Patents Examined by Chris L Chin
  • Patent number: 9575058
    Abstract: The present invention provides fluidic devices and systems that allow detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: February 21, 2017
    Assignee: Theranos, Inc.
    Inventors: Shaunak Roy, Malissa Takahashi, Ian Gibbons, Edmond Ku, Thanh Dang, Tammy Burd, Adam Vollmer, Elizabeth A. Holmes
  • Patent number: 9568415
    Abstract: A biosensor system and method of its use for detecting particles on the surface of an integrated circuit is disclosed. The system can include a light source and a plurality of optical sensors formed on an integrate circuit. The particles can be positioned the surface of the integrated circuit whereby the particles can cast a shadow or shadows that reduces the amount of light transmitted from the light source to the optical sensors. The surface of the integrated circuit can include one or more optical sensing areas whereby the presence of one or more particles may significantly or measurably reduce the amount of light incident on one or more optical sensor.
    Type: Grant
    Filed: April 8, 2013
    Date of Patent: February 14, 2017
    Assignee: Silicon BioDevices, Inc.
    Inventor: Octavian Florescu
  • Patent number: 9568479
    Abstract: The present invention relates to a diagnostic method for the detection of small quantities of amniotic fluid in the vagina. More specifically, the invention relates to the detection of PAMG-1 in the vagina using anti-PAMG-1 antibodies.
    Type: Grant
    Filed: November 13, 2012
    Date of Patent: February 14, 2017
    Assignee: N-Dia, Inc.
    Inventors: Boris Fuks, Dmitrii Dmitrievich Petrunin, Evgeny Il'ich Zaraisky, Marina Nikolayevna Boltovskaya, Svetlana Vladimirovna Nazimova, Nelly Andronikovna Starosvetskaya, Alexandr Konstantinov, Margarita Igorevna Marshiskaia
  • Patent number: 9562266
    Abstract: Sensors for target entities having functionalized thereon, at least one amine-terminated aptamer specific to the target entity, and methods of making and using the same are described.
    Type: Grant
    Filed: January 14, 2013
    Date of Patent: February 7, 2017
    Assignee: The University of Toledo
    Inventors: Brent D. Cameron, Dong-Shik Kim, Rui Zheng, Byung-Wook Park
  • Patent number: 9557329
    Abstract: The present invention related to a quantitative assay device and a method for the determination of an analyte, based on a test strip, which contains a porous test membrane allowing for capillary flow of the analyte and complexes of the analyte, a porous upstream membrane in fluid connection with the test membrane and a porous downstream membrane in fluid connection with the test membrane, wherein the test membrane contains two bands having deposited on there high and low concentrations of different calibrator agents and a test band capable of reacting with conjugated analyte complexes giving rise to a measurable signal.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: January 31, 2017
    Assignee: Assurance LLC
    Inventor: Jin Po Lee
  • Patent number: 9557271
    Abstract: An optical biomodule for detecting a disease(s) in a biological fluid (containing a disease specific biomarker(s)) in a fluidic container(s) or on a substrate(s), utilizing an enhanced fluorescence emission (due to integration of three-dimensional (3-D) protruded structure(s)) upon chemical binding of a disease specific biomarker(s) with its corresponding specific disease specific biomarker binder(s) is disclosed. Furthermore, the invention includes spatial multiplexing and optical multiplexing of disease specific biomarker binders.
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: January 31, 2017
    Inventors: Mohammad A. Mazed, Sayeeda Mazed
  • Patent number: 9557330
    Abstract: Devices and methods for the detection of antigens are disclosed. Devices and methods for detecting food-borne pathogens are disclosed.
    Type: Grant
    Filed: October 12, 2010
    Date of Patent: January 31, 2017
    Assignee: Invisible Sentinel, Inc.
    Inventors: Nicholas A. Siciliano, Martin Joseph Bouliane
  • Patent number: 9547004
    Abstract: A method and device for the rapid quantification of biomolecules (320) present in a nanochannel (210) is claimed. In particular, the present invention relates to a novel concept of liquid actuation and selectively functionalized surfaces in a nanochannel that create a concentration gradient of transitory immobilized biomolecules (340) across the nanochannel. The present concept enables the quantification of biomolecular interactions of interest (320).
