Abstract: Antiandrogenic compositions comprising an effective amount of at least one compound of the formula ##STR1## wherein X and Y are individually selected from the group consisting of hydrogen, halogen, --CF.sub.3, --NO.sub.3 and alkylthio of 1 to 4 carbon atoms and R is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, phenyl, benzyl and hydroxymethyl and an inert pharmaceutical carrier and a method of inducing antiandrogenic activity in warm-blooded animals as well as novel oxadiazines of formula I with the proviso that when R is other than benzyl or hydroxymethyl at least one of X and Y is alkylthio of 1 to 4 carbon atoms.

Abstract: A class of isoxazoles having a phenyl or substituted-phenyl group at the 3-position and a substituted-methyl group at the 5-position are useful for the control of fungal foliar phytopathogens.

Abstract: A process of supplying fluoride to teeth comprising applying to the teeth a source of fluoride ions and an orthophosphoric acid solution having a pH of about 3-4, then neutralizing the pH to about 7 with an aqueous neutralizing solution containing calcium ions and phosphate ions, wherein there is present about a stoichiometric amount of the phosphate ions relative to the calcium ions, the neutralizing solution having a pH of about 7.

Abstract: Mites and mite eggs are killed with an N-tetrachloroethylthio-substituted sulfonamide of the formula ##STR1## wherein R is alkyl, alkenyl, cycloalkyl or aryl, R.sup.1 is alkyl, alkenyl, cycloalkyl or aryl, and R.sup.2 is tetrachloroethyl, with the proviso that R and R.sup.1 are not both cycloalkyl or aryl.

Abstract: Fungicidal 3-amino-6-trifluoromethyl-2,4-dinitrodiphenylethers having the formula: ##STR1## where R is H or lower alkyl,X is halogen,n is 0, 1, 2 or 3, andR.sub.1 and R.sub.2 are selected from H and lower alkyl, or form a piperidinyl, morpholinyl, or pyrrolidinyl ring structure,Are prepared by two-step process involving reaction of 2,4-dichloro-3,5-dinitrotrifluoromethylbenzene with an amine, and condensation of the intermediate with a phenol.The compounds of the invention show good fungicidal activity against bean mildew, bean rust and tomato blight, and insecticidal activity against Mexican bean beetle.

Abstract: Sulfites derived from alkynols and glycol ethers of phenylphenols are provided which are useful as insecticides and acaricides and which exhibit substantially reduced phytotoxicity than similarly used compounds. This invention also deals with the use of the novel sulfites in treating plants.

Abstract: Novel cyclopropylmethylamine compounds of the formula: ##STR1## wherein Ar.sup.1 represents a phenyl group having one or more substituents selected from the group consisting of halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy and trifluoromethyl, of which at least one is present at the o- or m-position, Ar.sup.2 represents an unsubstituted phenyl group or a phenyl group substituted with one or more substituents selected from the group consisting of halogen and C.sub.1 -C.sub.4 alkyl, R represents hydrogen, C.sub.1 -C.sub.4 alkyl or C.sub.2 -C.sub.4 hydroxyalkyl and R' represents C.sub.1 -C.sub.4 alkyl or C.sub.2 -C.sub.4 hydroxyalkyl, and their non-toxic salts, which possess various useful pharmacological activities and can be produced by reduction of the corresponding compounds of the formula: ##STR2## wherein Ar.sup.1, Ar.sup.2, R and R' are each as defined above or by condensation of the corresponding compounds of the formula: ##STR3## wherein Ar.sup.1 and Ar.sup.

Abstract: A room temperature aqueous sterilizing composition comprising from 0.75 -4.0% by wt. of glutaraldehyde and from 4-15% by wt of phenol and a metal phenate, preferably sodium phenate.Optionally present are 1-5% by wt of sodium tetraborate, 2-10% by wt of a humectant such as glycerol, di-ethylene glycol or propylene glycol, and a surfactant. A preferred pH range is pH 7.0 - 7.4.

Abstract: An intrauterine contraceptive device comprising an elongated shank having divergent convoluted portions at its distal end, said convoluted portions being generally sinusoidal in nature, said device having incorporated in said shank a permanent magnet and having a substantial portion of its surface covered with a biologically inert, silicone elastomeric material which may contain an analgaesic or anti-fertility agent which is gradually released in utero. In a preferred embodiment of the invention, the proximal end of the shank contains a pair of downwardly extending divergent, resilient legs which tend to prevent inadvertent expulsion of the device. In another preferred embodiment, the lower end of the device is formed with one or more small refillable containers for certain types of medication which are released gradually into the vagina and the lower end of the uterus over a prolonged period of time for the prevention of such venereal diseases as gonorrhea, syphilis, trichomonas vaginalis and moniliasis.

