Patents Examined by Elizabeth Weimar
  • Patent number: 5578567
    Abstract: A pharmaceutical composition adapted for nasal administration and comprising hPTH or a N-terminal fragment thereof. Preferred carriers are optionally coated celluloses.
    Type: Grant
    Filed: August 25, 1993
    Date of Patent: November 26, 1996
    Assignee: Sandoz Ltd.
    Inventors: Fran.cedilla.ois Cardinaux, Christine Oechslein, Andreas Rummelt
  • Patent number: 4794080
    Abstract: A simultaneous sequential anaerobic fermentation process for the in vitro production of propionic and acetic acids is disclosed. The process comprises employing an obligatory two-component co-culture which maintains a relatively constant ratio of species populations over multiple passages. A first co-culture component is a Lactobacillus or Streptococcus which homofermentatively converts the hexose to lactic acid. A second microorganism in the co-culture is a Veillonella which is metabolically incapable of assimillating the hexose and converts the lactic acid product to propionic and acetic acids. The co-culture is inoculated into a nutrient growth feedstock such as whole whey or a clarified dairy whey lactose permeate which contains a metabolizable source of a hexose such as glucose, lactose or sucrose.
    Type: Grant
    Filed: April 16, 1984
    Date of Patent: December 27, 1988
    Assignee: IGENE Biotechnology, Inc.
    Inventors: Thomas D. Mays, Pamela N. Fornili
  • Patent number: 4792523
    Abstract: The invention concerns positive retroregulatory elements, which when ligated to selected DNA sequences coding for a gene product, enhance the expression of the gene product. Plasmids carrying the positive retroregulatory element ligated to selected DNA sequence and cells transformed by such plasmids are provided AND claimed. In addition, the invention relates to a method for enhancing expression of a gene product by ligating a positive retroregulatory element to a selected DNA sequence expressionable for a desired gene product.
    Type: Grant
    Filed: August 31, 1984
    Date of Patent: December 20, 1988
    Assignee: Cetus Corporation
    Inventors: Hing C. Wong, Shing Chang
  • Patent number: 4791058
    Abstract: It has now been found that grape pomace can be employed as a substrate for citric acid production using Aspergillus niger as the fermentation agent.
    Type: Grant
    Filed: May 10, 1985
    Date of Patent: December 13, 1988
    Assignee: Cornell Research Foundation, Inc.
    Inventor: Yong D. Hang
  • Patent number: 4784950
    Abstract: Methods are disclosed for producing proteins having biological activity for blood coagulation mediated by Factor VIIa. The proteins are produced by mammalian host cells which have been stably transfected with a DNA construct containing a nucleotide sequence which codes at least partially for either Factor VII. The nucleotide sequence comprises a first nucleotide sequence encoding a calcium binding domain, joined to a second nucleotide sequence positioned downstream of the first sequence. In particular, the first nucleotide sequence may be derived from a genomic clone or cDNA clone of Factor VII. The second sequence encodes a catalytic domain for the serine protease activity of Factor VIIA. The joined sequences code for proteins having substantially the same biological activity for blood coagulation as Factor VIIa.
    Type: Grant
    Filed: December 16, 1986
    Date of Patent: November 15, 1988
    Assignee: ZymoGenetics, Inc.
    Inventors: Frederick S. Hagen, Mark J. Murray, Sharon J. Busby, Kathleen L. Berkner, Margaret Y. Insley, Richard G. Woodbury, Charles L. Gray
  • Patent number: 4783403
    Abstract: L-phenylalanine is produced by using a microorganism belonging to the species Citrobacter freundii, Erwinia herbicola, Enterobacter cloacae, Klebsiella oxytoca, Salmonella typhimurium, Bacillus cereus, Flavobacterium suaveolens, Serratia marcescens, Pseudomonas putida, Enterobacter cloacae, Proteus mirabilis, Paracoccus denitrificans, Arthrobacter globiformis, Bacillus sphaericus, Corynebacterium hydrocarboclastus, Kluyvera micum or Microbacterium ammoniaphilum and having the ability to convert phenylpyruvic acid into L-phenylalanine in the presence of an amino group donor; or fumaric acid and ammonium ion or urea.
    Type: Grant
    Filed: February 1, 1985
    Date of Patent: November 8, 1988
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Kazumi Araki, Toshitsugu Ozeki, Yukiyoshi Ito, Shuichi Ishino, Hideharu Anazawa, Shigeru Kamimori
  • Patent number: 4780415
    Abstract: A method and apparatus for carrying out a degradation in an anaerobic medium, such as a methanogenesis, of organic products, by-products or waste from human, animal and/or plant origin, involving feeding said products to be degraded into a closed fermentation vessel, forcing said products to flow in a direction of circulation within said vessel and recovering the gas produced called biogas evolved above said body of degraded products, with the feeding and/or discharge of the products performed pneumatically, preferably through pneumatic thrust and, according to a preferred embodiment, by injection of gas, preferably biogas. A further improvement comprises using the biogas produced for homogenizing said body of products contained within said vessel, the pressure of injection being in relation to the actual density of the products, in the injection related section.
