Abstract: Disclosed are a sensitizing composition for thermal cancer therapy using electromagnetic waves and a method of treating cancer using the composition. The sensitizing composition includes a metal ion, a metal ion-bound material, metal ion-noncovalently bound apotransferrin (transferrin), or a metal ion-noncovalently bound apotransferrin derivative. The sensitizing composition enables selective delivery of the metal ion to tumorous tissue when administered in vivo, and thus the generation of heat in tumorous tissue in which the metal ion accumulates is increased upon thermal cancer therapy using electromagnetic waves, thereby maximizing efficacy of thermal cancer therapy using electromagnetic waves in treating cancer.
Type:
Grant
Filed:
November 4, 2022
Date of Patent:
September 12, 2023
Assignee:
JINIS CO., LTD.
Inventors:
Hyeon Jin Kim, Seong Tshool Hong, Hea Jong Chung, Heui Kwan Lee, Hea Guk Cho, Jae Gak Yu
Abstract: Provided is a coating having a uniform and strong UV protective effect over the entire skin. A method for producing a UV protective coating on skin comprising a step of applying a composition comprising a UV protective agent to the skin, and a step of electrostatically spraying a composition comprising component (a) and component (b) directly onto the skin to form a coating on the skin, in this order or vice versa: (a) one or more volatile substances selected from the group consisting of water, an alcohol and a ketone, (b) a polymer having a film-forming ability.
Abstract: Disclosed herein are solid compositions that comprise sincalide and are storage stable and which lack a buffer, and optionally, also lack a surfactant/solubilizer, wherein such compositions are storage stable. Also disclosed herein are liquid compositions that comprise sincalide, wherein such compositions are storage stable, and may lack buffer and/or surfactant/solubilizer. Also provided are methods of making and administering the solid or liquid storage stable compositions to a patient in need of, e.g., for the treatment, prevention, and/or diagnosis of gall bladder- and/or pancreatic disorders; or other diagnostic imaging.
Abstract: The present invention provides compositions comprising energy (e.g., light) absorbing submicron particles (e.g., nanoparticles comprising a silica core and a gold shell) and methods for delivering such particles via topical application. This delivery is facilitated by application of mechanical agitation (e.g. massage), acoustic vibration in the range of 10 Hz-20 kHz, ultrasound, alternating suction and pressure, and microjets.
Type:
Grant
Filed:
May 18, 2020
Date of Patent:
August 22, 2023
Assignee:
The General Hospital Corporation
Inventors:
Dilip Paithankar, Richard Dean Blomgren, Richard Rox Anderson, William A. Farinelli, Apostolos G. Doukas
Abstract: Gold implant having a cross-section in the range of 20-100, preferably in the range of 20-40 ?m for use in therapy to prevent or reduce capsular contracture. Further, the invention relates to a method of producing a gold-coated implant.
Abstract: The present invention relates to the use of scaffolds to enhance the viability of cells implanted in the integumentary system such that the cell may release an agent. The scaffold is capable of protecting the cell, as well as allowing for adequate nutrient delivery at the implant site through vascularisation in and around the scaffold.
Type:
Grant
Filed:
October 18, 2017
Date of Patent:
August 22, 2023
Assignee:
AUSTRALIAN FOUNDATION FOR DIABETES RESEARCH
Inventors:
Bernard Tuch, Tim Dargaville, Auvro Mridha, Paul Dalton, Vijayaganapathy Vaithilingam
Abstract: The present invention concerns a thermosensitive polymeric hydrogel comprising at least one thermosensitive copolymer, one aqueous solution, and a mucoadhesive excipient, wherein said thermosensitive polymeric hydrogel further comprises at least one immunostimulatory adjuvant and/or at least one cytokine and/or at least one chemokine and/or atleast one heat shockprotein. Another object of the invention is a thermosensitive polymeric hydrogel according to the invention for use in the treatment of tumors or metastasis in a subject having a cancer, preferably a metastatic cancer.
