Patents Examined by Diana G. Rivers
-
Patent number: 4918192Abstract: The present invention relates to novel acridinium esters which are useful as luminescent labels in specific binding assays such as immunoassays or nucleic acid hybridization assays. More particularly, polysubstituted aryl acridinium esters are highly stable labels for use in a chemiluminescent immunoassay.Type: GrantFiled: December 14, 1987Date of Patent: April 17, 1990Assignee: Ciba Corning Diagnostics Corp.Inventors: Say-Jong Law, Steve C. S. Chang, Stephen A. Palmacci, Roger S. Cubicciotti
-
Patent number: 4916224Abstract: Antiviral and antitumor compounds are disclosed of general formula: ##STR1## wherein Z is H, OH or NH.sub.2, Y is CH or N, the bond indicated by C.sub.1 '--C.sub.2 ' is absent or, in combination with the C.sub.1 '--C.sub.2 ' bond is the unit CH.dbd.CH, and X is selected from the group consisting of H, N(R.sub.2), SR, OR or halogen, wherein R is H, lower (C.sub.1 -C.sub.4)alkyl, aryl or mixtures thereof, and the pharmaceutically acceptable salts thereof.Type: GrantFiled: January 20, 1988Date of Patent: April 10, 1990Assignee: Regents of the University of MinnesotaInventors: Robert Vince, Mei Hua
-
Patent number: 4916225Abstract: Novel compounds, 9-substituted guanines, with the following general formula ##STR1## where R' is acetyl;R" is 2-tetrahydrofuryl or 2-tetrahydropyranyl.The proposed compounds have antiviral activity.Type: GrantFiled: July 14, 1988Date of Patent: April 10, 1990Assignees: Institut Organicheskogo Sinteza Akademii nauk Latviiskoi SSR, Belorussky Nauchno-Issledovatelsky Institute Epidemiologii i MikrobiologiiInventors: Regina A. Zhuk, Marger J. Lidak, Marina A. Madre, Veniamin I. Votyakov, Olga T. Andreeva, Evgeny I. Boreko, Ljudmila V. Korobchenko, Vyacheslav A. Rusyaev, Olga I. Starkova
-
Patent number: 4914106Abstract: A compound represented by the following formula ##STR1## wherein A represents a hydrogen atom or a lower alkanoyl group, Z represents an oxygen atom or the group ##STR2## in which R represents a hydrogen atom or a lower alkyl group, and X represents a halogen atom, the compound being useful for controlling androgen-dependent diseases, particularly for preventing abortion or for contraception.Type: GrantFiled: August 4, 1988Date of Patent: April 3, 1990Assignee: Teikoku Hormone Mfg. Co., Ltd.Inventors: Kenyu Shibata, Nobuaki Yamakoshi, Naoyuki Koizumi, Shigehiro Takegawa, Eiichiro Shimazawa, Mamoru Mieda
-
Patent number: 4912216Abstract: A perfluoro-(N-vinylamine) compound containing a >NCF.dbd.CF.sub.2 group is produced from a perfluoro-compound containing a group of the general formula: ##STR1## (wherein X stands for a fluorine atom or a --OM group having an alkali or alkaline earth metal ion for M) and having connected to the group of the general formula a perfluoro-alkyl group having a total of 2 to 6 carbon atoms contained in the main carbon chain thereof by heating the perfluoro-compound at a temperature in the range of 100.degree. C. to 500.degree. C. thereby effecting conversion of the group of the foregoing general formula into the aforementioned >NCF.dbd.CF.sub.2 group.Type: GrantFiled: July 10, 1987Date of Patent: March 27, 1990Assignees: Agency of Industrial Science & Technology, Ministry of International Trade & IndustryInventor: Takashi Abe
-
Patent number: 4912104Abstract: Novel tricyclic fused pyrimidine derivatives represented by the formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are independently C.sub.1-8 alkyl or C.sub.2-8 alkenyl;R.sup.3 is hydrogen, C.sub.1-3 alkyl, C.sub.2-3 alkenyl, C.sub.1-6 alkyl-CO-, optionally substituted benzoyl, C.sub.1-4 alkyl-O-CO-, carbamoyl or formyl; andA is C.sub.2-4 alkylene or C.sub.2-4 alkenylene which may be substituted with C.sub.1-3 alkyl, halogen, nitro, amino, oxo, or phenyl optionally substituted with 1 to 2 members selected from the class consisting of amino, nitro, hydroxy, methoxy and methyl, and a salt thereofare useful for antiinflammatory, analgesic, antipyretic, anti-allergic anti-psoriatic and liver-protecting agent.Type: GrantFiled: August 16, 1988Date of Patent: March 27, 1990Assignee: Takeda Chemical Industries, Ltd.Inventors: Takehiko Naka, Taketoshi Saijo, Hiroshi Satoh
-
Patent number: 4904811Abstract: A Z compound, substantially free of the E-isomers, of the formula ##STR1## in which Q represents Cl or OM,M represents hydrogen or an alkali metal atom,R represents optionally substituted cycloalkyl or the ##STR2## group, R.sup.1 represents hydrogen or alkyl, andX represents hydrogen, alkyl, alkenyl, alkinyl, cyano, optionally substituted cycloalkyl, optionally substituted aryl, or an optionally substituted heterocyclic ring which is optionally fused to a benzene ring.The compounds wherein Q is Cl are produced by reacting the compounds wherein Q is--OM with a chlorinating agent. The products are intermediates for fungicides.Type: GrantFiled: July 10, 1987Date of Patent: February 27, 1990Assignee: Bayer AktiengesellschaftInventor: Winfried Lunkenheimer
-
Patent number: 4904658Abstract: Substituted-6H,8H-pyrimido[1,2,3-cd]purine-8,10(9H)-diones and substituted-6H,10H-pyrimido[1,2-cd]purin-10-ones which are useful as cognition enhancing agents, anxiolytic agents and/or antihypertensive agents in the treatment of cognitive and relative neutral behavioral problems, anxiety and hypertension in mammals.Type: GrantFiled: April 15, 1988Date of Patent: February 27, 1990Assignee: American Cyanamid CompanyInventors: Shin S. Tseng, Joseph W. Epstein, Jeremy I. Levin
-
Patent number: 4904667Abstract: 1H-1,2,4-thiadiazolo[3,4-b]quinazolin-5-one-2,2-dioxides are disclosed. These compounds are useful as caridotonic agents. A preferred compound is 7-(n-cyclohexyl-N-methyl-4-amino-4-oxobutyloxy)-1H-1,2,4-thiadiazolo[3,4-b ]quinazolin-5-one-2,2-dioxide.Type: GrantFiled: February 24, 1989Date of Patent: February 27, 1990Assignee: Ortho Pharmaceutical CorporationInventors: James P. Demers, Richard B. Sulsky
-
Patent number: 4902798Abstract: An anthrapyridone compound of the following formula (I) and which is useful for coloring resins: ##STR1## wherein X.sup.1 is hydrogen, --NHCOR.sup.1, --CONR.sup.2 R.sup.3, --COR.sup.4, --SO.sub.2 R.sup.5 or --SO.sub.2 NR.sup.6 R.sup.7, in which R.sup.1 and R.sup.4 are each C.sub.1-4 alkyl, R.sup.2 and R.sup.3 are each hydrogen or C.sub.1-4 alkyl, R.sup.5 is C.sub.1-4 alkyl or hydroxyethyl, R.sup.6 and R.sup.7 are each hydrogen or C.sub.1-4 alkyl, X.sup.2 is hydrogen or imidomethyl of the formula (II): ##STR2## wherein n is a number of 1 to 2, X.sup.4 is hydrogen or carboxylic acid C.sub.1-4 alkyl-ester, X.sup.3 is hydrogen, halogen, hydroxyl, C.sub.1-4 alkyl or C.sub.1-4 alkoxyl, with the proviso that X.sup.1 is --NHCOR.sup.1, --CONR.sup.2 R.sup.3, --COR.sup.4, --SO.sub.2 R.sup.5 or --SO.sub.2 NR.sup.6 R.sup.7 when X.sup.2 is hydrogen, X.sup.2 is the imidomethyl of the formula (II) when X.sup.1 is the hydrogen, is provided, which is prepared by allowing the .alpha.Type: GrantFiled: November 30, 1987Date of Patent: February 20, 1990Assignees: Sumitomo Chemical Co., Ltd., Daiei Chemical Co., Ltd.Inventors: Toshio Nakamatsu, Yoshitugu Egashira, Yasuyuki Suzuki
-
