Patents Examined by Emily R. Berkeley
  • Patent number: 10416166
    Abstract: Reagents comprising MS active, fluorescent molecules with an activate functionality for reaction with amines useful in rapid tagging of biomolecules such as N-glycans, proteins, peptides, and amino acids, and uses thereof are taught and described. These MS active, fluorescent molecules may have three functional components such as a tertiary amino group or other MS active atom, a highly fluorescent moiety, and a functional group that rapidly reacts with amines.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: September 17, 2019
    Inventors: Darryl W. Brousmiche, Ying-Qing Yu
  • Patent number: 10416180
    Abstract: The invention relates to a station for uncovering a receptacle comprising a body in which a plurality of adjacent holes, initially sealed by a cover, are formed. The station comprises at least one cutting member for making at least one cut in the cover between two adjacent holes, so as to form at least one cover portion closing off at least one of the holes of the receptacle, i.e., the selected hole; and at least one heating gripping device which is arranged so as to heat and remove said cover portion, thereby opening the selected hole.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: September 17, 2019
    Inventors: Sébastien Bernay, Jean-Michel Brisebrat, Frédéric Buffiere
  • Patent number: 10413906
    Abstract: An improved deposition aid for manual sample preparation, particularly on flat MALDI sample supports, comprises a holder for a sample support with several sample sites, which is adapted to standardized sample supports for ionization with matrix-assisted laser desorption and a device which projects a two-dimensional optical image, or a suitable sequence of images, onto the sample sites. The image, or sequence of images, is constructed such that a selected sample site or group of selected sample sites is highlighted in a way which can be perceived by the human eye, at least with respect to neighboring, not-selected sample sites. The deposition aid also includes an interface for confirming the manual deposition and/or a device for the automatic detection of a manual deposition process; and a guidance system which selects a sample site or group of sample sites, and controls the device accordingly.
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: September 17, 2019
    Inventors: Christian Schmid, Martin Schürenberg
  • Patent number: 10392500
    Abstract: Compositions include an aqueous solution of an organic dye of molecular weight in the range of about 300 to about 1,000 and a density-enhancing material. An amount of the density-enhancing material in the aqueous solution is sufficient to achieve a density of about 1.0 to about 1.3 g/mL. The composition has a viscosity of about 3.5 to about 5.0 centipoise. The compositions are useful in assessing the adequacy of a liquid handling mixing device to mix a reaction mixture.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: August 27, 2019
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Jason Snyder, Richard H. Carter, Jr., Patricia Nichols, William D. Dunfee
  • Patent number: 10370695
    Abstract: A method of testing for pathogens can include applying a pathogen indicating substance to an object, the pathogen indicating substance having one characteristic when not in contact with a pathogen and another characteristic when in contact with a pathogen, and generating a signal indicative of the level of pathogen contamination on the object by quantifying the presence of the pathogen indicating substance with the pathogen indicating characteristic on the object. An apparatus for testing for pathogens can include a dispenser for dispensing a pathogen indicating substance, the pathogen indicating substance having one characteristic which is altered to another characteristic on contact with a pathogen, a main sensor for detecting a level of pathogen contamination by quantifying the pathogen indicating substance having the pathogen indicating characteristic, and a control unit for generating a signal indicative of the level of pathogen contamination detected by the sensor.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: August 6, 2019
    Inventor: Yogesh Kumar Kanhye
  • Patent number: 10364249
    Abstract: The present invention relates to a new class of substituted aza-triangulenium fluorescent dyes having a hydroxy group attached to an aryl as quenching group. The new substituted aza-triangulenium fluorescent dyes may be attached to a linker, conjugated to carrier molecule such as e.g. a protein, a nucleic acid, a lipid, or a saccharide, or deposited or immobilized on solid support materials. The substituted aza-triangulenium fluorescent dyes are useful for various purposes, including use in sensors for monitoring or determining the concentration of analytes, such as H+(pH), Na+, K+, Ca2+, O2, CO2, H2O2, ionic strength, redox potentials, metal ions, and metabolites.
