Patents Examined by Christine T Mui
  • Patent number: 10352917
    Abstract: The present invention provides a carboxylate-bridged binuclear iron-sulfur clusters fluorescent probe having the structure of Formula I. The preparation method comprises the following steps: anthracenylmethanamine and p-methoxycarbonylphenyl isocyanate have an addition reaction to get a substitutional methyl benzoate, which is hydrolyzed to get a corresponding carboxylic acid; react the resulting carboxylic acid with alkali to get carboxylate, and then coordinate with binuclear iron precursor to obtain the fluorescent probe. Compared with the prior art, the invention firstly provides the carboxylate-bridged binuclear iron-sulfur clusters of metal complex which similar to the central structure of bio-enzyme. The metal complex, as a fluorescent probe, has good selectivity to the fluorinion detection. The fluorescence titration experiment is simple and easy to operate and the fluorescence changes are sensitive.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: July 16, 2019
    Inventors: Yuhan Zhou, Jingping Qu, Xiaoliang Dong
  • Patent number: 10352940
    Abstract: Methods and devices are provided for analyzing acetone in breath. One such method comprises disposing a reactant in a reaction zone within the breath analysis device, wherein the reactant comprises a primary amine disposed on a surface, and wherein the reaction zone has an optical characteristic that is at a reference level. It also comprises pre-storing a liquid nitroprusside solution within the breath analysis device separately from the reactant. The method further comprises using the breath analysis device to cause the breath to contact the reactant in the reaction zone so that the acetone in the breath reacts with the reactant to form a reaction product and, after the reaction product has been formed, using the breath analysis device to cause the nitroprusside solution to contact and react with the reaction product and to facilitate a change in the optical characteristic of the reaction zone relative to the reference level.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: July 16, 2019
    Assignee: Invoy Holdings, LLC
    Inventors: Lubna M. Ahmad, Brent C. Satterfield, Rhett L. Martineau
  • Patent number: 10349834
    Abstract: One embodiment of the present invention provides an apparatus for analyzing substances within a liquid. The apparatus includes an absorber that comprises one or more layers of absorbent material for absorbing the liquid and one or more sensors embedded within the one or more layers of absorbent material. The sensors are configured to provide information associated with the substances included in the absorbed liquid. The apparatus further includes electrical conductive traces coupled to the one or more sensors, thereby facilitating transmission of outputs of the sensors.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: July 16, 2019
    Inventors: Michael Kuniavsky, Siqi Wang
  • Patent number: 10350599
    Abstract: A microfluidic exosome profiling platform integrating exosome isolation and targeted proteomic analysis is disclosed. This platform is capable of quantitative exosomal biomarker profiling directly from plasma samples with markedly enhanced sensitivity and specificity. Identification of distinct subpopulation of patient-derived exosomes is demonstrated by probing surface proteins and multiparameter analyzes of intravesicular biomarkers in the selected subpopulation. The expression of IGF-1R and its phosphorylation level in non-small cell lung cancer (NSCLC) patient plasma is assessed as a non-invasive alternative to the conventional biopsy and immunohistochemistry. Detection of ovarian cancer also is assessed. The microfluidic chip, which may be fabricated of a glass substrate and a layer of poly(dimethylsiloxane), includes a serpentine microchannel to mix a fluid and a microchamber for the collection and detection of exosomes.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: July 16, 2019
    Assignees: University of Kansas, Kansas State University Research Foundation
    Inventors: Zheng Zhao, Mei He, Yong Zeng
  • Patent number: 10345283
    Abstract: An apparatus, method, and system for on-the-go soil nitrate level sensing, and optionally using the sensing to inform or instruct nitrogen fertilizer application across the field. In one form, the apparatus includes a soil sensing tool which carries a diamond ATR cell in combination with an FTIR field ruggedized spectrometer. The optical surface of the diamond ATR cell can be adjusted in pitch and depth to the soil. A processor is programmed to manipulate acquired spectra to derive a prediction of nitrate level for a given soil position in the field. This can be used to modulate a fertilizer applicator operation or coupled with georeference data collected simultaneously to generate a map of soil nitrate levels for the field, which can be used as a prescription for nitrogen fertilizer application.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: July 9, 2019
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: David Laird, Natalia Rogovska, Chien-Ping Chiou
  • Patent number: 10335784
    Abstract: A lab-on-chip-based system is described for the direct and multiple sampling, control of the volume, fluid filtration, biochemical reactions, sample transfer, and dried spot generation on the conventional and commercial cards for dried fluid spot. Within an all-in-one integrated holder, the invention allows the complete process required to ensure a quantitative analysis of blood, plasma or any other fluids, modification and enrichment of molecule subsets, and formation of a dried fluid spot on the specific spot location of a passive cellulose, non-cellulose, absorbent, or non-absorbent membrane material sampling.