Type:
Grant
Filed:
August 31, 2017
Date of Patent:
August 15, 2023
Assignees:
Institut National de la Sante et de la Recherche Medicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Université de Paris, Assistance Publique—Hopitaux de Paris, Ecole Nationale Superieure de Chimie de Paris, Universite de Versailles—St. Quentin en Yvelines
Inventors:
Robert Malafosse, Nathalie Mignet, Vincent Boudy, Johanne Seguin, Kathia Lemdani, Claude Capron
Abstract: The present invention relates to a cosmetic composition for treating keratin fibres, preferably human keratin fibres such as the hair, comprising, in a cosmetically acceptable medium: —one or more chemical oxidizing agents, —one or more scleroglucan gums, —one or more phosphorus-based sequestrants. The present invention also relates to a process for treating keratin fibres, preferably human keratin fibres such as the hair, comprising the application of the composition to the keratin fibres. The process according to the invention is preferably a process for bleaching, dyeing or permanently reshaping keratin fibres.
Abstract: Angioplasty balloons coated with at least one limus drug, which may be in crystalline form, optionally with at least one excipient, and methods for manufacturing such coated angioplasty balloons.
Type:
Grant
Filed:
May 29, 2020
Date of Patent:
August 8, 2023
Assignee:
Medtronic Vascular, Inc.
Inventors:
Simone D'Onofrio, Massimo Morero, Federica Bellucci, Bradley E. Steele, Diane M. Haen
Abstract: Disclosed are compositions and methods for treating or ameliorating the symptoms of cancer (e.g., oral cancer) by using a poly-pharmaceutical drug, whose composition consists of relationally optimized ratios of bioactive compounds to enhance their pharmacological characteristics.
Type:
Grant
Filed:
April 2, 2019
Date of Patent:
July 18, 2023
Assignee:
Aveta Biomics, Inc.
Inventors:
Parag G. Mehta, Sharmila Mudgal, Lal Hingorani, Luis Z. Avila
Abstract: A dermal skin protectant and carrier comprising a combination of two different viscosity dimethicone components, wherein the difference between the two different viscosity dimethicone components is about 2.0 million cP or greater; and comprising at least one active ingredient.
Abstract: An implantable device for delivery of a macromolecular drug compound is provided. The device comprises a core having an outer surface and a membrane layer positioned adjacent to the outer surface of the core. The core comprises a core polymer matrix within which is dispersed a drug compound having a molecular weight of about 0.5 kDa or more, the polymer matrix containing a hydrophobic polymer. Further, the membrane layer comprises a membrane polymer matrix within which the macromolecular drug compound is optionally dispersed. The concentration of the macromolecular drug compound in the core is greater than the concentration of the macromolecular drug compound in the membrane layer.
Abstract: Disclosed are compositions comprising a) an antimicrobial agent, which is selected from the group consisting of biocides containing halogen atoms and/or containing phenolic moieties, formic acid, chlorine dioxide, chlorine dioxide generating compounds, dialdehydes; components containing an antimicrobial metal such as antimicrobial silver, and b) a polyamine, especially a polyethylenimine. The polyamine is effective as a booster for the antimicrobial agent.
Type:
Grant
Filed:
January 16, 2020
Date of Patent:
June 6, 2023
Assignee:
BASF SE
Inventors:
Janina Purschwitz, Stephan Hüffer, Alejandra Garcia Marcos, Menno Hazenkamp
Abstract: The present invention relates to a method for modifying release of a therapeutically active agent from an elastomeric matrix, comprising providing a core comprising an elastomeric matrix and a therapeutically active agent; dipping the core to a coating solution of an elastomer, wherein the elastomer comprises 20-35 wt-% of a filler, calculated from the total amount of filler and elastomer; curing the dipped core to provide a coated core. In this method the dipping is provided as a continuous process by pulling the core through the coating solution, using a pulling speed suitable for providing a coating thickness of ?-IOO the filler is selected from silica, titanium dioxide, barium sulphate, carbon and mixtures thereof; the elastomer comprised in the core and the elastomer comprised in the coating solution are independently selected from poly(dimethyl) siloxanes, polyethylene vinyl acetates (EVAs), polyurethanes (PUs), polyhydroxyethyl methacrylates (PHEMAs) and polymethyl methacrylates (PMMAs).
