Abstract: Extended release pyridostigmine dosage forms, suitable for maintaining stable plasma concentrations with reduced or minimized initial burst release/dose dumping of pyridostigmine, are provided. The dosage forms include matrix tablets, gastroretentive tablets, and pellets, the latter being suitable for dosing in capsules, tablets, and sachets, as well as for sprinkling on foodstuffs. The disclosure also provides methods for improving patient compliance by administering once-a-day extended release pyridostigmine bromide dosage forms that provide a superior controlled drug release.
Type:
Grant
Filed:
December 14, 2021
Date of Patent:
June 6, 2023
Assignee:
Amneal Complex Products Research LLC
Inventors:
Siva Ram Kiran Vaka, Dipen Desai, Wantanee Phuapradit, Navnit H. Shah, Namdev B. Shelke
Abstract: Antimicrobial compositions and methods for inhibiting microbial growth are disclosed. The antimicrobial compositions can include an antimicrobial agent that includes a dihydroxamic acid having a carbon chain length less than or equal to 7.
Type:
Grant
Filed:
June 29, 2017
Date of Patent:
May 23, 2023
Assignee:
Kimberly-Clark Worldwide, Inc.
Inventors:
Scott W. Wenzel, Andrew R. Kischnick, Corey T. Cunningham, Vinod Chaudhary
Abstract: Antimicrobial compositions and methods for inhibiting microbial growth are disclosed. The antimicrobial compositions can include an acyl lactylate, a glycol, and a carrier. The carrier can include water. Water can form at least about 90% by weight of the composition.
Type:
Grant
Filed:
May 31, 2017
Date of Patent:
May 23, 2023
Assignee:
Kimberly-Clark Worldwide, Inc.
Inventors:
Jeffery R. Seidling, Paige N. Anunson, Corey T. Cunningham
Abstract: Disclosed are compositions comprising a) an antimicrobial agent, which is selected from the group consisting of biocides containing halogen atoms and/or containing phenolic moieties, formic acid, chlorine dioxide, chlorine dioxide generating compounds, dialdehydes; components containing an antimicrobial metal such as antimicrobial silver, and b) a polyamine, especially a polyethylenimine. The polyamine is effective as a booster for the antimicrobial agent.
Type:
Grant
Filed:
February 19, 2013
Date of Patent:
May 16, 2023
Assignee:
BASF SE
Inventors:
Janina Purschwitz, Stephan Huffer, Alejandra Garcia Marcos, Menno Hazenkamp
Abstract: A method for producing a powder lead is disclosed, wherein at least one colourant, at least one filler and at least one binder are mixed with a carrier liquid, leads are shaped from the wet compound, the leads shaped in step b) are guided through a chamber in which they are exposed to a pulverulent covering agent, and the powdered leads are guided into a drying apparatus and dried therein.
Type:
Grant
Filed:
February 15, 2019
Date of Patent:
May 16, 2023
Inventors:
Katrin Hollmann-Raabe, Tamara Segets, Markus Schmitt, Irina Künstler, Stefan Mozer, Reinhard Pinzer, Christian Sprogar, Thomas Stadter
Abstract: Various aspects described herein relate to compositions comprising silk fibroin particles and methods of using the same, as well as devices and methods of delivering such compositions. The compositions described herein are suitable for injection into a site of defect in a soft tissue to provide bulking and/or augmentation effect to the soft tissue.
Type:
Grant
Filed:
March 12, 2021
Date of Patent:
May 9, 2023
Assignee:
Sofregen Medical, Inc.
Inventors:
Anh Hoang-Lindsay, Christopher P. Gulka, Jodie E. M. Giordano, Joseph E. Brown, Thomas L. Carroll
Abstract: An aqueous cosmetic includes water, a polyhydric alcohol and carminic acid. A content of the carminic acid is greater than or equal to 0.2 mass % and less than 2 mass % based on a total amount of the aqueous cosmetic.
Abstract: An object of the present invention is to provide a storage-stable injectable preparation comprising a composition comprising a poorly soluble drug as an active ingredient and a dispersion medium. Another object of the present invention is to provide a compact, lightweight prefilled syringe by filling a syringe with the injectable preparation. The present invention provides an injectable preparation comprising a composition comprising a poorly soluble drug, a dispersion medium, and a specific suspending agent, the composition having a viscosity of 40 pascal-seconds or more in at least one point in the shear rate range of 0.01 to 0.02 s?1 and having a viscosity of 0.2 pascal-seconds or less in at least one point in the shear rate range of 900 to 1,000 s?1, as measured.
