Patents Examined by Che S. Chereskin
  • Patent number: 5684239
    Abstract: The present invention describes the activity of a dicot wound inducible promoter in a monocot plant, the use of a monocot intron to enhance the activity of a dicot promoter in a transgenic monocot, and genetic constructs to introduce an exogenous genetic trait into a monocot plant using a wound inducible dicot promoter system.
    Type: Grant
    Filed: September 9, 1994
    Date of Patent: November 4, 1997
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Ray Wu, David McElroy, Deping Xu
  • Patent number: 5684238
    Abstract: DNA segments encoding the Erwinia herbicola enzymes geranylgeranyl pyrophosphate (GGPP) synthase, phytoene synthase, phytoene dehydrogenase-4H, lycopene cyclase, beta-carotene hydroxylase, and zeaxanthin glycosylase, DNA variants and analogs thereof encoding an enzyme exhibiting substantially the same biological activity, vectors containing those DNA segments, host cells containing the vectors and methods for producing those enzymes, zeaxanthin and zeaxanthin diglucoside by recombinant DNA technology in transformed host organisms are disclosed.
    Type: Grant
    Filed: July 22, 1993
    Date of Patent: November 4, 1997
    Assignee: Amoco Corporation
    Inventors: Rodney L. Ausich, Friedhelm Luetke Brinkhaus, Indrani Mukharji, John H. Proffitt, James G. Yarger, Huei-Che Bill Yen
  • Patent number: 5674701
    Abstract: A process for identifying a plant having disease tolerance comprising administering to a plant an inhibitory amount of ethylene and screening for ethylene insensitivity, thereby identifying a disease tolerant plant, is described. Plants identified by the foregoing process are also described.
    Type: Grant
    Filed: December 21, 1993
    Date of Patent: October 7, 1997
    Assignees: The Trustees of the University of Pennsylvania, The Regents of the University of California
    Inventors: Joseph R. Ecker, Brian J. Staskawicz, Andrew F. Bent, Roger W. Innes
  • Patent number: 5670706
    Abstract: Plants are provided with improved resistance against pathogenic fungi. They are genetically transformed with one or more polynucleotides which essentially comprise one or more genes encoding plant chitinases and .beta.-1,3-glucanases. Preferred are the intracellular forms of the said hydrolytic enzymes, especially preferred are those forms which are targeted to the apoplastic space of the plant by virtue of the modification of the genes encoding the said enzymes. Particularly preferred are plants exhibiting a relative overexpression of at least one gene encoding a chitinase and one gene encoding a .beta.-1,3-glucanase.
    Type: Grant
    Filed: April 19, 1993
    Date of Patent: September 23, 1997
    Assignees: MOGEN International, n.v., Rijksuniversiteit te Leiden
    Inventors: Bernardus J. C. Cornelissen, Leo Sjoerd Melchers, Elisabeth J. S. Meulenhoff, Jeroen S. C. van Roekel, Marianne Beatrix Sela-Buurlage, Alexandra Aleida Vloemans, Charles Peter Woloshuk, John Ferdinand Bol, Hubertus J. M. Linthorst
  • Patent number: 5667997
    Abstract: By this invention, further plant medium-chain acyl-ACP thioesterases are provided, as well as uses of long-chain thioesterase sequences in conjunction with medium-chain thioesterase sequences. In a first embodiment, this invention relates to particular medium-chain thioesterase sequences from elm and Cuphea, and to DNA constructs for the expression of these thioesterases in host cells for production of C8 and C10 fatty acids. Other aspects of this invention relate to methods for using plant medium-chain thioesterases or medium-chain thioesterases from non-plant sources to provide medium-chain fatty acids in plant cells. As a further aspect, uses of long-chain thioesterase sequences for anti-sense methods in plant cells in conjunction with expression of medium-chain thioesterases in plant cells is described.
    Type: Grant
    Filed: July 5, 1995
    Date of Patent: September 16, 1997
    Assignee: Calgene, Inc.
    Inventors: Toni Alois Voelker, Huw Maelor Davies, Deborah Knutzon
  • Patent number: 5668297
    Abstract: The invention relates to deacetylase genes, to processes for their isolation, and to their use, in particular for the production of transgenic plants using tissue-specific promoters. It is possible to prevent the development of certain parts in these plants in a targeted manner. With the aid of deacetylase genes, it is furthermore possible to identify and isolate tissue-specific promoters in transgenic plants.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: September 16, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Inge Broer, Doris Hillemann, Alfred Puhler, Wolfgang Wohlleben, Gunter Donn, Hubert Mullner, Klaus Bartsch
  • Patent number: 5665892
    Abstract: Sucrose phosphate synthase (SPS), its process for preparation, its cDNA, and utilization of cDNA to modify the expression of SPS in the plant cells are provided.
