Patents Examined by David J. Blanchard
  • Patent number: 10384045
    Abstract: A microprojection array comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a therapeutic macromolecule and a stabilizing excipient. Described herein are microstructures having a proximal and distal layer, wherein the distal layer which contains the therapeutic molecule does not rely on the presence of a structure-forming polymer to impart the mechanical strength necessary to penetrate the skin. Methods of forming the array, and methods of using the array are contemplated.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: August 20, 2019
    Assignee: Corium, Inc.
    Inventors: Zhongli Ding, Guohua Chen, Parminder Singh
  • Patent number: 10376457
    Abstract: The present invention teaches a hair straightening system including formulations that will safely and effectively straighten curly hair for at least 2-3 months after a single application, despite frequent washings of the hair. Methods for obtaining said formulations are disclosed. Hair straightening systems including shampoo and one or more conditioners are also provided.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: August 13, 2019
    Inventors: Marc Michael Baum, Janelle Marie Baum
  • Patent number: 10376448
    Abstract: The invention relates to a method for applying a cosmetic composition to hair. The method comprises the steps of removing a cosmetic composition from a sealed container, the composition comprising: a post-foaming emulsion comprising a weak acid, a weak base, a fatty acid, and a volatile buffering agent; a film forming agent; and an aqueous carrier; applying said composition to one or more eyelashes; and during or after said application to said one or more eyelashes, said cosmetic composition forms a foam, said foam resulting from the release of a gas, said gas being a reaction product of said post-foaming emulsion, and said reaction commencing after the evaporation of said volatile buffering agent, upon exposure of said cosmetic composition to atmospheric conditions.
    Type: Grant
    Filed: September 23, 2014
    Date of Patent: August 13, 2019
    Inventors: John R. Castro, Arlene G. Ting-Jenulis
  • Patent number: 10369248
    Abstract: Porous polymer composites and methods of preparing porous polymer composites are provided herein. In some embodiments, a method for preparing porous polymer composites may include mixing a first polymer with a solvent and a particulate filler to form a first polymer composition, wherein the amount of particulate filler in the first polymer composition is below a mechanical percolation threshold; and removing the solvent from the first polymer composition to concentrate the first polymer and particulate filler into a second polymer composition having a porous structure, wherein the particulate filler concentration in the second polymer composition is increased above the mechanical percolation threshold during solvent removal.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: August 6, 2019
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Randy A. Mrozek, Joseph L. Lenhart, Michael C. Berg, Eric J. Robinette
  • Patent number: 10369099
    Abstract: The present invention recognizes that medical devices, such as but not limited to contact lenses, can be made having a coating made at least in part using printing technologies to provide drug storage and drug release structures. The coating preferably includes at least one drug reservoir layer and a least one barrier layer, and can include structures, such as but not limited to capillary structures, which alone or in combination modulate the release of the drug from the coating. One aspect of the present invention is a medical device that incorporates a drug in at least one coating. A second aspect of the present invention is a method of making a medical device that incorporates a drug in at least one coating. A third aspect of the present invention is a method of using a medical device of the present invention to treat or prevent a disease, disorder or condition.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: August 6, 2019
    Inventor: Praful Doshi
  • Patent number: 10351451
    Abstract: An object of the present invention is to provide an ozone water having enhanced storage stability and a method for producing the ozone water. An ozone water of the present invention as a means for resolution is produced by dissolving 0.1 ?M to 1 mM of an organic iron compound and 1 to 300 mM of an inorganic salt in a water with ozone-microbubbles generated using an ozone gas at a concentration of 1 to 300 g/Nm3. The half-life of ozone of the ozone water of the present invention is 3 days or longer, for example, when the water filled in an airtight container under atmospheric pressure is stored under a temperature condition of 40° C.
    Type: Grant
    Filed: August 1, 2015
    Date of Patent: July 16, 2019
    Inventor: Masayoshi Takahashi
  • Patent number: 10342825
    Abstract: The present invention relates to low pH antimicrobial solutions comprising hypochlorous acid, water, and, optionally, a buffer. The inventive low pH antimicrobial solutions have a pH from about 4 to about 6 and are useful for treating impaired or damaged tissue and for disinfecting surfaces. Chemical processes for the production of the low pH antimicrobial solutions are also provided wherein chlorine gas is added to a buffer solution containing a buffering agent and water. The present invention also provides an electrochemical process for the production of the low pH antimicrobial solutions.
    Type: Grant
    Filed: June 15, 2010
    Date of Patent: July 9, 2019
    Assignee: Sonoma Pharmaceuticals, Inc.
    Inventor: Robert Northey
  • Patent number: 10342893
    Abstract: Compositions of, methods of making, and methods of using alkaline earth phosphate bone cements are disclosed. A bone cement composition includes a powder comprising a basic source of calcium, magnesium, or strontium, a setting solution comprising H3PO4 and a buffer, and a biocompatible polymer that is incorporated into the setting solution. The powder is mixed with the setting solution to form a bone cement paste that either (a) sets into a hardened mass, or (b) is irradiated with electromagnetic radiation to form dry powders, the dry powders then being mixed with a second setting solution to form a radiation-assisted bone cement paste that sets into a hardened mass.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: July 9, 2019
    Assignee: The University of Toledo
    Inventors: Sarit B. Bhaduri, Huan Zhou, Anand K. Agarwal, Vijay K. Goel
  • Patent number: 10335516
    Abstract: Bioactive porous bone graft implants in various forms suitable for bone tissue regeneration and/or repair, as well as methods of use, are provided. The implants are formed of bioactive glass and have an engineered porosity. The implants may take the form of a putty, foam, fibrous cluster, fibrous matrix, granular matrix, or combinations thereof and allow for enhanced clinical results as well as ease of handling.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: July 2, 2019
    Assignee: PROSIDYAN, INC.
    Inventors: Charanpreet S. Bagga, Steve B. Jung, Hyun W. Bae
  • Patent number: 10314772
    Abstract: The present disclosure relates to new UV-filters, method of producing the same and their use in compositions in particular, cosmetic/pharmaceutical or textile compositions, namely sunscreens cream or sunscreens textile article, in particular the present disclosure relates to hydroxyapatite based-compound comprising Ca9FeH(PO4)7 and/or ?-Fe2O3 in hematite form for use in a method for protecting the skin against UV radiation.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: June 11, 2019
    Inventors: Maria Manuela Estevez Pintado, Paula Castro, Clara Piccirillo
  • Patent number: 10314790
    Abstract: Pharmaceutical compositions of topiramate for once-a-day oral administration are provided. The formulations comprise a sustained-release component and an optional immediate-release component, the compositions of which can be selectively adjusted, respectively, to release the active ingredient along a pre-determined release profile. Method of treating or preventing pathological disorders in mammalian subjects comprising the administration of the novel formulations disclosed herein is also provided.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: June 11, 2019
    Inventors: Likan Liang, Hua Wang, Padmanabh P. Bhatt, Michael L. Vieira
  • Patent number: 10307408
    Abstract: The invention provides contact lens and contact lens storage compositions and methods for the treatment of presbyopia. The contact lens and contact lens storage compositions preferably comprise aceclidine and a cryoprotectant. The compositions optionally contain a cycloplegic agent.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: June 4, 2019
    Inventors: Gerald Horn, Lee Nordan
  • Patent number: 10300039
    Abstract: Disclosed herein are ferric citrate-containing tablets. In various embodiments, the tablets include ferric citrate formulations that meet certain dissolution, tableting and disintegration standards. In various aspects, the tablet formulations can include ferric citrate as the active ingredient and a binder. The formulations also can include a lubricant and/or a disintegrant (which, in some embodiments, can be the same as the binder).
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: May 28, 2019
    Inventor: Henry Trong Le
  • Patent number: 10293085
    Abstract: The present invention relates to a method for coating catheter balloons with the pharmacological agent paclitaxel and the biological and biodegradable polymer composition shellac and optionally further components. Moreover the present invention relates to paclitaxel and shellac coated catheter balloons obtained according to the coating methods disclosed herein as well as the use of such coated catheter balloons for the short time release of the pharmaceutically active agent paclitaxel for prophylaxis and treatment of restenosis especially restenosis caused by angioplasty. The coated catheter balloons can be used alone or in combination with a coated or uncoated stent crimped on the catheter balloon before or after the coating with shellac and paclitaxel.