Abstract: Formulations are described, containing silibinin or other active ingredients incorporated in lipid nanoparticle systems of the SLN and NLC type, and based on calixarenes, possibly mucoadhesive, or in micellar and nanoparticle systems based on amphiphilic inulin copolymers for use in the treatment of neurodegenerative ocular diseases. The versatility of the calixarene compound is also described, capable of charging and releasing active ingredients characterized by low water solubility, easy chemical and enzymatic degradation, low bioavailability, either of natural origin or not, to be used in the treatment of ocular diseases.
Type:
Grant
Filed:
August 3, 2020
Date of Patent:
April 25, 2023
Assignee:
DISTRETTO TECNOLOGICO SICILIA MICRO E NANO SISTEMI S.C.A.R.L.
Inventors:
Anna Rita Blanco, Maria Luisa Bondi', Gennara Cavallaro, Grazia Maria Letizia Consoli, Emanuela Fabiola Craparo, Gaetano Giammona, Mariano Licciardi, Giovanna Pitarresi, Guiseppe Granata, Patrizia Saladino, Clara La Marca, Irene Ceidda, Salvatore Papasergi, Patrizia Guarneri, Salvatore Cuzzocrea, Emanuela Esposito, Santa Viola
Abstract: Various aspects described herein relate to compositions comprising silk fibroin particles and methods of using the same, as well as devices and methods of delivering such compositions. The compositions described herein are suitable for injection into a site of defect in a soft tissue to provide bulking and/or augmentation effect to the soft tissue.
Type:
Grant
Filed:
March 12, 2021
Date of Patent:
April 11, 2023
Assignee:
Sofregen Medical, Inc.
Inventors:
Anh Hoang-Lindsay, Christopher P. Gulka, Jodie E. M. Giordano, Joseph E. Brown, Thomas L. Carroll
Abstract: Various aspects described herein relate to compositions comprising silk fibroin particles and methods of using the same, as well as devices and methods of delivering such compositions. The compositions described herein are suitable for injection into a site of defect in a soft tissue to provide bulking and/or augmentation effect to the soft tissue.
Type:
Grant
Filed:
October 31, 2017
Date of Patent:
April 4, 2023
Assignee:
Sofregen Medical, Inc.
Inventors:
Anh Hoang-Lindsay, Christopher P. Gulka, Jodie E. M. Giordano, Joseph E. Brown, Thomas L. Carroll
Abstract: The invention relates to methods for making injectable pharmaceutical compositions wherein particles present in the compositions are detected and analyzed, and the acceptance of the compositions is determined based on chemical and physical properties as well as toxicology and patient risks associated of the particles.
Type:
Grant
Filed:
April 2, 2019
Date of Patent:
February 14, 2023
Assignee:
AMGEN INC.
Inventors:
Andrew Phillip Spasoff, Susanne Therese Atkinson, Adrian Bennis, Erwin Freund
Abstract: An oily stick-shaped cosmetic containing (A) a partially hydrogenated jojoba ester, (B) Japan wax, (C) a higher fatty acid, and (D) a dimer acid ester.
Abstract: Oil compositions containing two or more mixtures selected from the group consisting of a lauroyl glutamic acid diester mixture having a melting point higher than 33° C., a lauroyl glutamic acid diester mixture having a melting point of 20 to 32° C., and a lauroyl glutamic acid diester mixture having a melting point of ?20° C. or lower can simultaneously achieve the texture properties (melting smooth feel, uniform spread over the lip surface, and transparent gloss), stability (such as improvement in breaking strength and improvement in temporal stability of the breaking strength), and the elasticity necessary for improving makeup duration of a lipstick.
