Patents Examined by Christine T Mui
  • Parts for diagnostic devices
    Patent number: 11666906
    Abstract: In some examples, a diagnostic device includes a reusable part to receive a container of a fluid, the reusable part reusable for a plurality of diagnostic tests. The diagnostic device further includes a disposable part detachably attached to the reusable part and comprising a sample collector to collect a target sample of a living being. The diagnostic device further includes a tester comprising a fluid channel to transport the fluid to combine the fluid and the target sample to form a fluid combination, and to use the fluid combination to diagnose a condition of the target sample.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: June 6, 2023
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Matthew J. Wagner, Donald Williams, Michele Huang, Rita Gozali, Sanjay Kumar Sinha, Barrett R. Crane, Peter-P Zhang, Doreen Ai Siang Chan
  • Microfluidic chip, head, and dispensing device for dispensing fluids containing an acidic component
    Patent number: 11666918
    Abstract: A microfluidic ejection chip includes a silicon substrate having a fluid passageway. The fluid passageway is defined by a silicon sidewall of the silicon substrate that is covered by a permanent passivation layer to protect the silicon sidewall from exposure to an acidic fluid. The permanent passivation layer is retained on the silicon sidewall at a conclusion of etching of the silicon substrate to form the fluid passageway.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: June 6, 2023
    Assignee: FUNAI ELECTRIC CO., LTD.
    Inventors: David L. Bernard, Sean T. Weaver
  • Cell classification chip
    Patent number: 11666915
    Abstract: A chip includes a micro-channel unit for hydraulically classifying cells in a blood sample. In a micro-channel unit, liquid flowing from a sub channel into a main channel pushes cells flowing in the main channel toward a side thereof on which a removal channel and a collection channel are disposed. Fluid containing non-nucleated RBCs among the pushed cells enters the removal channel, so that the non-nucleated RBCs are removed from a blood sample. A plurality of micro-channel units having the same patterns as each other are repeatedly stacked in a height direction. Inlets of the main channels, inlets of the sub channels, outlets of the removal channels, outlets of the collection channels, and outlets of the main channels, which are provided in the micro-channel units, are connected to respective pillar channels penetrating each of layers in a traversing manner.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: June 6, 2023
    Assignee: TL Genomics Inc.
    Inventors: Tomohiro Kubo, Madoka Ayano
  • Blood analysis method and blood test kit
    Patent number: 11661622
    Abstract: An object of the present invention is to provide a blood analysis method and a blood test kit, which are for performing quantitative analysis of components by precisely obtaining a dilution factor.
    Type: Grant
    Filed: June 26, 2019
    Date of Patent: May 30, 2023
    Assignee: FUJIFILM Corporation
    Inventors: Hikaru Urano, Haruyasu Nakatsugawa, Tatsuya Ishizaka, Shinya Sugimoto, Isao Yonekubo
  • Compositions and methods for biological sample processing
    Patent number: 11662281
    Abstract: Methods, apparatuses, and systems are provided for processing a biological sample. Exemplary methods comprise transferring a swab associated with an aliquot of the biological sample into a wash liquid, wherein a first portion of the aliquot is released into the wash liquid; and transferring the swab into a carrier liquid, wherein a second portion of the aliquot is released into the carrier liquid. The methods can provide efficient transfer of analyte such as cells or nucleic acid into the carrier liquid while releasing particulate matter, viscous polymers, or other undesired material into the wash liquid. Alternatively or in addition, the methods can also release desired material into the wash liquid, e.g., cells, which can be used in applications such as culturing.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: May 30, 2023
    Assignee: Gen-Probe Incorporated
    Inventor: Patrick Lynn Peterson
  • Devices, methods, and systems for collection of volatile organic compounds
    Patent number: 11660021
    Abstract: A system comprises a mouth piece to receive exhaled air; a breath chamber to receive exhaled air; a valve to direct exhaled air along a desired flow path, direct purge gas along a desired flow path, control the rate of flow of purge gas, control the rate of flow of exhaled air, block the flow of purge gas, and/or block the flow of exhaled air; a source of purge gas; a CO2 cartridge to remove CO2; a water cartridge to remove water; a breath cartridge to capture VOCs from exhaled air; a temperature control system to control the temperature of CO2 cartridge, a water cartridge, and/or a breath cartridge; a cryostat to contain and limit heat flow to a cryogenic liquid; a flow meter designed to measure the flow of exhaled air and/or purge gas; and a pressure transducer to measure a pressure, a flow rate, and/or a flow volume.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: May 30, 2023
    Assignee: Diagnose Early, Inc.
