Patents Examined by Ethel G. Love
  • Patent number: 4614796
    Abstract: Liposomes of steryl glucosides and/or steryl glucoside monopalmitates are useful for hemostatic, vascular stabilization and anti-shock effects, particularly in the form of injectable solutions.
    Type: Grant
    Filed: March 25, 1983
    Date of Patent: September 30, 1986
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Masanobu Kawamata, Koichi Ushimaru, Shuji Yamane
  • Patent number: 4614732
    Abstract: N.sup.6 -acenaphthyl adenosines and analogs thereof and pharmaceutically acceptable acid addition salts having highly desirable blood pressure lowering properties, processes for their manufacture and pharmaceutical compositions and methods for using said compounds and compositions are described.
    Type: Grant
    Filed: September 5, 1985
    Date of Patent: September 30, 1986
    Assignee: Warner-Lambert Company
    Inventors: Harriet W. Hamilton, William C. Patt, Bharat K. Trivedi
  • Patent number: 4613672
    Abstract: Process for production of tea catechins selected from (-) epicatechin, (-) epigallocatechin, (-) epicatechin gallate and (-) epigallocatechin gallate comprising extracting tea leaves with hot water or an aqueous solution of methanol, ethanol or acetone, washing the extract containing solution with chloroform, transferring the washed solution into an organic solvent, removing the solution and passing the resulting solution through a reversed phase column in the presence of an eluting solution. Tea catechins and methods of using the same are also disclosed.
    Type: Grant
    Filed: June 27, 1984
    Date of Patent: September 23, 1986
    Assignee: Mitsu Norin Co., Ltd.
    Inventor: Yukihiko Hara
  • Patent number: 4612303
    Abstract: A remedial or prophylactic agent for the treatment of obstructive respiratory diseases comprises a therapeutically effective amount of L-fucose.
    Type: Grant
    Filed: May 17, 1984
    Date of Patent: September 16, 1986
    Assignee: Eisai Co., Ltd.
    Inventors: Naoshi Homma, Jin Sato
  • Patent number: 4611003
    Abstract: Compounds of the formula ##STR1## in which R.sup.1 is hydrogen, halogen or alkyl,R.sup.2 is halogen, alkyl or alkylthio,X is oxygen or sulphur, andY is hydrogen, halogen, alkyl or halogenoalkyl,which possess pesticidal activity.
    Type: Grant
    Filed: June 13, 1983
    Date of Patent: September 9, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventors: Albrecht Marhold, Wilhelm Sirrenberg, Erich Klauke, Ingeborg Hammann, Benedikt Becker, Ingomar Krehan, Wilhelm Stendel
  • Patent number: 4609766
    Abstract: Process for preparing esters of 2-(6'-methoxy-2'-naphtyl)-propionic acid via rearrangement of new ketals of 2-halo-1-(6'-methoxy-2'-naphtyl)-propan-1-one in the presence of a Lewis acid.The esters thus obtained are useful as intermediate products for preparing Naproxen.
    Type: Grant
    Filed: May 17, 1985
    Date of Patent: September 2, 1986
    Assignee: Blaschim S.p.A.
    Inventors: Claudio Giordano, Aldo Belli, Fulvio Uggeri, Giovanni Villa
  • Patent number: 4609743
    Abstract: A process for the production of the beetle aggregation pheromone brevicomin comprising reacting acrolein dimer sequentially with ethyllithium, a methylating agent and aqueous protonic acid. In a modification of the process the acrolein dimer is reacted with ethyl Grignard reagent prior to reaction with an alkyllithium compound. The process includes distributing the brevicomin product to areas to be controlled for beetles.
    Type: Grant
    Filed: April 17, 1984
    Date of Patent: September 2, 1986
    Assignee: University of Pittsburgh
    Inventors: Theodore Cohen, Mahadevan Bhupathy
  • Patent number: 4605645
    Abstract: 5-fluoro-2'-deoxyuridine derivatives expressed by general formula (1) and their pharmacologically permissible salts ##STR1## wherein A indicates a saturated or unsaturated divalent aliphatic hydrocarbon group having 1 to 30 carbon atoms; the letter n indicates 0 or 1, and when n is 0, it indicates that Y is directly bound to an oxygen atom; Y represents a hydrogen atom, phenyl group, or substituted phenyl group; however, when Y is a hydrogen atom, n is 1; R indicates a hydrogen atom or alcohol-protecting group.These compounds have a very strong antitumor activity.
    Type: Grant
    Filed: December 9, 1982
    Date of Patent: August 12, 1986
    Assignee: Teijin Limited
    Inventors: Kenzo Watanabe, Yoshinori Kato, Masahiko Saito, Takeo Oba, Hisashi Fukushima, Takeshi Hara
  • Patent number: 4604382
    Abstract: This disclosure describes the preparation of 3'-amino-2',3'-dideoxycytidine and the pharmacologically acceptable salts thereof which are useful in inhibiting the growth of transplanted tumors in mammals.