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: July 30, 2019
    Assignee: Kobenhavns Universitet
    Inventors: Bo V. Laursen, Martin Rosenberg, Thomas Just Sorensen
  • Patent number: 10352917
    Abstract: The present invention provides a carboxylate-bridged binuclear iron-sulfur clusters fluorescent probe having the structure of Formula I. The preparation method comprises the following steps: anthracenylmethanamine and p-methoxycarbonylphenyl isocyanate have an addition reaction to get a substitutional methyl benzoate, which is hydrolyzed to get a corresponding carboxylic acid; react the resulting carboxylic acid with alkali to get carboxylate, and then coordinate with binuclear iron precursor to obtain the fluorescent probe. Compared with the prior art, the invention firstly provides the carboxylate-bridged binuclear iron-sulfur clusters of metal complex which similar to the central structure of bio-enzyme. The metal complex, as a fluorescent probe, has good selectivity to the fluorinion detection. The fluorescence titration experiment is simple and easy to operate and the fluorescence changes are sensitive.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: July 16, 2019
    Inventors: Yuhan Zhou, Jingping Qu, Xiaoliang Dong
  • Patent number: 10345318
    Abstract: A method is described for the diagnostic determination of the risk caused by an altered oxidative balance, comprising the photometric measurement of total cholesterol, hydroperoxides, and antioxidant capacity, on the basis of which the protective index, the oxidative index and the risk index caused by an altered oxidative balance (or ‘OBRI’) are calculated. This latter index has proved to be particularly dependable and reliable in determining the status of the oxidative balance in relation to cholesterol levels, being highly predictive of cardiovascular risk.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: July 9, 2019
    Assignee: H&D S.R.L.
    Inventor: Gabriele Callegari
  • Patent number: 10335784
    Abstract: A lab-on-chip-based system is described for the direct and multiple sampling, control of the volume, fluid filtration, biochemical reactions, sample transfer, and dried spot generation on the conventional and commercial cards for dried fluid spot. Within an all-in-one integrated holder, the invention allows the complete process required to ensure a quantitative analysis of blood, plasma or any other fluids, modification and enrichment of molecule subsets, and formation of a dried fluid spot on the specific spot location of a passive cellulose, non-cellulose, absorbent, or non-absorbent membrane material sampling.
    Type: Grant
    Filed: August 29, 2017
    Date of Patent: July 2, 2019
    Assignee: DBS System SA
    Inventors: Didier Maillefer, Julien Deglon, Aurelien Thomas, Julien Dumont
  • Patent number: 10317386
    Abstract: A method of measuring nitrate concentration in an aqueous sample includes mixing the aqueous sample with a water-soluble thioether chosen to reduce nitrate in the aqueous sample to nitrite in the presence of a water soluble catalyst, and a water soluble reagent system adapted to interact with nitrite to generate a color; measuring color generation, and correlating the color generation to nitrate concentration.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: June 11, 2019
    Assignee: HACH COMPANY
    Inventors: Darren Kent MacFarland, Angella Nicholle Greenawalt
  • Patent number: 10302535
    Abstract: A filtration device is disclosed for filtering debris from a biofluid sample. In at least one embodiment, the filtration device provides a collection container having a collection chamber defined by a flexible wall, a mouth fluidly communicating with the collection chamber and formed through the collection container at a top end, and a filter device defining a bottom to the collection chamber. A quantitative container has a quantitative chamber in fluid communication with the filter device with the filter device separating the collection chamber from the quantitative chamber. A biofluid sample is introduced into the collection chamber through the mouth, and when the mouth with a collection chamber cap, the flexible wall of the collection container is squeezed to reduce the volume of the collection chamber and force the biofluid sample through the filter device, the filtered biofluid sample thereafter being contained within the quantitative chamber.
    Type: Grant
    Filed: August 7, 2016
    Date of Patent: May 28, 2019
    Assignee: CellectGen, Inc.
    Inventors: Robert Gellibolian, Adam Markaryan
  • Patent number: 10295496
    Abstract: A biosensor system can comprise a sensor chip and a measurement device. The sensor chip comprises a capillary and electrodes disposed within the capillary. The height of the capillary is set to be less than the maximum value of the sum of the diffusion distance of an electron-transfer mediator and the diffusion distance of an analyte at the upper limit of the measurement guaranteed temperature of the biosensor system. The measurement device applies an open circuit voltage, a voltage that is lower than during concentration measurement, or the like to the electrodes of the sensor chip.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: May 21, 2019
    Inventor: Motonori Uchiyama
  • Patent number: 10294252
    Abstract: The present disclosure provides a new series of compounds exhibiting high fluorescence quantum yields in the solid state. In one embodiment, the compounds include a series of 2,3,4,5-tetraphenylgermoles with the same or different 1,1-substituents. In another embodiment, substituted germafluorenes, germa-fluoresceins/rhodamines, and germapins are described. These germanium heterocycles possess ideal photophysical and thermostability properties, which makes them excellent candidates for chemical or biological sensors, host materials for electroluminescent devices and solar cells, and emissive and for electron-transport layer components in organic light emitting diode devices.