    Inventors: Chris Wheeler, Chris Todd, Jeffrey A. Schuster, Karl-Magnus Larsson
  • Systems, devices and methods for microfluidic analysis
    Patent number: 11654431
    Abstract: Described herein are various inventions and embodiments thereof, directed to systems, devices, and methods for analysis of a biofluid, as well as controlling a biofluid analysis system using a microfluidic device. Embodiments of biofluid analysis systems disclosed herein may provide analysis of a biofluid to identify and characterize one or more analytes. An apparatus may include a first layer defining a first opening and a second opening. The first layer may be substantially transparent. A second layer may be coupled to the first layer and define a microfluidic channel that establishes a fluid communication path between the first opening and the second opening. At least a portion of the second layer may be substantially opaque.
    Type: Grant
    Filed: October 3, 2019
    Date of Patent: May 23, 2023
    Assignee: Zoetis Services LLC
    Inventors: Robert Justice Shartle, Sherb M. Edmondson, Jr., Bob Larson
  • Microfluidic chip and driving method thereof
    Patent number: 11654433
    Abstract: A microfluidic chip and a driving method thereof are provided. The microfluidic chip includes a base substrate, a driving circuit array, a first decoding circuit, and a second decoding circuit, the driving circuit array, the first decoding circuit, and the second decoding circuit are all integrated on the base substrate; the first decoding circuit is configured to generate and output a target scan driving signal to the driving circuit array; the second decoding circuit is configured to generate and output a target driving voltage signal to the driving circuit array; and the driving circuit array is configured to control an operation of a liquid droplet over the driving circuit array based on the target scan driving signal and the target driving voltage signal.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: May 23, 2023
    Assignees: BEIJING BOE OPTOELECTRONICS TECHNOLOGY CO., LTD., BOE TECHNOLOGY GROUP CO., LTD.
    Inventors: Feng Long, Zongze He, Xiuyun Chen, Yuxuan Chen, Yu Zhang, Pin Xiao
  • Bisphenol hypersorbents for enhanced detection of, or protection from, hazardous chemicals
    Patent number: 11654415
    Abstract: The invention relates to strong hydrogen-bond acidic sorbents. The sorbents may be provided in a form that limits or eliminates intramolecular bonding of the hydrogen-bond acidic site between neighboring sorbent molecules, for example, by providing steric groups adjacent to the hydrogen-bond acidic site. The hydrogen bond site may be a phenolic structure based on a bisphenol architecture. The sorbents of the invention may be used in methods for trapping or detecting hazardous chemicals or explosives.