    Type: Grant
    Filed: January 17, 1983
    Date of Patent: August 5, 1986
    Assignee: Research Corporation
    Inventors: Tai-Shun Lin, William H. Prusoff
  • Patent number: 4603124
    Abstract: A surfactant having the capacity of reducing the surface tension in pulmonary alveoli significantly is provided. The surfactant consists essentially of, based on the total weight of the surfactant, 50.6-85.0% of a chlorine phosphogylceride, 4.5-37.6% of an acid phospholipid, 4.6-24.6% of a fatty acid or its analogue and 0.1-10.0% of a lipoprotein derived from the lung of a mammal. These components cooperate to form a kind of film at a gas-liquid interface within pulmonary alveoli and reduce the surface tension. A pharmaceutical composition comprising the surfactant is useable for the clinical treatment of respiratory distress syndrome.
    Type: Grant
    Filed: February 27, 1984
    Date of Patent: July 29, 1986
    Assignee: Tokyo Tanabe Company, Limited
    Inventors: Tsunetomo Takei, Yosaku Kanazawa, Kazuo Masuda, Yuji Tanaka
  • Patent number: 4603212
    Abstract: The present invention relates to novel compounds and processes. In particular, the invention relates to novel analogs of the aminocyclitol antibiotic spectinomycin. More particularly, it relates to novel processes for synthesizing analogs of spectinomycin; both known analogs and the novel analogs of the present invention. Additionally, the invention includes novel intermediates.The novel analogs of spectinomycin disclosed herein are useful as antimicrobial agents.
    Type: Grant
    Filed: October 18, 1983
    Date of Patent: July 29, 1986
    Assignee: The Upjohn Company
    Inventor: David R. White
  • Patent number: 4602935
    Abstract: Cyclohexane-1,3-dione derivatives of the formula ##STR1## where R.sup.1 is alkyl, R.sup.2 is alkyl, unsubstituted or halogen-substituted alkenyl or alkynyl, X is a saturated or unsaturated five-membered or six-membered heterocyclic structure which carries one or more substituents, and Z is hydrogen, methoxycarbonyl, ethoxycarbonyl, methyl or cyano, and salts of these compounds are used for controlling undesirable plant growth.
    Type: Grant
    Filed: July 6, 1984
    Date of Patent: July 29, 1986
    Assignee: BASF Aktiengesellschaft
    Inventors: Rainer Becker, Dieter Jahn, Michael Keil, Walter Himmele, Bruno Wuerzer
  • Patent number: 4600787
    Abstract: Aromatic compounds which contain perfluorinated side-chains bonded via a heteroatom are prepared by treating aromatic compounds, which contain side-chains which are perhalogenated, but only partially fluorinated, and bonded via heteroatom, with a catalyst capable of transferring halogen atoms.
    Type: Grant
    Filed: April 23, 1984
    Date of Patent: July 15, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventors: Albrecht Marhold, Erich Klauke
  • Patent number: 4600709
    Abstract: The invention relates to novel benzodioxole derivatives of the general formula I ##STR1## in which R.sub.1 represents an unsubstituted or substituted, aliphatic, aromatic or heteroaromatic radical,alk represents an alkylene, alkenylene or alkylidene radical having a maximum of 5 carbon atoms,n.sub.1 represents 0, 1 or 2n.sub.2 represents 0 or 1,R.sub.2, R.sub.3 and R.sub.4 each represents, independently of the others, hydrogen, lower alkyl, lower alkoxy or halogen, andA represents the radical --O--R.sub.5, wherein R.sub.5 represents hydrogen or an unsubstituted or substituted, aliphatic or araliphatic hydrocarbon radical, or A represents the radical ##STR2## in which either R.sub.6 and R.sub.7 each represents, independently of the other, hydrogen or lower alkyl, or R.sub.6 and R.sub.
    Type: Grant
    Filed: December 7, 1984
    Date of Patent: July 15, 1986
    Assignee: Ciba-Geigy AG
    Inventors: Marc E. Ballenegger, Paul Zbinden
  • Patent number: 4600707
    Abstract: Benzothien-3-yl adenosine; benzothien-3-yl adenosine, S-oxide; and benzothien-3-yl adenosine, S,S-dioxide compounds or pharmaceutically acceptable acid addition salts having highly desirable central nervous system and antihypertensive properties, processes for their manufacture and pharmaceutical compositions and methods for using said compounds and compositions are described.
