Patents Examined by Choon P. Koh
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Patent number: 6113604Abstract: A method for fixing a bone block in a bone tunnel comprising the steps of placing the bone block in the bone tunnel, advancing spaced-apart first and second metal wires through the bone, transversely of the bone tunnel, so as to intersect the bone block and extend through the bone block, removing one of the wires and replacing the one removed wire with a first absorbable rod, and removing the other of the wires and replacing the other removed wire with a second absorbable rod, whereby to retain the bone block in the bone tunnel with the absorbable rods.Type: GrantFiled: January 28, 1998Date of Patent: September 5, 2000Assignee: Ethicon, Inc.Inventors: Gregory R. Whittaker, Harold M. Martins, Joan M. Sullivan, Ronald L. Taylor, Jr.
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Patent number: 6113629Abstract: The hydrogel for the treatment of aneurysms acts as a carrier for both a radiopaque agent allowing the hydrogel to be visualized under fluoroscopy and a therapeutic agent such as one or more human growth factors. The hydrogel is delivered through a catheter into the aneurysm, where the hydrogel becomes more viscous upon reaching body temperature, or upon exposure to bodily fluids, to block blood flow into the aneurysm. In addition to stopping blood flow into the aneurysm, the delivery of human growth factors to the aneurysm site promotes the growth of a cellular layer across the neck of the aneurysm. The hydrogel may be of a type that dissolves over time or one which remains as a permanent occlusive agent within the aneurysm.Type: GrantFiled: May 1, 1998Date of Patent: September 5, 2000Assignee: Micrus CorporationInventor: Christopher G. M. Ken
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Patent number: 6113636Abstract: Approaches are described for depositing antimicrobial elemental metal and/or metal compounds within a medical article. The medical article generally includes biocompatible material that can contact bodily fluids. In particular, antimicrobial elemental metal can be deposited on and in a biocompatible material such as tissue. Chemical, photochemical and electrochemical processes for depositing elemental metal are described. In addition, an antimicrobial metal compound can be deposited by precipitation of the compound from a solution of metal cation. Antimicrobial metal deposits may reduce the incidence of infection associated with contacting a recipient medical patient with the biocompatible material.Type: GrantFiled: November 20, 1997Date of Patent: September 5, 2000Assignee: St. Jude Medical, Inc.Inventor: Matthew F. Ogle
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Patent number: 6110212Abstract: It is a general object of the invention to provide a method of effecting repair or replacement or supporting a section of a body tissue. Specifically to provide an elastin or elastin-based biomaterial suitable for use as a stent, for example, a vascular stent, or as conduit replacement, as an artery, vein or a ureter replacement. The biomaterial can also be used as a stent or conduit covering or coating or lining. It is also an object of the invention to provide a method of securing an elastin or elastin-based biomaterial to an existing tissue without the use of sutures or staples.Type: GrantFiled: February 7, 1997Date of Patent: August 29, 2000Assignees: Kenton W. Gregory, Sisters of ProvidenceInventor: Kenton W. Gregory
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Patent number: 6110204Abstract: The present invention relates to an implant for use in the human body, an implant substrate being coated with a material which contains chemical compounds between one or more metals (M) of group IV A of the periodic system, nitrogen (N) and oxygen (O), 2 to 45% of the volume in the coating material being formed by voids whose sizes range from (0.4 nm).sup.3 to (50 nm).sup.3, and the remaining volume having a composition of a metal of group IV A of the periodic system to nitrogen to oxygen of 1:(0.1 to 1.7):(0.1 to 1.7), a material having formula MN.sub.x O.sub.y (wherein x,y=0.1-1.7) resulting.The invention also relates to the use of this implant for implantation into the animal or human body.Type: GrantFiled: February 9, 1998Date of Patent: August 29, 2000Assignee: Huber & SchusslerInventors: Miladin Lazarov, Isabella Mayer
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Patent number: 6110198Abstract: The present invention provides modular intraluminal tubular prostheses, particularly stents and stent-grafts, for the treatment of disease conditions, particularly aneurysms. Modular sections of the prostheses, or "prosthetic modules," may be selectively combined to form a composite prosthesis having characteristics which are tailored to the specific requirements of the patient. Each prosthetic module preferably includes one or more standard interface ends for engaging another module, the module/module interface typically comprising ends which overlap and/or lock within a predetermined axial range. Advantageously, the axial length, cross-section, perimeter, resilient expansive force, axial flexibility, liner permeability, liner extensibility, radial conformability, liner/tubal wall sealing and anchoring, and other prosthetic characteristics may be varied along the axis of the composite prosthesis, and also along the axis of each prosthetic module.Type: GrantFiled: January 5, 1999Date of Patent: August 29, 2000Assignee: Medtronic Inc.Inventors: Thomas J. Fogarty, Kirsten Freislinger, Steven Weinberg, Brian J. Cox, Michael A. Evans, Steven W. Kim, Jay A. Lenker