    Type: Grant
    Filed: December 27, 1993
    Date of Patent: September 9, 1997
    Assignee: Calgene, Inc.
    Inventors: Charles Van Assche, Danielle Lando, Jean Michel Bruneau, Toni Alois Voelker, Monica Gervais
  • Patent number: 5658773
    Abstract: The present invention relates generally to methods for modifying the sucrose content of fruit. In particular, it relates to methods for increasing fruit sucrose content by inhibiting the expression of acid invertase. Additionally, it relates to methods for decreasing fruit sucrose content and increasing fruit hexose content by over expressing acid invortase.
    Type: Grant
    Filed: August 26, 1994
    Date of Patent: August 19, 1997
    Assignee: The Regents of the University of California
    Inventors: Alan B. Bennett, Ellen M. Klann
  • Patent number: 5658781
    Abstract: The invention provides insecticidally effective peptides isolatable from Diguetia spider venom, methods for preparing and using insecticides, and DNA encoding such insecticidally effective peptides.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: August 19, 1997
    Assignees: FMC Corporation, NPS Pharmaceuticals, Inc.
    Inventors: Karen J. Krapcho, J. R. Hunter Jackson, Bradford Carr VanWagenen, Robert Marden Kral, Jr.
  • Patent number: 5659123
    Abstract: New modified Cry proteins, particularly modified CryIIIA proteins, having significantly altered toxicity, and DNA sequences encoding these proteins, are designed. Analysis of solvent-accessible amino acid positions in domain II of the CryIIIA protein by alanine-scanning mutagenesis identified individual amino acids involved in corn rootworm toxicity. Random replacement of these amino acids identifies modified proteins with improved toxicity. A combination of all or most thus identified improved amino acids in a single protein yields modified CryIIIA proteins with significantly improved toxicity. Particularly regions protruding from the Cry molecule and located at the apex of the Cry proteins, were identified as involved in toxicity.
    Type: Grant
    Filed: August 26, 1994
    Date of Patent: August 19, 1997
    Assignee: Plant Genetic Systems, N.V.
    Inventors: Jeroen Van Rie, Stefan Jansens, Marnix Peferoen
  • Patent number: 5659121
    Abstract: DNA constructs comprise a DNA sequence homologous to some or all of the pectinesterase gene encoded by the clone pB8 (Sequence ID No.1), under control of a transcriptional initiation region operative in plants for transcribing this DNA sequence, optionally in the antisense direction to produce RNA complementary to the gene mRNA. From such constructs may be derived transformed plant cells and plants in which expression of pectinesterase genes is inhibited: fruit from the plants (such as tomatoes) can show modified ripening properties.
    Type: Grant
    Filed: September 30, 1994
    Date of Patent: August 19, 1997
    Assignee: Zeneca Limited
    Inventors: Colin Roger Bird, Donald Grierson, Lisa Naomi Hall
  • Patent number: 5658563
    Abstract: The invention provides insecticidally effective peptides isolatable from Diguetia spider venom, methods for preparing and using insecticides, and DNA encoding such insecticidally effective peptides.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: August 19, 1997
    Assignees: FMC Corporation, NPS Pharmaceuticals, Inc.
    Inventors: Karen J. Krapcho, J. R. Hunter Jackson, Bradford Carr VanWagenen, Robert Marden Kral, Jr.
  • Patent number: 5656496
    Abstract: A dark- and light-regulated chlorophyll a/b (Cab) binding protein promoter/regulatory system from maize is disclosed. This promoter/regulatory system is capable of accounting for as much as 80% of the total Cab mRNA in the dark and results in enhancement of expression from 3- to 6-fold after conditions of illumination. This Cab promoter/regulatory system may be recombined with structural genes for expression in plant cells.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: August 12, 1997
    Assignee: Mycogen Plant Science, Inc.
    Inventors: Peter H. Quail, Thomas D. Sullivan, Alan H. Christensen
  • Patent number: 5654495
    Abstract: By this invention, methods to produce C14 fatty acids in plant seed oils are provided. In a first embodiment, this invention relates to particular C14 preferring acyl-ACP thioesterase sequences from Cuphea palustris, camphor and nutmeg, and to DNA constructs for the expression of these thioesterases in host cells for production of C14 fatty acids. Other aspects of this invention relate to methods for using other plant medium-chain thioesterases or medium-chain thioesterases from non-plant sources to provide C14 fatty acids in plant cells. In this regard, the production of C14 fatty acids in plant cells as the result of expression from an elm medium chain acyl-ACP thioesterase and a bacterial luxD gene is provided.
