Patents Examined by Elizabeth K So
  • Patent number: 10729906
    Abstract: A circuit includes first and second current control sub-circuits connected in series between a DC supply voltage node and a reference voltage node and third and fourth current control sub-circuits connected in series between the DC supply voltage node and the reference voltage node. The circuit also includes a DC/DC converter with a first input terminal coupled to the first load node between the first and second current control sub-circuits, a second input terminal coupled to a second load node between the third and fourth current control sub-circuits, a first output terminal, and a second output terminal. The circuit further includes output electrodes, a routing sub-circuit for selectively coupling the output electrodes to the output terminals, and a controller configured for operating the routing sub-circuit and the current control sub-circuits to cause the DC/DC converter to supply biphasic pulses for at least one of the pairs of output electrodes.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: August 4, 2020
    Assignee: Vanderbilt University
    Inventors: Michael Goldfarb, Kevin Ha, Don Truex
  • Patent number: 10702326
    Abstract: The present invention relates to medical devices and methods for treating a lesion such as a vascular stenosis using non-thermal irreversible electroporation (NTIRE). Embodiments of the present invention provide a balloon catheter type NTIRE device for treating a target lesion comprising a plurality of electrodes positioned along the balloon that are electrically independent from each other so as to be individually selectable in order to more precisely treat an asymmetrical lesion in which the lesion extends only partially around the vessel.
    Type: Grant
    Filed: July 16, 2012
    Date of Patent: July 7, 2020
    Assignees: Virginia Tech Intellectual Properties, Inc., AngioDynamics, Inc.
    Inventors: Robert E. Neal, II, Paulo A. Garcia, Rafael V. Davalos, Peter Callas
  • Patent number: 10688230
    Abstract: A malleable cannula. The malleable cannula includes a polymeric jacket and a malleable member. The malleable member, being surrounded by the jacket, includes a proximal end, a distal end, and a lumen extending therebetween and along a lengthwise axis of the malleable cannula. The malleable member further includes a longitudinal strut that is parallel to the lengthwise axis and a plurality of transverse struts coupled to and extending laterally away from the longitudinal strut and at least a portion of the lumen. The malleable member is configured to assume and maintain a shape of the malleable cannula.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: June 23, 2020
    Assignee: CircuLite, Inc.
    Inventor: Robert C. Farnan
  • Patent number: 10588539
    Abstract: An electrode with varying impedances includes a plurality of layers that are compressed together with varying compressions forces. A first compression force is used at the perimeter of the electrode and a second compression force is used towards the center of the electrode. The first compression force at the perimeter is lesser than the second compression force towards the center and creates a greater measured impedance at the perimeter of the electrode than at the center of the electrode.
    Type: Grant
    Filed: February 7, 2017
    Date of Patent: March 17, 2020
    Inventor: Tomasz Andrzej Kosierkiewicz
  • Patent number: 10493275
    Abstract: Spinal cord modulation for inducing paresthetic and anesthetic effects, and associated systems and methods are disclosed. A representative method in accordance with an embodiment of the disclosure includes creating a therapeutic effect and a sensation in a patient by delivering to the patient first pulses having a first set of first signal delivery parameters and second pulses having a second set of second signal delivery parameters, wherein a first value of at least one first parameter of the first set is different than a second value of a corresponding second parameter of the second set, and wherein the first pulses, the second pulses or both the first and second pulses are delivered to the patient's spinal cord.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: December 3, 2019
    Assignee: Nevro Corp.
    Inventors: Konstantinos Alataris, Andre B. Walker, Jon Parker
  • Patent number: 10470675
    Abstract: A wireless vibrometer employs an antenna array to significantly boost the signal-to-noise ratio of faint received signals twin small objects vibrating at acoustic frequencies. This technique may be used to provide an improved physiological monitor (such as a pulse detector) or for long-range eavesdropping using the emitted power from a cell phone or the like.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: November 12, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Xinyu Zhang, Teng Wei, Shu Wang, Anfu Zhou
  • Patent number: 10449357
    Abstract: Techniques for automatically analyzing neural activity within a target neural region. In one example, electrical stimulation is applied to the target neural region at an initial current level that approximates a typical threshold-Neural Response Telemetry (NRT) level. An NRT measurement of neural activity within the target neural region in response to the stimulation is recorded. A machine-learned expert system, which is configured with a decision tree that includes at least two levels of nodes which consider parameters relating to the NRT measurement, respectively, is utilized to predict, based on one or more features of the neural activity, whether the NRT measurement includes a neural response or does not include a neural response.
    Type: Grant
    Filed: July 5, 2017
    Date of Patent: October 22, 2019
    Assignee: Cochlear Limited
    Inventors: Andrew Botros, Matthijs Killian, Bastiaan van Dijk
  • Patent number: 10449379
    Abstract: An automated external defibrillator (“AED”) (10) employing a self-test circuit (11) and an encoded status indicator. The self-test circuit (11) automatically tests AED (10) and dependent upon the tests, generates both a base status signal (110) indicative of an operational readiness of AED (10) and a test status signal (120) indicative of self-test information of AED (10). The encoded status indicator concurrently visually indicates both the base status signal (110) and the test status signal (120) with the visual indication of the base status signal (110) being perceivable to a human eye and the visual indication of the test status signal (120) being unperceivable to the human eye. The encoded status indicator may employ a light source (14) for emitting a status light (20) and an encoder (13) to intensity modulate the status light (20) as emitted by the light source (14) as a function of an encoding of the base status signal (110) and the test status signal (120) by the encoder (13).
