Patents Examined by Christine T Mui
  • Patent number: 11830715
    Abstract: The invention relates to the detection of fatty acids. In a particular aspect, the invention relates to methods for detecting very long chain fatty acids and branched chain fatty acids by mass spectrometry.
    Type: Grant
    Filed: May 24, 2021
    Date of Patent: November 28, 2023
    Assignee: Quest Diagnostics Investments Incorporated
    Inventor: Scott Goldman
  • Patent number: 11826027
    Abstract: The present description relates to a sample collection device comprising a receptacle and a closure member configured to seal the receptacle. Within the closure member is provided a reservoir configured to contain a stabilization fluid capable of preserving and stabilizing a collected sample. The reservoir includes an outlet which is sealed by a sealing member. The sealing member may be openable to allow communication, or mixture, between the contents of the reservoir and the contents of the receptacle. The closure member may also include a peel foil on the end of the closure member having the outlet to ensure sterility of and to avoid tampering with the outlet and the reservoir. The method includes collecting a sample from the user using the sample collection device, mixing the sample with the stabilization fluid, and analyzing the sample thus collected.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: November 28, 2023
    Inventors: Travis Sessions, Aaron Devore, Dan H. O'Neill
  • Patent number: 11819840
    Abstract: A pipette tip for and method of automatically maintaining pipette tip depth in a fluid during a fluid transfer operation is disclosed. The pipette tip includes, for example, two electrodes that run substantially the full length of the pipette tip for measuring the resistance therebetween when submerged in a conductive fluid. A method is provided of automatically maintaining the depth of the pipette tip in a liquid throughout a pipetting operation, as the liquid surface rises or falls in its container, without any prior knowledge of the container geometry.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: November 21, 2023
    Assignee: FORMULATRIX, INC.
    Inventors: David Wikholm, Rasmus Lindblom
  • Patent number: 11819323
    Abstract: The embodiments disclose a method including making electrodes using an electrically conductive material for impedimetric detection of analytical targets in an electrochemical sensing platform device, collecting patient samples in a solution compartment of the electrochemical sensing platform device, binding primers and aptamers to electrodes for functionalizing electrodes for detecting and binding targeted viruses and bacterial pathogens, incubating oral fluid samples in the solution compartment using a heater, measuring electrode impedance changes, recording measured electrode impedance changes in a memory device, and integrating wireless technologies into the electrochemical sensing platform device configured for transmitting recorded measured data.
    Type: Grant
    Filed: October 18, 2021
    Date of Patent: November 21, 2023
    Inventor: Gregory J. Hummer
  • Patent number: 11813615
    Abstract: The present disclosure relates to a flow cell receiver. The flow cell receiver can include at least one platen, having a plurality of ports. The flow cell receiver can include magnets. The flow cell receiver can be configured to automatically align, secure, and retain a flow cell carrier containing a flow cell.
    Type: Grant
    Filed: October 11, 2022
    Date of Patent: November 14, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Sandor Kovacs, David Baranson, Eli N. Glezer
  • Patent number: 11815507
    Abstract: The present disclosure provides systems and methods for sorting a cell. The system may comprise a flow channel configured to transport a cell through the channel. The system may comprise an imaging device configured to capture an image of the cell from a plurality of different angles as the cell is transported through the flow channel. The system may comprise a processor configured to analyze the image using a deep learning algorithm to enable sorting of the cell.
    Type: Grant
    Filed: February 11, 2021
    Date of Patent: November 14, 2023
    Assignee: Deepcell, Inc.
    Inventors: Mahdokht Masaeli, Mahyar Salek, Hou-Pu Chou, Soroush Kahkeshani, Prashast Khandelwal, Syed Tariq Shafaat
  • Patent number: 11808750
    Abstract: Sampling devices for sampling an aqueous source (e.g., field testing of ground water) for multiple different analytes are described. Devices include a solid phase extraction component for retention of a wide variety of targeted analytes. Devices include analyte derivatization capability for improved extraction of targeted analytes. Thus, a single device can be utilized to examine a sample source for a wide variety of analytes. Devices also include an isotope dilution capability that can prevent error introduction to the sample analysis and can correct for sample loss and degradation from the point of sampling until analysis as well as correction for incomplete or poor derivatization reactions. The devices can be field-deployable and rechargeable.
    Type: Grant
    Filed: April 29, 2021
    Date of Patent: November 7, 2023
    Assignee: Battelle Savannah River Alliance, LLC
    Inventors: Andrew J. Boggess, Stephen L. Crump, Thomas L. White
  • Patent number: 11802264
    Abstract: Apparatuses and methods are described for the use of optically driven bubble, convective and displacing fluidic flow to provide motive force in microfluidic devices. Alternative motive modalities are useful to selectively dislodge and displace micro-objects, including biological cells, from a variety of locations within the enclosure of a microfluidic device.
    Type: Grant
    Filed: October 12, 2020
    Date of Patent: October 31, 2023
    Assignee: PHENOMEX INC.
