Patents Examined by Chris L Chin
  • Patent number: 9778249
    Abstract: Methods of quantifying the efficiency of a drug molecule for its targeted receptor, using a differential binding force to quantify the efficiency of a drug molecule to its targeted receptor.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: October 3, 2017
    Inventors: Shoujun Xu, Qiongzheng Hu, Yuhong Wang, Te-Wei Tsai
  • Patent number: 9733250
    Abstract: The present invention provides devices and methods for capturing rare cells. The devices and methods described herein can be used to facilitate the diagnosis and monitoring of metastatic cancers.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: August 15, 2017
    Assignee: The Regents of the University of California
    Inventors: Hsian-Rong Tseng, Shutao Wang, Hao Wang, Kan Liu
  • Patent number: 9726680
    Abstract: The present invention related to a reaction vessel and an assay device. A reaction vessel for analysis a sample containing an analyte to be determined, which includes a casing, a first reagent and at least one independent individual element. The casing includes an opening and a detection zone. The opening may be formed on the edge of the casing and used to introduce the sample. The detection zone is disposed at a corner of the casing and used to detect the analyte. The reagent is interacted with the sample. The independent individual element is individually separating from the casing and providing a space and a flow channel for mixing the sample and the first reagent. The sample and the reagent are mixed in the independent individual element so as to determine the analyte in the detection zone, and thereby increasing accuracy of analyte detection.
    Type: Grant
    Filed: November 6, 2013
    Date of Patent: August 8, 2017
    Inventors: Hui-Sheng Hou, Pin-Hsun Huang, Chia-Chi Wu
  • Patent number: 9725315
    Abstract: Provided are devices and methods for polymer analysis, in which labeled polymers are translocated along nanochannels that have illuminated detection regions within. As a labeled polymer translocates along the nanochannel and the labels pass over the illuminated detection regions, the labels become detectable (e.g., where different labels fluoresce in response to different wavelengths present at different illumination regions), and the user generates a spatial map of the location of the various labels along the length of the polymer. The location of the labels is then correlated to one or more structural characteristics of the polymer.
    Type: Grant
    Filed: September 27, 2010
    Date of Patent: August 8, 2017
    Inventors: Michael Austin, Parikshit A. Deshpande, Alexey Sharonov, Valeriy Bogdanov
  • Patent number: 9684003
    Abstract: Disclosed is a detection method, including steps of: providing an elongated carrier with a plurality of recognition substances fixed thereon; bringing a first end of the elongated carrier in contact with a liquid sample to permit the liquid sample to move towards an opposite second end along the elongated carrier, therewith a plurality of coloring elements in the liquid sample forming a colored band on the elongated carrier; and determining whether the liquid sample contains analytes based on the length of the colored band. Accordingly, the analytes can be detected by recognizing the agglutination based on the length of the colored band. Additionally, the present invention also provides a detection device and a detection kit for the aforementioned detection process.
    Type: Grant
    Filed: August 23, 2016
    Date of Patent: June 20, 2017
    Assignee: National Tsing Hua University
    Inventor: Chao-Min Cheng
  • Patent number: 9678070
    Abstract: The invention provides an apparatus and methods for the electrochemical detection and/or quantitation of an analyte in a sample, wherein the device comprises a substrate and a detector, wherein the substrate comprises a labeled binding agent, wherein the label is an enteric material particle that encapsulates a ferrocene methanol redox species.
    Type: Grant
    Filed: April 29, 2015
    Date of Patent: June 13, 2017
    Assignee: Church & Dwight Co., Inc.
    Inventors: Albert R. Nazareth, Shang Li, Giles H. W. Sanders, Anthony Edward George Cass, Marian Rehak
  • Patent number: 9658163
    Abstract: A metal substrate obtained by agglomerating 5 nm to 100 nm metal nano-particles (including clusters) having SERS activity on a metal substrate having a lower electrode potential (higher ionization tendency) than the electrode potential of the metal nano-particles, and fixing the metal nano-particles in an optimally agglomerated state that acts as hot sites, when a detection specimen is adsorbed in a non-dried state, and a predetermined laser light is irradiated, the surface enhanced Raman scattered (SERS) light of antigen detection specimen can be detected by surface Raman resonance in an optimally agglomerated state.
    Type: Grant
    Filed: March 4, 2010
    Date of Patent: May 23, 2017
    Assignee: MYTECH CO., LTD.
