Patents Examined by Dennis J Parad
  • Patent number: 10010505
    Abstract: New liposomes are described, comprising: (i) phosphatidic acid and/or cardiolipin; (ii) apolipoprotein E (ApoE) or derivatives thereof. The so modified liposomes, administered systemically, obtain a dramatic in-vivo reduction of the amyloid plaque in the central nervous system, allowing an effective treatment of neurodegenerative diseases, in particular Alzheimer's disease.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: July 3, 2018
    Inventors: Massimo Masserini, Francesca Re, Giulio Sancini, Gianluigi Forloni, Mario Salmona
  • Patent number: 9968552
    Abstract: Oral pharmaceutical dosage form comprising tromethamine and a NSAID selected from the group comprising ibuprofen, naproxen and flurbiprofen, characterized in that it also comprises a compound selected from the group comprising glycine, vitamin B6 and mixtures thereof.
    Type: Grant
    Filed: December 16, 2004
    Date of Patent: May 15, 2018
    Inventors: Leonardo Marchitto, Francesca Mariotti, Lorella Ragni
  • Patent number: 9949980
    Abstract: A method of inhibiting HPV virus infection is disclosed. In one embodiment, the method involves exposing a papillomavirus to an effective amount of a compound selected from the group consisting of Compound 13, Compound 14, and analogs of Compounds 13 and 14. In another embodiment, the method involves administering an inhibitor selected from the group consisting of Compound 13, Compound 14, and analogs of Compounds 13 and 14 to a susceptible tissue or cell.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: April 24, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Paul F. Lambert, Paul G. Ahlquist, Dohun Pyeon, Hao Shun Huang
  • Patent number: 9937159
    Abstract: Embodiments of the present invention provide a method for treatment of respiratory disorders such as asthma, chronic obstructive pulmonary disease, and chronic sinusitis, including cystic fibrosis, interstitial fibrosis, chronic bronchitis, emphysema, bronchopulmonary dysplasia and neoplasia. The method involves administration, preferably oral, nasal or pulmonary administration, of anti-inflammatory and anti-proliferative drugs (rapamycin or paclitaxel and their analogs) and an additive.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: April 10, 2018
    Assignee: Lutonix, Inc.
    Inventor: Lixiao Wang
  • Patent number: 9931348
    Abstract: A method for repairing an injury of cartilage in a patient by local administration of an organovanadium agent or use of an implantable device for delivery of an organovanadium agent. Implantable devices containing an organovanadium agent and methods of making these implantable devices are also disclosed.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: April 3, 2018
    Inventors: Sheldon S. Lin, David N. Paglia, James P. O'Connor, Aaron Wey, Joseph Benevenia, Virak Tan
  • Patent number: 9925396
    Abstract: The invention relates to adhesive articles containing at least one colorant and/or at least one active agent as well as to methods of using such articles on mucosis or keratin materials to achieve a desired result or benefit and to methods of making such adhesive articles.
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: March 27, 2018
    Assignee: L'OREAL
    Inventors: Guillaume Kergosien, William Meathrel
  • Patent number: 9913928
    Abstract: The present invention relates to a macroporous, resorbable and injectable apatitic calcium-phosphate cement with a high compressive strength useful as bone cement and releasing a bone resorption inhibitor, preparation method and uses thereof.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: March 13, 2018
    Inventors: Jean-Michel Bouler, Bruno Bujoli, Pascal Janvier, Ibrahim Khairoun, Jean-Noël Argenson
  • Patent number: 9895296
    Abstract: Provided is a cosmetic preparation superior in stability and feel. The cosmetic preparation contains an (a) organopolysiloxane emulsion in an amount of not smaller than 0.1% by mass. This organopolysiloxane emulsion is obtained through emulsion polymerization and contains octamethylcyclotetrasiloxane in an amount of not larger than 1,000 ppm by mass.
    Type: Grant
    Filed: November 28, 2013
    Date of Patent: February 20, 2018
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Yuji Ando, Shinji Irifune
  • Patent number: 9878041
    Abstract: A tissue adhesive including cyanoacrylate and polyethylene glycol (PEG), wherein the PEG remains a polyether and wherein the tissue adhesive is bioabsorbable. A tissue adhesive including cyanoacrylate bulk monomer and cyanoacrylate nanoparticles containing a therapeutic therein. A kit for applying tissue adhesive, including the tissue adhesive described above and an applicator. Methods of accelerating degradation of a cyanoacrylate tissue adhesive applying a tissue adhesive, closing an internal wound, administering a therapeutic to tissue, treating cancer, and preventing infection in a wound. Methods of method of making a bioabsorbable tissue adhesive and making a therapeutic tissue adhesive.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: January 30, 2018
    Assignee: Adhezion Biomedical, LLC
    Inventors: Jeoung Soo Lee, Charles Kenneth Webb, Robert Zimmerman, Rafael Ruiz, Sr., Sheng Zhang
  • Patent number: 9872935
    Abstract: The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: January 23, 2018
    Assignee: Covidien LP
    Inventors: Steven Bennett, Nathaniel Mast, Kevin Lavigne, Walter Skalla
  • Patent number: 9855372
    Abstract: Implants for tissue repair/regeneration include a porous layer combined with dry materials that are activated to form a hydrogel upon contact with aqueous physiological fluids.
