Patents Examined by Dennis J Parad
  • Drug delivery formulation for controlling of initial burst and manufacturing method thereof
    Patent number: 10307373
    Abstract: Provided is a drug delivery system for control of initial burst of a drug. More particularly, there are provided a drug delivery formulation including: a granule containing a biodegradable polymer and a drug; and a temperature-sensitive hydrogel, and a method for preparing the same. The presently disclosed drug delivery formulation can be prepared via a relatively simple process and allows a drug to be released slowly at a constant rate without initial burst and thus maintains a constant blood level of the drug for a long period of time. Consequently, it is capable of preventing the initial burst of the existing injection-type drug delivery formulations and slow-release granules and providing a desired release profile, including sustained release with time.
    Type: Grant
    Filed: February 8, 2011
    Date of Patent: June 4, 2019
    Assignee: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Moon Suk Kim, Da Yeon Kim
  • Combination comprising N-acetyl-L-cysteine and its use
    Patent number: 10300038
    Abstract: A combination of N-acetyl-L-cysteine, selenium in the form of selenomethionine and melatonin, and a medical product or pharmaceutical composition comprising such combination, useful for the treatment of a variety of diseases and conditions is described. The combination of N-acetyl-L-cysteine, selenium in the form of selenomethionine and melatonin is also useful for cosmetic treatment of skin and as an antibacterial agent.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: May 28, 2019
    Assignee: IASOMAI AB
    Inventors: Tiziana Parasassi, Graziella Costa, Ewa Krasnowska, Eugenia Pittaluga
  • Vaginal inserted estradiol pharmaceutical compositions and methods
    Patent number: 10258630
    Abstract: In one aspect, compositions and methods for the treatment of vulvovaginal atrophy (VVA) are provided. In one embodiment, the method comprises administering an estrogen to a subject having VVA by inserting a dosage form comprising a liquid pharmaceutical composition.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: April 16, 2019
    Assignee: TherapeuticsMD, Inc.
    Inventors: Sebastian Mirkin, Julia M. Amadio, Brian A. Bernick
  • Granular composition for oral administration
    Patent number: 10245284
    Abstract: The present invention relates to a granular composition for oral suspension characterized by the presence of an insoluble resin and a silica gel.
    Type: Grant
    Filed: August 19, 2015
    Date of Patent: April 2, 2019
    Assignee: ALPEX PHARMA S.A.
    Inventors: Federico Stroppolo, Gabriele Granata
  • Antimicrobial and antiviral polymeric materials
    Patent number: 10238117
    Abstract: The present invention relates to an antimicrobial and antiviral polymeric drawn fiber and polymeric fiber-based materials comprising same, wherein the drawn fiber is a polymer fiber containing cuprous oxide particles dispersed therein, with particle size ranges from about 0.25 to about 0.65 micron. The invention also relates to processes for preparing the same.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: March 26, 2019
    Assignee: CUPRON, INC.
    Inventor: Vikram Kanmukhla
  • Guided bone regeneration membrane and manufacturing method thereof
    Patent number: 10159737
    Abstract: A guided bone regeneration material is disclosed. The guided bone regeneration material includes biodegradable fibers produced by an electrospinning method. The biodegradable fibers produced by the method include a silicon-releasing calcium carbonate and a biodegradable polymer. The silicon-releasing calcium carbonate is a composite of siloxane and calcium carbonate of vaterite phase. The biodegradable fibers may be coated with apatite. When the guided bone regeneration material is immersed in a neutral aqueous solution, silicon species ions are eluted from the calcium carbonate. The guided bone regeneration material excels in bone reconstruction ability.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: December 25, 2018
    Assignees: NATIONAL UNIVERSITY CORPORATION NAGOYA INSTITUTE OF TECHNOLOGY, YABASHI INDUSTRIES CO., LTD., YAMAHACHI DENTAL MFG., CO., ORTHOREBIRTH CO., LTD.
    Inventors: Toshihiro Kasuga, Yoshio Ota, Takashi Wakita
  • Method of killing bedbug eggs
    Patent number: 10143199
    Abstract: The present invention relates to a method of pre-rinsing laundry and treating other surfaces employing a composition that can kill bedbug eggs. The composition includes an anionic compound and is at pH just above neutral, e.g., about 7 to about 9.
    Type: Grant
    Filed: November 20, 2012
    Date of Patent: December 4, 2018
    Assignee: Ecolab USA Inc.
