Abstract: A test tube for containing a liquid and electrically connected to a blockchain network is provided. The test tube includes a tube body, a cover, at least one overlay unit, a chipset and a detection module. The tube body contains the liquid. The cover is disposed at the top of the tube body and including at least one drip tube. The overlay unit covers the drip tube. The chipset is disposed on the tube body and includes a blockchain tracer. The blockchain tracer records the source of the liquid and a transportation history of the test tube in the blockchain network for tracing. The detection module is disposed on the tube body and electrically connected to the chipset, for measuring a liquid property of the liquid.

Abstract: The objective of the present invention is to provide a fluid handling device capable of easily isolating droplets. This objective is achieved by means of a fluid handling device which includes a first flow passage through the interior of which, when a fluid containing a droplet is delivered, the droplet can move, a first chamber which captures the droplet moving through the first flow passage, a second chamber into which the droplet captured by the first chamber can move, and a second flow passage providing communication between the first chamber and the second chamber, wherein the second flow passage is capable of selectively allowing the droplet to pass, or restricting passage of the droplet.

Abstract: Provided is an analysis method capable of qualitatively determining resins adhering to crushed polysilicon with high sensitivity and further capable of quantitatively determining the resins with high precision. The analysis method comprises removing organic volatile components from crushed polysilicon by heating, then raising a temperature of the crushed polysilicon in a stream of an inert gas, collecting resin decomposition products produced at the heating temperature, and analyzing decomposition products unique to the resins, to thereby identify the types of the resins adhering to the crushed polysilicon. Moreover, it is also possible to prepare a standard curve regarding each of the decomposition products unique to the resins and to determine an adhesion quantity of each of the adhering resins based on the standard curve.

Abstract: An instrument for energizing molecules contained in a sample solution may include a droplet generator configured to generate droplets of the sample solution. The droplet generator illustratively has an elongated nozzle defining an orifice at one end thereof from which the droplets exit the droplet generator, and the orifice illustratively defines a first longitudinal axis centrally therethrough. A molecule energizing source is configured to produce a molecule energizing field, and is positioned relative to the nozzle orifice such that the molecule energizing field extends into at least some of the generated droplets along a direction non-parallel with the first longitudinal axis. The molecule energizing field illustratively carries energy which heats at least one of the generated droplets sufficiently to induce structural changes in at least one molecule contained in the at least one of the generated droplets.

Abstract: The disclosure is related to a liquid processing module, a liquid testing system and a testing method. The liquid processing module includes a base, a first valve and at least one negative pressure generator. The base has a first groove and at least one first opening. The first opening is connected to the first groove. The first valve is slidably located in the first groove. The negative pressure generator is configured to generate or remove negative pressure at the first opening in response to the first opening and the first groove being connected with each other.

Abstract: Provided herein are methods and devices that allow for efficient management of many different sampling locations within a facility. A method for operating a biological sampler, a particle counter, and like air sampling, analysis, and/or monitoring equipment or instrumentation is described, such as by sampling an environment at a sampling position with the biological sampler and storing sample data and other useful information in memory in association with unique identifier(s) including sampling location(s) for the samples. Also provided are associated devices for carrying out the methods.

Abstract: Described herein are cartridges and devices for operating said cartridges for analyzing a biological sample, such as a blood or saliva sample. Also described herein is an impedance sensor for analyzing a biological sample. Further described herein are methods of determining a cell count or detecting an analyte in a biological sample, which can include transporting the biological sample through a sensor comprising a channel or pore; applying an electrical current or voltage to the channel or pore; detecting an impedance within the channel or pore; and determining a cell count or detecting the analyte based on the detected impedance. Also described herein is an electrowetting electrode array that is configured to transport aqueous solutions using low voltage, such as about 50 volts or less. Further described herein are methods of transporting an aqueous liquid using electrowetting electrodes.

Abstract: The present disclosure relates a low magnification dark-field microscope system and method for producing a dark-field image. The method includes transferring a biological specimen to a surface of a sample plate, and pre-treating the biological specimen using one or more pre-treatment steps selected from (1) heating the biological specimen using a heating device; (2) applying ultrasound energy using an ultrasound transducer and ultrasound generator; and (3) doping the biological specimen with a metallic nanoparticle. Following pre-treatment, the method includes imaging a region of interest the biological specimen on the sample plate using a dark-field microscope to generate a dark-field image of the biological specimen.

Abstract: A fluid handling device has an introduction port, a first flow channel which is connected to the introduction port and in which a droplet can move when a fluid including the droplet is caused to flow therein, a first chamber for capturing the droplet moving through the first flow channel, and a second chamber through which the droplet captured by the first chamber can move via the first flow channel. The liquid handling device is capable of switching between a first state in which a droplet moving through the first flow channel is captured by the first chamber, and a second state in which the droplet captured by the first chamber moves to the second chamber via the first flow channel.

