Patents Examined by Claire M. Kaufman
  • Patent number: 6599717
    Abstract: Vascular Endothelial Growth Factor Receptor (dmVEGFR) nucleic acids and proteins that have been isolated from Drosophila melanogaster are described. The dmVEGFR nucleic acids and proteins can be used to genetically modify metazoan invertebrate organisms, such as insects and worms, or cultured cells, resulting in dmVEGPR expression or mis-expression. The genetically modified organisms or cells can be used in screening assays to identify candidate compounds which are potential therapeutics that interact with dmVEGFR protein. They can also be used in methods for studying dmVEGFR activity and identifying other genes that modulate the function of, or interact with, the dmVEGFR gene.
    Type: Grant
    Filed: September 29, 2000
    Date of Patent: July 29, 2003
    Assignee: Exelixis, Inc.
    Inventors: Allen James Ebens, Jr., R. Glenn Hammonds, Jonathan C. Heller, Greg Weddell, John W. Winslow
  • Patent number: 6551822
    Abstract: The present invention concerns isolated nucleic acid molecules encoding the novel TIE ligands NL1, NL5, NL8, and NL4, the proteins encoded by such nucleic acid molecules, as well as methods and means for making and using such nucleic acid and protein molecules.
    Type: Grant
    Filed: December 8, 1998
    Date of Patent: April 22, 2003
    Assignee: Genentech, Inc.
    Inventors: Paul J. Godowski, Austin L. Gurney, Kenneth Hillan, David Botstein, Audrey Goddard, Margaret Roy, Napoleone Ferrara, Daniel Tumas, Ralph Schwall
  • Patent number: 6521234
    Abstract: The present invention concerns isolated nucleic acid molecules encoding the novel TIE ligands NL2, NL3 and FLS139, the proteins encoded by such nucleic acid molecules, as well as methods and means for making and using such nucleic acid and protein molecules.
    Type: Grant
    Filed: October 16, 2000
    Date of Patent: February 18, 2003
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney
  • Patent number: 6511811
    Abstract: Methods and compositions are provided for the treatment of insulin-resistance through the inhibition of protein kinase C-mediated phosphorylation of the amino acid residue Ser1270 of the insulin receptor. Methods for testing candidate compounds suitable for inhibition of serine-phosphorylation by protein kinase C are also provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 28, 2003
    Assignee: The Regents of the University of California
    Inventors: Jerrold M. Olefsky, Tahir S. Pillay
  • Patent number: 6500934
    Abstract: Bivalent agonists having affinity for one or more G-protein coupled receptors, comprising two agonist or two antagonist ligand domains, wherein the distance between the ligand domains can range from about 40 to about 250 Å, and further comprising a backbone, wherein the backbone is covalently bonded to the two ligand domains, are provided. Additionally, bivalent agonists are provided that comprise one agonist and one antagonist ligand domain. In a specific embodiment, the bivalent agonists are peptide dimers, wherein the backbone comprises two spacer regions, two polylysine regions, and a disulfide bond region, such that the order in which the ligand domains, spacer regions, polylysine regions and disulfide bond region are covalently bonded together is: (ligand domain)-(spacer region)-(polylysine region)-(disulfide bond region)-(polylysine region)-(spacer region)-(ligand domain). Such peptide dimers are prepared from oxidative dimerization of their corresponding monomers.
    Type: Grant
    Filed: July 24, 1996
    Date of Patent: December 31, 2002
    Inventors: Michael Rush Lerner, Michael D. Carrithers
  • Patent number: 6492331
    Abstract: The present invention concerns isolated nucleic acid molecules encoding the novel TIE ligands NL1, NL5 and NL8, the proteins encoded by such nucleic acid molecules, as well as methods and means for making and using such nucleic acid and protein molecules.
    Type: Grant
    Filed: June 14, 1999
    Date of Patent: December 10, 2002
    Assignee: Genentech, Inc.
    Inventors: Paul J. Godowski, Austin L. Gurney
  • Patent number: 6492139
    Abstract: Novel vertebrate homologues of Smoothened, including human and rat Smoothened, are provided. Compositions including vertebrate Smoothened chimeras, nucleic acid encoding vertebrate Smoothened, and antibodies to vertebrate Smoothened, are also provided.
    Type: Grant
    Filed: April 27, 2000
    Date of Patent: December 10, 2002
    Assignee: Genentech, Inc.
    Inventors: Frederic J. de Sauvage, Arnon Rosenthal, Donna M. Stone
  • Patent number: 6465214
    Abstract: The invention is drawn to anti-thrombin proteins from the salivary glands of the species, Simulium. Methods for recombinant production of the protein as well as biomedical uses are provided.
    Type: Grant
    Filed: April 21, 2000
    Date of Patent: October 15, 2002
    Assignee: Auburn University
    Inventors: Mary S. Cupp, Eddie W. Cupp
  • Patent number: 6461823
    Abstract: The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity.
    Type: Grant
    Filed: November 24, 1999
    Date of Patent: October 8, 2002
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Craig A. Rosen, James G. Pan, Reiner L. Gentz, Vishva M. Dixit
  • Patent number: 6455496
    Abstract: The present invention concerns isolated nucleic acid molecules encoding the novel TIE ligands NL2, NL3 and FLS 139, the proteins encoded by such nucleic acid molecules, as well as methods and means for making and using such nucleic acid and protein molecules.
