Patents Examined by Christopher L. Chin
  • Patent number: 10739337
    Abstract: The disclosure relates to the extraction and detection of pathogens using carbohydrate-functionalized biosensors. Immobilized carbohydrate moieties on the biosensor provide a means for non-specific binding of a plurality of target analytes. When a sample containing the target analyte is applied or otherwise transported to the biosensor detection surface, non-specific binding interactions between the carbohydrate moiety and the analyte immobilize/retain the analyte at the detection surface. The carbohydrate moiety is a stable binding pair member that allows on-sensor rinsing of a sample to enhance detection of an analyte in the sample. Specific analyte identification can be achieved with an analyte probe having a detection moiety and a binding pair member specific to the target analyte of interest.
    Type: Grant
    Filed: August 29, 2012
    Date of Patent: August 11, 2020
    Inventors: Evangelyn C. Alocilja, Barbara Christine Cloutier, Michael J. Anderson
  • Patent number: 10732177
    Abstract: Compositions, methods, and devices for the detection of multiple analytes with a single signal are provided.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: August 4, 2020
    Inventors: Nicholas Siciliano, Louis Leong, Martin Patrick Keough, Ashley Shaniece Brown
  • Patent number: 10724930
    Abstract: Sandwich separation is based on forming a sandwich complex with a magnetic bead, buoyant bead, and a target. Once a sandwich formation is created, the sandwich can be separated using its dual physical properties, namely magnetism and buoyancy. Sandwich separation is highly specific, allows for removal of the beads that do not have any attached target, and reduces the number of background beads. Sandwich separation can also be used to allow for target detection in raw specimen. Also, improvement of detection capability is accomplished by performing AMBR measurements on a solid interface, where the rotational period speeds up and allows for dramatically reduced time-to-result.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: July 28, 2020
    Inventors: Brandon H. McNaughton, Paivo Kinnunen, John G. Younger
  • Patent number: 10718759
    Abstract: Disclosed herein are a transparent immunoassay apparatus and method. The transparent immunoassay apparatus includes a sample pad configured to allow a liquid specimen to be dropped thereonto, a first porous pipe configured to move the dropped specimen in a lateral flow manner, an immunobinding reaction unit configured to generate a detectable signal from binding of a previously applied reactant and the specimen between transparent upper and lower plates of the immunobinding reaction unit, a second porous pipe configured to move the specimen, having passed through the immunobinding reaction unit, in a lateral flow manner, and an absorption pad configured to absorb the specimen transferred from the second porous pipe.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: July 21, 2020
    Inventors: Yo-Han Choi, Ki-Bong Song
  • Patent number: 10705084
    Abstract: Devices and methods for the detection of analytes are disclosed. Devices and methods for detecting food-borne pathogens are disclosed.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: July 7, 2020
    Inventors: Nicholas A. Siciliano, Martin Joseph Bouliane, Louis Leong
  • Patent number: 10688492
    Abstract: Methods and systems are provided for isolating fetal cells from a maternal blood supply in order to perform non-invasive prenatal testing. In one example, a system for non-invasive prenatal testing includes a substrate coated with a cell-capturing surface, the cell-capturing surface including an array of pillar-like structures, each pillar-like structure including a plurality of intersecting arms.
    Type: Grant
    Filed: May 2, 2019
    Date of Patent: June 23, 2020
    Inventor: Lian Liu
  • Patent number: 10690667
    Abstract: A single-use multiplex, or assay, screening test for the detection of one or more of a plurality of unrelated febrile illnesses is provided. The febrile illnesses for which the test is designed are unrelated, in that the illnesses may be caused, by way of example, by infection from viruses, bacterium and/or parasites; by infection from viruses, bacterium, parasites or other contagions that are animal borne; by infection from viruses, bacterium, parasites, or other contagions that can be aerosolized for transmission; by infection from viruses, bacterium, parasites or other contagions that are transmitted from direct contact; by infection from viruses, bacterium, parasites or other contagions that are generally transmitted in the tropics and/or subtropics; and/or by infection from a virus, bacteria, parasite sharing one or more related feature and which causes a febrile illness.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: June 23, 2020
    Assignee: Chembio Diagnostic Systems, Inc.