Patent number: 4900737Abstract: Compounds of formula (I) ##STR1## (wherein R.sup.1 is a hydrogen atom or a methyl group;R.sup.2 is a hydrogen atom or a hydroxyl, C.sub.1-4 alkoxy or C.sub.2-4 alkanoyloxy group;R.sup.3 is a hydrogen atom, or (when R.sup.2 is other than a hydrogen atom) optionally a hydroxyl, C.sub.1-4 alkoxy or C.sub.2-4 alkanoyloxy group, or R.sup.2 and R.sup.3 together are a methylenedioxy group;R.sup.4 is a hydrogen or halogen atom or a methyl group;R.sup.5 and R.sup.6 is each a hydrogen atom or a group --OCOCH.sub.2 NR.sup.7 R.sup.8 [where R.sup.7 and R.sup.8, which may be the same or different, each is a hydrogen atom or a C.sub.3-7 cycloalkyl group or a straight or branched C.sub.1-4 alkyl group optionally substituted by a hydroxyl group, or --NR.sup.7 R.sup.8 forms a saturated heterocyclic amino group which has 5-7 ring members and optionally contains in the ring an oxygen or sulphur atom or a group --NH-- or --N(R) where R is a C.sub.Type: GrantFiled: September 28, 1988Date of Patent: February 13, 1990Assignee: Glaxo Group LimitedInventors: Gordon H. Phillipps, Esme J. Bailey, Michael G. Lester
-
Patent number: 4898942Abstract: An improved process for the production of Diazinon substantially free of toxic by-products in high yield and very high purity which involves mixing 2-isopropyl-4-methyl-6-hydroxypyrimidine with solid sodium or potassium hydroxide in a ketone or ether solvent at a temperature of about 50.degree.-60.degree. C. until a homogeneous mixture is formed, adding diethylthiophosphoryl chloride to the homogeneous mixture, keeping the mixture at a temperature of 55.degree.-80.degree. C. until the reaction is complete, and separating the Diazinon formed.Type: GrantFiled: August 30, 1988Date of Patent: February 6, 1990Assignee: Makhteshim Chemical Works, Ltd.Inventors: David Ovadia, Ernestine Mandler
-
Patent number: 4898943Abstract: Novel tricyclic triazolopyrimidine compounds represented by formula (I) shown in the specification and physiologically acceptable salts thereof are disclosed. These compounds have an excellent anti-allergic activity and are useful for treatment and prophylaxis of allergic diseases.Type: GrantFiled: February 8, 1988Date of Patent: February 6, 1990Assignee: Daiichi Seiyaku Co., Ltd.Inventors: Sumiro Isoda, Shunzo Aibara, Tamotsu Miwa, Hiroyuki Fujiwara, Shuichi Yokohama, Hiroo Matsumoto
-
Patent number: 4898941Abstract: A process for preparing a diphenylalkene derivative of the formula [II] ##STR1## which comprises oxidizing a diphenylalkanoic acid derivative of the formula [I] ##STR2## wherein R.sub.1 and R.sub.2 are each substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl or substituted or unsubstituted aryl, R.sub.1 and R.sub.2 may form a heteroring together theirwith or with an adjacent benzene ring, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10 and R.sub.11 are each hydrogen atom, halogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted hydroxyl or substituted or unsubstituted amino, R.sub.12 and R.sub.13 are each hydrogen atom or substituted or unsubstituted alkyl, X is carboxyl, amide, ester or halide thereof.Type: GrantFiled: August 11, 1987Date of Patent: February 6, 1990Assignee: Kanzaki Paper Manufacturing Co., Ltd.Inventors: Nobuo Kanda, Haruo Omura, Yukihiro Abe, Mitsuru Kondo
-