    Type: Grant
    Filed: April 26, 2010
    Date of Patent: May 21, 2019
    Inventor: Michael Orlowski
  • Patent number: 10292934
    Abstract: An object of the present application is to provide an orally-disintegrating tablet having excellent tablet hardness and disintegrability, and including a disintegrative particulate composition. This invention relates to a disintegrative particulate composition comprising the four components consisting of a first disintegrator component of an acid-type carboxymethylcellulose, a second disintegrator component other than the acid-type carboxymethylcellulose, an excipient of a sugar or sugar alcohol, and crystalline cellulose; and to an orally-disintegrating tablet, including the disintegrative particulate composition and a medicinal ingredient.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: May 21, 2019
    Inventors: Takahiro Hiramura, Kiyoshi Ikura, Sae Ishikawa, Tomohito Okabayashi, Naohiro Hashikawa, Tetsuro Morita, Kimiko Ikeda
  • Patent number: 10272108
    Abstract: An antimicrobial therapeutic hydrogel composition comprises a pharmaceutical and/or medical grade silver salt, and an Aloe vera gel or extract. The composition could also include stabilizing agents, a non-ionic surfactant, polyol, and hydrophilic hygroscopic polymers. The resulting product has potent antimicrobial activity against bacteria, protozoa, fungi and viruses. The antimicrobial therapeutic composition can serve as a treatment for burns and as a wound/lesion dressing that either donates or receives moisture to provide a physiologic environment for accelerated wound healing and the relief of pain.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: April 30, 2019
    Inventors: Kenneth M Yates, Celia A Proctor, Dan H Atchley
  • Patent number: 10272107
    Abstract: The present invention provides methods for treating an inflammatory brain disease and for treating a traumatic brain injury in a human having an inflammatory component applying transdermal pharmaceutical compositions comprising chromium, magnesium, and thiamine as active ingredient compounds that act as neuroprotective iron chelators and brain glucose-uptake enhancement that are suitable for the treatment of traumatic brain injury. The invention further relates to methods of delivering the pharmaceutical compositions that target the brain and/or central nervous system certain novel iron chelators of the type described in the specification.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: April 30, 2019
    Inventor: Kenneth O. Russell
  • Patent number: 10272131
    Abstract: A method of stabilizing linaclotide in a solid dosage form, said method comprising a) preparing a composition of linaclotide, acesulfame and pharmaceutically acceptable excipients and b) converting the composition into a solid dosage form.
    Type: Grant
    Filed: August 11, 2015
    Date of Patent: April 30, 2019
    Assignee: Sun Pharmaceutical Industries Ltd.
    Inventors: Rajamannar Thennati, Shirish Kulkarni, Sanjay Poptani, Vimal Kaneria, T. Nathamani
  • Patent number: 10272033
    Abstract: Biopharmaceuticals, such as vaccine agents and probiotics, are encapsulated in carbohydrate-glass particles and embedded in an amorphous polymer substrate to produce polymeric compositions containing ambient-temperature stable biopharmaceuticals for syringeless administration to patients such as via dissolvable films, micro-needle patches and similar medical delivery devices. The amorphous polymer substrate is soluble in both water and volatile organic solvents, yet the carbohydrate-glass particles are insoluble in organic solvents. A method for formulation of the polymeric compositions containing ambient-temperature stable biopharmaceuticals includes combining biopharmaceuticals encapsulated in carbohydrate-glass particles with polymer in organic solvent and evaporating the organic solvent to yield a water soluble polymeric composition containing ambient-temperature stable biopharmaceuticals.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: April 30, 2019
    Inventor: Victor Bronshtein
  • Patent number: 10272044
    Abstract: The apparatus and methods of the present invention are of use for the production of emulsion-based microparticles containing a biological or chemical agent. In particular, the apparatus provides a vessel; packing material situated inside such vessel and may further provide material capable of insertion into both ends of said vessel for enclosure of the packing material. In a particular embodiment, the apparatus is a packed bed apparatus. The methods include production of emulsion based microparticles containing a biological or chemical agent. The usefulness of the present invention is that the apparatus and methods of the present invention provide for a low-shear, non-turbulent, production of emulsion-based microparticles that provides a narrow, reproducible, particle size distribution, capable of use with both large and small volumes that is capable of being conveniently scaled up while providing predictable emulsion properties.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: April 30, 2019
    Assignee: Evonik Corporation
    Inventor: Ehud Zeigerson