    Inventors: Volker L. S. Kurz, Troy A. Lionberger, Eric K. Sackmann, Kai W. Szeto, Paul M. Lebel, Brandon R. Bruhn, Keith J. Breinlinger, Eric D. Hobbs, Andrew W. McFarland, J. Tanner Nevill, Xiaohua Wang
  • Patent number: 11795449
    Abstract: This disclosure relates to a nucleic acid collection column that collects a nucleic acid from a liquid sample containing the nucleic acid. The nucleic acid collection column includes a sample injection portion having an opening into which the liquid sample containing the nucleic acid is injected, a support adsorption portion that houses a support for adsorbing the nucleic acid and in which the nucleic acid is adsorbed on the support, and a discharge portion that discharges a liquid passed through the support adsorption portion. The support includes aluminum oxide having a surface where a water-soluble neutral polymer is adsorbed. A space that houses the support in the support adsorption portion has a cylindrical shape, and has a volume of 0.13 ?L or more and 13.5 ?L or less. An aspect ratio (d1/d2) of the space satisfies 1.0?d1/d2<15.0.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: October 24, 2023
    Assignee: Toray Industries, Inc.
    Inventors: Shota Sekiguchi, Takahiro Motoshiromizu, Masateru Ito
  • Patent number: 11788962
    Abstract: A device and method for detecting the presence of bacteria in a sample are provided. A multi-step process for sample preparation is utilized and a microfluidic device is disclosed. The detection is performed using microfluidics and physical changes in multiple samples in differential mode.
    Type: Grant
    Filed: January 25, 2021
    Date of Patent: October 17, 2023
    Inventors: Govind Rao, Yordan Kostov, Mustafa Al-Adhami, Chandrasekhar Gurramkonda
  • Patent number: 11788969
    Abstract: A real-time, on-line method and analytical system for determining halohydrocarbons in water which operate by (1) extracting on-line samples; (2) purging volatile halohydrocarbons from the water (e.g., with air or nitrogen); (3) carrying the purge gas containing the analytes of interest over a porous surface where the analytes are adsorbed; (4) recovering the analytes from the porous surface with heat (thermal desorption) or solvent (solvent elution) to drive the analytes into an organic chemical mixture; (5) generating an optical change (e.g., color change) in dependence upon a reaction involving the analytes and a pyridine derivative; and (6) measuring optical characteristics associated with the reaction to quantify the volatile halogenated hydrocarbon concentration.
    Type: Grant
    Filed: October 19, 2020
    Date of Patent: October 17, 2023
    Assignee: AMS Trace Metals, Inc.
    Inventors: Harmesh K. Saini, Michael J. West, Qin Wang, James Garvey, Paul Rand, Mark Angelo, David Johnston, Robert Ormond, Ye Han
  • Patent number: 11779901
    Abstract: The invention relates to strong hydrogen-bond acidic sorbents. The sorbents may be provided in a form that limits or eliminates intramolecular bonding of the hydrogen-bond acidic site between neighboring sorbent molecules, for example, by providing steric groups adjacent to the hydrogen-bond acidic site. The hydrogen bond site may be a phenolic structure based on a bisphenol architecture. The sorbents of the invention may be used in methods for trapping or detecting hazardous chemicals or explosives.
    Type: Grant
    Filed: April 21, 2022
    Date of Patent: October 10, 2023
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: R. Andrew McGill, Courtney A. Roberts
  • Patent number: 11779923
    Abstract: The present invention relates to a microfluidic device, a method for manufacturing a microfluidic device, and a method for provision of double emulsion droplets using a microfluidic device. Furthermore, the present invention relates to an assembly configured to supply pressure to the microfluidic device for provision of double emulsion droplets. Furthermore, the present invention relates to a kit comprising a plurality of microfluidic devices and a plurality of fluids configured for use with the microfluidic device for provision of double emulsion droplets. The microfluidic device comprises a transfer conduit comprising a first transfer conduit part having a first affinity for water; and a collection conduit comprising a first collection conduit part having a second affinity for water being different from the first affinity for water. A well section and a microfluidic section of the microfluidic device are fixedly connected to each other.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: October 10, 2023
    Assignee: SAMPLIX APS
    Inventors: Thomas Kvist, Esben Bjørn Madsen, Solène Cherre, Marie Just Mikkelsen
  • Patent number: 11768133
    Abstract: A testing device for testing the level of a selected chemical in central heating system water in a central heating system circuit comprises: a sample chamber for holding a sample of central heating system water, the sample chamber being connected to the central heating system circuit; means for controlling filling of the sample chamber with central heating system water from the central heating system circuit, and emptying of the sample chamber; at least one valve for isolating the sample of central heating system water from the heating circuit during testing; and optical testing apparatus including a light source and a detector, for measuring an optical property of the sample of central heating system water isolated within the sample chamber and thereby making a determination as to whether or not the level of the selected chemical in the water is greater than a predetermined threshold level.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: September 26, 2023
    Assignee: ADEY HOLDINGS (2008) LIMITED