    Inventors: Kim R. Smith, Erik Olson, Yvonne Killeen, Victor Man, Joelle Olson, Erin Loosbrock
  • Device and method for sustained release of antipsychotic medications
    Patent number: 10137081
    Abstract: A drug delivery device comprising a non-erodible, non-porous housing member defining a reservoir is provided. The reservoir is loaded with a dry formulation of a selected salt of a neuroleptic agent. The housing member has one or more porous partitions, where the pores of the partitions are sufficiently small to retain the insoluble powder particles within the reservoir yet large enough to allow diffusion of the active agent once the device is hydrated. A therapeutic dose of the drug is released from the device at a constant rate over a period of approximately 2-6 months.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: November 27, 2018
    Assignee: Delpor, Inc.
    Inventor: Gregory Alan Watkins
  • Systems and methods for improved delivery of osteoinductive molecules in bone repair
    Patent number: 10130678
    Abstract: Systems and methods for preparing synthetic osteoinductive bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.
    Type: Grant
    Filed: December 29, 2015
    Date of Patent: November 20, 2018
    Assignee: Bioventus, LLC.
    Inventors: Eric Vanderploeg, Howard Seeherman, Christopher G. Wilson, John Wozney, Christopher T. Brown, John A. Kambouris
  • Guided bone regeneration membrane and manufacturing method thereof
    Patent number: 10092650
    Abstract: A guided bone regeneration material is disclosed. The guided bone regeneration material includes biodegradable fibers produced by an electrospinning method. The biodegradable fibers produced by the method include a silicon-releasing calcium carbonate and a biodegradable polymer. The silicon-releasing calcium carbonate is a composite of siloxane and calcium carbonate of vaterite phase. The biodegradable fibers may be coated with apatite. When the guided bone regeneration material is immersed in a neutral aqueous solution, silicon species ions are eluted from the calcium carbonate. The guided bone regeneration material excels in bone reconstruction ability.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: October 9, 2018
    Assignees: National University Corporation, Nagoya Institute of Technology, Yabashi Industries Co., LTD, Yamahachi Dental Mfg., Co, Orthorebirth Co. Ltd.
    Inventors: Toshihiro Kasuga, Yoshio Ota, Takashi Wakita
  • Nucleation of drug delivery balloons to provide improved crystal size and density
    Patent number: 10080821
    Abstract: Drug delivery balloons have densely packed crystals of small particle size of the drug thereon. An amorphous drug coating is applied to a balloon surface and annealed to provide the crystals. The balloon surface is nucleated to induce formation of drug crystals in the annealing step to provide the crystals in high density with small size.
    Type: Grant
    Filed: June 14, 2010
    Date of Patent: September 25, 2018
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Steve Kangas, Michael Sean Owens, Jon Patterson, Dave Ekberg, Erik Haun, Eric Henderson, Aaron Foss, Yen-Lane Chen
  • Electrospun dextran fibers and devices formed therefrom
    Patent number: 10046081
    Abstract: The invention generally relates to dextran fibers which are preferably electrospun and devices formed from such fibers. In particular, such devices may include substances of interest (such as therapeutic substances) associated with the electrospun fibers. Upon exposure to a liquid the electrospun fibers dissolve immediately and the substances of interest are released into the liquid. Exemplary devices include bandages formed from electrospun dextran fibers and associated agents that promote hemostasis, such as thrombin and fibrinogen.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: August 14, 2018
    Assignees: The Henry M Jackson Foundation for the Advancement of Military Medicine, Inc., Virginia Commonwealth University
    Inventors: Gary Bowlin, David Simpson, James Bowman, Stephen Rothwell
  • Onychomycosis treatment apparatus and method
    Patent number: 10039782
    Abstract: A system and method includes delivery of a redox gas solution to treat onychomycosis, wherein the redox gas solution comprises a reactive species dissolved in a perfluorocarbon liquid, and wherein the reactive species may include, alone or in combination, one or more of reactive oxygen, reactive nitrogen, reactive chlorine, or reactive bromine species, and the perfluorocarbon liquid may include perfluorodecalin.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: August 7, 2018
    Assignee: DeviceFarm, Inc.