    Type: Grant
    Filed: February 23, 2000
    Date of Patent: September 24, 2002
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney
  • Patent number: 6455266
    Abstract: The cDNA that encodes a glycoprotein receptor from the tobacco hornworm which binds a Bacillus thuringiensis toxin has been obtained and sequenced. The availability of this cDNA permits the retrieval of DNAs encoding homologous receptors in other insects and organisms as well as the design of assays for the cytotoxicity and binding affinity of potential pesticides and the development of methods to manipulate natural and/or introduced homologous receptors and, thus, to destroy target cells, tissues and/or organisms.
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: September 24, 2002
    Assignee: University of Wyoming
    Inventor: Lee A. Bulla
  • Patent number: 6448032
    Abstract: Novel DNA fragments encoding novel polypeptides having properties of melanotropic hormone receptors, especially DNA molecules encoding melanocyte stimulating hormone receptors (MSH receptors), as well as polypeptides which are MSH receptors, are disclosed. The use and engineering of melanotropic hormone receptor DNA and polypeptides for production of monoclonal antibodies for diagnostic and therapeutic purposes, as well as the engineering of drugs, cell lines, vectors, and DNA for therapeutic and diagnostic purposes are also disclosed.
    Type: Grant
    Filed: February 21, 1995
    Date of Patent: September 10, 2002
    Inventors: Jarl Wikberg, Vijay Chhajlani
  • Patent number: 6444642
    Abstract: The invention relates to methods of treating diseases and disorders of the muscle tissues in a vertebrate by the administration of compounds which bind the p185erbB2 receptor. These compounds are found to cause increased differentiation and survival of cardiac, skeletal and smooth muscle.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: September 3, 2002
    Assignee: CeNes Pharmaceuticals, Inc.
    Inventors: Robert Sklar, Mark Marchionni, David I. Gwynne
  • Patent number: 6433147
    Abstract: The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity and methods for using DR4 polynucleotides and polypeptides.
    Type: Grant
    Filed: May 5, 2000
    Date of Patent: August 13, 2002
    Assignees: Human Genome Sciences, Inc., The Regents of the University of Michigan
    Inventors: Jian Ni, Craig A. Rosen, James G. Pan, Reiner L. Gentz, Vishva M. Dixit
  • Patent number: 6432667
    Abstract: The present invention provides for an isolated nucleic acid molecule encoding TIE ligand-3 or TIE ligand-4. In addition, the invention provides for a receptorbody which specifically binds TIE ligand-3 or TIE ligand-4. The invention also provides an antibody which specifically binds TIE ligand-3 or TIE ligand-4. The invention further provides for an antagonist of TIE. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE receptor, a method of blocking the growth or differentiation of a cell expressing the TIE receptor and a method of attenuating or preventing tumor growth in a human.
    Type: Grant
    Filed: November 16, 1998
    Date of Patent: August 13, 2002
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: David M. Valenzuela, Pamela F. Jones, George D. Yancopoulos
  • Patent number: 6423502
    Abstract: The cDNA that encodes a glycoprotein receptor from the tobacco hornworm which binds a Bacillus thuringiensis toxin has been obtained and sequenced. The availability of this cDNA permits the retrieval of DNAs encoding homologous receptors in other insects and organisms as well as the design of assays for the cytotoxicity and binding affinity of potential pesticides and the development of methods to manipulate natural and/or introduced homologous receptors and, thus, to destroy target cells, tissues and/or organisms.
    Type: Grant
    Filed: October 23, 1998
    Date of Patent: July 23, 2002
    Assignee: University of Wyoming
    Inventor: Lee A. Bulla
  • Patent number: 6413770
    Abstract: The present invention concerns isolated nucleic acid molecules encoding the novel TIE ligands NL1, NL5, NL8, and NL4, the proteins encoded by such nucleic acid molecules, as well as methods and means for making and using such nucleic acid and protein molecules.
    Type: Grant
    Filed: August 19, 1998
    Date of Patent: July 2, 2002
    Assignee: Genentech, Inc.
    Inventors: Paul Godowski, Austin Gurney, Kenneth J. Hillan, David Botstein, Audrey Goddard, Margaret Roy, Napoleone Ferrara, Daniel Tumas, Ralph Schwall
  • Patent number: 6407216
    Abstract: Novel vertebrate homologues of Smoothened, including human and rat Smoothened, are provided. Compositions including vertebrate Smoothened chimeras, nucleic acid encoding vertebrate Smoothened, and antibodies to vertebrate Smoothened, are also provided.
    Type: Grant
    Filed: September 20, 1999
    Date of Patent: June 18, 2002
    Assignee: Genentech, Inc.
    Inventors: Frederick J. de Sauvage, Arnon Rosenthal, Donna M. Stone
  • Patent number: 6384205
    Abstract: This invention describes a novel human glutamate receptors, designated mGluR4. This invention also encompasses nucleic acids encoding this receptor, or a fragment thereof, as well as methods employing this receptor and the nucleic acid compounds.
    Type: Grant
    Filed: August 18, 2000
    Date of Patent: May 7, 2002
    Assignee: Eli Lilly and Company
    Inventors: Rama M. Belagaje, Su Wu
  • Patent number: 6384192
    Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
    Type: Grant
    Filed: October 20, 1997
    Date of Patent: May 7, 2002
    Assignees: President & Fellows of Harvard College, Imperial Cancer Research Technology, Ltd.
    Inventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin