Abstract: Polymeric eye inserts are provided that may be dissolvable when placed in the cul-de-sac of the eye. These inserts may contain one or more polymers as well as a softener/plasticizer so that, when inserted into the eye, they may absorb tears, and dissolve and slowly release lubricant into the tear film to lubricate and protect the ocular surface for an extended duration of time. Increased retention time on the ocular surface for longer lasting relief may reduce dosing frequency and patient burden typically associated with topical drop usage. These polymeric eye inserts also may include one or more pharmaceutically active agents.

Abstract: A disintegrating oral tablet suitable for active pharmaceutical ingredients includes a population of particles and at least one flavor ingredient. The population of particles includes directly compressible (DC) and non-directly compressible (non-DC) sugar alcohol particles, the non-DC particles providing the tablet with a plurality of discrete non-DC areas, and the non-DC areas resulting in a burst of the at least one flavor ingredient upon mastication of the tablet.

Abstract: The disclosure provides stable formulations of cationic biocides that are primarily used in the treatment and prevention of infections. The disclosure is also concerned with processes for forming stable emulsions of cationic biocides and petrolatum.

Abstract: Compositions and methods for the treatment of onychomycosis. The compositions include a pharmaceutically effective amount of polyhexamethylene biguanide (PHMB), polyaminopropyl biguanide (PAPB), and/or chlorhexidine (CHG) in a petrolatum carrier.

Abstract: A method of manufacturing a cosmetic composition by preparing a mixture that includes a sucrose esters and one or more solvents. The sucrose ester can have a fatty acid portion having from about 12 to about 24 carbon atoms and the sucrose esters can be selected from the group consisting of mono-ester, di-ester, tri-ester, tetra-ester, and mixtures thereof. The one or more solvents can have Hildebrand Solubility Parameter of from about 23 to about 31.5(J/cm3)1/2 and Polar component of Hansen Solubility Parameter of from about 4.5 to about 10.5 (J/cm3)1/2. The sucrose ester can be dissolved in the cosmetic compositions, even when the sucrose ester is contained at higher levels in the compositions and/or even when the sucrose esters are contained in an aqueous phase of the cosmetic composition.

Abstract: Microparticles comprising carboxylated, sulfated, or phosphated cellulose nanocrystals (CNCs) and pigment nanoparticles are provided. In these particles, the cellulose nanocrystals and the pigment nanoparticles are agglomerated together thereby forming said microparticle, and wherein the pigment nanoparticles are bound to the surface of the cellulose nanocrystals. Cosmetic preparations comprising these microparticles are also provided. Finally, a method for producing the microparticles is provided. The method comprises the steps of a) producing an aqueous suspension of carboxylated, sulfated, or phosphated CNCs with pigment nanoparticles bound thereto; and b) drying said aqueous suspension to produce the microparticles.

Abstract: Cosmetic compositions, kits thereof, and methods of making and using such cosmetic compositions. The cosmetic compositions comprising about 0.1 to about 25 wt. % of citric acid, about 0.2 to about 40 wt. % of one or more urea compound, and about 20 wt. % or more water wherein all weight percentages are based on the total weight of the cosmetic composition. Additionally, the cosmetic compositions are typically formulated to have a molar ratio of the citric acid of (a) to the urea compound of (b) is 1 or less.

Abstract: An anhydrous broad-spectrum mineral sunscreen composition (e.g., compact or stick; which may be untinted, tinted, or contain shimmer-imparting ingredients) consisting essentially of: (a) two photoprotective metal oxides that block, reflect, refract or otherwise attenuate ultraviolet radiation (i) at least one zinc oxide particle, preferably uncoated and having an average particle size of greater than about 100 nanometers (ii) and at least one titanium dioxide particle, preferably coated, (b) two Siliceous Compounds—(i) an amorphous spherical silica and (ii) a mixture of diatomaceous algae comprising at least two, preferably three, and still more preferably all four of Fragilaria zeilleri, Gomphonema angustatum, Navicula radiosa, and Cyclotella andancensis, wherein each algal species has photonic and porous silica crystals and (c) two Film-Forming Polymers, preferably copolymers of dimethicone.

Abstract: The present invention relates to a composition intended for dyeing keratin fibres, in particular of human keratin fibres such as the hair, comprising one or more acrylate-functionalized polymers and one or more silicones chosen from silicones functionalized with one or more mercapto groups, amino silicones, and mixtures thereof, and one or more pigments.

