Patents Examined by Christine T Mui
  • Patent number: 11364497
    Abstract: A microfluidic system includes, in an example, a substrate and at least two microfluidic devices embedded into the substrate, at least one of the microfluidic devices being different from a remaining number of microfluidic devices. A microfluidic apparatus includes at least two microfluidic devices embedded into a substrate, at least a first microfluidic device of the microfluidic devices being heterogenous to at least a second microfluidic device of the microfluidic devices and a microfluidic channel to fluidically couple the microfluidic devices to each other.
    Type: Grant
    Filed: October 12, 2017
    Date of Patent: June 21, 2022
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Chien-Hua Chen, Michael W. Cumbie
  • Patent number: 11364496
    Abstract: An apparatus includes a polymer base layer having a surface. A die has a surface that is substantially coplanar with the surface of the polymer base layer. The die includes a fluidic actuator to control fluid flow across the surface of the die. A fluidic channel is coupled to the polymer base layer to provide a fluidic interconnect between the die and a fluidic input/output port.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: June 21, 2022
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Chien-Hua Chen, Michael W. Cumbie, Viktor Shkolnikov
  • Patent number: 11364493
    Abstract: A microfluidic apparatus may include, in an example, a substrate, at least one silicon die embedded into the substrate, and a planarization layer layered over, at least, a portion of the substrate that interfaces with the silicon die to prevent a fluid from contacting an edge of the silicon die.
    Type: Grant
    Filed: October 12, 2017
    Date of Patent: June 21, 2022
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Michael W. Cumbie, Chien-Hua Chen
  • Patent number: 11366132
    Abstract: Since a detergent is a consumption article, it is desirable that a use amount of the detergent be as small as possible in a limit that the washing effect is not substantially reduced. Provided is an automatic analyzer which includes a syringe pump which is connected to a probe and performs the body aspiration and discharge, a feed pump which feeds washing water for washing the inside of the probe to the probe via the syringe pump and a controller which controls the dispensing mechanism and the syringe pump, in which the controller, in a case of washing the probe by sucking a detergent in the probe a plurality of times, controls the syringe pump so as to discharge the detergent after sucking the detergent and to suck the next detergent without feeding the washing water to the probe by the feed pump.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: June 21, 2022
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Takamichi Mori, Akihiro Nojima, Isao Yamazaki
  • Patent number: 11366065
    Abstract: Disclosed are a point-of-care system and method, the system including: an aptamer-based diagnostic reagent; a diagnostic instrument for detecting a Raman signal through a Raman analysis technique; and a diagnostic kit to be operated on the basis of a lateral flow method, wherein blood and the diagnostic reagent are reacted so as to detect a Raman signal when the placement of the diagnostic kit is detected, thereby allowing the type of acute febrile illness to be identified.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: June 21, 2022
    Inventors: Doo Ryeon Chung, Min Hee Kang, Nam Yong Lee, Min Young Lee, Kyu Sung Lee, Jae Bum Choo, Sang Yeop Lee, Joon Ki Hwang
  • Patent number: 11358137
    Abstract: A tubular structure for producing droplets and a method of using the tubular structure to produce droplets are provided. The tubular structure includes microchannel structures, and is used for droplet generation, droplet collection, nucleic acid amplification and/or in situ droplet detection, etc.
    Type: Grant
    Filed: December 26, 2019
    Date of Patent: June 14, 2022
    Assignee: Industrial Technology Research Institute
    Inventors: Shaw-Hwa Parng, Su-Jan Lee, Ping-Jung Wu, Ruey-Shyan Hong, Yu-Yin Tsai
  • Patent number: 11358143
    Abstract: Methods of mitigating lipoprotein interference in in vitro diagnostic assays for target hydrophobic analytes are disclosed, as well as compositions, kits, and devices useful in said methods. A pretreatment reagent is utilized that includes at least one enzyme that digests lipoprotein.