    Type: Grant
    Filed: March 19, 1984
    Date of Patent: October 25, 1988
    Assignees: Gilbert Ducellier, Andre Pavia, Union Industrielle et d'Entreprise, Valorga
    Inventors: Gilbert Ducellier, Andre Pavia
  • Patent number: 4780414
    Abstract: A novel mutant microorganism Streptococcus zooepidemicus HA-116 ATCC 39920, has been produced. The microorganism produces large amounts of high molecular weight hyaluronic acid. The invention provides a method of obtaining such microorganisms.The invention also concerns a method of obtaining sodium hyaluronate which comprises growing with vigorous agitation a microorganism of the genus Streptococcus under appropriate conditions in a suitable nutrient medium containing a sugar component as a carbon source. The sugar component is present in a substantially constant concentration between 0.2 and 10 grams per liter. The medium has a substantially constant pH between about 6.0 and 7.5 and includes a substantially constant magnesium ion concentration above 0.05 grams per liter. The sodium hyaluronate excreted into the medium by the organism is purified using methods involving precipation, redissolving and reprecipating the hyaluronate.
    Type: Grant
    Filed: January 9, 1986
    Date of Patent: October 25, 1988
    Assignee: Bio-Technology General Corp.
    Inventors: Abraham Nimrod, Benjamin Greenman, Dov Kanner, Moshe Landsberg, Yaffa Beck
  • Patent number: 4774179
    Abstract: A process for preparing a 7-aminocephalosporanic acid compound which comprises treating a cephalosporin C compound with an enzyme-producing microorganism belonging to the genus Pseudomonas or a material obtained by subjecting the microorganism to chemical and/or physical treatment. A direct hydrolysis of the cephalosporin C compound into the 7-aminocephalosporanic acid compound and D-.alpha.-aminoadipic acid can be attained by the microorganism or material.
    Type: Grant
    Filed: July 9, 1985
    Date of Patent: September 27, 1988
    Assignee: Asahi Kasei Kogyo Kabushiki Kaisha
    Inventors: Shigeaki Ichikawa, Keizou Yamamoto, Kenji Matsuyama
  • Patent number: 4774184
    Abstract: The invention is a process for the production by fermentation of the antibacterial and antiparasitic agents designated LL-D42067.alpha., to methods for its recovery and concentration from crude solutions and to processes for its purification. The invention includes within its scope the biologically pure culture of the antibiotic.
    Type: Grant
    Filed: August 14, 1985
    Date of Patent: September 27, 1988
    Assignee: American Cyanamid Company
    Inventors: Taikwang M. Lee, Donald B. Borders, Joseph J. Goodman, Raymond T. Testa, William M. Maiese, David P. Labeda
  • Patent number: 4772556
    Abstract: The present invention relates to a stable, allopolyploid, somatic fusion product useful in the fermentation arts and especially in the production of fuel alcohols. More particularly, the present invention relates to a novel allopolyploid yeast strain, Saccharomyces diastaticus NCYC 1460, which is the product of the spheroplast fusion of:(a) a hybrid, diploid strain of Sacch. diastaticus; and(b) a fusion partner which is a polyploid brewing yeast strain of the species Saccharomyces uvarum (carlsbergensis).The fusion product of the present invention is capable of an enhanced rate of fermentation and a generally higher degree of final attenuation than is typical of either of the fusion partners. Moreover the fusion product also evidences enhanced osmo- and thermo-tolerances and its multiple, non-allelic DEX gene complement renders the organism well suited to the fermentation of substrates containing dextrins and oligosaccharides.
    Type: Grant
    Filed: July 14, 1986
    Date of Patent: September 20, 1988
    Assignee: Labatt Brewing Company, Limited
    Inventors: Graham G. Stewart, Ingeborg Russell, Chandrakant J. Panchal
  • Patent number: 4771131
    Abstract: The toxin gene encoding a protein toxic to beetles of the order Coleoptera, named M-7, has been cloned and expressed. M-7 is a novel Bacillus thuringiensis strain which has been deposited with a recognized culture repository. The microbe is now known as B. thuringiensis strain san diego.
    Type: Grant
    Filed: June 16, 1986
    Date of Patent: September 13, 1988
    Assignee: Mycogen Corporation
    Inventors: Corinna Herrnstadt, Edward Wilcox
  • Patent number: 4769317
    Abstract: Procedures are disclosed for eliminating immune competent cells from a population of human epidermal cells. The cells free of immune competent cells are used for growing tissue sheets suitable for transplantation to recipients unrelated to the donor.