    Type: Grant
    Filed: February 6, 2012
    Date of Patent: January 17, 2017
    Assignee: ABIONIC SA
    Inventors: Nicolas Durand, Iwan Märki, Stéphane Broillet, Annick Mayor, Theo Lasser
  • Patent number: 9535061
    Abstract: A three-in-one apparatus for analyzing liquids, such as some body fluids, uses labeled molecular affinity binding, such as immunochromatography. The multi-functional diagnostic test device can detect an analyte, such as an antibody or antigen, which may indicate a particular condition. The multi-functional diagnostic test device provides multi-functional formats to apply in multiple different sampling methods, including the “dip”, “cassette” and “collection” formats. The diagnostic test device can accommodate a plurality of test strips, such as 18 test strips for analyzing up to 90 analytes.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: January 3, 2017
    Assignee: DNT SCIENTIFIC RESEARCH, LLC
    Inventors: Naishu Wang, Michael Chang Chien
  • Patent number: 9528939
    Abstract: A scanning sensor system, methods of use and kits for detecting a biologically active analyte are provided. The scanning senor system includes a light source, a detector, a substrate comprising a plurality of waveguides and a plurality of optical sensing sites in optical communication with one or more waveguide of the substrate, and at least one adapter configured to couple with the substrate and provide optical communication between the light source, the waveguides of the substrate, and the detector.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: December 27, 2016
    Assignee: iNDx Lifecare, Inc.
    Inventor: Reuven Duer
  • Patent number: 9518926
    Abstract: The invention is a surface plasmon resonance (SPR) sensor to determine the presence and quantity of biological or chemical entities in an analyte. The sensor comprises a metal periodic structure deposited as a thin layer of a noble metal, comprising a one dimensional array of nanoslits or a two dimensional array of nanoholes on a transparent dielectric substrate, a nm-thick layer of transparent dielectric protection layer on top of the metal periodic structure and a functionalization layer, which acts as a binding layer to biological or biochemical entities in an analyte that is in contact with the functionaliztion layer.
    Type: Grant
    Filed: February 14, 2012
    Date of Patent: December 13, 2016
    Assignee: Ben-Gurion University of the Negev Research & Development Authority
    Inventor: Ibrahim Abdulhalim
  • Patent number: 9513300
    Abstract: This invention relates to non-surgical assays that can be used to determine whether an animal that has a non-postpartum anestrous period of three months or greater, such as a dog or a cat, has been spayed. In particular, the present invention relates to devices, kits and methods that allow correlation of levels of Anti-Müllerian Hormone with the state of being spayed.
    Type: Grant
    Filed: May 5, 2009
    Date of Patent: December 6, 2016
    Assignee: CORNELL UNIVERSITY
    Inventor: Ned J. Place
  • Patent number: 9494596
    Abstract: The present invention relates to a diagnostic method for the detection of small quantities of amniotic fluid in the vagina. More specifically, the invention relates to the detection of PAMG-1 in the vagina using anti-PAMG-1 antibodies.
    Type: Grant
    Filed: August 19, 2013
    Date of Patent: November 15, 2016
    Assignee: N-Dia, Inc.
    Inventors: Boris Fuks, Dmitrii D. Petrunin, Evgeny I. Zaraisky, Marina N. Boltovskaya, Svetlana V. Nazimova, Nelly A. Starosvetskaya, Alexandr Konstantinov, Margarita I. Marshiskaia
  • Patent number: 9487592
    Abstract: An antibody-fragment-immobilizing substrate includes a substrate and at least one set of antibody fragments, wherein the antibody fragments of each set includes at least two types of separate antibody fragments that are capable of recognizing one type of antigen and that are independently immobilized on the substrate in a positional relationship that allows each of the antibody fragments in one set to bind to the same antigen.
