Patents Examined by Emily R. Berkeley
  • Patent number: 10605799
    Abstract: A method of selective detection of a concentration of a metal ion species in a subject is provided in which a biofluid sample is obtained from the subject. The biofluid sample is exposed to a functionalized porous aromatic polymer. The polymer selectively captures and concentrates the metal ion species from the biofluid. Subsequently, the biofluid is washed from the polymer. The polymer is then exposed to a solution comprising a colorimetric indicator that extracts the metal ion species from the washed polymer thereby changing a color of the solution as a function of an amount of the metal ion species in the polymer. The concentration of the metal ion species in the subject is then spectroscopically determined from the color of the solution.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: March 31, 2020
    Assignee: The Regents of The University of California
    Inventors: Christopher J. Chang, Jeffrey R. Long, Sumin Lee, Gokhan Barin
  • Patent number: 10605802
    Abstract: A saturation indication system includes a sorbent body with a film backing being irreversibly bonded to the sorbent body. A universal indicating ink formulation is at least partially coated onto the film backing such that the ink formulation is disposed between the film backing and the sorbent body. The universal indicating ink formulation includes a resin and a dye dispersed in the resin. The dye is configured to indicate a state of saturation of the sorbent body, with the resin and the dye being soluble in a plurality of categories of sorbates consisting of hydrophobic sorbates, hydrophilic sorbates, neutral sorbates, and amphiphilic sorbates.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: March 31, 2020
    Assignee: Brady Worldwide, Inc.
    Inventors: Matthew Kasper, Michael Labelle, Nicholas Krogman, Bethany Grillo
  • Patent number: 10591493
    Abstract: Compounds are of the formula (Ia), (Ib), (Ic), or are stereoisomers thereof, wherein: R1 is hydrogen, (C1-C20)alkyl; (C3-C20)alkenyl; (C3 C20)alkynyl; (C1-C6)alkyl-O—; (C3-C20)cycloalkyl; (C1 C20)haloalkyl; (C6-C20)aryl optionally substituted; (C6-C20)heteroaryl optionally substituted; R2 and R2? are hydrogen; (C1-C20)alkyl; (C1-C6)alkyl-O—; (C1-C6)haloalkyl; halogen; cyano; and nitro; Z1 to Z4 are diradicals of formula (III) wherein A1 and A2 are O— or NR3-, wherein R3 is selected from the group consisting of hydrogen and (C1-C20)alkyl; and G is (C1-C6)alkyl; —P(?S)R5-; —P(?O)R4; —P(?O)(OR4)-; —P(?O)(NR6R7)-; —S(?O)2-; S(?O)—; or —C(?O)—; and Y1 to Y4 are (C1-C8)alkyl; (C3-C7)cycloalkyl; (C6-C20)aryl optionally substituted; or (C6-C20)heteroaryl optionally substituted; and FG1 and FG2 are H, OH, or NHR8.
    Type: Grant
    Filed: July 28, 2015
    Date of Patent: March 17, 2020
    Assignees: FUNDACIO INSTITUT CATALA D'INVESTIGACIO QUIMICA (ICIQ), INSTITUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS, UNIVERSITAT ROVIRA I VIRGILI
    Inventors: Louis Adriaenssens, Pau Ballester, Francisco Javier Andrade, Pascal Blondeau, Francesc Xavier Rius, Tomas De Aquino Guinovart Pavon, Daniel Hernandez Alonso
  • Patent number: 10589269
    Abstract: A device for microfluidic transport includes a first fluid reservoir, a second fluid reservoir spaced from the first fluid reservoir, a main fluid channel communicated with the first fluid reservoir and the second fluid reservoir, an auxiliary fluid channel communicated with the main fluid channel, and a fluid actuator within the auxiliary fluid channel asymmetric to the main fluid channel such that operation of the fluidic actuator is to induce fluid flow in the main fluid channel from the first reservoir toward the second reservoir.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: March 17, 2020
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Alexander Govyadinov, Erik D Torniainen, Pavel Kornilovich
  • Patent number: 10589276
    Abstract: Disclosed herein is a multi-functional microfluidics device capable of isolation of nucleic acids, purification of nucleic acids, performance of Polymerase Chain Reactions (PCRs), in situ hybridization of nucleic acids, fluorescent signal detections and the like. The apparatus comprises an integration of a plurality of reagent chambers, a sample input, a reaction chamber, a detection chamber, and a waste chamber; wherein the plurality of reagent chambers is fluidly connected to the reaction chamber, and is configured to store a plurality of reagents; wherein the sample input is fluidly connected to the reaction chamber, and is configured to receive a sample; wherein the waste chamber is fluidly connect to the reaction chamber and is configured to receive a reaction waste from the reaction chamber.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: March 17, 2020
    Assignee: SHENZHEN GENORIVISION TECHNOLOGY CO., LTD.