    Type: Grant
    Filed: February 2, 1995
    Date of Patent: August 5, 1997
    Assignee: Calgene, Inc.
    Inventors: Toni Alois Voelker, Huw Maelor Davies
  • Patent number: 5650310
    Abstract: The invention relates to deacetylase genes, to processes for their isolation, and to their use, in particular for the production of transgenic plants using tissue-specific promoters. It is possible to prevent the development of certain parts in these plants in a targeted manner. With the aid of deacetylase genes, it is furthermore possible to identify and isolate tissue-specific promoters in transgenic plants.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 22, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Inge Broer, Doris Hillemann, Alfred Puhler, Wolfgang Wohlleben, Gunter Donn, Hubert Mullner, Klaus Bartsch
  • Patent number: 5650553
    Abstract: The present invention is directed to nucleic acid sequences for ethylene insensitive, EIN loci and corresponding amino acid sequences. The present invention is also directed to nucleic acid sequences for hookless1, HLS1, alleles and amino acid sequences.
    Type: Grant
    Filed: June 17, 1994
    Date of Patent: July 22, 1997
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Joseph Ecker, Madge Rothenberg, Anne Lehman, Gregg Roman
  • Patent number: 5646029
    Abstract: This invention provides plant arabinogalactan proteins (AGPs) and their genes. AGPs were isolated from Nicotiana alata, Nicotiana plumbaginafolia, and Pyrus communis. Amino acid sequences of isolated AGP peptide fragments are presented. Isolated AGP fragments were used to synthesize oligonucleotide probes to prepare oligonucleotide primers for PCR or prepare RNA probes to screen cDNA libraries of N. alata, N. plumbaginafolia, and P. communis. cDNA clones encoding amino acid sequences of isolated AGP fragments were isolated. The invention presents for the first time an intact AGP amino acid sequence derived from a corresponding AGP gene. The instant invention further provides methods useful in obtaining AGP genes encoding an AGP peptide comprising a specific isolated hydroxyproline-rich (OAST-rich) sequence or a specific isolated hydroxyproline-poor sequence.
    Type: Grant
    Filed: July 18, 1994
    Date of Patent: July 8, 1997
    Assignee: Cooperative Research Centre for Industrial Plant Biopolymers
    Inventors: Chao-Guang Chen, Shaio-Lim Mau, He Du, Alison M. Gane, Antony Bacic, Adrienne E. Clarke
  • Patent number: 5641876
    Abstract: The present invention describes the genomic nucleotide sequence of, and isolation of a strong intron-dependent promoter for, rice actin genes.
    Type: Grant
    Filed: October 27, 1993
    Date of Patent: June 24, 1997
    Assignee: Cornell Research Foundation, Inc.
    Inventors: David McElroy, Ray Wu
  • Patent number: 5639870
    Abstract: The present invention relates to a nucleic acid isolate comprising a sequence of nucleotides encoding, or complementary to a sequence encoding, a flavonoid 3'-hydroxylase or a functional derivative thereof. The present invention also relates to transgenic plants carrying and/or expressing the above-mentioned nucleic acid material.
    Type: Grant
    Filed: November 30, 1994
    Date of Patent: June 17, 1997
    Assignee: International Flower Developments Pty., Ltd.
    Inventors: Timothy Albert Holton, Edwina Cecily Cornish, Yoshikazu Tanaka
  • Patent number: 5639663
    Abstract: Genetic markers of this invention provide a biochemically assayable reporter activity and a conditionally selectable growth advantage. They comprise a first gene which encodes a product whose activity can be assdyed biochemically e.g., .beta.-glucuronidase, to a second gene which confers a conditional growth advantage such as antibiotic resistance in a transformed cell (e.g., neomycin phosphotransferase-II). The marker genes and their translational products are stable in cells. The genetic markers provide for the positive genetic selection and the biochemical and histochemical screening of transformed cells. They can be used as probes for identification and isolation of novel genetic regulatory elements, such as promoters, and the genes they regulate.
    Type: Grant
    Filed: January 21, 1994
    Date of Patent: June 17, 1997
    Assignee: National Research Council of Canada
    Inventors: William L. Crosby, Raju S. Datla, Joe K. Hammerlindl, Gopalan Selvaraj