Abstract: Vascular X-ray contrast media comprise ferrite powder coated with a negatively charged colloid such as silicate colloid, gold colloid, silver colloid or platinum colloid. Such media can be used for the medical X-ray diagnosis of small blood vessels. By applying an external magnetic field, the media can be maintained in the vessel or organ being examined.

Abstract: This invention relates to halogen derivatives of alkynoxymethylamines and to uses thereof. The present invention may be ideally illustrated by the following equation:RN(CH.sub.2 OR'C.tbd.CH).sub.2 + 2NaOX .fwdarw.RN(CH.sub.2 OR'C.tbd.CX).sub.2 + 2NaOHwhere R is a substituted group, preferably hydrocarbon, such as alkyl, cycloalkyl, aryl, etc., R' is hydrocarbon, preferably alkylene, and where X is halogen.This invention further specifically relates to the use of the halogen derivatives of alkynoxymethylamines as microbiocides in the treatment of aqueous or hydrocarbon systems.

Abstract: Parenterally administrable oil-in-water emulsions formed from nutritive oils, such as soybean and sunflower oils, are improved first by treating the nutritive oil with silicic acid to remove undesirable components such as peroxides, pigments, thermal and oxidative decomposition products, certain unsaponifiable matter such as sterols, and polymers. Purification is effected by treating the oil with silicic acid or silica gel either directly, or as a solution thereof in a suitable solvent, such as hexane. Autoxidation of the purified oil is prevented by adding to the purified oil a tocopherol antioxidant, .gamma.-tocopherol being preferred. There is also added a metal scavenging agent such as ascorbyl palmitate.

Abstract: Adamantane derivatives such as .beta.-(1-adamantyl)-.alpha.,.alpha.-dimethylethylamine hydrochloride, .beta.-(1-adamantyl)-.alpha.-methylethylamine hydrochloride, d-.beta.-(1-adamantyl)-.alpha.-methylethylamine hydrochloride, and 1-.beta.-(1-adamantyl)-.alpha.-methylethylamine hydrochloride have anorectic activity.The hydrazine derivatives of the above compounds are antihypertensive agents, and monoamine oxidase inhibitors.

Abstract: A method for lowering intraocular pressure in mammals by administering thereto an effective amount of antazoline, i.e., 2-(N-benzylanilinomethyl)-2-imidazoline or its pharmacologically acceptable acid addition salts, preferably antazoline phosphate.

Abstract: A method and composition for treatment of bacterial and fungus infections of the skin such as acne and athlete's foot is provided wherein an aqueous solution of a water soluble fluoride and a surface active agent is applied to a skin area affected by the infection.

Abstract: This disclosure relates to novel iodine-polyvinylpyrrolidone products in which, by novel preparation methods, the iodine is adherently bound within solid polyvinylpyrrolidone, with solidified cinnamic alcohol adherently distributed therethrough and, in preferred instances, with solidified tannic acid adherently dispersed therewithin, and all in preferred proportions.

Abstract: In an insecticidal article comprising an insecticidally effective amount of at least one volatile phosphoric or thiophosphoric acid ester and a solid polyurethane carrier material, the improvement wherein said polyurethane is an elastomeric polyurethane, whereby the article retains its activity over a long period of time. The polyurethane is formed of a polyisocyanate and a mixture of a long chain polyol and a short chain polyol and/or polyamine.

Abstract: Intraocular pressure in warm-blooded animals is reduced by topically applying to the eye thereof, an effective ophthalmologically acceptable amount of a compound of the formula: ##STR1## wherein R represents a member selected from the group consisting of hydrogen or a C.sub.1 -C.sub.5 straight or branched alkyl group; and wherein R.sub.1 and R.sub.

Abstract: This invention relates to new and improved means for killing spores on instruments and the like utilizing the combination of glutaraldehyde and a detergent selected from the group consisting of nonionic, anionic and ampholytic surface active agents. The sporicidal kill activity of glutaraldehyde is enhanced by said detergents.

Abstract: Chlorhexidene solutions are employed to sterilize and soak both hard and soft contact lenses.