    Inventors: Mukash Jassal, Simon Downie
  • Patent number: 11759778
    Abstract: The present disclosure provides an electrode plate, a microfluidic chip, and a method of manufacturing the electrode plate. In one embodiment, an electrode plate includes: a substrate, an electrode and a surface contact layer stacked in sequence, and a droplet inlet hole passing through the substrate, the electrode and the surface contact layer. The surface contact layer comprises a super-hydrophobic region and a hydrophilic region, and the droplet inlet hole is disposed in the hydrophilic region. The microfluidic chip includes: a first electrode plate formed by the abovementioned electrode plate, and a second electrode plate provided on a side of the first electrode plate close to the surface contact layer. The first electrode plate is provided opposite to the second electrode plate and a liquid channel is formed between the first electrode plate and the second electrode plate.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: September 19, 2023
    Inventors: Xiaoxin Song, Feng Zhang, Wenqu Liu, Zhijun Lv, Zhao Cui, Qi Yao
  • Patent number: 11745178
    Abstract: A fluid processing cassette includes first and second covers, with an interior wall positioned between the covers. The interior wall includes a first surface facing the first cover and defining a portion of a plurality of macrofluidic channels. A second surface of the interior wall faces the second cover and defines a portion of a plurality of microfluidic channels. At least one opening defined in the interior wall provides fluid communication between at least one of the macrofluidic channels and at least one of the microfluidic channels. An additional interior wall may also be positioned between the covers, with each interior wall secured to a different one of the covers and to the other interior wall. The additional interior wall may be positioned between the first cover and the interior wall, with macrofluidic channels defined on each side of the additional interior wall.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: September 5, 2023
    Assignee: Fenwal, Inc.
    Inventor: Christopher J. Wegener
  • Patent number: 11745179
    Abstract: Systems and methods for transfection using a microfluidic device are disclosed. Microdroplets encapsulate cells, transfection molecules, and cationic lipid transfection reagent. Droplet chaotic advection in a rendering channel of the system results in a uniform lipid-DNA complex (lipoplex) formation, which can improve gene delivery efficacy. The shear stress exerted on cell membranes during the chaotic mixing increases membrane permeability, which when combined with the co-confinement of cell and lipoplex, improves transfection efficiency of the cell. The systems and methods can be used for a variety of applications such as gene therapy, in vitro fertilization, regenerative medicine, cancer treatment, and vaccines.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: September 5, 2023
    Inventors: Abraham P. Lee, Xuan Li, Yue Yun
  • Patent number: 11747239
    Abstract: An analytical toilet comprising a bowl for receiving excreta from a user; a flush mechanism for cleaning the bowl after use; at least one analytical test device wherein a sample of excreta is analyzed; a manifold comprising conduits and valves for distributing one or more fluids to and from the at least one receptacle; and a digital control device controlling the valves to distribute the sample to the analytical test device for analysis; and distribute fluid to remove the sample from the analytical test device after analysis and to clean the analytical test device is disclosed.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: September 5, 2023
    Assignee: Hall Labs LLC
    Inventors: David R. Hall, David Crismon, Joshua Larsen, Jared Reynolds, Kevin Jeffrey Campbell
  • Patent number: 11749437
    Abstract: On-platform pumps provide greater flexibility and design freedom and are a key feature of organs-on-chip platforms. On-platform electromagnetic (EM) pumps have been developed for use with the organ-on-chip platforms. The EM pump uses electrical energy, which may be supplied by a battery, making the pump portable. The EM pump uses an EM actuator having a low energy consumption. The actuator's low energy consumption is achieved by a latching design which requires only a short pulse of energy to switch its state and where springs store some of the actuator kinetic energy, which is then recovered in the reverse stroke. This further reduces the energy consumption of the actuator. Also provided are injection-molded, single-use platforms with onboard diaphragm micro-pumps and various valve and pump geometries. The EM actuators easily integrate with these platforms, demonstrating pumping at a constant flowrate, no measurable temperature rise, and valve sealing against varying back-pressure.
    Type: Grant
    Filed: May 1, 2019
    Date of Patent: September 5, 2023
    Inventors: Brij Mohan Bhushan, Daniel R. Rathbone, David L. Trumper, Minkyun Noh, Jun Young Yoon
  • Patent number: 11747310
    Abstract: Methods are provided for making rapid labeled dextran ladders and other calibrants useful in liquid chromatography. The methodologies include a two-step process comprising a reductive amination step of providing a reducing glycan and reacting it with a compound having a primary amine to produce an intermediate compound. The intermediate compound is then rapidly tagged with a rapid tagging reagent to produce the rapid labeled dextran ladder.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: September 5, 2023
    Assignee: Waters Technologies Corporation
    Inventors: Michael F. Morris, Matthew A. Lauber, Darryl W. Brousmiche