    Type: Grant
    Filed: June 14, 1983
    Date of Patent: September 6, 1988
    Inventor: John M. Hefton
  • Patent number: 4767705
    Abstract: Apple pomace, the residue left from juice extraction, can be employed as a substrate for citric acid production using Aspergillus niger as the fermentation agent.
    Type: Grant
    Filed: November 19, 1984
    Date of Patent: August 30, 1988
    Assignee: Cornell Research Foundation, Inc.
    Inventor: Yong D. Hang
  • Patent number: 4766076
    Abstract: The invention comprises a novel starter medium for the commercial propagation of acid producing bacteria, such as those used in food fermentation processes. The compositions are unique in that they contain a highly effective buffering ingredient which is a sodium, potassium, or ammonium salt or double salt of a linear aliphatic dibasic acid having from three to seven carbon atoms. The salts are present in an amount sufficient to maintain the growth medium at pH levels of about 5.0 or above during the time in which the bacteria are multiplying in the culture medium. Disodium or diammonium succinate, glutarate, or adipate are materials which have been found to be particularly effective. These may be used in combination with nutrients such as whey, whey permeate, nonfat dried milk, yeast extract, and diammonium phosphate. The addition of trace quantities of certain metals promotes the growth and activity of the acid producing bacteria.
    Type: Grant
    Filed: June 19, 1984
    Date of Patent: August 23, 1988
    Assignee: The State of Oregon acting by and through the Oregon State Board of Higher Education on behalf of Oregon State University
    Inventors: William E. Sandine, James W. Ayres
  • Patent number: 4764389
    Abstract: A fruit ripening system wherein a continuous inflow of fresh air and ethylene gas is provided into a fruit ripening chamber in correct proportions to form a fruit ripening gas mixture that will predictably ripen fruit in a very short period of time, regardless of the previous state of ripening of the fruit. At the same time, the ripening chamber is continuously purged of carbon dioxide that is a byproduct of the ripening process so that during the ripening process a concentration of carbon dioxide sufficient to materially impede the ripening process is never allowed to build up. Critical parameters are defined for ripening temperature, the minimum ethylene gas concentration, time of exposure to the ethylene gas, and purging of carbon dioxide.
    Type: Grant
    Filed: October 5, 1987
    Date of Patent: August 16, 1988
    Assignee: LaBarge Universal Ripener, Inc.
    Inventor: Louis P. LaBarge
  • Patent number: 4764471
    Abstract: An improved bioreactor and process for continuously propagating microorganisms, such as yeast, wherein the culture medium is purified in contact with a spirally-wound ultrafiltration membrane and then passed through the outer surfaces of a tubular membrane material for further purification before contact with microorganisms flowing in the interior of the tubular membrane material.
    Type: Grant
    Filed: January 4, 1984
    Date of Patent: August 16, 1988
    Assignee: Nabisco Brands, Inc.
    Inventor: Michael S. Ripka
  • Patent number: 4764372
    Abstract: The subject invention concerns a novel and useful insecticide with activity against insect pests of the order Coleoptera. Pests in this order do heavy damage to crops, e.g., corn. The insecticide of the subject invention is a novel B. thuringiensis microbe given the specie designation M-7. The spores or crystal of this microbe are useful to control Coleoptera pests in various environments.
    Type: Grant
    Filed: March 22, 1985
    Date of Patent: August 16, 1988
    Assignee: Mycogen Corporation
    Inventors: Corinna Herrnstadt, George G. Soares, Jr.
  • Patent number: 4759471
    Abstract: A process for preparing fruit juice beverages capable of being sold in cups via dispensing vending machines which comprises the steps of subjecting a fruit juice containing solid matter to milling, deaeration, homogenization and optional pasteurization, the milled juice being dispensed through a flow quantity control means substantially without clogging at the flow quantity control means.
    Type: Grant
    Filed: July 16, 1985
    Date of Patent: July 26, 1988
    Assignee: Kirin Beer Kabushiki Kaisha
    Inventor: Yutaka Takahashi
  • Patent number: 4759941
    Abstract: A hopping material useful as a kettle additive in preparing anactinic malt beverages is prepared by a method which includes first forming an aqueous suspension of crude hops, containing alpha acids and cellulosic material and alkali hydroxide and an alkali borohydride. The suspension, which has a pH above about 10.5, is heated to isomerize and reduce the alpha acids initially present in the hops. The pH is lowered to about 2 to convert the reduced iso-alpha acids to their free acid forms so that they are adsorbed on cellulosic hop material in the reaction mixture. The cellulosic material which now contains the free isomerized and reduced alpha acids is isolated and is useful as an anactinic kettle additive which can be stored for prolonged periods with no decomposition.
    Type: Grant
    Filed: April 30, 1985
    Date of Patent: July 26, 1988
    Assignee: Miller Brewing Company
    Inventors: Etzer Chicoye, Walter H. Fly, Henry Goldstein