    Inventors: Rui Ding, Peiyan Cao
  • Patent number: 10571374
    Abstract: A method of extracting an analyte from a sample is described. The sample is added to a sample container. A liquid solvent and a gas are added into the sample container. The addition of the gas is controlled to establish an elevated pressure within the sample container. The liquid solvent is heated to an elevated temperature that is below the boiling temperature of the liquid solvent at the elevated pressure. A type of gas is used that does not transition to a supercritical fluid at the elevated temperature and pressure used in the extraction process. The analyte can dissolve from the solid sample into the liquid solvent. Next, at least a portion of the liquid solvent containing the dissolved analyte can be removed from the sample container for subsequent analysis.
    Type: Grant
    Filed: August 10, 2016
    Date of Patent: February 25, 2020
    Assignee: Dionex Corporation
    Inventors: Kannan Srinivasan, SM Rahmat Ullah
  • Patent number: 10564076
    Abstract: Aspects of the present disclosure include a system for analytical sample preparation. In some embodiments, the system includes a container having disposed therein an analytical sample treatment composition including ?-cyclodextrin and/or an ?-cyclodextrin co-polymer. Also provided is a method of reducing matrix effects in an analytical sample. In some embodiments, the method includes: contacting a sample including a matrix-interfering agent and an analyte with a cyclodextrin composition to produce a matrix-cyclodextrin complex, wherein the cyclodextrin composition comprises an ?-cyclodextrin and/or an ?-cyclodextrin co-polymer; separating the complex from the contacted sample to produce a matrix-reduced composition; and detecting the analyte in the matrix-reduced composition. Kits and compositions for use in the subject systems and methods are also provided.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: February 18, 2020
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Derick Lucas, Bruce Richter, David Long
  • Patent number: 10564171
    Abstract: A microfluidic diagnostic chip may comprise a substrate, a plurality of fluidic slots extending through the substrate, a plurality of microfluidic channels each coupled to a respective one of the plurality of fluidic slots to receive a plurality of fluids from the plurality of fluidic slots, and a mixing region in fluid communication with the plurality of fluidic slots to receive the plurality of fluids such that the plurality of fluids are to mix. A diagnostic chip may comprise a number of fluid slots defined through a substrate and a plurality of microfluidic channels coupled to the fluid slots to receive from the fluid slots a plurality of different fluids wherein the microfluidic channels combine and mix the plurality of different fluids.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: February 18, 2020
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Nicholas Matthew Cooper McGuinness, Chantelle Elizabeth Domingue, Manish Giri, Ed Friesen
  • Patent number: 10527600
    Abstract: Methods, apparatus and compositions are described for the measurement of metal and/or metalloid elements, including selenium in samples. More specifically, the invention provides a sensor and/or array of sensors to measure metal and/or metalloid analytes, e.g. sensor and/or array of sensors having a chelator molecule, the chelator molecule including a peptide which has a phenylalanine derivative.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: January 7, 2020
    Assignee: Icagen, Inc.
