Patents Examined by David B. Springer
  • Patent number: 5639780
    Abstract: The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: June 17, 1997
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Cheuk Kun Lau, Cameron Black, Daniel Guay, Jacques-Yves Gauthier, Yves LeBlanc, Patrick Roy, Yves Ducharme, Pierre Hamel
  • Patent number: 5637731
    Abstract: This disclosure describes novel substituted oxotremorine derivatives of formula I having nitrogen, oxygen or sulfur groups and the prodrug forms of these derivatives. The compounds have cholinergic activity. Also disclosed are methods for treating diseases of the central nervous system in mammals employing the compounds, pharmaceutical preparations containing the compounds and the processes for the production of the compounds.
    Type: Grant
    Filed: April 30, 1996
    Date of Patent: June 10, 1997
    Assignee: American Home Products Corporation
    Inventors: Eugene J. Trybulski, Richard H. Kramss, Herbert J. Brabander
  • Patent number: 5637556
    Abstract: For controlling the dispersion of solids, e.g., cuttings, in water-based fluid used during operations such as drilling, completion or workover operations in a well crossing at least one permeable geologic formation, there is added to the fluid an optimized amount of a water soluble polymer HM PAM based on acrylamide and hydrophobic units. In a variant, a useful amount of hydrophobically modified cellulose derivative, e.g., modified hydroxyethylcellulose, HMHEC, is also added, thus forming a fluid containing HM PAM and HM HEC. The process has particular application to slim-hole and/or strongly deviated drilling.
    Type: Grant
    Filed: May 4, 1995
    Date of Patent: June 10, 1997
    Assignees: Institut Francais du Petrole, Dowell Schlumberger, Inc.
    Inventors: Jean-Fran.cedilla.ois Argillier, Annie Audibert, Louise Bailey, Paul I. Reid
  • Patent number: 5637611
    Abstract: Use of a compound of general formula (I): ##STR1## wherein: R.sup.1 represents hydrogen, halogen, trifluoromethyl, nitro, hydroxy, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, arylC.sub.1-6 alkoxy, --CO.sub.2 R.sup.4, --(CH.sub.2).sub.n CN, --(CH.sub.2).sub.n CONR.sup.5 R.sup.6, --(CH.sub.2).sub.n SO.sub.2 NR.sup.5 R.sup.6, C.sub.1-6 alkanoylamino (CH.sub.2).sub.n, or C.sub.1-6 alkylsulphonylamino (CH.sub.2).sub.n ;R.sup.4 represents hydrogen, C.sub.1-6 alkyl or arylC.sub.1-6 alkyl;R.sup.5 and R.sup.6 each independently represent hydrogen or C.sub.1-6 alkyl, or R.sup.5 and R.sup.6 together with the nitrogen atom to which they are attached form a ring;n represents 0, 1 or 2; andR.sup.2 and R.sup.3 each independently represent hydrogen, C.sub.1-6 alkyl or benzyl or together with the nitrogen atom to which they are attached form a pyrrolidino, piperidino or hexahydroazepino ring;or a physiologically acceptable salt thereof, in the manufacture of a medicament for the treatment of a condition where a 5-HT.sub.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: June 10, 1997
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Francis D. King, Laramie M. Gaster, Alberto J. Kaumann, Rodney C. Young
  • Patent number: 5635458
    Abstract: The present invention provides a water-based drilling fluid that reduces water adsorption and hydration of argillaceous rocks. The drilling fluid comprises a glycol with a molecular weight of less than about 200, an organic cationic material such as salts of choline or an organic salt of potassium, a filtration control agent, a viscosifier and water.
    Type: Grant
    Filed: March 1, 1995
    Date of Patent: June 3, 1997
    Assignee: M-I Drilling Fluids, L.L.C.
    Inventors: Li-Jein J. Lee, Arvind D. Patel
  • Patent number: 5635457
    Abstract: A non-toxic, inexpensive synthetic fluid for use in wellbore fluids (e.g., drilling fluids) is selected from the group consisting of (A) fluids having (I) a pour point greater than about -30.degree. C. (-22.degree. F.) and (II) a cetane index greater than 50, and comprising (i) at least about 95 weight percent hydrocarbons containing 11 or more carbon atoms, (ii) greater than 5 weight percent hydrocarbons containing 18 or more carbon atoms, (iii) at least about 50 weight percent isoparaffins, (iv) at least about 80 weight percent total paraffins, (v) less than 10 weight percent naphthenics, (vi) less than 0.1 weight percent aromatics, and (vii) at least 2 hydrocarbons containing a consecutive number of carbon atoms, and (B) fluids comprising (i) at least about 95 weight percent hydrocarbons containing 10 or more carbon atoms and (ii) at least about 90 weight percent n-paraffins.