Abstract: Methods for the diagnosis of CRC, colorectal polyps in general and adenomatous polyps in particular by measurement of metabolites in urine are described. In some embodiments, certain metabolites are identified as being elevated or reduced in concentration or quantity in subjects with CRC and/or colorectal polyps as compared with subjects without CRC or colorectal polyps. The measurement of these metabolites in urine can indicate the presence of CRC or colorectal polyps in general or adanomatous polyps in particular in a subject.

Abstract: In one embodiment, a method is provided comprising analyte testing on one or more types of samples.

Abstract: A method of predicting the responsiveness of a patient to a pharmaceutical drug by measuring metabolites in a biological sample from the patient is disclosed. Specific drug metabolites in blood from breast cancer patients are analyzed using NMR spectroscopy whereby responsiveness of the human cancer patients before, during and after treatment with a cancer drug is assessed by measuring the change in clinical outcomes. Data obtained is used to identify particular NMR resonances that are strongly correlated with whether the patient is responsive or resistant to each drug. As such, models for predicting the responsiveness of a patient to each drug based on metabolites from the patient are provided.

Abstract: A dog clutch system for holding the position of a volume adjustment screw for a pipetting system, the system comprising: —a first toothed wheel comprising first teeth; —a second toothed wheel comprising second teeth; —a return spring capable of urging the first and second wheels against each other, the second teeth of the second wheel forming a number N of concentric annular rows, and the second wheel having at least one tooth overlap area in which the N annular rows of second teeth have, respectively, N overlap sectors that overlap each other in a radial direction, and within which the teeth are angularly offset.

Abstract: Systems and methods for a treatment of chemical sensors placed in a wellbore. A method may comprise providing a chemical sensor disposed in a sensing chamber, wherein the chemical sensor is on an optical fiber installed in a wellbore; optically interrogating the chemical sensor with the optical fiber; and pumping a treatment fluid through a fluid supply line and into the sensing chamber.

Abstract: Methods of calibration are provided. A method comprises introducing a material with cell-like properties and a known mass into a sensor on a measurement instrument to generate a calibration reading and adjusting an output module of the measurement instrument until the measurement instrument calibrates to the known mass for the material.

Abstract: A microfluidic chip that can have a body defining a microfluidic network including a test volume, one or more ports, and one or more channels in fluid communication between the port(s) and the test volume. Gas can be removed from the test volume before a sample liquid is introduced therein by reducing pressure at a first one of the port(s), optionally while the liquid is disposed in the port. Liquid in the first port can be introduced into the test volume by increasing pressure at the first port. The microfluidic network can define one or more droplet-generating regions in which at least one of the channel(s) defines a constriction and/or two or more of the channels connect at a junction. Liquid flowing from the first port can pass through at least one of the droplet-generating region(s) and to the test volume.

Abstract: The present disclosure provides a digital PCR system. The system includes a droplet formation assembly and a droplet orifice assembly. The droplet formation assembly includes a heat conducting plate and a cover plate, at least one inverted U-shaped step is placed on a side surface of the cover plate, the heat conducting plate, the cover plate and the inverted U-shaped step together form a droplet formation chamber having an opening at a bottom. The droplet orifice assembly is connected below the droplet formation assembly, and includes a plurality of droplet orifices, the droplet orifice is connected with the droplet formation chamber, and a vaporization component is placed in the droplet orifice, the vaporization component vaporizes a digital PCR solution in the droplet orifice and rapidly pushes the digital PCR solution into a droplet forming oil in the droplet formation chamber, to form a digital PCR droplet.

Abstract: The present invention relates to a tube assembly for dripping. According to an embodiment, a tube assembly for dripping includes a tube (100) having a hole (H) at an upper portion thereof, and a filter tip (200) having a tip (210) including, an insertion part (211) inserted into the hole (H) of the tube (100) and, an expansion part (212) connected to the insertion part (211) and having a diameter that is larger than that of the hole (H), and a discharge pipe (213) connected to the expansion part (212) and acting as a passage, through which a solution (S) stored in the interior of the tube (100) is discharged, wherein a discharge adjusting part (213a) having a discharge hole (h) having a predetermined diameter (d1) is formed in the interior of the discharge pipe (213) that is spaced apart from a lower end of the discharge pipe (213) by a predetermined distance.

Abstract: The invention further relates to a method for producing said pipetting device.

Abstract: In order for it to be possible for the user of a manual metering apparatus (1) to be provided with different options for adjusting a manual metering apparatus (1), in particular a pipette, the manual metering apparatus (1) according to the invention is proposed, in the case of which the operating element (5) for operating the volume adjusting mechanism (3) of the manual metering apparatus (1) is constructed in two pieces and comprises a display adjusting element (7) which is connected to the volume display (4) of the manual metering apparatus (1), and the volume adjusting element (8) which is connected to the volume adjusting mechanism (3) of the manual metering apparatus (1). The display adjusting element (7) and the volume adjusting element (8) are connected to one another via the releasable coupling (9), with the result that a volume adjustment leads to a corresponding adjustment of the volume display and vice versa, as long as the coupling (9) is closed.