Patents Examined by Douglas F White
  • Patent number: 10792316
    Abstract: The invention relates to a dry compositions for lactic acid bacteria and in particular to a dry composition comprising from 109 to 1013 cfu/g of the composition of lactic acid bacteria cells, wherein the composition is characterized by that it also comprises following amounts of protective agents (all amounts of protective agents below are given relative to 1 g of lactic acid bacteria cells in the composition): from 6 to 9 g of trehalose, from 0.1 to 1 g of inulin and from 0.5 to 3 g of hydrolyzed casein, and by that it does not comprise a salt of alginic acid. The composition has an improved storage stability of the cell of interest. Comparison experiments have been made between compositions with and without alginate and it has been found that there is substantially no difference between compositions with or without alginate with regard to stability. Further, the invention relates to a method for preparing a dry lactic acid bacteria composition.
    Type: Grant
    Filed: April 6, 2016
    Date of Patent: October 6, 2020
    Assignee: CHR. HANSEN A/S
    Inventors: Birgitte Yde, Jakob Blenker Svendsen
  • Patent number: 10786539
    Abstract: This invention relates to the use of Lactobacillus delbrueckii to elicit a plant cell of an Iridaceae and the use of these elicited cells in treating sensitive skins.
    Type: Grant
    Filed: January 29, 2014
    Date of Patent: September 29, 2020
    Assignee: L'OREAL
    Inventors: Richard Martin, Pascal Hilaire
  • Patent number: 10729810
    Abstract: The present invention relates to novel bone compositions for locally delivering a therapeutic agent to the site of a bone defect. Therapeutic agents may promote repair of the bone defect and/or treat conditions or disorders such as pain, inflammation, cancer, and infection. The compositions include calcium phosphate cements and a demineralized bone matrix or a collagen sponge. The compositions are useful for implantation in a patient at the site of a bone defect.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: August 4, 2020
    Inventors: Stephen Douglas Barrett, Joseph Michael Colombo, Bradlee David Germain, Andriy Kornilov, James Bernard Kramer, Adam Uzieblo, Gregory William Endres, Fred Lawrence Ciske, Thomas Allen Owen, James Paul O'Malley
  • Patent number: 10682380
    Abstract: Disclosed herein are compositions comprising an isolated cellulose degrading fungus and pharmaceutical substances produced by the fungus.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: June 16, 2020
    Assignee: Menon Renewable Products, Inc.
    Inventors: Suresh Menon, Samantha S Orchard, Jessica Badger, David Lipson, Sara Guidi, Jagadish C Sircar, Kashinatham Alisala
  • Patent number: 10647953
    Abstract: An article suitable for inducing quasispherical cell clustering is provided. The article comprising: a layer suitable for culturing quasispherical cell clusters, the layer comprising a bulk region comprising an interpenetrating network of at least one predominantly positively charged polyelectrolyte and at least one predominantly negatively charged positive polyelectrolyte, a back surface region, and a front surface region, wherein the front surface region comprises a net negative fixed surface charge density of between about 0.4 micromole per m2 and about 1.5 micromole per m2.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: May 12, 2020
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Joseph B. Schlenoff, Carlos Arias
  • Patent number: 10610524
    Abstract: A composition interacts with a biological cell system that includes bioactive molecules with biomolecular surfaces, cellular components and water molecules with a specific density. The composition includes a biologically active component that is constructed to increase an activity of a biological cell system by increasing the hydration of one or more components of that cell system. The biologically active component may include a primary carbohydrate clathrate subcomponent that increases the H-bonded structure of water, and a secondary solute subcomponent. The biologically active component may include an inclusion complex that is made up of a clathrate component and a complex-forming compound. The clathrate subcomponent may include amyloses or cyclodextrins. There is also a beverage and a method that improves cellular hydration in an animal, such as a human.
    Type: Grant
    Filed: November 4, 2015
    Date of Patent: April 7, 2020
    Assignee: Eastpond Laboratories Limited
    Inventor: Lajos Szente
  • Patent number: 10597427
    Abstract: The present invention provides a diabetes-inducing bacterium and use thereof, and a reagent and a detection method for detecting the bacterium. According to the present invention, enteric colonization of the diabetes-inducing bacterium can be prevented, and diabetes can be treated and/or prevented.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: March 24, 2020
    Assignee: AJINOMOTO CO., INC.