Abstract: In a delayed release formulation comprising a core containing a drug and a delayed release coating for providing intestinal release, release of the drug in the colon is accelerated by including an isolation layer between the core and the delayed release coating. The delayed release coating comprises an inner layer and an outer layer. The outer layer comprises a pH dependently soluble polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a soluble polymeric material which is soluble in intestinal fluid or gastrointestinal fluid, said soluble polymeric material being selected from the group consisting of a polycarboxylic acid polymer that is at least partially neutralised, and a non-ionic polymer, provided that, where said soluble polymeric material is a non-ionic polymer, said inner layer comprises at least one additive selected from a buffer agent and a base.
Type:
Grant
Filed:
March 18, 2020
Date of Patent:
December 27, 2022
Assignee:
Tillotts Pharma AG
Inventors:
Felipe José Oliveira Varum, Roberto Carlos Bravo González, Thomas Buser, Abdul Waseh Basit, Ana Cristina Freire
Abstract: There is provide an extended release dosage form comprising a release modifying excipient comprising high amylose starch, cross-linked hydroxypropylated amylopectin, and a pre-gelatinized common starch; wherein the release modifying excipient is substantially free of crosslinks between amylose and amylopectin and substantially free of crosslinks between amylose and amylose. It has been found that the extended release properties of conventional cross-linked high amylose starches (e.g., Contramid®) can be reproduced by intimately mixing i) cross-linked chemically modified amylopectin; ii) a high amylose, non-chemically modified starch and; iii) a pre-gelatinized common starch. Producing a release modifying excipient in this way means that no chemical cross linking between (a) amylose and amylopectin or (b) amylose and amylose has occurred—properties heretofore considered vital for Contramid® function.
Type:
Grant
Filed:
June 11, 2021
Date of Patent:
December 20, 2022
Assignee:
ALTUS FORMULATION INC.
Inventors:
Marc Lemieux, Bradut Mitrasca, Sonia Gervais, Damon Smith
Abstract: The present invention relates to a water-releasing stick-type cosmetic and, specifically, to a water-releasing stick-type cosmetic containing: an oily portion; and a water-releasing ingredient that is spread out in the oily portion, wherein the water-releasing ingredient has water particles encompassed by a plurality of plate-shaped materials to which emulsifiers are bound. According to the present invention, provided is a water-releasing stick-type cosmetic, which can provide a moist and cool feeling by directly supplying a large quantity of water, has excellent dosage form stability by having a hardness suitable for stick cosmetics, and simultaneously has excellent application texture, excellent storage stability and excellent color tone.
Abstract: In a delayed release formulation comprising a core containing a drug and a delayed release coating for providing intestinal release, release of the drug in the colon is accelerated by including an isolation layer between the core and the delayed release coating. The delayed release coating comprises an inner layer and an outer layer. The outer layer comprises a pH dependently soluble polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a soluble polymeric material which is soluble in intestinal fluid or gastrointestinal fluid, said soluble polymeric material being selected from the group consisting of a polycarboxylic acid polymer that is at least partially neutralised, and a non-ionic polymer, provided that, where said soluble polymeric material is a non-ionic polymer, said inner layer comprises at least one additive selected from a buffer agent and a base.
Type:
Grant
Filed:
June 2, 2017
Date of Patent:
December 6, 2022
Assignee:
Tillotts Pharma AG
Inventors:
Felipe Josè Oliveira Varum, Roberto Carlos Bravo González, Thomas Buser, Abdul Waseh Basit, Ana Cristina Freire
Abstract: Network materials which exhibit both shear thinning and self-healing properties are disclosed. The networks contain particles and gel-forming compounds. The networks are useful for a variety of biomedical uses, including drug delivery.
Type:
Grant
Filed:
June 8, 2021
Date of Patent:
December 6, 2022
Assignee:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventors:
Eric A. Appel, Mark W. Tibbitt, Robert S. Langer
Abstract: The present invention relates to a method of capturing and stabilising volatile thiol malodour generated on the human skin, comprising steps of: i) contacting the human skin with a substrate, ii) absorbing said thiol into the substrate, and iii) reacting said thiol with a thiol-capture agent. The invention also relates to a method of quantifying said thiol, a method of assessing the deodorizing performance of a cosmetic composition on the human skin.
Type:
Grant
Filed:
April 12, 2019
Date of Patent:
November 8, 2022
Assignee:
CONOPCO, INC.
Inventors:
Susan Bates, David Mark Haddleton, Rachel Alice Hand, Gavin William Kirby, Ezat Khoshdel