    Type: Grant
    Filed: February 4, 2015
    Date of Patent: October 22, 2019
    Inventor: Lukasz Pawel Kutek
  • Patent number: 10441302
    Abstract: A manipulator adapted to grasp and draw tissue comprises first and second arms having proximal ends and distal ends separated by a distance. First and second grasping surfaces each connected to and extending from respective distal ends of the first and second arms are biased toward each other by a respective spring force. When the first and second arms are actuated to reduce the distance, the manipulator is configured such that tissue arranged between the first and second grasping surfaces resist actuation of the first and second arms. The first and second arms are further actuatable to overcome the spring force of the first and second grasping surfaces so that the first and second grasping surfaces pivot at respective pivot points such that the distance between the distal ends of the first and second arms is reduced.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: October 15, 2019
    Inventor: Peter Ferenc Banfalvi
  • Patent number: 10413721
    Abstract: An implantable medical device (IMD) can include a cardiac pacemaker or an implantable cardioverter-defibrillator (ICD). Various portions of the IMD, such as a device body, a lead body, or a lead tip, can be provided to reduce or dissipate a current and heat induced by various external environmental factors. According to various embodiments, features can be incorporated into the lead body, the lead tip, or the IMD body to reduce the creation of an induced current, or dissipate the induced current and heat created due to an induced current in the lead. For example, an IMD can include at least one outer conductive member and a first electrode. The first electrode can be in electrical communication with the at least one outer conductive member. The first electrode can dissipate a current induced in the at least one outer conductive member via a first portion of the anatomical structure.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: September 17, 2019
    Assignee: MEDTRONIC, INC.
    Inventor: Mark T. Marshall
  • Patent number: 10406348
    Abstract: A device for delivery of electrical current to an area of the skin includes a first pad shaped in the form of a base having four finger-shaped protrusions; a second pad shaped in the form of a palm having a single thumb-shaped protrusion, where the first pad and the second pad each comprises a conductive layer and preferably has tabs on the edges; a first electrical connection system electrically connected to the conductive layer of the first pad; a second electrical connection system electrically connected to the conductive layer of the second pad; a controller circuit connected to the first electrical connection system and second electrical connection system; and a wearable power source. Alternatively, the device may also have the shape of a foot or other body part.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: September 10, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Justin H. Huelman, Véronique Paule-Alberte D Peiffer
  • Patent number: 10384053
    Abstract: Methods and apparatus for inducing neurogenesis within a human. The invention utilizes an implantable signal generator to deliver high frequency stimulation to deep brain tissue elements. The implanted device delivers treatment therapy to the brain to thereby induce neurogenesis by the human. A sensor may be used to detect various symptoms of nervous system discovery. A microprocessor algorithm may then analyze the output from the sensor to regulate the stimulation and/or drug therapy delivered to the brain.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: August 20, 2019
    Assignee: Functional Neuromodulation Inc.
    Inventors: Andres M. Lozano, Hiroki Toda
  • Patent number: 10384056
    Abstract: A system for functional electrical stimulation can include a cuff and a stimulation device. The cuff can be attachable to a nerve or a muscle filament. The cuff can include an elastic collar configured to exert a force on the nerve or the muscle filament to reshape the nerve or the muscle filament to the internal configuration of an opening in the elastic collar. The stimulation device can be coupled to the cuff and configured to provide a stimulation waveform to the cuff.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: August 20, 2019
    Inventors: Dominique M. Durand, Dustin Tyler, Benjamin Cottrill
  • Patent number: 10362997
    Abstract: A system (100) for monitoring and diagnosing heart conditions includes a sensor array (102) with accelerometers, an electrocardiogram sensor, and a system to synchronously capture and process (103, 105, or 106) composite heart signals. The system performs separation, identification and marking (201-205 or 501-509) of the signals, to extract information in cardiac vibrations. Machine learning, auditory scene analysis, or spare coding approaches can be used to resolve source separation problems. Analysis of the composite signals separates different vibration signals (302, 303, 304, 305), identifies streams for particular valve signal, and marks them with event time information with respect to a synchronous electrocardiogram signal (306). The psychoacoustic analysis mimics human auditory processing to enhance hearing of heart valve sounds by separating valve vibrations from the composite signal, and providing extraction, identification, marking and display of individual valve signals.
