameter defining the biomechanical attribute of the portion of the second flap attaching to the posterior wall.