    Inventors: Keishi Kameyama, Kikuji Itoh
  • Patent number: 10500231
    Abstract: The present invention relates to the fields of medicine, cell biology, molecular biology and genetics. In particular, the present invention provides methods to isolate and purify microvesicles from cell culture supernatants and biological fluids. The present invention also provides pharmaceutical compositions of microvesicles to promote or enhance wound healing, stimulate tissue regeneration, remodel scarred tissue, modulate immune reactions, alter neoplastic cell growth and/or mobility, or alter normal cell growth and/or mobility. The present invention also provides compositions of microvesicles to be used as diagnostic reagents, and methods to prepare the compositions of microvesicles.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: December 10, 2019
    Assignee: University of Miami
    Inventors: Evangelos V. Badiavas, Arsalan Q. Shabbir, Stephen C. Davis
  • Patent number: 10471177
    Abstract: Disclosed in certain embodiments is a composition comprising a biological material and transition metal atoms selected from the group consisting of Group IVB, Group VB, Group VIB of the Periodic Chart and a combination thereof, bound to a surface of the biological material.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: November 12, 2019
    Assignee: Orthobond Corporation
    Inventors: Randell Clevenger, Rong Dong, Jordan Katz
  • Patent number: 10463763
    Abstract: Methods of making and osteoinductive compositions are provided. The method includes mixing isolated periosteum tissue with a demineralized bone matrix to form the osteoinductive composition. The periosteum tissue is isolated from the surface of large bones such as femur, tibia, humerus or a mixture thereof. The demineralized bone matrix can include a plurality of surface demineralized or fully demineralized bone fibers, bone chips, bone particles or mixtures thereof. In the osteoinductive composition the substantially isolated periosteum tissue is from about 0.5% wt. to about 10% wt. A method for repairing a bone defect is also provided. The method of treatment includes applying to the bone defect a substantially effective amount of a mixture of isolated periosteum tissue and demineralized bone matrix.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: November 5, 2019
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: William F. McKay
  • Patent number: 10415065
    Abstract: The disclosed subject matter relates generally to a method for modifying oil, and specifically to a process for increasing the concentration of polyunsaturated fatty acid in an oil composition.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: September 17, 2019
    Assignee: DSM IP Assets B.V.
    Inventors: Jaroslav A. Kralovec, Weijie Wang, James Colin Barrow
  • Patent number: 10377985
    Abstract: Differentiation and stability of neural stem cells can be enhanced by in vitro or in vivo culturing with one or more extracellular matrix (ECM) compositions, such as collagen I, IV, laminin and/or a heparan sulfate proteoglycan. In one aspect of the invention, adult mammalian enteric neuronal progenitor cells can be induced to differentiate on various substrates derived from components or combinations of neural ECM compositions. Collagen I and IV supported neuronal differentiation and extensive glial differentiation individually and in combination. Addition of laminin or heparan sulfate to collagen substrates unexpectedly improved neuronal differentiation, increasing neuron number, branching of neuronal processes, and initiation of neuronal network formation. In another aspect, neuronal subtype differentiation was affected by varying ECM compositions in hydrogels overlaid on intestinal smooth muscle sheets.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: August 13, 2019
    Inventor: Khalil Bitar
  • Patent number: 10306908
    Abstract: It is an object of the present invention to provide a bacterial strain belonging to Lactobacillus brevis subspecies brevis, which has more potent antiallergic activity than the known lactic acid bacteria strains and produces ?-aminobutyric acid (GABA). It is another object of the present invention to provide beverages and foods containing cells of the aforementioned bacterial strain belonging to Lactobacillus brevis subspecies brevis, as well as antiallergic agents containing them as an active ingredient. The present invention provides a bacterial strain belonging to Lactobacillus brevis subspecies brevis, which: is capable of growing in effervescent alcoholic beverages, produces ?-aminobutyric acid (GABA), and has antiallergic activity.