    Type: Grant
    Filed: January 3, 2017
    Date of Patent: July 30, 2019
    Assignee: Aventusoft, LLC
    Inventors: Kaustubh Kale, Luis Gonzalo Sanchez Giraldo
  • Patent number: 10363094
    Abstract: A method for forming a resonating structure within a body lumen, the method including advancing a flexible microwave catheter into a body lumen of a patient, the flexible microwave catheter including a radiating portion at the distal end of the flexible microwave catheter, the radiating portion configured to receive microwave energy, and at least one centering device proximate the radiating portion configured to deploy radially outward from the flexible microwave catheter; positioning the radiating portion near tissue of interest; deploying the at least one centering device radially outward from the flexible microwave catheter within the body lumen such that a longitudinal axis of the radiating portion is substantially parallel with and at a fixed distance from a longitudinal axis of the body lumen near the targeted tissue; and delivering microwave energy to the radiating portion such that a circumferentially balanced resonating structure is formed with the body lumen.
    Type: Grant
    Filed: April 9, 2012
    Date of Patent: July 30, 2019
    Assignee: COVIDIEN LP
    Inventors: Joseph D. Brannan, Jason A Case, Casey M. Ladtkow, Kurt R. Smith
  • Patent number: 10327653
    Abstract: A method and apparatus for monitoring heart rate. The method includes receiving a digital heart monitoring signal, determining the integrity of said signal with a “hand detect” signal that confirms electrical connection to the subject, dividing the digital heart monitoring signal into at least one frame, generating a folded correlation value for the center sample in the at least one frame, identify the number of peaks folded correlation values based on amplitude and distance parameters of the digital heart monitoring signal in the at least one frame, removing false peaks and collecting peaks corresponding to a length of time, determining the heart rate based on the identified peaks wherein the identified peaks relate to a minimum distance between valid heart beat peaks based on a heart rate estimate, computing the weighted average of heart rate value based on the number of previous heart rate values.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: June 25, 2019
    Inventors: Steven T. Dunbar, Sourabh Ravindran
  • Patent number: 10314649
    Abstract: A surgical instrument, such as an electrical ablation device, includes an elongate member having therealong disposed a first electrode extending along an axis. A first expandable portion extends along the axis and defines a first perimeter of the first electrode and has an associated first diameter with respect to the axis. The first expandable portion includes a first framework selectively expandable to transition the first expandable portion from a contracted state to an expanded state. The first framework is selectively contractible to transition the first expandable portion from the expanded state to the contracted state. When the first framework is expanded, the first diameter is expanded and the first expandable portion is transitioned from the contracted state to the expanded state. When the first framework is contracted, the first diameter is contracted and the first expandable portion is transitioned from the expanded state to the contracted state.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: June 11, 2019
    Assignee: Ethicon Endo-Surgery, Inc.
    Inventors: Gregory J. Bakos, David N. Plescia, Gary L. Long, Peter K. Shires
  • Patent number: 10315028
    Abstract: A medical electrical lead and a method of its use. The lead has an elongated lead body having an outer circumference and provided with an electrode. A push tube is mounted circumferentially around the lead body and the lead body is longitudinally movable with respect thereto. A fixation helix is mounted to the push tube, extending along a generally helical axis around the outer circumference of the lead body. The lead may be employed by advancing the lead to a desired location for the fixation helix and then rotating the push tube to secure the helix to tissue. The lead body may then be moved longitudinally with respect to the push tube to place the electrode in a desirable location.
    Type: Grant
    Filed: April 23, 2014
    Date of Patent: June 11, 2019
    Assignee: Medtronic, Inc.
    Inventors: John L Sommer, Linda L Franke
  • Patent number: 10300285
    Abstract: Electrical stimulation sources and amplitudes are allocated to implantable electrodes based on impedance values for controlled delivery of electrical stimulation therapy to a patient. Allocation may include assigning implantable electrodes, in a group of active electrodes, to clusters based on impedance values of the electrodes, coupling the electrode clusters to respective stimulation sources, and defining respective stimulation amplitudes delivered by the stimulation sources to the electrode clusters. Each cluster may include electrodes having relatively similar impedance values, such that electrodes in each cluster present less variation in impedance relative to impedance variation across the group of electrodes. With reduced variation in impedance, in some examples, variation in current outflow through electrodes in each cluster may be reduced, promoting more uniform distribution of stimulation current across the group of active electrodes and a more uniform stimulation field.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: May 28, 2019
    Assignee: Medtronic Bakken Research Center B.V.
    Inventors: Mattias Bengt Johan Astrom, Mark Hage, Hubert Cecile François Martens, Kambiz Nanbakhsh, Erik van Veenendaal
  • Patent number: 10299736
    Abstract: Methods, devices, and systems according to present principles provide ways to diagnose frailty and assess the severity of its clinical status—e.g., non-frail, pre-frail, and frail, especially as measured and quantified during activities of daily living. Systems and methods according to present principles objectively quantify physical activity behaviors and identify specific motor tasks, which indicate clinical frailty syndrome behaviors such as flopping, cautious-sitting, non-uniform walking fluctuations, cognitive decline, slowness, weakness, and exhaustion. Additionally, the systems and methods allow improved sensitivity and specificity of frailty identification by further assessing physiological parameters such as heart rate, respiration rate, and skin temperature in response to, or recovery from, specific activities.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: May 28, 2019
    Inventors: Bijan Najafi, Saman Parvaneh, Martha Jane Mohler, David G. Armstrong, Mindy Joy Fain, Marvin J. Slepian