    Inventors: Yuki Hasegawa, Katsuyuki Hasegawa
  • Patent number: 9658221
    Abstract: The invention features methods and diffraction-based devices for the detection of specific analytes. The devices of the invention contain a periodic dielectric multilayer, which allows for the propagation of Bloch surface waves (BSWs) at the surface of the multilayer, thereby increasing the sensitivity of the device.
    Type: Grant
    Filed: August 28, 2009
    Date of Patent: May 23, 2017
    Assignee: The Governing Council of the University of Toronto
    Inventors: Marco Liscidini, John Sipe
  • Patent number: 9658218
    Abstract: Methods and reagents are disclosed for determining a total amount of an analyte in an unknown sample suspected of containing the analyte in the presence of endogeneous interfering substances. The methods involve measuring an amount [Y] of the portion of the analyte in the unknown sample that is bound by endogeneous binding substances employing an assay for the analyte. An amount [Z] of analyte in the unknown sample that is not bound by endogeneous binding substances is determined by the formula: [Z]=a[Y]+b, wherein “a” and “b” are predetermined by conducting the assay on samples containing known amounts of the analyte but substantially free from endogeneous interfering substances. Adding [Y] and [Z] yields the total amount [X] of the analyte in the unknown sample.
    Type: Grant
    Filed: May 7, 2012
    Date of Patent: May 23, 2017
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Tie Quan Wei
  • Patent number: 9658158
    Abstract: A diagnostic device includes a photodiode formed by a body of semiconductor material having a first surface, an integrated optical structure on the first surface and having a second surface, and at least one detection region on the second surface. The at least one detection region includes at least one receptor that binds to a corresponding target molecule that can be mated with a corresponding marker, which, when excited by radiation having a first wavelength, emits radiation having a second wavelength that can be detected by the photodiode. The integrated optical structure includes at least a first layer of a first material having a first refractive index. The first layer has a thickness substantially equal to an integer and odd multiple of one fourth of the first wavelength divided by the first refractive index.
    Type: Grant
    Filed: May 24, 2013
    Date of Patent: May 23, 2017
    Inventors: Lucio Renna, Clelia Carmen Galati, Natalia Maria Rita Spinella, Piero Giorgio Fallica
  • Patent number: 9651542
    Abstract: Among others, the present invention provides micro-devices for detecting or treating a disease, each comprising a first micro sensor for detecting a property of the biological sample at the microscopic level, and an interior wall defining a channel, wherein the micro sensor is located in the interior wall of the micro-device and detects the property of the biological sample in the microscopic level, and the biological sample is transported within the channel.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: May 16, 2017
    Assignee: Anpac Bio-Medical Science Co., Ltd
    Inventors: Chris Chang Yu, Xuedong Du
  • Patent number: 9651489
    Abstract: An assay device includes: a liquid sample receiving zone; a capture zone in fluid communication with the sample receiving zone having capture elements bound thereto, the capture zone having a substrate and projections which extend substantially vertically from the substrate, the projections having a rhombus-shaped cross-section and the projections arranged on the substrate with the corners of the projections facing upstream in a direction toward the sample receiving zone. The projections have a height, cross-section and a distance between one another that defines a capillary space between the projections capable of generating capillary flow parallel to the substrate surface; and a sink in fluid communication with the capture zone having a capacity to receive liquid sample flowing from the capture zone. The sample receiving zone, the capture zone and the sink define a fluid flow path. Preferably, the rhombus-shaped cross-section is a square or a diamond.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: May 16, 2017
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: Zhong Ding, David Bergman
  • Patent number: 9638616
    Abstract: Devices and methods for gravimetric sensing are disclosed. A gravimetric sensor includes a piezoelectric resonator and an encapsulating layer formed on the surface of the resonator. The encapsulating layer defines a channel within the encapsulating layer on the surface of the resonator. The sensor is fabricated by forming a piezoelectric resonator, forming a sacrificial layer on a surface of the piezoelectric resonator, forming an encapsulating layer over the sacrificial layer on the resonator, and etching the sacrificial layer to remove the sacrificial layer and form a channel on the surface of the resonator. The sensor is used by supplying the liquid to the channel of the gravimetric sensor, operating the piezoelectric resonator, detecting a change in a resonant frequency of the resonator, and determining a presence of the analyte in the liquid from the change in resonant frequency of the resonator.
