Patents Examined by Christopher L. Chin
  • Patent number: 11067573
    Abstract: A chip for localized surface plasmon resonance (LSPR) biosensing and imaging having a glass coverslip compatible for use in a standard microscope and at least one array of functionalized plasmonic nanostructures patterned onto the glass coverslip with electron beam nanolithography. The nanostructures can be regenerated allowing the chip to be used multiple times. Also disclosed is a method for determining the fractional occupancy values for surface-bound receptors as a function of time for LSPR biosensing from the spectroscopic response of the array and modeling the photon count in each spectrometer channel, allowing for a functional relationship to be determined between the acquired spectrum and the fractional occupancy of binding sites on the array. Additionally disclosed is a method for the spatiotemporal mapping of receptor-ligand binding kinetics in LSPR imaging using the chip and projecting a magnified image of the array to a CCD camera and monitoring the binding kinetics of the array.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: July 20, 2021
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Marc P. Raphael, Joseph A Christodoulides, Jeff M Byers
  • Patent number: 11065615
    Abstract: We describe assay modules (e.g., assay plates, cartridges, multi-well assay plates, reaction vessels, etc.), processes for their preparation, and method of their use for conducting assays. Reagents may be present in free form or supported on solid phases including the surfaces of compartments (e.g., chambers, channels, flow cells, wells, etc.) in the assay modules or the surface of colloids, beads, or other particulate supports. In particular, dry reagents can be incorporated into the compartments of these assay modules and reconstituted prior to their use in accordance with the assay methods. A desiccant material may be used to maintain and stabilize these reagents in a dry state.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: July 20, 2021
    Assignee: MESO SCALE TECHNOLOGIES, LLC
    Inventors: Eli N. Glezer, Bandele Jeffrey-Coker, Jeffery D. Debad, Sudeep M. Kumar, George B. Sigal, Gisbert Spieles, Michael Tsionsky, Michael Warnock
  • Patent number: 11067568
    Abstract: Described are embodiments of an invention for detecting target antigens in a biological sample using a sample assembly. Detection may be accomplished by performing a method comprising: sweeping a head module over the sample assembly, wherein said head module includes at least one magneto-resistive read sensor configured to detect target antigens via nanoparticles within the sample assembly; and detecting at least one particular antigen among the target antigens. Preferably, detecting the target antigens via the nanoparticles is based at least in part on detecting unique magnetic properties of particular nanoparticles specifically associated with different types of the target antigens. Detection using a magnetic read/write head in the sample assembly facilitates automation of sample detection with high speed and fidelity. Corresponding systems are also disclosed.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: July 20, 2021
    Assignee: International Business Machines Corporation
    Inventors: Dylan J. Boday, Stephen L. Schwartz, Anna W. Topol, Sandra L. Waters, Daniel J. Winarski
  • Patent number: 11061026
    Abstract: Disclosed herein are devices, systems, methods and kits for performing immunoassay tests to detect for at least progesterone or analytes of progesterone on a sample in association with diagnosing problems and issues associated with corpus luteum functionality. The immunoassay devices and methods may be used in conjunction with diagnostic reader systems and/or a base unit for obtaining a sensitive read-out of the immunoassay results. The immunoassay devices and methods may utilize a competitive binding-like assay and a sandwich binding assay to detect at least progesterone or analytes of progesterone in a sample.
    Type: Grant
    Filed: January 2, 2020
    Date of Patent: July 13, 2021
    Assignee: MFB Fertility, Inc.
    Inventor: Amy Beckley
  • Patent number: 11054416
    Abstract: The present disclosure is directed towards characterizing liquids through the use of magnetic discs that rotate in response to dynamic magnetic fields. In some embodiments, a light beam is transmitted into the liquid while the magnetic discs rotate, and one or more parameters of a light beam signal associated with the transmitted light beam are identified. Various characteristics of the liquid may be detected based on the one or more parameters of the light beam signal.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: July 6, 2021
    Assignee: University of Florida Research Foundation
    Inventors: David P. Arnold, Nicolas Garraud
  • Patent number: 11047859
    Abstract: The invention relates to a method for normalization of a label-free system for calibration-free concentration analysis. The method comprises (1) providing a solution containing a control macromolecular particle of a known concentration at a pH lower than the pI of the macromolecular particle and a low ionic strength; (2) contacting the solution with a negatively charged optical sensor surface at a first flow rate to allow electrostatic binding of the macromolecular particle to the surface and obtaining a first sensorgram; (3) contacting the solution with the optical sensor surface at a second flow rate to allow electrostatic binding of the macromolecular particle to the surface and obtaining a second sensorgram; and (4) fitting the sensorgrams to a binding equation to determine a measured concentration of the control; wherein the optical sensor surface is not immobilized with a ligand for the control and the contacting steps are performed under mass transport limitations.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: June 29, 2021
    Assignee: CYTIVA SWEDEN AB
    Inventor: Olof Karlsson
  • Patent number: 11029310
    Abstract: A device and a method for isolating a target from a sample are provided. The target is bound to solid phase substrate to form a target bound solid phase substrate. The device includes a first plate having a first region for receiving at least a portion of the sample. A second plate is spaced from the first plate by a distance and has a first region for receiving a reagent. A force attracts the target bound solid phase substrate toward the first region of the second plate such that the target bound solid phase substrate in the portion of the sample are drawn through the air gap and into the reagent by the force.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: June 8, 2021
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David J. Beebe, Scott M. Berry
  • Patent number: 11016087
    Abstract: Provided is an implement for inspection capable of measuring the concentration of a test substance with high accuracy. The implement for inspection according to the present invention is an implement for inspection used for measuring the concentration of a test substance that includes a compound for reacting with a test substance to form a granular substance or a compound which is for being bound to the test substance and is a granular substance, and a wall portion having a periodic structure on its surface.
