Abstract: The present invention relates to novel azanorbornane derivatives having the formula ##STR1## wherein R.sup.1 through R.sup.12 are defined as below, and to novel intermediates used in their synthesis. The compounds having formula I are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders.

Abstract: An improvement in a method for the inhibition of scale deposition on the surfaces of a well coproducing oil and scale forming brines, said method comprising injecting into the well reservoir an acidic aqueous solution at a first pH containing dissolved therein a scale inhibitor, multivalent metal cations, and a heat-sensitive pH-increasing substance which decomposes at elevated temperatures liberating an alkaline compound such that the solution is inherently heated by the higher ambient reservoir temperature to a temperature at which the alkaline compound is liberated from the heat-sensitive substance thus raising the pH of the solution to a point at which a sparingly soluble multivalent metal salt of the scale inhibitor is phase separated from the solution on the porous surfaces of the reservoir rock formation, providing for a slow release of inhibitor into the produced brines when the well is in its production phase.

Abstract: An oil-based fluid system has been discovered using a distribution of salt particle sizes, an oil or water/oil emulsion, a suspending agent for suspending the salt particles in the oil and a filtration control agent. It is important that the salt particles be distributed across a wide size range to effectively prevent filtration or fluid loss into the formation. Since the filter cake particles do not invade the well bore, no high pressure spike occurs during the removal of the filter cake. This high pressure spike indicates damage to the formation and well bore surface, which damage typically reduces overall permeability of the formation. The rheological properties of the fluid allow it to be used in a number of applications where protection of the original permeable formation is desirable. The applications include, but are not limited to, drilling fracturing and controlling fluid losses during completion operations, such as gravel packing or well bore workovers.

Abstract: Compound of the general formula ##STR1## wherein R is an ester-activating group, m and n are identical or different and 0-6, p =0, 2-4, and q and s=1, p=0 if s=0 and p=2-4 if s=1. The compound is novel and suitable for the reproducible coupling of immunological substances at a high yield.

Abstract: Drilling fluid for improving the osmotic efficiency of a shale during the drilling of a well, the drilling fluid containing ethoxylated/propoxylated polyol and at least one other additive such as glucoside, glycerol, glycol, or polyglycerol.

Abstract: The tetrazolylphenyl pivalate of the the following general formula or a pharmaceutically acceptable salt thereof: ##STR1## wherein R.sup.1 and R.sup.2 each represents a hydrogen atom, a lower alkyl group or other substituents; an elastase-inhibitory composition, a composition for preventing and treating emphysema and a composition for preventing and treating endotoxin-induced lung disorders each comprising the foregoing tetrazolylphenyl pivalate derivative or a non-toxic or acid-addition salt thereof.

Abstract: The 4-arylcyclopenta[c]pyrroles of the following formula are effective analgesics: ##STR1## including stereoisomers and pharmaceutically acceptable salts thereof, wherein ##STR2## with the proviso that where there is a 4-position hydroxy then such is trans to the 3a and 6a hydrogens.

Abstract: A bisquinolinol or bisbenzoquinolinol compound is disclosed which has the formula CH.sub.2 .dbd.C(CH--R.sup.1).sub.2 wherein R.sup.1 represents a 8-hydroxy-7-quinolyl group which may have an alkyl group at the 2-position thereof or a 10-hydroxy-9-benzoquinolyl group which may have an alkyl group at the 2-position thereof. The bisquinolinol and bisbenzoquinolinol compounds may be obtained by thermal rearrangement of a bisquinoline or bisbenzoquinoline compound of the formula CH.sub.2 .dbd.C(CH.sub.2 --O--R.sup.2).sub.2 wherein R.sup.2 represents a 8-quinolyl group which may have an alkyl group at the 2-position thereof or a 10-benzoquinolyl group which may have an alkyl group at the 2-position thereof. The bisquinolinol and bisbenzoquinolinol compounds are useful as an extractant for metal ions.

Abstract: The invention relates to the products: ##STR1## in which: R.sub.1 =alkyl, alkenyl, alkynyl, alkylthio,R.sub.2B, R.sub.3B representing:hydrogen, mercapto, formyl, acyl, carboxy nitro, cyano,--PO.sub.3 (R).sub.2, R representing hydrogen, alkyl, aryl, amino or carbamoyl,the R.sub.4B radicals; ##STR2## n=0 to 2 X'=arylR.sub.4B either represents --(CH.sub.2).sub.m1 --S(O).sub.m2 --X--R.sub.10, m1=0 to 4, m2=0 to 2either m1 is different from 0, X--R.sub.10 represents amino, or whatever m1 is, X represents a single bond or --NH--, --NH--CO--, --NH--CO--NH--,R.sub.10 =alkyl, alkenyl or aryl, or hydrogen, alkyl, alkenyl, alkynyl, acyl or amino,--S--S--R.sub.4B ', R.sub.4B ' represents R.sub.4B except for amino and alkoxy, and one of R.sub.2B and R.sub.3B represents --OR.sub.4B : ##STR3## m=0 to 2, Y.sub.B ---Y.sub.1B --B--Y.sub.2B,Y.sub.1B =aryl,B=a single bond or --CO--, --O--, --NH--CO--, --CO--NH--, --O--O--(CH.sub.2).sub.p --,p=1 to 3,Y.sub.