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Patent number: 6110207Abstract: To be able to secure the tendon replacement member without additionally weakening the tibia in the case of an implant for securing a tendon replacement member to a channel receiving the tendon replacement member in the region of the tibia close to the knee, it is proposed that the implant is in the form of a disc with passages for threads connected to the tendon replacement member and is dimensioned so that it completely covers the outlet opening of the channel from the tibia.Type: GrantFiled: October 21, 1998Date of Patent: August 29, 2000Assignee: Aesculap AG & Co. KGInventors: Juergen Eichhorn, Nicola Giordano, Karl-Ernst Kienzle
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Patent number: 6110206Abstract: The invention provides a substantially non-immunogenic ligament or tendon xenograft for implantation into humans. The invention further provides a method for preparing a ligament xenograft by removing at least a portion of a ligament from a non-human animal to provide a xenograft; washing the xenograft in saline and alcohol; subjecting the xenograft cellular disruption treatment, such as exposure to ultraviolet radiation, immersion in alcohol, ozonation, freeze/thaw cycling, and optionally chemical crosslinking. In addition to or in lieu of the above treatments, the methods include digestion of the carbohydrate moieties of the xenograft with a glycosidase, preferably a galactosidase, and more preferably .alpha.-galactosidase. The invention also provides articles of manufacture produced by one or more of the above-identified methods of the invention.Type: GrantFiled: March 6, 1998Date of Patent: August 29, 2000Assignee: CrossCart, Inc.Inventor: Kevin R. Stone
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Patent number: 6110209Abstract: The invention disclosed is a method and material for repairing focal arthritic defects in a mammalian joint, especially in a human knee. The invention disclosed provides an articular cartilage cancellous bone paste in an effective amount for enhancing formation of cartilage. The paste can include a cartilage-stimulating factor.Type: GrantFiled: November 5, 1998Date of Patent: August 29, 2000Inventor: Kevin R. Stone
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Patent number: 6106549Abstract: A method for positioning a graft within a vasculature is described. The method comprises positioning a guide wire extending from an entry opening past a treatment zone to an exit opening. The guide wire has an attachment portion that is connected to a first string extending from a distal end of the graft. The guide wire is manipulated to move the string through the vasculature until the first string extends out the exit opening with a second string connected to the proximal end of the graft extending out the entry opening. The first string is disconnected from the guide wire and the first and second strings are manipulated to position the graft at the treatment zone.Type: GrantFiled: May 7, 1999Date of Patent: August 22, 2000Inventor: Syde A. Taheri
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Patent number: 6099563Abstract: Disclosed is a method of enhancing the biocompatibility of a substrate by providing the substrate with a continuous bio-active surface coating. This method includes applying to the substrate a first coating which includes an aqueous dispersion or emulsion of a polymer containing an organic acid functional group and an excess of a polyfunctional cross-linking agent which is reactive with the organic acid groups of the polymer. A continuous bio-active surface coating is then formed over the dried first coating by applying thereover a bio-active agent containing an organic acid functional group or metal salt thereof. The first and second coatings are then dried to covalently bond the organic acid functional groups of the bio-active agent to the polymer through the excess unreacted polyfunctional cross-linking agent.Type: GrantFiled: December 11, 1998Date of Patent: August 8, 2000Assignee: Boston Scientific CorporationInventor: Sheng-Ping Zhong
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Patent number: 6099557Abstract: The present invention provides a soft-tissue prosthesis which is formed from a tubular textile substrate and a liner. The liner is affixed to the intraluminal surface of the tubular textile portion of the soft-tissue prosthesis to form a fluid-tight barrier on the intraluminal surface of the prosthesis. The liner is preferably formed from a polymer. Thus, the soft-tissue prosthesis formed in accordance with the present invention provides the advantages of both a textile prosthesis and a polymer prosthesis.Type: GrantFiled: February 5, 1999Date of Patent: August 8, 2000Assignee: Meadox Medicals, Inc.Inventor: Peter J. Schmitt
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Patent number: 6099559Abstract: An endovascular support assembly, or stent assembly, and a covered endovascular support assembly, or stent-graft assembly, with caps on either or both ends for improved and uniform deployment of the assembly. Additionally, the caps serve to capture the graft material between the caps and the endovascular support device or stent.Type: GrantFiled: May 28, 1998Date of Patent: August 8, 2000Assignee: Medtronic Ave, Inc.Inventor: John E. Nolting