    Type: Grant
    Filed: April 21, 2022
    Date of Patent: May 23, 2023
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: R. Andrew McGill, Courtney A. Roberts
  • Composition for preparing biological material having excellent light transmissivity and use of composition
    Patent number: 11656159
    Abstract: The present invention relates to a clearing technique which uses a solution containing at least one of a compound having a delipidation ability, a compound having a biochrome decoloring ability, a compound having a decalcification ability, a compound having a refractive index adjusting ability, and a compound having a tissue swelling ability. The clearing technique is suitable for use in high-throughput and low-magnification imaging which involves a simple process.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: May 23, 2023
    Assignee: RIKEN
    Inventors: Hiroki Ueda, Kazuki Tainaka, Tatsuya Murakami
  • Terbium and dysprosium complexes with optimised antenna, used as luminescent markers
    Patent number: 11649253
    Abstract: The present technology relates to luminescent lanthanide complexes comprising a chelating agent, formed of a macrocycle or ligand, complexing a lanthanide ion Ln3+ selected from terbium and dysprosium, the chelating agent comprising at least one group of the structure (B) below; and a process for detecting a biomolecule using said lanthanide complex comprising coupling a luminescent lanthanide complex of the present technology having a reactive group with said biomolecule.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: May 16, 2023
    Assignees: ECOLE NORMALE SUPERIEURE DE LYON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON 1
    Inventors: Amandine Roux, Anh-Thy Bui, Olivier Maury, Chantal Andraud
  • Bisphenol hypersorbents for enhanced detection of, or protection from, hazardous chemicals
    Patent number: 11648529
    Abstract: The invention relates to strong hydrogen-bond acidic sorbents. The sorbents may be provided in a form that limits or eliminates intramolecular bonding of the hydrogen-bond acidic site between neighboring sorbent molecules, for example, by providing steric groups adjacent to the hydrogen-bond acidic site. The hydrogen bond site may be a phenolic structure based on a bisphenol architecture. The sorbents of the invention may be used in methods for trapping or detecting hazardous chemicals or explosives.
    Type: Grant
    Filed: April 21, 2022
    Date of Patent: May 16, 2023
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: R. Andrew McGill, Courtney A. Roberts
  • Methods of in situ antigen retrieval of a biological sample and imaging thereof
    Patent number: 11642670
    Abstract: The invention relates to a device and method for in situ temperature-induced antigen retrieval of samples wherein all steps are performed under a pressure higher than the atmospheric pressure on a sample immobilized on a sample support which can be further subjected to staining and imaging on the same sample support, optionally by cycle multiplexing that enables imaging of various molecular targets through multi-molecular read-outs on the same sample in a rapid, highly sensitive and reliable manner.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: May 9, 2023
    Assignee: LUNAPHORE TECHNOLOGIES SA
    Inventors: Giulia Cappi, Marta Comino, Marco Ammann, Diego Gabriel Dupouy, Ata Tuna Ciftlik
  • Portable wide field fluorimeter systems
    Patent number: 11635379
    Abstract: The present disclosure features portable wide field fluorimeter systems, e.g., in the form of low-cost mobile platforms, and methods to perform fluorometric assays to detect a change in fluorescence intensity in liquid samples, e.g., caused by the presence of a target analyte, e.g., a protein, e.g., an enzyme (e.g., ?-lactamase) expressed by a target pathogen in a liquid sample in a point-of-care setting. In some implementations, a portable system for detecting a change in fluorescence intensity in a liquid sample includes a microfluidic device, an optical assembly including an emission filter and one or more lenses, and an analyzer device that collects and processes a fluorescent signal for the detection of a target analyte produced by the target pathogen present in the liquid sample.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: April 25, 2023
    Assignee: The General Hospital Corporation
    Inventors: Akilan Palanisami, Tayyaba Hasan
  • Diagnostic detection chip devices and methods of manufacture and assembly
    Patent number: 11628435
    Abstract: Diagnostic detection chip device designs that reduce cost of fabrication and assembly are described herein. Such chip device designs include features that facilitate use of the chip within a chip carrier device with integrated fluid flow control features and compatibility with conventional sample cartridges and sample processing systems. Associated methods of manufacture and assembly of the chip devices are also provided herein.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: April 18, 2023
    Assignee: Cepheid
    Inventor: Douglas B. Dority
  • Apparatus and method for the non-destructive measurement of hydrogen diffusivity
    Patent number: 11624743
    Abstract: Apparatuses and methods of measuring a hydrogen diffusivity of a metal structure including during operation of the metal structure, are provided. A hydrogen charging surface is provided at a first location on an external surface of the structure. In addition, a hydrogen oxidation surface is provided at a second location adjacent to the first location on the external surface of the structure. Hydrogen flux is generated and directed into the metal surface at the charging surface. At least a portion of the hydrogen flux generated by the charging surface is diverted back toward the surface. A transient of the diverted hydrogen fluxes measured, and this measurement is used to determine the hydrogen diffusivity of the metal structure in service.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: April 11, 2023
    Assignee: SAUDI ARABIAN OIL COMPANY
    Inventors: Abderrazak Traidia, Mohammed Alshahrani, Sebastien A. Duval
  • Identification and use of glycopeptides as biomarkers for diagnosis and treatment monitoring
    Patent number: 11624750
    Abstract: Provided herein are methods for identifying new biomarkers for various diseases using proteomics, peptidomics, metabolics, proteoglycomics, glycomics, mass spectrometry and machine learning. The present disclosure also provides glycopeptides as biomarkers for various diseases such as cancer and autoimmune diseases.