    Type: Grant
    Filed: June 11, 2013
    Date of Patent: May 21, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Janet Braddock-Wilking, Teresa Lynn Bandrowsky, James Bryan Carroll, II
  • Patent number: 10288606
    Abstract: The present invention provides an analysis method for simultaneously detecting or quantifying plural species of target substances by measuring the light emission from plural carriers within a single container from outside of the container, these carriers comprising a plurality of substances that are respectively immobilized thereon for capturing the plural species of target substances, wherein the light emission from a desired carrier is selectively received by measuring the emission from the carriers through an optical filter.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: May 14, 2019
    Inventors: Takaki Sugimoto, Tetsuya Ueda, Shuichi Kobayashi, Hideji Tajima
  • Patent number: 10267775
    Abstract: The present specification discloses methods for determining the presence one or more analytes in a test sample, materials useful to perform the disclosed methods, and kits comprising reagents useful to practice the disclosed methods.
    Type: Grant
    Filed: May 30, 2015
    Date of Patent: April 23, 2019
    Assignee: TECAN SP, INC.
    Inventors: Qi Huang, Philip A. Dimson, Karsten R. Liegmann
  • Patent number: 10246557
    Abstract: Disclosed is a curable sealant composition including: (i) a thiol-terminated prepolymer and/or monomers thereof, wherein the thiol-terminated prepolymer is a polythioether or a polysulfide; (ii) an “ene” crosslinker having a molecular weight of about 100 to about 5000; and (iii) a pH indicator molecule including a quantum dot functionalized with a pH-responsive ligand. Methods for determining a sufficient cure state of a composition by combining the thiol-terminated prepolymer and/or monomers thereof and the “ene” crosslinker with a pH indicator molecule, including a quantum dot functionalized with a pH-responsive ligand, and (ii) then subjecting a resultant mixture of (i) to curing conditions until the mixture changes its color are also disclosed.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: April 2, 2019
    Inventors: Katherine L. Frank, Andrew M. Zweig
  • Patent number: 10239056
    Abstract: A micro flow channel chip having high shape accuracy is provided. A micro flow channel chip includes a base material 12 having a groove 121 formed on one surface; and a resin film 14 joined to the surface of the base material 12 so as to cover the groove 121 of the base material 12, in which the resin film 14 contains a (meth)acrylic resin (A), and the (meth)acrylic resin (A) contains a structural unit (A1) represented by Formula (1). (In Formula (1), R1 and R2 each independently represent a hydrogen atom, a methyl group, an ethyl group, or a propyl group; and R3 represents an alkyl group having 3 to 6 carbon atoms).
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: March 26, 2019
    Inventor: Hirohito Taniguchi
  • Patent number: 10239055
    Abstract: The present invention relates to a pipette comprising a tip removal mechanism adapted for lifting an inner mechanism of the pipette with regard to a body of the pipette when the user presses the tip removal button. The present invention further relates to a method for disengaging a disposable tip attached to a tip cone of a pipette of the present invention, and to a method for pipetting with a pipette according to the present invention.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: March 26, 2019
    Inventor: Ville Juhani Hintikka
  • Patent number: 10227287
    Abstract: Described is a method of detecting and/or determining levels of incorporation of monolignol ferulate conjugate esters into lignin by derivatizing the lignin, reductively cleaving the lignin, labeling the cleavage products, and then detecting cleavage products derived from monolignol ester conjugates via differential attachment of the label.
    Type: Grant
    Filed: December 31, 2015
    Date of Patent: March 12, 2019
    Inventors: John Ralph, Steven D Karlen, Fachuang Lu, Dharshana Padmakshan
  • Patent number: 10207229
    Abstract: The disclosure relates to a process and related article for functionalizing a porous membrane by contacting the membrane with a polyacid polymer at low pH to stably adsorb a polyacid layer on the membrane pore surface. The resulting functionalized membrane is characterized by a high density of free acid groups, resulting in a higher specific capacity for its intended application. The process allows functionalization of porous membranes in a very simple, one-step process. Such functional membranes may find multiple uses, including rapid, selective binding of proteins for their purification or immobilization.
    Type: Grant
    Filed: August 30, 2016
    Date of Patent: February 19, 2019
    Inventors: Merlin L. Bruening, Gregory L. Baker, Somnath Bhattacharjee, Yiding Ma