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Patent number: 6099564Abstract: An orbital implant motility peg comprising a means for placement in vivo in a non-drilled integrated orbital implant. The peg or portions thereof can be fabricated from titanium, a titanium alloy, stainless steel, a CoCr alloy, alumina, platinum or tantalum. The means for placement can comprise an external surface of the peg which comprises threads, to facilitate screwing into the implant, and/or a slot capable of receiving a screwdriver tip, a receptacle capable of receiving a Phillips screwdriver tip, a polygonal surface capable of being held by a wrench, or a receptacle capable of being engaged by an Allen wrench.Type: GrantFiled: July 1, 1997Date of Patent: August 8, 2000Inventor: Arthur C. Perry
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Patent number: 6096081Abstract: A dowel (300) is provided by obtaining a plug from the shaft (diaphysis) of various long bones. The dowel (300) has an intra-medullary canal (30) which can be packed with any of a variety of osteogenic materials. The dowel (300) has a cortical surface (10) into which an instrument attachment hole (15) may be machined and onto which an alignment mark (16) may be inscribed for proper orientation of the intra-medullary canal (30) or a driver slot (56) which may be used to assist in further machining of the bone dowel (300). The dowel (300) ha a chamfered insertion end and has improved biomechanical and vertebral fusion induction properties as compared to standard dowels known in the art. A threaded (31) or grooved (32) dowel (300) and an apparatus (400) for efficient production thereof are also provided.Type: GrantFiled: July 13, 1998Date of Patent: August 1, 2000Assignee: University of Florida Tissue Bank, Inc.Inventors: Nicholas E. Grivas, Jamie M. Grooms, Kevin Carter, David Dulebohn
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Patent number: 6093166Abstract: A method and apparatus for performing coronary artery bypass surgery establishes a channel leading directly from a chamber of a heart into a coronary artery. The coronary artery bypass procedure may be performed with or without cardiopulmonary bypass.Type: GrantFiled: April 3, 1998Date of Patent: July 25, 2000Assignee: Heartstent, LLCInventors: Mark B. Knudson, William L. Giese
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Patent number: 6093205Abstract: A prosthesis for the replacement of an intervertebral disc of the spine comprises a block of an elastomeric material, which is held under compression by an encapsulating textile fabric. A preferred version of the invention (see FIG. 8) has continuations of the encapsulating fabric forming an interdigitation, with the continuation of the upper fabric passing through a hole in the lower fabric and being attached to the lower vertebral body and the continuation of the lower fabric crossing to its fixation site on the upper vertebral body.Type: GrantFiled: June 25, 1998Date of Patent: July 25, 2000Assignee: Bridport-Gundry PLC c/o Pearsalls ImplantsInventors: Alan Rory Mor McLeod, Andre Jackowski
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Patent number: 6092529Abstract: A method is disclosed for using tubular material to replace a semilunar heart valve (i.e., an aortic or pulmonary valve). To create such a replacement valve, the native valve cusps are removed from inside an aorta or pulmonary artery, and the inlet end of a tubular segment is sutured to the valve annulus. The outlet (distal) end of the tube is either "tacked" at three points distally, or sutured longitudinally along three lines; either method will allow the flaps of tissue between the suture lines to function as movable cusps. This approach generates flow patterns that reduce turbulence and closely duplicate the flow patterns of native semilunar valves. An article of manufacture is also disclosed, including a sterile biocompatible synthetic material which has been manufactured in tubular form, by methods such as extrusion or coating a cylindrical molding device, to avoid a need for a suture line or other seam to convert a flat sheet of material into a tubular shape.Type: GrantFiled: February 3, 1999Date of Patent: July 25, 2000Assignee: 3F Therapeutics, Inc.Inventor: James L. Cox
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Patent number: 6083259Abstract: A radially expandable surgical stent 10 is provided for implantation into a body lumen. The stent 10 includes a series of circumferential elements 20 circumscribing a central axis 4 of the stent 10 and axially spaced from each other by gaps 40. Each circumferential element 20 includes a wave-like series of bends 30. Each bend 30 has one side defining a trough 32 in and an opposite side defining a crest 36. The trough 32 is that side of the bend 30 most distant from adjacent circumferential elements 20. The crest 36 is that side of each bend 30 closest to adjacent circumferential elements 20. Axial elements 50 span each gap 40 with ends of each axial element 50 attaching to circumferential elements 20 at troughs 32. Some of the axial elements 50 are configured as tie bars 51 extending linearly axially between adjacent circumferential elements 20. Other axial elements 50 can be configured as double bend links 60 extending between adjacent circumferential elements 20.Type: GrantFiled: November 16, 1998Date of Patent: July 4, 2000Inventor: John J. Frantzen
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Patent number: 6080190Abstract: An intraluminal stent comprising fibrin is capable of reducing the incidence of restenosis at the site of vascular injury such as that produced by an angioplasty procedure.Type: GrantFiled: April 29, 1998Date of Patent: June 27, 2000Assignee: Medtronic, Inc.Inventor: Robert S. Schwartz