Abstract: A medical composition and devices made from the composition for the delivery of extracts obtained from Boswellia genus, similar compounds synthetically derived, and in particular derivatives of triterpenes is disclosed. The medical device may be implantable, or alternatively a device which contacts the interior of a mammalian body. The medical device may be comprised, of or present an absorbable component containing Boswellia derivatives, or an eluting component. When administered into a particular body site, the Boswellia component may be released substantially and immediately, released slowly, or not released, into the body and residing actively on the medical device surface.

Abstract: Bioactive porous bone graft implants in various forms suitable for bone tissue regeneration and/or repair, as well as methods of use, are provided. The implants are formed of bioactive glass and have an engineered porosity. The implants may take the form of a putty, foam, fibrous cluster, fibrous matrix, granular matrix, or combinations thereof and allow for enhanced clinical results as well as ease of handling.

Abstract: The present disclosure is broadly concerned with petrolatum-based compositions as a suspension matrix for the active ingredients. The disclosure is also concerned with processes for forming stable emulsions of active ingredients in petrolatum.

Abstract: The present disclosure provides an herbicidal compound according to Formula I, which is a pyridine ring-substituted pyridazinol compound, as well as derivatives of the compound, an herbicidal composition comprising the compound, preparation methods thereof, and applications thereof.

Abstract: A device for mixing a bone material with a liquid is provided. The device comprises a chamber having a proximal end and a distal end, and the bone material disposed within the chamber, the bone material comprising a DBM pellet of milled and lyophilized demineralized bone fibers; and a plunger having at least a portion slidably disposed within the proximal end of the chamber and configured to dispense the bone material mixed with liquid from the distal end of the chamber, when the plunger is in an extended position.

Abstract: A uniformly hydrated composition is provided and methods of making the uniformly hydrated composition. The method comprises providing a plurality of lyophilized porous macroparticles in a chamber, the plurality of lyophilized porous macroparticles each having an average diameter from about 0.1 mm to about 10 mm and comprising ceramic material and polymer; and mixing each of the plurality of lyophilized porous macroparticles with a fluid in the chamber to uniformly hydrate each of the plurality of lyophilized porous macroparticles to form a uniformly hydrated composition. Hydratable compositions are also provided.

Abstract: This invention relates to methods and compositions for inhibiting the transmission of enveloped viruses, which entails applying a composition containing a high molecular weight hydrophobically-modified polymer to an infectable or ingestible surface that may contain viruses and wherein said anti-viral composition is substantially free of surfactant having an HLB greater than about 12.

Abstract: Provided herein are microneedle particles, compositions that include microneedle particles, methods of treating skin, and methods of delivering a substance of interest. The microneedle particles may include one or more microneedles, and the microneedle particles may be configured to prevent the entire microneedle particle from penetrating the biological tissue. The microneedle particles may be dispersed in a liquid medium to form a composition. A biological tissue may be contacted with the microneedle particles to pre-treat the biological tissue, and a substance of interest may be applied to the pre-treated biological tissue.

Abstract: The present invention relates to the treatment or prevention of conditions linked to reduced muscle mass or reduced muscle protein synthesis rate. A subject matter of the invention is a composition comprising complexes of whey protein micelles and pectin for use in the treatment or prevention of a condition selected from the group consisting of sarcopenia, muscle atrophy and negative nitrogen balance. Further aspects of the invention relate to the non-therapeutic use of a composition comprising complexes of whey protein micelles and pectin and a food composition.

Abstract: A 9-(5-bromo-2-hydroxyphenyl)-10-[3-(dimethylamino)propyl]-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione compound, its synthesis, and its use as an antimicrobial agent.

Abstract: A composite material for use, for example, as an orthopedic implant, that includes a porous reinforced composite scaffold that includes a polymer, reinforcement particles distributed throughout the polymer, and a substantially continuously interconnected plurality of pores that are distributed throughout the polymer, each of the pores in the plurality of pores defined by voids interconnected by struts, each pore void having a size within a range from about 10 to 500 nm. The porous reinforced composite scaffold has a scaffold volume that includes a material volume defined by the polymer and the reinforcement particles, and a pore volume defined by the plurality of pores. The reinforcement particles are both embedded within the polymer and exposed on the struts within the pore voids. The polymer may be a polyaryletherketone polymer and the reinforcement particles may be anisometric calcium phosphate particles.