    Type: Grant
    Filed: August 29, 2017
    Date of Patent: July 2, 2019
    Assignee: DBS System SA
    Inventors: Didier Maillefer, Julien Deglon, Aurelien Thomas, Julien Dumont
  • Patent number: 10330662
    Abstract: A method of screening solvents for the solubilization of petroleum hydrocarbons is disclosed. The method includes dissolving petroleum hydrocarbons in a selected solvent to form a first solution, adding an ionic liquid to the first solution and blending to form a second solution and measuring absorbance of the second solution using spectroscopic techniques. The solubilization of petroleum hydrocarbons in the solvent is then determined based on the difference between the measured absorbance of the first and second solution. A system for screening solvents for the solubilization of petroleum hydrocarbons is also disclosed. The system can be used in removal of wax deposition in refinery process equipment, process flow lines, during piping operations, upgradation of wax, prevention of clogging of pipelines, processing of sludge or for removing sludge from petroleum tank installations and enhancing the crude oil flow.
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: June 25, 2019
    Inventors: Jitendra Sangwai, Ramesh Gardas, Sivabalan Sakthivel, Sugirtha Velusamy, Srinivasan V Raju, Prashant Dhodapkar
  • Patent number: 10330693
    Abstract: A cartridge for dispensing fluid is presented. The cartridge comprises a valve. The valve comprises a pumping chamber for pumping the fluid. The valve positions a pumping chamber conduit. The pumping chamber conduit is connected to the pumping chamber. The cartridge further comprises a plunger for changing the volume of the pumping chamber. The cartridge further comprises a reservoir conduit for connecting the reservoir with the valve. The valve positions the pumping chamber conduit to connect with the reservoir conduit. The cartridge further comprises an outlet conduit for dispensing the fluid. The valve further rotates the pumping chamber conduit to connect with the outlet conduit.
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: June 25, 2019
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Christoph Boehm, Peter Kupser, Norbert Oranth, Juergen Spinke, Thorsten Brueckner, Timo Klein
  • Patent number: 10330691
    Abstract: A diagnostic analyzer includes a track, a light-blocking member, a motor, and an optical testing device. The track moves a reaction vessel held by the track. The light-blocking member is disposed adjacent to the track. The light-blocking member moves from a first position apart from the track to a second position closer to the track. When the light-blocking member is disposed in the first position a sample contained within the reaction vessel held by the track is exposed to light. When the light-blocking member is disposed in the second position the sample contained within the reaction vessel held by the track is blocked from exposure to the light. The motor moves the light-blocking member between the first and the second positions. The optical testing device is disposed adjacent to the track for optically testing the sample contained within the reaction vessel held by the track when the at least one light-blocking member is disposed in the second position.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: June 25, 2019
    Inventors: Joseph P. Donohue, Ryan Patrick Johnson
  • Patent number: 10319576
    Abstract: A laser ablation cell (1) comprises a flow channel (11) having an essentially constant cross-sectional area so as to ensure a strictly laminar flow in the flow channel. A sample chamber (21) is provided adjacent to a lateral opening (14) of the flow channel. A laser beam (41) enters the sample chamber (21) through a lateral window (16) and impinges on a surface (24) of a sample (23) to ablate material from the sample. The sample may be positioned in such a distance from the flow channel that the laser-generated aerosol mass distribution has its center within the flow channel. This leads to short aerosol washout times. The laser ablation cell is particularly well suited for aerosol generation in inductively coupled plasma mass spectrometry (ICPMS), including imaging applications.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: June 11, 2019
    Inventors: Detlef Günther, Daniel Grolimund, Hao Wang
  • Patent number: 10315137
    Abstract: A sensing system for detecting degradation of a machine fluid is disclosed. The sensing system may comprise a tag having electrical contacts. The tag may be configured to transmit a wireless signal when the electrical contacts are in electrical communication. The sensing system may further comprise a dissolvable element separating the electrical contacts and obstructing electrical communication between the electrical contacts. The dissolvable element may be configured to dissolve and allow electrical communication between the electrical contacts when an acid content of the machine fluid reaches a level indicative of the degradation of the machine fluid.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: June 11, 2019
    Assignee: Caterpillar Inc.