    Type: Grant
    Filed: October 9, 2020
    Date of Patent: April 11, 2023
    Assignee: Venn Biosciences Corporation
    Inventors: Aldo Mario Eduardo Silva Carrascoso, Carolyn Ruth Bertozzi, Carlito Bangeles Lebrilla, Lieza Marie Araullo Danan-Leon
  • Single piece droplet generation and injection device for serial crystallography
    Patent number: 11624718
    Abstract: A single-piece hybrid droplet generator and nozzle component for serial crystallography. The single-piece hybrid droplet generator component including an internally-formed droplet-generation channel, an internally-formed sample channel, a nozzle, and a pair of electrode chambers. The droplet-generation channel extends from a first fluid inlet opening to the nozzle. The sample channel extends from a second fluid inlet opening to the droplet-generation channel and joins the droplet-generation channel at a junction. The nozzle is configured to eject a stream of segmented aqueous droplets in a carrier fluid from the droplet-generation channel through a nozzle opening of the single-piece component. The pair of electrode chambers are positioned adjacent to the droplet-generation channel near the junction between the droplet-generation channel and the sample channel.
    Type: Grant
    Filed: May 12, 2020
    Date of Patent: April 11, 2023
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Alexandra Ros, Daihyun Kim, Diandra Doppler, Jorvani Cruz Villarreal, Richard Kirian, Reza Nazari, Sahir Gandhi
  • Squeezable sample preparation device
    Patent number: 11618017
    Abstract: An improved biological sample preparation device and method of using the device, the device including a squeezable tube and a tip assembled to the squeezable tube. The tip includes a filter and a wick configured to enable controlled delivery to a diagnostic device by capillary action. The device provides precise and repeatable sample volume dispensing control, reduces potential contamination in the working environment, increases ease of use, and improves safety for healthcare workers.
    Type: Grant
    Filed: June 28, 2022
    Date of Patent: April 4, 2023
    Assignee: Porex Corporation
    Inventors: Asa C. Burke, Rene Desquenne, Guoqiang Mao
  • Volume-free reagent addition and exclusion-based sample preparation for streamlined multi-step assays
    Patent number: 11618021
    Abstract: A method of sample preparation for streamlined multi-step assays is provided. The method includes the step of providing a microfluidic device including a reservoir defined by a surface configured to repel an aqueous solution. A dried reagent is provided on a portion of the surface and the reservoir is filled with an oil. A first droplet formed from the aqueous solution is positioned on the dried reagent so to pick-up and re-dissolve the dried reagent therein so as to expose the portion of the surface. In addition, a second droplet of an aqueous solution may be deposited on a hydrophilic spot patterned on the surface. A magnetic force may be configured to interact magnetically with the paramagnetic beads within the first droplet to move the droplet through the oil in the reservoir or to move the paramagnetic beads from the first droplet, through the oil, into the second droplet.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: April 4, 2023
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David J. Beebe, Joshua M. Lang, Duane S. Juang, Scott M. Berry, Tamara S. Rodems