    Type: Grant
    Filed: October 16, 2009
    Date of Patent: January 2, 2018
    Inventor: Sébastien Ladet
  • Patent number: 9832994
    Abstract: An antibacterial composition comprising thymol and totarol. This combination provides synergistic effect against gram negative and gram positive bacteria.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: December 5, 2017
    Inventors: Regina Hourigan, Rehana Gafur, Jairajh Mattai, James Masters, Laurence Du-Thumm, Shira Pilch
  • Patent number: 9814252
    Abstract: Disclosed herein are polar lipid mixtures, comprising glycerophospholipids such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidyl-inositol (PI), and sphingolipids such as sphyngomyelin (SM). Most importantly, the ratio of phospholipids in said mixture is comparable to that of HMF, and is represented by SM>PC>PE>PS>PI or SM=PC>PE>PS>PI. Processes for the preparation of said mixtures and uses thereof are also described herein.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: November 14, 2017
    Assignee: ENZYMOTEC LTD.
    Inventors: Avidor Shulman, Rassan Zuabi, Gai Ben Dror, Yoni Twito, Dori Pelled, Yael Herzog
  • Patent number: 9795582
    Abstract: A combination of N-acetyl-L-cysteine, selenium in the form of selenomethionine and melatonin, and a medical product or pharmaceutical composition comprising such combination, useful for the treatment of a variety of diseases and conditions is described. The combination of N-acetyl-L-cysteine, selenium in the form of selenomethionine and melatonin is also useful for cosmetic treatment of skin and as an antibacterial agent.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: October 24, 2017
    Assignee: IASOMAI AB
    Inventors: Tiziana Parasassi, Graziella Costa, Ewa Krasnowska, Eugenia Pittaluga
  • Patent number: 9789060
    Abstract: The present disclosure relates to a carrier for oromucosal, especially sublingual administration of physiologically active substances, especially of medicinal drugs, which consists of at least one elastic layer (1) of polymer nanofibers workable according to the shape of the selected wall of mouth cavity to which it should be applied and in this elastic layer (1) of polymer nanofibers a drug and/or other physiologically active substance are deposited in a releasable manner.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: October 17, 2017
    Inventors: Denisa Stranska, Adela Klabanova, Pavel Dolezal, Petr Vrbata, Pavel Berka, Marie Musilova
  • Patent number: 9789195
    Abstract: Methods for efficient preparation of drug-polymer (or oligomer) conjugates useful in the preparation of particles, including microparticles and nanoparticles, for delivery of the drug in vivo for therapeutic applications are provided. The invention also provides nanoparticles prepared by nanoprecipitation using drug-polymer/oligomer conjugates of the invention. The drug conjugates are formed during polymerization of the polymer or oligomer in which the drug is employed as an initiator of the polymerization of the monomers which form the polymer and/or oligomer. More specifically, the drug conjugates are formed by ring-opening polymerization of cyclic monomers in the presence of an appropriate ring-opening polymerization catalyst and the initiator (the drug). The method is particularly useful for formation of polymer/oligomer conjugates with drugs and other chemical species containing one or more hydroxyl groups or thiol groups.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: October 17, 2017
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Jianjun Cheng, Rong Tong
  • Patent number: 9782512
    Abstract: The invention relates to a wound dressing which is particularly suitable for therapeutically dressing wounds. Said wound dressing consists of a multi-layered structure comprising at least one layer containing at least one hydrocolloid, preferably collagen, (“hydrocolloid layer” or “collagen layer”) and at least one layer containing an activated carbon (“activated carbon layer”).
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: October 10, 2017
    Assignee: Blücher GmbH
    Inventors: Hasso von Blücher, Raik Schönfeld, Frank Pallaske
  • Patent number: 9775882
    Abstract: Medical devices and methods including polymers having biologically active agents therein are disclosed. The medical devices can be useful as implantable devices such as orthopedic implants.
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: October 3, 2017
    Assignee: Medtronic, Inc.
    Inventors: Phillip Edward McDonald, Christopher M. Hobot
  • Patent number: 9757483
    Abstract: A diagnostic formulation is provided comprising a tropane having a radioactive concentration of at least 1.6 mCi/mL at least about 51 hours post creation. The diagnostic formulation optionally comprises a radiolabeled dopamine transporter (DAT) ligand useful in the diagnosis of Parkinson's disease (PS). One example of a radiolabeled dopamine transporter (DAT) ligand example is [123I]-2?-carbomethoxy-3?-(4-flurophenyl)-N-(3-iodo-E-allyl) nortropane.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: September 12, 2017
    Assignee: Alseres Pharmaceuticals, Inc.
    Inventors: Chris Sterzinger, Cara Ferreira, David Leyh, Richard Thorn
  • Patent number: 9750843
    Abstract: The present invention relates to a haemostatic material comprising a carrier layer and a material for wound contact comprising at least one haemostat in particulate, granular, powder, flake or short fibrous form. Such a haemostatic material is useful, for example, in reducing or stopping bleeding of a physiological target site in a person or animal, and can also be used to stem bleeding during medical procedures.
    Type: Grant
    Filed: April 27, 2009
    Date of Patent: September 5, 2017
    Inventors: Craig Hardy, Andrew Darby, Guy Eason