    Inventors: Philip C. Spengler, Jeffrey R. Ries, Hind Abi-Akar
  • Patent number: 10317386
    Abstract: A method of measuring nitrate concentration in an aqueous sample includes mixing the aqueous sample with a water-soluble thioether chosen to reduce nitrate in the aqueous sample to nitrite in the presence of a water soluble catalyst, and a water soluble reagent system adapted to interact with nitrite to generate a color; measuring color generation, and correlating the color generation to nitrate concentration.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: June 11, 2019
    Assignee: HACH COMPANY
    Inventors: Darren Kent MacFarland, Angella Nicholle Greenawalt
  • Patent number: 10315381
    Abstract: A two layer and/or a three-layer device is disclosed that allows samples therein to remain at a warmer or a colder temperature than would be ordinarily possible without the use of the two or three-layer device. The two-layer device contains an interior layer that comprises the sample, and a middle or intermediate layer that comprises chemical species that undergoes an exothermic or endothermic reaction. The three layer device further has an outer layer that contains an insulating layer. When the three layer device is used for samples, the temperature of the sample can remain at a temperature around 11° C. or less for at least about 5.5 to 6 hours.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: June 11, 2019
    Inventor: Medhat N. Elmasry
  • Patent number: 10317397
    Abstract: Provided is a microparticle separation system capable of continuously separating microparticles from a solution in a short period of time in which microparticles having different particle diameters are mixed, without the need to use antibodies or the like. The microparticle separation system comprises a microparticle separation chip; a thin plate for a sample liquid; a thin plate for a sheath liquid; and suctioning means and/or a suctioning device for suctioning the sheath liquid; and the microparticle separation chip comprises a single capture site for capturing to-be-captured microparticles being formed using the at least three pillars having one end provided on the substrate and the other end open upward.
    Type: Grant
    Filed: April 9, 2015
    Date of Patent: June 11, 2019
    Inventors: Fumihito Arai, Taisuke Masuda, Woneui Song
  • Patent number: 10309809
    Abstract: An apparatus for detecting stagnant drinking water includes a generator for producing electrical energy, an energy store for storing that energy, a control and analysis unit which detects the charge state of the energy store and a signal transmitter which emits a signal depending on the charge state of the energy store.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: June 4, 2019
    Assignee: Neoperl GmbH
    Inventor: Christof Ruhnke
  • Patent number: 10302535
    Abstract: A filtration device is disclosed for filtering debris from a biofluid sample. In at least one embodiment, the filtration device provides a collection container having a collection chamber defined by a flexible wall, a mouth fluidly communicating with the collection chamber and formed through the collection container at a top end, and a filter device defining a bottom to the collection chamber. A quantitative container has a quantitative chamber in fluid communication with the filter device with the filter device separating the collection chamber from the quantitative chamber. A biofluid sample is introduced into the collection chamber through the mouth, and when the mouth with a collection chamber cap, the flexible wall of the collection container is squeezed to reduce the volume of the collection chamber and force the biofluid sample through the filter device, the filtered biofluid sample thereafter being contained within the quantitative chamber.
    Type: Grant
    Filed: August 7, 2016
    Date of Patent: May 28, 2019
    Assignee: CellectGen, Inc.
    Inventors: Robert Gellibolian, Adam Markaryan
  • Patent number: 10300486
    Abstract: A microfluidic system is presented that includes a cartridge and a container. The cartridge includes a plurality of microfluidic channels coupled to one or more chambers. The container holds dry chemicals and includes a housing with a first opening and a second opening smaller than the first opening. The container is designed to be inserted into an opening of the cartridge, such that the container is independently secured within the opening. The insertion of the container allows for the container to be fluidically coupled with a microfluidic channel of the plurality of microfluidic channels via the second opening.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: May 28, 2019
    Inventors: Holger Engel, Jordi Carrera Fabra
  • Patent number: 10295496
    Abstract: A biosensor system can comprise a sensor chip and a measurement device. The sensor chip comprises a capillary and electrodes disposed within the capillary. The height of the capillary is set to be less than the maximum value of the sum of the diffusion distance of an electron-transfer mediator and the diffusion distance of an analyte at the upper limit of the measurement guaranteed temperature of the biosensor system. The measurement device applies an open circuit voltage, a voltage that is lower than during concentration measurement, or the like to the electrodes of the sensor chip.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: May 21, 2019
    Inventor: Motonori Uchiyama
  • Patent number: 10293573
    Abstract: Provided is a method for producing a micro flow channel chip that is used for a treatment or analysis of a liquid sample, the method being capable of producing a micro flow channel chip with high shape accuracy and high efficiency. The method includes a step of forming a groove on one surface of a base material; a lamination step of forming an adhesive resin layer on at least one surface of a resin film, and thereby obtaining a first laminate; and an adhesion step of arranging the surface of the base material where a groove has been formed and the adhesive resin layer of the first laminate to face each other, and bonding the base material and the first laminate such that the adhesive resin layer covers the groove, in which the glass transition temperature of the adhesive resin layer is 25° C. or lower.
    Type: Grant
    Filed: December 23, 2016
    Date of Patent: May 21, 2019
    Inventor: Hirohito Taniguchi
  • Patent number: 10288606
    Abstract: The present invention provides an analysis method for simultaneously detecting or quantifying plural species of target substances by measuring the light emission from plural carriers within a single container from outside of the container, these carriers comprising a plurality of substances that are respectively immobilized thereon for capturing the plural species of target substances, wherein the light emission from a desired carrier is selectively received by measuring the emission from the carriers through an optical filter.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: May 14, 2019
    Inventors: Takaki Sugimoto, Tetsuya Ueda, Shuichi Kobayashi, Hideji Tajima