    Type: Grant
    Filed: October 23, 2009
    Date of Patent: November 8, 2016
    Assignees: FUJIFILM Corporation, THE UNIVERSITY OF TOKYO
    Inventors: Koichi Minami, Hirohiko Tsuzuki, Hiroshi Ueda, Masaki Ihara
  • Patent number: 9475024
    Abstract: A plurality of individual single column test elements are provided for use in a clinical testing apparatus in an open-topped cartridge in which each test element is defined by a single test column that includes a quantity of a test material, such as gel material or a bead matrix, including a cover strip used to access the contents of the test column. The number of individual test elements provided in a cartridge can be varied, depending on the test(s) to be performed.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: October 25, 2016
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: Raymond F. Jakubowicz, Mark Sawczuk
  • Patent number: 9475049
    Abstract: Devices and methods for the detection of analytes are disclosed. Devices and methods for detecting food-borne pathogens are disclosed.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: October 25, 2016
    Assignee: Invisible Sentinel, Inc.
    Inventors: Nicholas A. Siciliano, Martin Joseph Bouliane, Louis Leong
  • Patent number: 9470681
    Abstract: Apparatuses for determining whether a substance is carried in a fluid are disclosed. One such apparatus includes a body having: a plurality of spaced-apart capture surfaces configured to contact the fluid and capture the substance from the fluid; and a plurality of fluid guiding surfaces spaced apart by a predetermined distance from respective at least portions of respective ones of the plurality of capture surfaces. Another such apparatus includes: a fluid conduit to direct flow of the fluid; and at least one element removably positioned in the fluid conduit and having at least one capture surface configured to contact the fluid and capture the substance from the fluid.
    Type: Grant
    Filed: January 14, 2011
    Date of Patent: October 18, 2016
    Assignee: The University of British Columbia
    Inventors: Deborah Roberts, Mina Hoorfar, Sina Jomeh, Rony Das
  • Patent number: 9464985
    Abstract: Apparatus and methods are disclosed that are configured to permit nanoplasmonic spectroscopy sensing in the form of colorimetric sensing. An example apparatus involves: (a) an array layer having a top surface and a bottom surface, wherein a plurality of nanoholes are defined in the top surface of the array layer, wherein the plurality of nanoholes each have at least one sidewall surface and a bottom surface, (b) a thin metal film disposed on the top surface of the array layer and on the bottom surface of each of the plurality of nanoholes, and (c) a plurality of nanoparticles disposed on the at least one sidewall surface of the plurality of nanoholes.
    Type: Grant
    Filed: January 16, 2014
    Date of Patent: October 11, 2016
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Gang Logan Liu, Manas Ranjan Gartia, Austin Yin Kyai Hsiao
  • Patent number: 9465036
    Abstract: The invention relates to a new type of element encoded particles suitable for the attachment of bio molecules to enable massively multiplex bio-analytical methods, and to calibrate and tune the elemental flow cytometer mass spectrometer (FC-MS).
    Type: Grant
    Filed: November 2, 2007
    Date of Patent: October 11, 2016
    Assignee: Fluidigm Canada Inc.
    Inventors: Mitchell A. Winnik, Cedric Vancaeyzeele, Vladimir I. Baranov
  • Patent number: 9462998
    Abstract: A device for determining the presence and/or quantity of one or more analytes in a sample of human body fluid has a container for receiving a sample of body fluid, with an interior that is delimited by a base and by a circumferential surface. It further comprises at least one test strip and a holding element for receiving and holding the one or more test strips. The holding element is designed such that it has a shape corresponding and adapted to the peripheral circumferential surface of the container. The device further comprises an elongate sampling element having an absorbent sampler that takes up the sample of body fluid and by means of which the sample of body fluid is transferred into the container. The sampling element can include an indicator strip for determining whether the amount of liquid sample sufficient for carrying out an assay.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: October 11, 2016
    Assignee: EXPRESS DIAGNOSTICS INT'L, INC.
    Inventors: Matthias W. Engel, Leslie Wilson, Paul Johnson