    Inventors: Jeffrey N Roe, Timothy C Grammer, Michael P O'Neil
  • Polymer hydrogels for in vivo applications and methods for using and preparing same
    Patent number: 10039831
    Abstract: Compositions and methods are described for a polymer hydrogel created by a cycloaddition reaction between an azide and an alkyne that proceeds rapidly without catalyst to produce the polymer hydrogel in less than ninety seconds. The polymer hydrogel can be used in in vivo applications for the localized delivery of therapeutic agent in aqueous solutions. An example of therapeutic delivery of a protein in a mouse model is demonstrated.
    Type: Grant
    Filed: March 19, 2012
    Date of Patent: August 7, 2018
    Assignees: Georgia Tech Research Corporation, Children's Healthcare of Atlanta, Inc.
    Inventors: Niren Murthy, Christopher Hermann, David Scott Wilson, Xinghai Ning, Barbara D. Boyan, Zvi Schwartz, Robert Guldberg, Tamim Diab
  • Onychomycosis treatment system and method
    Patent number: 10039723
    Abstract: A system and method includes delivery of a redox gas solution to treat onychomycosis, wherein the redox gas solution comprises a reactive species dissolved in a perfluorocarbon liquid, and wherein the reactive species may include, alone or in combination, one or more of reactive oxygen, reactive nitrogen, reactive chlorine, or reactive bromine species, and the perfluorocarbon liquid may include perfluorodecalin.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: August 7, 2018
    Assignee: DeviceFarm, Inc.
    Inventors: Jeffrey N Roe, Timothy C Grammer, Raul Ignacio Barrera-Barraza, Eric Tridas
  • Liposomes active in-vivo on neurodegenerative diseases
    Patent number: 10010505
    Abstract: New liposomes are described, comprising: (i) phosphatidic acid and/or cardiolipin; (ii) apolipoprotein E (ApoE) or derivatives thereof. The so modified liposomes, administered systemically, obtain a dramatic in-vivo reduction of the amyloid plaque in the central nervous system, allowing an effective treatment of neurodegenerative diseases, in particular Alzheimer's disease.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: July 3, 2018
    Assignee: UNIVERSITA DEGLI STUDI DI MILANO-BICOCCA
    Inventors: Massimo Masserini, Francesca Re, Giulio Sancini, Gianluigi Forloni, Mario Salmona
  • Pharmaceutical oral dosage form comprising a non-steroidal anti-inflammatory drug, and having good palatability
    Patent number: 9968552
    Abstract: Oral pharmaceutical dosage form comprising tromethamine and a NSAID selected from the group comprising ibuprofen, naproxen and flurbiprofen, characterized in that it also comprises a compound selected from the group comprising glycine, vitamin B6 and mixtures thereof.
    Type: Grant
    Filed: December 16, 2004
    Date of Patent: May 15, 2018
    Assignee: AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F.S.p.A.
    Inventors: Leonardo Marchitto, Francesca Mariotti, Lorella Ragni
  • Drugs to prevent HPV infection
    Patent number: 9949980
    Abstract: A method of inhibiting HPV virus infection is disclosed. In one embodiment, the method involves exposing a papillomavirus to an effective amount of a compound selected from the group consisting of Compound 13, Compound 14, and analogs of Compounds 13 and 14. In another embodiment, the method involves administering an inhibitor selected from the group consisting of Compound 13, Compound 14, and analogs of Compounds 13 and 14 to a susceptible tissue or cell.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: April 24, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Paul F. Lambert, Paul G. Ahlquist, Dohun Pyeon, Hao Shun Huang
  • Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
    Patent number: 9937159
    Abstract: Embodiments of the present invention provide a method for treatment of respiratory disorders such as asthma, chronic obstructive pulmonary disease, and chronic sinusitis, including cystic fibrosis, interstitial fibrosis, chronic bronchitis, emphysema, bronchopulmonary dysplasia and neoplasia. The method involves administration, preferably oral, nasal or pulmonary administration, of anti-inflammatory and anti-proliferative drugs (rapamycin or paclitaxel and their analogs) and an additive.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: April 10, 2018
    Assignee: Lutonix, Inc.
    Inventor: Lixiao Wang
  • Vanadium compounds as therapeutic adjuncts for cartilage injury and repair
    Patent number: 9931348
    Abstract: A method for repairing an injury of cartilage in a patient by local administration of an organovanadium agent or use of an implantable device for delivery of an organovanadium agent. Implantable devices containing an organovanadium agent and methods of making these implantable devices are also disclosed.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: April 3, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Sheldon S. Lin, David N. Paglia, James P. O'Connor, Aaron Wey, Joseph Benevenia, Virak Tan