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: June 14, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Tie Wei, Jie Li, Yun Yue
  • Patent number: 11352379
    Abstract: The present disclosure provides a new series of compounds exhibiting high fluorescence quantum yields in the solid state. In one embodiment, the compounds include a series of 2,3,4,5-tetraphenylgermoles with the same or different 1,1-substituents. In another embodiment, substituted germafluorenes, germa-fluoresceins/rhodamines, and germapins are described. These germanium heterocycles possess ideal photophysical and thermostability properties, which makes them excellent candidates for chemical or biological sensors, host materials for electroluminescent devices and solar cells, and emissive and/or electron-transport layer components in organic light emitting diode devices.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: June 7, 2022
    Assignee: The Curators Of The University Of Missouri
    Inventors: Janet Braddock-Wilking, Teresa Lynn Bandrowsky, James Bryan Carroll, II
  • Patent number: 11351530
    Abstract: A photocatalyst can be regenerated with increasing efficiency, turnover number and turnover frequency in the presence of air by irradiating the photocatalyst with a first range of wavelengths of light that excite the photocatalyst to an intermediate and irradiating the intermediate with a second range of wavelengths of light that turns the intermediate to the photocatalyst.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: June 7, 2022
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Hadley Sikes Johnson, Hector Alan Aguirre Soto
  • Patent number: 11351547
    Abstract: Micro-fluidic chip comprises substrate and plurality of driving circuits on substrate, each of plurality of driving circuits comprising: driving electrode comprising first electrode plate and second electrode plate made of different materials on substrate, first electrode plate being electrically coupled to second electrode plate; and detecting sub-circuit comprising first signal terminal electrically coupled to first electrode plate and second signal terminal electrically coupled to second electrode plate, wherein micro-fluidic chip further comprises: voltage supply sub-circuit configured to supply driving voltage to first signal terminal to control droplet to move toward driving circuit during droplet driving stage, and configured to supply constant voltage to first signal terminal, during temperature detecting stage, and wherein detecting sub-circuit is configured to measure voltage difference between first signal terminal and second signal terminal, and obtain temperature of droplet on second electrode pl
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: June 7, 2022
    Assignees: BEIJING BOE OPTOELECTRONICS TECHNOLOGY CO., LTD., BOE TECHNOLOGY GROUP CO., LTD.
    Inventors: Yue Geng, Peizhi Cai, Fengchun Pang, Le Gu, Chuncheng Che, Nan Zhao
  • Patent number: 11353462
    Abstract: Methods and devices are provided for analyzing acetone in breath. One such method comprises disposing a reactant in a reaction zone within the breath analysis device, wherein the reactant comprises a primary amine disposed on a surface, and wherein the reaction zone has an optical characteristic that is at a reference level. It also comprises pre-storing a liquid nitroprusside solution within the breath analysis device separately from the reactant. The method further comprises using the breath analysis device to cause the breath to contact the reactant in the reaction zone so that the acetone in the breath reacts with the reactant to form a reaction product and, after the reaction product has been formed, using the breath analysis device to cause the nitroprusside solution to contact and react with the reaction product and to facilitate a change in the optical characteristic of the reaction zone relative to the reference level.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: June 7, 2022
    Assignee: Invoy Holdings Inc.
    Inventors: Lubna M. Ahmed, Brent C. Satterfield, Rhett L. Martineau
  • Patent number: 11353461
    Abstract: Methods for derivatization of biomolecules including glycans or other biopolymers with one or more fluorescent, MS active compounds by reductive amination or rapid tagging in order to produce derivatized glycan having a pKa>7 and between about 200 ?2 and about 1000 ?2 of nonpolar surface area are described.