    Type: Grant
    Filed: February 9, 2017
    Date of Patent: May 25, 2021
    Assignees: SEKISUI CHEMICAL CO., LTD., UNIVERSITY PUBLIC CORPORATION OSAKA
    Inventors: Yoshinori Akagi, Nobuhiko Inui, Kazuhiko Imamura, Takamasa Kouno, Shigeru Nomura, Tatsuro Endo
  • Patent number: 11016090
    Abstract: The present invention relates to novel lateral flow devices using two dimensional features, preferably, uniform two dimensional test and control features, and the methods for detecting an analyte using the lateral flow devices, and processes for making the lateral flow devices.
    Type: Grant
    Filed: January 3, 2018
    Date of Patent: May 25, 2021
    Assignee: SYMBOLICS, LLC
    Inventors: Brendan O'Farrell, Thomas C. Tisone
  • Patent number: 11009506
    Abstract: Provided is a kit for asthma diagnosis comprising a strip including a base part, a first reaction part formed on the base part, and a developing membrane formed between the first reaction part and the base part, in which the first reaction part includes a monoclonal antibody expressed from a hybridoma cell line of Accession Number KCLRF-BP-00389 (Accession Date: Jan. 9, 2017, Accession Institute: Korea Cell Line Research Foundation (KCLRF)) and the second reaction part includes a monoclonal antibody expressed from a hybridoma cell line of Accession Number KCLRF-BP-00389 (Accession Date: Jan. 9, 2017, Accession Institute: Korea Cell Line Research Foundation (KCLRF)).
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: May 18, 2021
    Assignee: INJE UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventor: Chang-Keun Kim
  • Patent number: 11002734
    Abstract: Devices and methods incorporate mucolytic agents into a point-of-care testing device. The sample is loaded, and then the sample travels until it encounters one or more lysis agents and/or mucolytic agents. The mucolytic agent is preferably pre-loaded onto the collection device. In a preferred embodiment, the mucolytic agent is localized between the sample application zone and the conjugate zone. In embodiments with a sample compressor, one or more mucolytic agents may be pre-loaded and dried on the sample compressor, the sample collector, in various locations on the test strip, or in the running buffer.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: May 11, 2021
    Assignee: Rapid Pathogen Screening, Inc.
    Inventors: Uma Mahesh Babu, Robert P. Sambursky
  • Patent number: 11002732
    Abstract: Disclosed is method of improving flow of a liquid sample in an assay device, as well as a method of performing an assay on a liquid sample for the detection of one or more analytes of interest. The methods use the addition of a reagent, such as a wash reagent, to wet the fluid flow path of a sample prior to sample addition, thereby improving flow of the sample through the fluid flow path that has been wetted as opposed to flow of the sample through the fluid flow path that has not been wetted. The reagent wets the fluid flow path between the sample addition zone and the wicking zone.
    Type: Grant
    Filed: May 18, 2016
    Date of Patent: May 11, 2021
    Assignee: ORTHO-CLINICAL DIAGNOSTICS, INC.
    Inventors: Zhong Ding, Philip C. Hosimer, Edward Scalice
  • Patent number: 10996221
    Abstract: A device for performing a multiplex lateral flow immunoassay is provided in which a liquid sample, such as a biological sample, is simultaneously tested for the presence of multiple analytes of interest. Methods that employ the device in the simultaneous detection of multiple analytes of interest within a liquid test sample are also provided.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: May 4, 2021
    Assignee: InBios International, Inc.