    Inventors: Benjamin P. Warner, Chang-Tai Hsieh, Emilia Solomon, Lori Peterson, Douglas Krafte, Nathan Zahler
  • Patent number: 10527627
    Abstract: The present disclosure relates to urinary polyamines useful as prostate cancer biomarkers. In particular, the present disclosure provides a novel, highly-sensitive and specific, method for detecting and quantifying urinary polyamines using lanthanide complexes or citrate capped gold nanoparticles.
    Type: Grant
    Filed: October 16, 2017
    Date of Patent: January 7, 2020
    Assignee: New Life Medicine Technology Company Limited
    Inventor: Ka Leung Wong
  • Patent number: 10527629
    Abstract: The present invention relates to a set of two or more mass labels. Each mass label comprises: X-L-M-Re; X is a reporter moiety having exact mass; L is a bond cleavable by collision in a mass spectrometer; M is a mass modifier; Re is a) a reactive functionality for attaching the mass label to an analyte or b) the analyte. Each mass label in the set has the same integer mass; wherein the set comprises two or more subsets of mass labels, each subset comprising one or more mass labels; wherein, when the subset comprises two or more mass labels, the exact mass of the reporter moiety X of each mass label in the subset is different from the exact mass of the reporter moiety X of the mass labels in the same subset and in all other subsets; each mass label is distinguishable by mass spectrometry.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: January 7, 2020
    Assignee: ELECTROPHORETICS LIMITED
    Inventors: Andrew Hugin Thompson, Stefan Kienle, Karsten Kuhn, Nikolai Woellmer
  • Patent number: 10520486
    Abstract: Provided is a novel method of suppressing non-specific protein adsorption. The above-mentioned object can be achieved by treating a solid phase with a solid phase-treating liquid containing a phosphorylcholine group-containing polymer as a main component, and treating a specimen with a specimen-treating liquid containing, as a main component, a polymer having a phosphorylcholine group, a hydroxy group, and a hydrophobic group, followed by addition of the treated specimen to the treated solid phase.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: December 31, 2019
    Assignees: National University Corporation Kyoto Institute of Technology, NOF Corporation
    Inventors: Yoichi Kumada, Yasutaka Kawaguchi, Aranna Nemoto, Fumio Nakashima, Nobuyuki Sakamoto
  • Patent number: 10502720
    Abstract: Methods are provided for making rapid labeled dextran ladders and other calibrants useful in liquid chromatography. The methodologies include a two-step process comprising a reductive amination step of providing a reducing glycan and reacting it with a compound having a primary amine to produce an intermediate compound. The intermediate compound is then rapidly tagged with a rapid tagging reagent to produce the rapid labeled dextran ladder.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: December 10, 2019
    Assignee: Waters Technologies Corporation
    Inventors: Michael F. Morris, Matthew A. Lauber, Darryl W. Brousmiche
  • Patent number: 10488424
    Abstract: A device (10) and method for analyzing blood coagulation in a blood sample. The device (10) includes a housing (12) having an analytical membrane (14) partially enclosed in a housing. The analytical membrane (14) includes a porous hydrophilic sample portion (34), a porous hydrophilic analytical portion (36), and a porous hydrophilic wicking portion (38). The porosity of the analytical portion (36) differs from the porosity of the sample portion (34). The method utilizes the device to analyze blood coagulation in a whole blood sample from the distance travelled by the red blood cell leading edge (50) in a predetermined period of time.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: November 26, 2019
    Assignee: University of Cincinnati
    Inventors: Andrew J. Steckl, Giovanni M. Pauletti, Hua Li
  • Patent number: 10466161
    Abstract: The present invention pertains to method and apparatus for determining corrosion rate or loss of metal, due to chemical reaction with a corrosive testing fluid under defined shear rate and varied pressure and temperature conditions. This apparatus features a coaxially positioned cylindrical shaped rotating cup and a static cylindrical coupon, or a static cylindrical cup and a rotating coupon located in a test chamber. This defined shear rate corrosion tester can rotate various speeds through a magnetic drive mechanism. Due to its configuration, the corrosion tester is easy to couple with different kinds of testing chambers on demand, and it requires low maintenance and ease of cleaning.