    Type: Grant
    Filed: June 19, 2017
    Date of Patent: June 7, 2022
    Assignee: Waters Technologies Corporation
    Inventors: Darryl W. Brousmiche, Matthew A. Lauber
  • Patent number: 11344887
    Abstract: The present disclosure relates to a microfluidic chip and a control method thereof, a droplet generation device and a microsphere preparation device. The microfluidic chip includes a matrix (3), and a first flow channel (1) and a second flow channel (2) provided in the matrix (3), wherein the first flow channel (1) and the second flow channel (2) intersect to form an intersection area, sheared phase fluid can flow in from the first flow channel (1), shearing phase fluid can flow in from the second flow channel (2) so as to separate the sheared phase fluid into discrete droplets in the intersection area, and the cross-sectional areas of the first flow channel (1) and the second flow channel (2) range from 0.1 mm2 to 1 mm2. The microfluidic chip can increase the flow rate and improve the efficiency of forming droplets; and the efficiency of generating the droplets is increased on the basis of ensuring the cell activity in order to meet the requirements of 3D biological printing.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: May 31, 2022
    Assignee: REVOTEK CO., LTD
    Inventors: Yushi Huang, Yaya Zhang
  • Patent number: 11346787
    Abstract: There are provided a detection sensor, a detection sensor kit, a sensor device, a method for producing a detection sensor and a detection method which enable measurement by a simple operation. A detection sensor includes a detecting element, a first member and a second member. The detecting element detects a detection object contained in a sample. The first member includes a first channel portion, and the first channel portion includes a first storage section which stores a reagent which is fed to the detecting element. The second member is movable relative to the first member and includes a second channel portion. In the detection sensor, the first member and the second member are joined with each other and form a joined channel in which the first channel portion and the second channel portion communicate with each other.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: May 31, 2022
    Assignee: KYOCERA CORPORATION
    Inventor: Hiroyasu Tanaka
  • Patent number: 11340210
    Abstract: The embodiments disclose a method including functionalizing a biosensor with a biologic analytical target prior to installation into a detection cartridge, depositing a test subject bodily fluid test sample onto the biosensor surface, inserting the detection cartridge into a portable detection cartridge reader, measuring the electrical impedance of the bodily fluid test sample across biosensor energized electrodes, providing algorithms for analyzing measured electrical impedance data of the bodily fluid test sample obtained in the detection cartridge, identifying and determining the presence of biologic analytical target molecules in the bodily fluid test sample, and transmitting results of the test results to the test subject.
    Type: Grant
    Filed: May 18, 2021
    Date of Patent: May 24, 2022
    Inventors: Matthew Hummer, Gregory J. Hummer
  • Patent number: 11331673
    Abstract: A reagent management apparatus utilizing a flexible sheet that is foldable along scores into a disposable liner which may be freestanding via a “three point” structure. The disposable liner includes a reservoir for reagents and allows the pouring off of unused reagent into a storage container. The disposable liner may be used with a permanent base in certain cases.
    Type: Grant
    Filed: September 3, 2019
    Date of Patent: May 17, 2022
    Inventor: Bambi Lyn Cahilly
  • Patent number: 11327090
    Abstract: In example implementations, a method is provided. The method may be executed by a processor of a fluid dispensing apparatus. The method includes dispensing a fluid onto a surface from a dispenser during an alignment procedure. The surface is ejected for alignment verification. The surface is then received for re-execution of the alignment procedure after the alignment verification. The dispenser is re-used to dispense fluid onto the surface during re-execution of the alignment procedure.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: May 10, 2022
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: David H. Ochs, Kenneth Ward
  • Patent number: 11327060
    Abstract: Enantiomers may be analyzed by: (1) reacting a mixture of a first compound and a second compound that are a pair of enantiomers with an axially chiral compound that is one of a pair of axially chiral isomers, to generate a derivative mixture containing a first derivative obtained by a reaction of the first compound with the axially chiral compound and a second derivative obtained by a reaction of the second compound with the axially chiral compound; (2) separating the first derivative and the second derivative in the derivative mixture; and (3) detecting the separated first derivative and second derivative by mass spectrometry.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: May 10, 2022
    Assignee: Ajinomoto Co., Inc.
    Inventors: Masashi Harada, Sachise Karakawa, Kazutaka Shimbo, Naoyuki Yamada
  • Patent number: 11325100
    Abstract: The invention relates to strong hydrogen-bond acidic sorbents. The sorbents may be provided in a form that limits or eliminates intramolecular bonding of the hydrogen-bond acidic site between neighboring sorbent molecules, for example, by providing steric groups adjacent to the hydrogen-bond acidic site. The hydrogen bond site may be a phenolic structure based on a bisphenol architecture. The sorbents of the invention may be used in methods for trapping or detecting hazardous chemicals or explosives.
    Type: Grant
    Filed: November 1, 2018
    Date of Patent: May 10, 2022
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Courtney A. Roberts, R. Andrew McGill
  • Patent number: 11319331
    Abstract: The present disclosure shows a molecular probe SF-1 which is useful for selective detection of hypochlorous acid (HOCl) over other reactive oxygen species (ROS) and a process for the preparation thereof.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: May 3, 2022
    Assignee: Council of Scientific & Industrial Research
    Inventors: Firoj Ali, Sunil Babanrao Aute, Anila Hoskere Ashok, Suman Pal, Amitava Das