    Inventors: James William Needham, Syamal Raychaudhuri
  • Patent number: 10989651
    Abstract: A molecular sensor that utilises dichroism can be used to identify the presence of specific molecules in a substance. The molecular sensor includes a sensor element comprising (i) a scaffold moiety and (ii) one or more receptor molecules for the target molecule attached to the scaffold moiety to form a scaffold/receptor complex, wherein the scaffold/receptor complex is modified to incorporate a chromophore and the modified scaffold/receptor complex has a high aspect ratio.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: April 27, 2021
    Assignee: The University of Birmingham
    Inventors: Timothy Dafforn, Matthew Hicks
  • Patent number: 10962533
    Abstract: Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.
    Type: Grant
    Filed: November 27, 2017
    Date of Patent: March 30, 2021
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Kristin Weidemaier, Erin Gooch Carruthers, Adam C. Curry, Melody M. H. Kuroda, Ammon David Lentz, Michael Justin Lizzi, Eric A. Fallows, Donald E. Gorelick, Jack Kessler, Spencer Lovette, Jeffrey S. Ojala, Mark A. Talmer
  • Patent number: 10962531
    Abstract: A first sample solution including exosomes including first to third detection target substances is mixed with a first buffer solution including first nanoparticles including first binding substances which bind to the first detection target substances. The first detection target substances and the first binding substances are bound together, so as to form first complexes of the exosomes and the first nanoparticles. The first complexes are isolated from a mixed solution of the first sample solution and the first buffer solution. The second detection target substances and the second binding substances are bound together, so as to capture the first complexes on a substrate. The second binding substances are fixed onto the substrate. A second buffer solution including second nanoparticles including third binding substances which bind to the third detection target substances is reacted with the first complexes.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: March 30, 2021
    Assignee: JVC KENWOOD CORPORATION
    Inventors: Makoto Itonaga, Yuichi Hasegawa, Koji Tsujita, Masayuki Ono, Shigehiko Iwama, Makoto Igarashi
  • Patent number: 10955411
    Abstract: A system and method for sample droplet processing, the system including a substrate, an electrode array network coupled to the substrate and configured to provide a pattern of controlled electric fields for manipulation of the set of sample droplets; a first layer in communication with the electrode array network, the first layer separating the electrode array network from fluid of the set of sample droplets; and a second layer opposing the first layer and displaced from the first layer to define a region wherein droplets of the set of sample droplets can reside. In some variations, the system can additionally include an electronics subsystem coupled to at least one of the substrate and the electrode array network, and a control module in communication with the electronics subsystem, wherein the control module generates and manipulates the pattern of controlled electric fields.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: March 23, 2021
    Assignee: PSOMAGEN, INC.
    Inventors: Zachary Apte, Nathan Saichek, Jessica Richman
  • Patent number: 10942173
    Abstract: The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: March 9, 2021
    Assignee: Abbott Point of Care Inc.
    Inventors: Gary Vandersleen, Pierre Emeric, Paul Wasserman, Narendra Soman, Graham Davis, Cary Miller
  • Patent number: 10942177
    Abstract: Presented herein are methods, systems, and apparatus for single analyte detection or multiplexed analyte detection based on amplified luminescent proximity homogeneous assay (“alpha”) technology, but using hollow polymer fiber optics doped with ‘acceptor bead’ dye (e.g., thioxene, anthracene, rubrene, and/or lanthanide chelates) or ‘donor bead’ dye (e.g., phthalocyanine) that carry a signal generated by the dopant via singlet oxygen channeling.
    Type: Grant
    Filed: February 25, 2020
    Date of Patent: March 9, 2021
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Roger Bossé, Wael I. Yared, Peter A. Harvey, Kevin Groves, Ilias Faqir, Michael Meltzer
  • Patent number: 10935551
    Abstract: An ultra-high sensitivity dual-gated biosensor based on an MOS transistor, which is applicable to detection of a series of early tumors. The sensor is prepared and processed by using SOI wafers, and a unique dual-gated structure is realized by ion implantation technique. The sensor is prepared by an ultraviolet lithography combined with an NLD etching method, realizing trace, instant and marker-free detection of tumor markers. The method detects a change in capacitance in the channel during binding of antigen antibodies. The detection method involved in the invention is more stable and strong in anti-interference, can meet the demands in the aspect of detection range and sensitivity, and especially has extremely outstanding detection sensitivity, and can detect a sample with a lowest concentration in the range of 1 fg/ml˜1 ng/ml.
    Type: Grant
    Filed: November 1, 2018
    Date of Patent: March 2, 2021
    Assignee: WUXI PEOPLE'S HOSPITAL
    Inventors: Tong Wang, Yanfeng Jiang, Ye Zhang, Hang Chen, Jialin Sun, Hang Li