    Type: Grant
    Filed: April 9, 2015
    Date of Patent: June 4, 2019
    Assignee: Sapporo Holdings Limited
    Inventors: Syuichi Segawa, Yasukazu Nakakita, Yoshihiro Takata, Hisako Yasui
  • Patent number: 10294456
    Abstract: Disclosed is a method for culturing mesenchymal stem cells, comprising culturing mesenchymal stem cells in a medium containing calcium in a concentration of from 2.1 to 3.8 mM and magnesium in a concentration of from 1.0 to 3.0 mM under a hypoxic condition of 2 to 5% oxygen. The culturing method can increase the population of mesenchymal stem cells even with a small number of passages by improving mesenchymal stem cells in proliferative capacity and viability. In addition, the mesenchymal stem cells prepared by the culturing method are effectively used not only as a safe cell therapeutic agent due to their lacking immunogenicity, but also as a cartilage regenerating medicine owing to their excellent secretion of cytokines.
    Type: Grant
    Filed: January 11, 2017
    Date of Patent: May 21, 2019
    Assignee: MEDIPOST CO., LTD
    Inventors: Yoon-Sun Yang, Won Il Oh, Sun Jae Kwon, Mi Yeon Lee, Hong Bae Jeon
  • Patent number: 10279081
    Abstract: Composite grafts including a biocompatible, synthetic scaffold; and a biological tissue component obtained or derived from a deceased donor tissue, wherein the biological tissue component is embedded in the biocompatible, synthetic scaffold, are provided as systems relating thereto. Methods of manufacture and methods of treatment using such grafts are also provided.
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: May 7, 2019
    Assignee: ALLOSOURCE
    Inventors: Adrian C. Samaniego, Matthew Southard, Kenneth Blood
  • Patent number: 10251917
    Abstract: This document provides methods and materials for treating a mammal (e.g., a human) having one or more tumors. For example, embolic agents including an amnion tissue preparation (e.g., amnion coated embolic agents) that can be used in arterial embolization to reduce or eliminate blood flow in a blood vessel that supplies a tumor are provided.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: April 9, 2019
    Inventor: Gary M. Petrucci
  • Patent number: 10251978
    Abstract: A method of preparing a bone graft. An osteoconductive matrix is placed in a receptacle. Bone marrow aspirate is provided that includes plasma, progenitor cells, hematopoietic cells, endothelial cells, red blood cells, white blood cells, platelets, bone, cartilage, thrombus or combinations thereof. The bone marrow aspirate is passed through the receptacle. At least a portion of bone marrow aspirate is retained in the receptacle. The portion of the bone marrow aspirate retained in the receptacle becomes associated with the osteoconductive matrix to form the bone graft.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: April 9, 2019
    Assignee: Fortus Medical, Inc.
    Inventor: Robert Assell
  • Patent number: 10232083
    Abstract: Provided are a tissue structure mimetic used for regenerating a tissue and a method for manufacturing the same, and more particularly, a 3-dimensional tissue structure mimetic which consists of a complex of extracellular matrix protein and bone mineral, wherein the complex is specifically bound to a regeneration-functional peptide to thereby be capable of implementing environment of a tissue requiring restoration, and a method for manufacturing the same. In the tissue structure mimetic according to the present invention, bone mineral components are finely dispersed in the extracellular matrix protein to have excellent mechanical strength of the tissue structure mimetic and conductivity which provides a migration path of cells involved in tissue regeneration. Further, environment of the tissue may be implemented by the peptide contained in the tissue structure mimetic to finally remarkably increase tissue regeneration capacity.
    Type: Grant
    Filed: April 1, 2014
    Date of Patent: March 19, 2019
    Inventors: Chong-Pyoung Chung, Yoon Jeong Park, Jue-Yeon Lee
  • Patent number: 10231997
    Abstract: Methods and compositions involving exosomes or lipid nanovesicles are provided. For example, certain aspects relate to compositions comprising exosomes obtained from cells that have been induced to undergo oxidative stress or stimulated. Furthermore, some aspects of the invention provide methods of treating a subject at risk or having a demyelinating disorder using the compositions.
    Type: Grant
    Filed: August 15, 2013
    Date of Patent: March 19, 2019
    Assignee: The University of Chicago
    Inventors: Kae M. Pusic, Yelena Y. Grinberg, Richard P. Kraig, Aya D. Pusic
  • Patent number: 10213459
    Abstract: Mitochondrial compositions and therapeutic methods of using same. Compositions of partially purified functional mitochondria and methods of using the compositions to treat conditions which benefit from increased mitochondrial function by administering the compositions to a subject in need thereof.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: February 26, 2019
    Inventors: Natalie Yivgi-Ohana, Uriel Halavee