    Inventors: Javanbakhsh Esfandiari, Angelo H. Gunasekera
  • Patent number: 10690596
    Abstract: The surface plasmon-enhanced fluorescence measurement device has: a light source that irradiates the diffraction grating with a linearly polarized excitation light; a rotating part that changes the direction of the optical axis of the excitation light with respect to the diffraction grating when seen in plan view, or changes the polarization direction of the excitation light with respect to the diffraction grating; a polarizer that extracts linearly polarized light from the fluorescence emitted from the fluorescent substance; and a light detection unit that detects the linearly polarized light extracted by the polarizer.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: June 23, 2020
    Assignee: Konica Minolta, Inc.
    Inventors: Yukito Nakamura, Kosuke Nagae, Takatoshi Kaya
  • Patent number: 10689688
    Abstract: Methods and systems for detecting chemical and biological agents using oligonucleotide aptamers. A sensor includes a detection aptamer that has a binding domain for the chemical or biological agent, and is bound to fibers of a textile such as a patch or article of clothing. The detection aptamer can be stabilized and enhanced through a stabilization agent such as trehalose or through binding to a nanoparticle which is then bound to the fiber. Binding of the chemical and biological agent of interest to the detection aptamer can be reported to the user or wearer of the textile in a variety of ways, including visually and electrically.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: June 23, 2020
    Assignee: SRC, Inc.
    Inventor: Adam J. Lowe
  • Patent number: 10690663
    Abstract: The invention relates to a processing device (110) and a method for manufacturing such a device. In a preferred embodiment, a mixture of magnetic particles (MP), a matrix material, and a volatile carrier is deposited onto binding sites (112) of a reaction surface (113). The deposited mixture is then dried while the magnetic particles (MP) are pulled away from the reaction surface (113) by a magnetic field (B). Thus unspecific binding of magnetic particles to the binding sites can be prevented.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: June 23, 2020
    Assignee: Koninklijke Philips N.V.
    Inventors: Ron Martinus Laurentius Van Lieshout, Emiel Peeters
  • Patent number: 10684227
    Abstract: A method for the detection of binding affinities comprises providing a device having a planar waveguide (2) arranged on a substrate (3) and an optical coupler (4). Coherent light (1) of a predetermined wavelength is coupled into the planar waveguide (2) such that the coherent light propagates along the planar waveguide (2), with an evanescent field (6) of the coherent light propagating along an outer surface (5) of the planar waveguide (2). Target samples (8) attached to binding sites (7) are arranged along a plurality of predetermined lines (9) on the outer surface (5) of the planar waveguide (2). At a predetermined detection location, light of the evanescent field which is scattered by target samples (8) bound to binding sites (7) arranged along the predetermined lines (9) is detected.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: June 16, 2020
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Christof Fattinger
  • Patent number: 10684172
    Abstract: A spectroscopic assay is provided. The assay comprises: a motive particle configured to move within a solution, the motive particle comprising a first analyte binding reagent for selectively binding to a target analyte; and a spectroscopic reporter particle configured to provide a predetermined spectroscopic signal in response to being interrogated by a spectrometer, the spectroscopic reporter particle comprising a second analyte binding reagent for selectively binding to the target analyte, wherein the motive particle and the spectroscopic reporter particle are configured to provide a sandwich assay in the presence of the target analyte via the first and second analyte binding reagents.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: June 16, 2020
    Inventors: Keith Carron, Shane Buller, Mark Watson
  • Patent number: 10677735
    Abstract: Presented herein are methods, systems, and apparatus for single analyte detection or multiplexed analyte detection based on amplified luminescent proximity homogeneous assay (“alpha”) technology, but using hollow polymer fiber optics doped with ‘acceptor bead’ dye (e.g., thioxene, anthracene, rubrene, and/or lanthanide chelates) or ‘donor bead’ dye (e.g., phthalocyanine) that carry a signal generated by the dopant via singlet oxygen channeling.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: June 9, 2020
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Roger Bossé, Wael I. Yared, Peter A. Harvey, Kevin Groves, Ilias Faqir, Michael Meltzer
  • Patent number: 10670615
    Abstract: A system for determining a concentration of hemoglobin A1C includes a first lateral flow test strip, the first lateral flow test strip providing for a percent of HbA1C concentration; a second lateral flow test strip, the second lateral flow test strip providing for the total amount of hemoglobin; an antibody-microparticle stripe on each of the first and second lateral flow test strips; a conjugate stripe on each of the first and second lateral flow test strips; and a sample treatment buffer. The sample treatment buffer is strongly denaturing, and antibodies in the antibody-microparticle strip are covalently bound to microparticles.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: June 2, 2020
    Assignee: Polymer Technology Systems, Inc.