    Type: Grant
    Filed: August 7, 2017
    Date of Patent: November 5, 2019
    Inventor: Hongfeng Bi
  • Patent number: 10444249
    Abstract: Provided is a compound including a repeating unit (A) having a carboxyl group on a side chain thereof and a repeating unit (B) having a carboxylate group having an ester residue exhibiting an aggregation-induced emission capability on a side chain thereof and the compound is useful as a polyvalent metal ion sensor such as calcium ions that is capable of reversible sensing and of being integrated into a device.
    Type: Grant
    Filed: April 11, 2014
    Date of Patent: October 15, 2019
    Assignee: JAPAN SCIENCE AND TECHNOLOGY AGENCY
    Inventors: Takanori Fukushima, Fumitaka Ishiwari, Hanako Hasebe, Takao Someya, Tsuyoshi Sekitani
  • Patent number: 10444149
    Abstract: A method may comprise: exposing a substituted chromone dissolved in a solvent to a sample; taking a fluorescence measurement of the sample after exposure to the substituted chromone; and determining a presence or absence of one or more ions in the sample, a concentration of the one or more ions in the sample, or both based on the fluorescence measurement.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: October 15, 2019
    Assignee: Ohio Northern University
    Inventor: Jake R. Zimmerman
  • Patent number: 10436684
    Abstract: Aspects of the present disclosure include a solid phase sorbent for preparation of analytical samples. The solid phase sorbent includes particles that are surface modified with an ?-cyclodextrin moiety. Also provided is a method of reducing matrix effects in an analytical sample. In some embodiments, the method includes contacting a sample comprising a matrix-interfering agent and an analyte with ?-cyclodextrin modified particles to produce a contacted sample wherein the matrix-interfering agent binds to the ?-cyclodextrin modified particles; separating the ?-cyclodextrin modified particles from the contacted sample to produce a matrix-reduced composition; and detecting the analyte in the matrix-reduced composition. Systems for practicing the subject methods are provided that include the subject solid phase sorbent.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: October 8, 2019
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Bruce Richter, Derick Lucas, David Long, Limian Zhao
  • Patent number: 10436790
    Abstract: Mass spectrometry (MS) active, fluorescent rapid tagging reagent is provided having three substituent groups: (a) a tertiary amino group or other MS active atom; (b) a highly fluorescent moiety; and (c) a reactive group that can react with an amine. The reactive group provides rapid tagging of desired bio-molecules. The fluorescent moiety provides the fluorescent signal. The tertiary amino group provides the MS signal.
    Type: Grant
    Filed: August 13, 2014
    Date of Patent: October 8, 2019
    Assignee: WATERS TECHNOLOGIES CORPORATION
    Inventors: Darryl W. Brousmiche, Ying-Qing Yu, Matthew Lauber
  • Patent number: 10436773
    Abstract: A mobile device based multi-analyte testing analyzer for use in medical diagnostic monitoring and screening, and a method of manufacturing the same are disclosed. A reflectance based, colorimetric test strip reader for use with a mobile device having a jack plug receiving socket, said test strip reader adapted for removably receiving a test strip having a test strip longitudinal axis, comprising a housing; a jack plug operably coupled to and extending from said housing and adapted for operable coupling with said jack plug receiving socket; a test strip adapter including structure defining a test strip receiving channel; a light source oriented within said housing for directing light toward said test strip receiving channel to illuminate a test strip arranged within said test strip adapter; and a light sensor oriented within said housing to sense light reflected from a test strip carried by said test strip receiving channel.
    Type: Grant
    Filed: January 18, 2016
    Date of Patent: October 8, 2019
    Assignee: Jana Care, Inc.
    Inventors: Michal Depa, Sidhant Jena, Gaurav Rohatgi, Aron O. Zingman