    Type: Grant
    Filed: April 17, 1995
    Date of Patent: June 3, 1997
    Assignee: Union Oil Company of California
    Inventor: Donald C. Van Slyke
  • Patent number: 5633387
    Type: Grant
    Filed: April 10, 1996
    Date of Patent: May 27, 1997
    Assignee: Nihon Bayer Agrochem K.K.
    Inventor: Fritz Maurer
  • Patent number: 5631374
    Abstract: The present invention is directed to derivatives of aroyl-2-quinoline-carboxaldehyde and their use in detection and quantification of minute amounts of primary amines.
    Type: Grant
    Filed: October 28, 1993
    Date of Patent: May 20, 1997
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Milos V. Novotny, Donald Wiesler, Jinping Liu, You-Zung Hsieh
  • Patent number: 5629323
    Abstract: Amide Derivatives of formula (I) wherein R.sup.1 is a mono or bicyclic heteroaryl radical, R.sup.2 is cycloalkyl, R.sup.3 and R.sup.4 each represent hydrogen or lower alkyl, and R.sup.5 is a group of formula (A) or (B) or (C): R.sup.8 --CH.sub.2 --CH.sub.2 -- or (D) or (E): R.sup.9 OCH.sub.2 CHOHCH.sub.2 -- or (F): R.sup.9 OCH.sub.2 CH.sub.2 -- and their pharmaceutically acceptable salts are 5-HT.sub.1A binding agents and may be used, for example, as anxiolytics.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: May 13, 1997
    Assignee: John Wyeth & Brother, Ltd.
    Inventors: Ian A. Cliffe, Anderson D. Ifill
  • Patent number: 5629419
    Abstract: An improved process for preparing a 4-mercaptopyrrolidine compound [I]: ##STR1## wherein R is H, lower alkyl or lower alkanoyl, R.sup.1 is H or SH-protecting group, and X is O or S, which comprises reacting halogenobutyric acid compound [VI], or a salt thereof, with amine compound [VII], or a salt thereof, and if necessary, followed by thiocarbonylating the product and/or removing the protecting group, said 4-mercaptopyrrolidine compound [I] being useful as intermediate for carbapenem antibacterial agents.
    Type: Grant
    Filed: November 8, 1995
    Date of Patent: May 13, 1997
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Hiroshi Ohmizu, Masahiko Seki, Takeshi Yamanaka
  • Patent number: 5629331
    Abstract: The present invention relates to a process for the preparation of the 2-n.butyl-3-[[2'-(tetrazol-5-yl)biphenyl-4-yl]methyl]-1,3-diazaspiro [4.4]-non-1-en-4-one by reaction of the corresponding nitrile with an alkaline azide and triethylamine hydrochloride, recovering the 2-n.butyl-3-[[2'-(tetrazol-5-yl)biphenyl-4-yl]methyl]-1,3-diazaspiro[4.4]n on-1-en-4-one in form of one of its alkaline salts in aqueous solution, by neutralization of said alkaline salt and crystallization of the 2-n.butyl-3-[[2'-(tetrazol-5-yl)-biphenyl-4-yl]methyl]-1,3-diazaspiro[4.4] non-1-en-4-one thus precipitated either in a solvent containing less than 10% of water or in a solvent containing more than 10% of water in order to obtain two differents crystalline forms. Furthermore a novel crystalline form of 2-n.butyl-3-[[2'-(tetrazol-5-yl)biphenyl-4-yl]methyl]-1,3-diazaspiro[4.4] non-1-en-4-one and pharmaceutical compositions containing it are described.