    Inventors: Charles Z. Xie, Jane Kyung, Tu-Anh Nguyen, Annie V. Mendoza, Keith Moskowitz
  • Patent number: 10670590
    Abstract: Provided are methods and compositions for detecting a target molecule or particle suspected to be present in a sample using a polymer scaffold, a fusion molecule, and a pore.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: June 2, 2020
    Assignee: Ontera Inc.
    Inventors: Trevor J. Morin, William B. Dunbar, Daniel Alexander Heller
  • Patent number: 10670586
    Abstract: Disclosed is a test instrument for measuring an analyte in a liquid sample by a noble metal colloid aggregation measurement method. The test instrument involves a reaction chamber in which at least the liquid sample is to be reacted with a reagent, wherein the reagent is adhered on at least a part of a surface constituting the reaction chamber in a dried state, and the reagent enables the measurement of the analyte by a noble metal colloid aggregation measurement method.
    Type: Grant
    Filed: April 4, 2011
    Date of Patent: June 2, 2020
    Assignee: NITTO BOSEKI CO., LTD.
    Inventors: Ryo Kojima, Kenta Noda, Yoshiro Sato, Natsuki Sato, Kaduho Ashizawa
  • Patent number: 10656147
    Abstract: Methods and apparatus for processing fluids on a macro- or micro-scale are described. In various aspects, a fluid may have a plurality of elongated (i.e., substantially rod-shaped) magnetic elements disposed therein within a fluid container. An illustrative fluid container is an actuator electrode or a processing vial of a microfluidic device, such as a digital microfluidic device. A magnet component may be configured to generate a magnetic force sufficient to influence the movement of the plurality of elongated magnetic elements within the fluid to be processed. For example, the magnetic force (or magnetic force gradient) may influence the plurality of elongated magnetic elements to rotate, spin, and/or move laterally side-to-side. The shape and movements of the plurality of elongated magnetic elements facilitate the rapid and efficient processing of the fluid, such as fluid mixing and/or fluid separation.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: May 19, 2020
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: John L. Campbell, Thomas R. Covey, Chang Liu, Subhasish Purkayastha
  • Patent number: 10656164
    Abstract: A method of determining risk of preterm labor in an asymptomatic pregnant woman can include: obtaining a vaginal fluid sample from an asymptomatic pregnant woman; contacting the vaginal fluid sample with a PAMG-1 antibody that binds with PAMG-1; detecting whether the PAMG-1 antibody binds with PAMG-1 in the vaginal fluid sample to form a PAMG-1-antibody complex; and providing the determined risk to the pregnant woman. When the PAMG-1-antibody complex forms, the asymptomatic pregnant woman is determined to be susceptible to preterm labor because PAMG-1 is detected in the vaginal sample. When the PAMG-1-antibody complex does not form, the asymptomatic pregnant woman is determined to be not susceptible to preterm labor because the PAMG-1 is not detected in the vaginal sample.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: May 19, 2020
    Assignee: Qiagen Sciences, LLC
    Inventors: Ruben Salinas, Anthony Ausiello
  • Patent number: 10648974
    Abstract: Ethyl glucuronide (EtG) lateral flow immunoassay test strips, devices, and methods, useful for testing for alcohol ingestion for alcohol abuse or related diseases and treatment monitoring.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: May 12, 2020
    Inventors: Paul Kenneth Johnson, Jacqueline Ann Gale
  • Patent number: 10641705
    Abstract: A label-free method for the spatio-temporal mapping of protein secretions from individual cells in real time by using a chip for localized surface plasmon resonance (LSPR) imaging. The chip is a glass coverslip compatible for use in a standard microscope having at least one array of functionalized plasmonic nanostructures patterned onto it. After placing a cell on the chip, the secretions from the cell are spatially and temporally mapped using LSPR imaging. Transmitted light imaging and/or fluorescence imaging may be done simultaneously with the LSPR imaging.
    Type: Grant
    Filed: October 16, 2017
    Date of Patent: May 5, 2020
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Marc P. Raphael, Joseph A. Christodoulides, Jeff M. Byers, James B. Delehanty