    Type: Grant
    Filed: January 25, 1985
    Date of Patent: July 15, 1986
    Assignee: Warner-Lambert Company
    Inventor: William Patt
  • Patent number: 4600788
    Abstract: This invention relates to new products of the general formula ##STR1## where R.sub.1 =H, OH, OCOCH.sub.3, OSO.sub.2 CH.sub.3, branched or unbranched alkyl containing 1 to 5 carbon atoms. R.sub.2 =NHCOR.sub.3, NHCOCH.sub.2 X, NHSO.sub.2 CH.sub.3, N(SO.sub.2 CH.sub.3).sub.2, SO.sub.2 N(CH.sub.3).sub.2, SO.sub.2 NHCH.sub.3, SO.sub.2 NCH.sub.3 CH.sub.2 CH.sub.2 OH, SO.sub.2 NH.sub.2 wherein R.sub.3 is a lower alkyl containing 1 to 4 carbon atoms; and X is NR.sub.4 R.sub.5 or ##STR2## wherein R.sub.4 and R.sub.5 are both independently lower alkyls containing 1 to 4 carbon atoms and ##STR3## is piperidine, pyrrolidine or morpholine. These products can be in the form of pharmaceutically acceptable derivatives such as esters, amides, salts. When R.sub.2 contains an amino function, the product can be in the form of an acid salt.These products are prepared from their methyl esters either by reaction between ##STR4## and paramethoxycarbonylbenzoic acid chloride or by means of derivative I such as R.sub.2 is NH.sub.2.
    Type: Grant
    Filed: March 22, 1984
    Date of Patent: July 15, 1986
    Assignee: Societe Cortial, S.A.
    Inventors: Marie-Helene Creuzet, Claude Feniou, Francoise Guichard, Gisele Prat, Jacqueline Mosser, Henri Pontagnier
  • Patent number: 4599327
    Abstract: 2,6-di-O-methyl-beta-cyclodextrin complexes of compounds of the formula (1a) ##STR1## wherein R.sup.2' stands for C.sub.1 to C.sub.12 alkyl or a group of the formula ##STR2## in which R.sup.11 is C.sub.1 to C.sub.4 alkyl;R.sup.12 is hydrogen or C.sub.1 to C.sub.4 alkyl;n is 0 or 1;p is 1 to 4;r is 1 to 4; andR.sup.3' and R.sup.4' are each C.sub.1 to C.sub.4 alkyl, or pharmaceutically salts thereof are disclosed, having analgesic activity.
    Type: Grant
    Filed: December 2, 1983
    Date of Patent: July 8, 1986
    Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RT
    Inventors: Mihaly Nogradi, Dezso Korbonits, Agnes Gottsegen, Sandor Antus, Zsuzsa Furst, Jozsef Knoll, Jozsef Szejtli, Agnes Stadler, Gabor Kovacs, Katalin Marmarosi
  • Patent number: 4598090
    Abstract: The present invention relates to new condensed benzopyrone derivatives, to a process for their preparation and to pharmaceutical compositions containing them.
    Type: Grant
    Filed: March 22, 1984
    Date of Patent: July 1, 1986
    Assignee: Farmitalia Carlo Erba, S.p.A.
    Inventors: Gianfederico Doria, Carlo Passarotti, Ada Buttinoni
  • Patent number: 4596795
    Abstract: The administration of sex hormones, particularly testosteorne, progesterone and estradiol in the form of their complexes or inclusions with specific derivatives of cyclodextrins by the sublingual or buccal route results in effective transfer of these hormones into the systemic circulation, followed by only gradual elimination. To be effective in the above mode of administration, the derivatives of cyclodextrins must carry one or several substituents, each containing one or several hydroxy groups. Specially preferred are the following complexes: hydroxypropylbeta-cyclodextrin and poly-beta-cyclodextrin.
    Type: Grant
    Filed: April 25, 1984
    Date of Patent: June 24, 1986
    Assignee: The United States of America as represented by the Secretary, Dept. of Health & Human Services
    Inventor: Josef Pitha
  • Patent number: 4596880
    Abstract: Benzyl esters of the formula ##STR1## in which n is 1,2,3,4, or 5,R.sup.2 is hydrogen, C.sub.1-4 -alkyl, cyano or ethynyl,R.sup.3 is the radical of a carboxylic acid customary in pyrethroids or pyrethroid-like compounds, andat least one R.sup.1 is fluoroalkoxy or fluoroalkylmercapto, or two together are fluoromethylene- or fluoroethylene-dioxy, and the others, if present, are hydrogen or various radicals,which possess arthropodicidal properties. Various alcohols, amines, aldehydes, halides, and the like, corresponding to the alcohol moieties of the esters are also synthesized.
    Type: Grant
    Filed: November 2, 1983
    Date of Patent: June 24, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventors: Reinhard Lantzsch, Albrecht Marhold, Wolfgang Behrenz, Ingeborg Hammann