Type:
Grant
Filed:
September 19, 2018
Date of Patent:
June 6, 2023
Assignee:
Bayer OY
Inventors:
Manja Ahola, Risto Hakala, Piia Hara, Antti Keinänen, Henriikka Korolainen, Jyrki Pihlaja
Abstract: Extended release pyridostigmine dosage forms, suitable for maintaining stable plasma concentrations with reduced or minimized initial burst release/dose dumping of pyridostigmine, are provided. The dosage forms include matrix tablets, gastroretentive tablets, and pellets, the latter being suitable for dosing in capsules, tablets, and sachets, as well as for sprinkling on foodstuffs. The disclosure also provides methods for improving patient compliance by administering once-a-day extended release pyridostigmine bromide dosage forms that provide a superior controlled drug release.
Type:
Grant
Filed:
December 14, 2021
Date of Patent:
June 6, 2023
Assignee:
Amneal Complex Products Research LLC
Inventors:
Siva Ram Kiran Vaka, Dipen Desai, Wantanee Phuapradit, Navnit H. Shah, Namdev B. Shelke
Abstract: Antimicrobial compositions and methods for inhibiting microbial growth are disclosed. The antimicrobial compositions can include an antimicrobial agent that includes a dihydroxamic acid having a carbon chain length less than or equal to 7.
Type:
Grant
Filed:
June 29, 2017
Date of Patent:
May 23, 2023
Assignee:
Kimberly-Clark Worldwide, Inc.
Inventors:
Scott W. Wenzel, Andrew R. Kischnick, Corey T. Cunningham, Vinod Chaudhary
Abstract: Antimicrobial compositions and methods for inhibiting microbial growth are disclosed. The antimicrobial compositions can include an acyl lactylate, a glycol, and a carrier. The carrier can include water. Water can form at least about 90% by weight of the composition.
Type:
Grant
Filed:
May 31, 2017
Date of Patent:
May 23, 2023
Assignee:
Kimberly-Clark Worldwide, Inc.
Inventors:
Jeffery R. Seidling, Paige N. Anunson, Corey T. Cunningham
Abstract: Disclosed are compositions comprising a) an antimicrobial agent, which is selected from the group consisting of biocides containing halogen atoms and/or containing phenolic moieties, formic acid, chlorine dioxide, chlorine dioxide generating compounds, dialdehydes; components containing an antimicrobial metal such as antimicrobial silver, and b) a polyamine, especially a polyethylenimine. The polyamine is effective as a booster for the antimicrobial agent.
Type:
Grant
Filed:
February 19, 2013
Date of Patent:
May 16, 2023
Assignee:
BASF SE
Inventors:
Janina Purschwitz, Stephan Huffer, Alejandra Garcia Marcos, Menno Hazenkamp
Abstract: A method for producing a powder lead is disclosed, wherein at least one colourant, at least one filler and at least one binder are mixed with a carrier liquid, leads are shaped from the wet compound, the leads shaped in step b) are guided through a chamber in which they are exposed to a pulverulent covering agent, and the powdered leads are guided into a drying apparatus and dried therein.
Type:
Grant
Filed:
February 15, 2019
Date of Patent:
May 16, 2023
Inventors:
Katrin Hollmann-Raabe, Tamara Segets, Markus Schmitt, Irina Künstler, Stefan Mozer, Reinhard Pinzer, Christian Sprogar, Thomas Stadter
Abstract: Various aspects described herein relate to compositions comprising silk fibroin particles and methods of using the same, as well as devices and methods of delivering such compositions. The compositions described herein are suitable for injection into a site of defect in a soft tissue to provide bulking and/or augmentation effect to the soft tissue.
Type:
Grant
Filed:
March 12, 2021
Date of Patent:
May 9, 2023
Assignee:
Sofregen Medical, Inc.
Inventors:
Anh Hoang-Lindsay, Christopher P. Gulka, Jodie E. M. Giordano, Joseph E. Brown, Thomas L. Carroll