    Type: Grant
    Filed: October 17, 1995
    Date of Patent: May 13, 1997
    Assignee: Sanofi
    Inventors: Antoine Caron, Dominique Chantreux, Colette Bouloumie
  • Patent number: 5629320
    Abstract: This invention relates to 3-quinolyl-substituted dihydropyridine derivatives, such as ##STR1## or a pharmaceutically acceptable salt thereof. These compounds are used in treating cardiovascular disease.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: May 13, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: J urgen Stoltefuss, Siegfried Goldmann, Alexander Straub, Martin Bechem, Rainer Gross, Siegbert Hebisch, Joachim H utter, Howard-Paul Rounding
  • Patent number: 5629321
    Abstract: The invention relates to a novel compound which is represented by the formula (1) and has an excellent platelet aggregation inhibiting action based on fibrinogen antagonism. The platelet aggregation inhibitor containing the compound of the formula (1) as an effective ingredient are effective for prevention and curing of thrombosis and restenosis or reocclusion after percutaneous transluminal coronary angioplasty or percutaneous transluminal coronary recanalization.
    Type: Grant
    Filed: October 18, 1995
    Date of Patent: May 13, 1997
    Assignee: Mitsui Toatsu Chemicals, Inc.
    Inventors: Kunio Okumura, Isao Yokoyama, Toshiyuki Shimazaki, Michihiko Miyamoto, Hiroyuki Yamashita, Kenji Kibayashi, Takanori Yutaka, Kouhei Yazawa
  • Patent number: 5627143
    Abstract: There is disclosed a biodegradable wellbore fluid having a continuous oil phase comprising an n-alk-1-ene having from 12 to 20 carbon atoms or a linear polyunsaturated olefin having one of the double bonds in the 1-position and having from 12 to 22 carbon atoms, or a mixture thereof.
    Type: Grant
    Filed: January 31, 1995
    Date of Patent: May 6, 1997
    Assignee: Dowell Schlumberger Incorporated
    Inventor: Christopher A. Sawdon
  • Patent number: 5625082
    Abstract: There is provided a process for preparing intermediates having the structure ##STR1## from the corresponding aldehydes having the structure ##STR2##
    Type: Grant
    Filed: November 3, 1994
    Date of Patent: April 29, 1997
    Assignee: American Home Products Corporation
    Inventors: Robert F. Doehner, Jr., Jerry M. Barton, David G. Kuhn
  • Patent number: 5622969
    Abstract: This invention relates to pharmaceutical N-benzyl dihydroindole compounds having the general formula: ##STR1## and their use as LTD.sub.4 antagonists.
    Type: Grant
    Filed: March 31, 1995
    Date of Patent: April 22, 1997
    Assignee: Eli Lilly and Company
    Inventor: J. Scott Sawyer
  • Patent number: 5620989
    Abstract: The present invention is directed to compounds of the formula (I) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, and R.sup.
    Type: Grant
    Filed: April 13, 1995
    Date of Patent: April 15, 1997
    Assignee: Merck Sharp & Dohme Limited
    Inventors: Timothy Harrison, Angus M. MacLeod, Graeme I. Stevenson, Brian J. Williams
  • Patent number: 5621105
    Type: Grant
    Filed: June 6, 1996
    Date of Patent: April 15, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Uwe Petersen, Thomas Schenke, Klaus Grohe, Klaus-Dieter Bremm, Rainer Endermann, Karl G. Metzger
  • Patent number: 5621115
    Abstract: This invention pertains to methods for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo-[1,2-a]pyrrole-1-carboxylic acids represented by formula (I): ##STR1## In a first embodiment, the method comprises the sequential steps of cyclizing, via a free radical ring closure reaction, and hydrolyzing a compound represented by formula (IV): ##STR2## wherein R.sub.1 is lower alkyl.
    Type: Grant
    Filed: February 21, 1996
    Date of Patent: April 15, 1997
    Assignee: Ohmeda Pharmaceutical Products Division Inc.
    Inventors: Ralph A. Lessor, Linas V. Kudzma, Keith Ramig
  • Patent number: 5616725
    Abstract: Pyrrolo[3,4-c]pyrroles of formula ##STR1## wherein D and E are each independently of the other a group of formula ##STR2## The symbols Q, R.sub.8, R.sub.9, R.sub.10, R.sub.11, X, Y, Z, m and n are as defined in claim 1.These pyrrolo[3,4-c]pyrroles are distinguished by outstanding solid state fluorescence in the UV range as well as by the ease with which they can be converted to pyrrolopyrrole pigments even in the substrate in which they are incorporated.
    Type: Grant
    Filed: October 11, 1995
    Date of Patent: April 1, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: John S. Zambounis, Zhimin Hao, Abul Iqbal