Abstract: Novel derivatives of fatty acid analogs that have from one to three heteroatoms in the fatty acid moiety which can be oxygen, sulfur or nitrogen, are disclosed in which the carboxy-terminus has been modified to form various amides, esters, ketones, alcohols, alcohol esters and nitriles thereof.These compounds are useful as substrates for N-myristoyltransferase (NMT) and/or its acyl coenzyme, and as anti-viral and anti-fungal agents or pro-drugs of such agents. Illustrative of the disclosed compounds are fatty acid amino acid analogs of the structure ##STR1## in which X is the ethyl or t-butyl ester of an amino acid such as Gly, L--Ala, L--Ile, L--Phe, L--Trp, L--Thr or an amide such as NHCH.sub.2 C.sub.6 H.sub.5 or NH(CH.sub.2).sub.2 C.sub.6 H.sub.

Abstract: A water-base fluid of optimized composition for solving problems encountered during operations such as drilling, completion or workover operations in a well crossing at least one permeable geologic formation contains (i) a hydrophilic/hydrophobic polymer, (ii) an acrylamide-base polymer of hydrophobic unit, (iii) a hydrophobically modified cellulose derivative, and (iv) a polysaccharide type polymer.The fluid can be used in a process implemented in a well drilled through at least one formation having a given permeability and is for particular application to slim-hole and/or deviated drilling.

Abstract: There is disclosed a process for producing a 2-(tetrazol-5-yl)-4-oxo-4H-benzopyran of general formula (1): ##STR1## which comprises reacting a hydroxyacetophenone of general formula (2): ##STR2## with a tetrazole compound of general formula (3): ##STR3## in the presence of a base in a solvent composed mainly of at least one selected from hydrocarbons, halogenated hydrocarbons and alcohols, and then treating the reaction mixture under acidic conditions.

Abstract: The present invention relates to novel substituted alkyldiamine derivatives and pharmaceutically acceptable salts thereof which are useful tachykinin antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions including asthma, cough, and bronchitis.

Abstract: The invention concerns new aminoalkylmaleimides of the general formula I ##STR1## in which R.sub.1 and R.sub.2 are the same or different and represent hydrogen or a C.sub.1 -C.sub.4 alkyl group and A represents a straight-chain or branched, saturated or unsaturated alkylene group with 2 to 6 carbon atoms which is interrupted, if desired, by an oxygen or sulphur atom or a carbonyl group, as well as their corresponding acid addition salts.The present invention also concerns amidoalkylmaleimide derivatives formed from compounds of the general formula I and immunological binding partners. In addition, the invention concerns immunological conjugates which can be produced by reaction of the amidoalkylmaleimide derivatives with peptides or proteins.The subject matter of the present invention are also the corresponding processes of production of the compounds according to the present invention as well as the use of these conjugates in diagnostic methods of determination, in particular in immunoassays.

Abstract: This invention comprises a process for preparing benzopyran derivatives represented by formula (I) ##STR1## in which, R.sup.1 is C.sub.1-20 alkyl, C.sub.2-20 alkenyl, C.sub.2-20 alkynyl, or a group of structure (i), (ii) or (iii).

Abstract: .beta.- or .gamma.-Ketoesters and .beta.- or .gamma.-ketoamides are asymmetrically reduced with a Ru(II)-BINAP derived catalyst at about 40.degree. C. and about 50 N/mm.sup.2 of hydrogen in the presence of a strong acid.

Abstract: This invention is directed to heteroannulated indazoles namely to 2,5-disubstituted quinolino-, isoquinolino-, phthalazino-, and quinoxalino- annulated indazole-6(2H)-ones and related mono N-oxides.These compounds have been shown to have antitumor activity.

Abstract: The invention concerns tachykinin antagonists. The compounds are nonpeptides which have utility in treating disorders mediated by tachykinins. Such disorders are respiratory, inflammatory, gastrointestinal, ophthalmic, allergies, pain, vascular, diseases of the central nervous system, and migraine. Methods of preparing compounds and novel intermediates are also included.The compounds are expected to be especially useful in asthma and rheumatoid arthritis.

Abstract: The present invention provides amphoteric acetates, diacetates, and glycinates which may be added to drilling fluids in order to minimize hydration and prevent erosion loss of water-sensitive shale substrates.

Abstract: A process for producing 5-aminotetrazole comprising the steps of: reacting cyanamide with hydrazine in a solvent to form a salt of aminoguanidine; adding thereto an acid and then a nitrite to form a salt of diazoguanidine; and cyclizing the salt of diazoguanidine, upon heating, to thereby produce the 5-aminotetrazole, without isolating the intermediate product and also a process for producing 5-aminotetrazole or a metal salt thereof in the form of powder by spray drying.