    Type: Grant
    Filed: November 1, 2011
    Date of Patent: May 2, 2017
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Chiara Zuniga, Matteo Rinaldi, Gianluca Piazza
  • Patent number: 9618518
    Abstract: The current invention relates to a magnetic immunodiagnostic method for the demonstration of antibody/antigen complexes of blood group and phenotype. Such a method involves the research and/or identification of antibodies or antigens, preferably anti-antigen antibodies or antigens of a blood group. This method implements a suspension of magnetic particles coated with an antibody anti-glycophorin A that can recognize and specifically magnetize erythrocytes. The invention also includes a device and kit for carrying out one such method.
    Type: Grant
    Filed: July 21, 2011
    Date of Patent: April 11, 2017
    Assignee: DIAGAST
    Inventors: Laurence Fauconnier, Yves Barbreau, Arnaud Boulet, Maha Zakhour
  • Patent number: 9599615
    Abstract: The present invention relates to novel lateral flow devices using two dimensional features, preferably, uniform two dimensional test and control signal readout patterns, and the methods for detecting an analyte using the lateral flow devices.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: March 21, 2017
    Assignee: Symbolics, LLC
    Inventors: Brendan O'Farrell, Thomas C. Tisone
  • Patent number: 9594078
    Abstract: The present application discloses an analyte detection apparatus having at least one reservoir area and a wicking membrane, wherein a labeled specific binding partner is impregnated on the reservoir area; and a region on the wicking membrane where at least one chemical component is immobilized.
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: March 14, 2017
    Assignee: ACCESS BIO, INC.
    Inventors: Young Ho Choi, Jaean Jung
  • Patent number: 9593808
    Abstract: A polymeric micro-arm apparatus and method to use the same. The apparatus comprises of an elongated hollow polymeric structure with a distal end and a proximal end, an opening near the distal end, a main body attached to the polymeric structure means to move the polymeric structure, means to generate fluid flow through the opening, means to measure a flowrate of the fluid flow through the opening; and an element embedded in the polymeric structure, wherein the element is configured to detect when the polymeric structure contacts an object and measures the force that the object exerts upon the polymeric structure.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: March 14, 2017
    Inventor: Angelo Gaitas
  • Patent number: 9588111
    Abstract: The present invention relates to a membrane sensor having a multi-hole film attached thereto and a method for measuring immunological reactions or enzymatic reactions using the same. More specifically, the present invention relates to a membrane sensor in which a multi-hole film is joined to the top of a membrane on which receptors are immobilized, and a method for measuring immunological reactions or enzymatic reactions using the same. The present invention makes it possible to adjust the sensitivity of membrane biosensors by adjusting the hole size in the multi-hole film and so makes it possible to measure analytes with a high degree of sensitivity using just a small amount of sample, and makes it possible to simultaneously measure diverse types of analyte by attaching various types of receptor on the membrane sensor.
    Type: Grant
    Filed: November 24, 2010
    Date of Patent: March 7, 2017
    Assignee: INGIBIO, LTD.
    Inventors: Min Gon Kim, Yong Beom Shin, Young Kyeng O, Hyo Arm Joung
  • Patent number: 9587009
    Abstract: The invention relates generally to solid supports for chromatography. In specific embodiments the invention provides for solid supports suitable for affinity chromatography along with methods, systems and kits which use the same.
    Type: Grant
    Filed: July 7, 2014
    Date of Patent: March 7, 2017
    Assignee: EMD Millipore Corporation
    Inventors: Nanying Bian, Senthil Ramaswamy, Neil Soice, Chen Wang, Yuan Wong
  • Patent number: 9574245
    Abstract: Devices and methods are provided for electrically lysing cells and releasing macromolecules from the cells. A microfluidic device is provided that includes a planar channel having a thickness on a submillimeter scale, and including electrodes on its upper and lower inner surfaces. After filling the channel with a liquid, such that the channel contains cells within the liquid, a series of voltage pulses of alternating polarity are applied between the channel electrodes, where the amplitude of the voltage pulses and a pulsewidth of the voltage pulses are effective for causing irreversible electroporation of the cells. The channel is configured to possess thermal properties such that the application of the voltage produces a rapid temperature rise as a result of Joule heating for releasing the macromolecules from the electroplated cells. The channel may also include an internal filter for capturing and concentrating the cells prior to electrical processing.
    Type: Grant
    Filed: January 25, 2013
    Date of Patent: February 21, 2017
    Inventors: Samad Talebpour, Aye Aye Khine, Robert Maaskant, Tino Alavie