Patent number: 4897479Abstract: Compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof are disclosed. In these compounds, R.sup.1 is halogen, --SR.sup.4 wherein R.sup.4 is H or alkyl of 1 to 4 carbon atoms, --OCH.sub.3, --OSO.sub.2 Ar wherein Ar is phenyl or alkyl substituted phenyl wherein the alkyl group has 1 to 6 carbon atoms, --NR.sup.4 R.sup.5 wherein R.sup.4 is as defined above and R.sup.5 is H, alkyl of 1 to 4 carbon atoms, amino, alkanoyl of 1 to 8 carbon atoms, benzoyl, methoxy or hydroxy or R.sup.1 is --N(CH.sub.3).sub.3.sup.+ X.sup.-whereinX is halogen or --OSO.sub.2 Ar wherein Ar is phenyl or alkyl substituted phenyl wherein the alkyl group has 1 to 6 carbon atoms;R.sup.2 is H, alkanoyl of 1 to 8 carbon atoms or benzoyl;R.sup.3 is A or B whereinA is ##STR2## and B is ##STR3## wherein R.sup.6 and R.sup.7 are independently selected from H and ##STR4## wherein R.sup.8 and R.sup.9 are independently selected from pharmaceutically acceptable cations and H, or R.sup.6 and R.sup.Type: GrantFiled: February 29, 1988Date of Patent: January 30, 1990Assignee: Merck & Co., Inc.Inventors: Richard L. Tolman, Wallace Ashton, Malcolm Maccoss
-
Patent number: 4897477Abstract: A new process for the stereospecific synthesis of alkaloids of the vinblastine and vincristine type including the synthesis of vinblastine and vincristine as well novel alkaloids which are active as anti-tumor agents.Type: GrantFiled: January 26, 1988Date of Patent: January 30, 1990Assignee: University of Vermont & State Agricultural CollegeInventor: Martin Kuehne
-
Patent number: 4897400Abstract: There are disclosed compounds having the formula ##STR1## wherein R is hydrogen, loweralkyl or loweralkylcarbonyl; R.sub.1 is hydrogen, loweralkyl, loweralkylcarbonyl, aryl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralkyl, oxygen-bridged arylloweralkyl or oxygen-bridged diarylloweralkyl; R.sub.2 and R.sub.3 are independently H or CH.sub.3 ; X is hydrogen, loweralkyl, cycloalkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, formyl, loweralkylcarbonyl, arylcarbonyl, --SH, loweralkylthio, --NHCOR.sub.4 or --NR.sub.5 R.sup.6 where R.sup.4 is hydrogen or loweralkyl, and R.sub.5 and R.sub.6 are independently hydrogen, loweralkyl or cycloalkyl; Y and Z are independently a direct bond, CR.sub.7 R.sub.8 or CR.sub.7 R.sub.8 -CR.sub.9 R.sub.10 ; and P and Q are independently CR.sub.7 'R.sub.8 ', CR.sub.7 'R.sub.8 '-CR.sub.9 'R.sub.10 ' or CR.sub.7 'R.sub.8 '-CR.sub.9 'R.sub.10 '--CR.sub.11 R.sub.12, where each of R.sub.7 through R.sub.12 and R.sub.7 ' through R.sub.10 ' is independently H or CH.Type: GrantFiled: February 13, 1987Date of Patent: January 30, 1990Assignee: Hoeschst-Roussel Pharmaceuticals, Inc.Inventor: Gregory M. Shutske
-
Patent number: 4895854Abstract: This invention relates to antitumor alkaloid compositions, a process of producing the compositions and a method for inhibiting tumors utilizing the compositions. More particularly, the compositions are antitumor alkaloids which are derived from marine organisms, i.e., the marine sponge genus Haliclona.Type: GrantFiled: August 5, 1988Date of Patent: January 23, 1990Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Tatsuo Higa, Ryuichi Sakai
-
Patent number: 4895853Abstract: This invention relates to antitumor alkaloid compositions, a process of producing the compositions and a method for inhibiting tumors utilizing the compositions. More particularly, the compositions are antitumor alkaloids which are derived from marine organisms, i.e., the marine sponge Amphimedon sp.Type: GrantFiled: December 18, 1986Date of Patent: January 23, 1990Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Tatsuo Higa, Ryuichi Sakai, Shigeo Kohmoto, May S. Lui
-
Patent number: 4895852Abstract: This invention relates to antitumor alkaloid compositions, a process of producing the compositions and a method for inhibiting tumors utilizing the compositions. More particularly, the compositions are antitumor alkaloids which are derived from marine organisms, i.e., the marine sponge Xestospongia, sp.Type: GrantFiled: November 24, 1987Date of Patent: January 23, 1990Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Tatsuo Higa, Ryuichi Sakai, Toshio Ichiba