Patents Examined by Ethel G. Love
  • Azole dinucleotide compounds and methods for their production
    Patent number: 4544741
    Abstract: A class of novel azole dinucleotide compounds and methods for their production are provided. Compounds of the class typically have pharmacological properties and are well tolerated, being useful, for example, in treating leukemias in warm blooded animals.
    Type: Grant
    Filed: March 29, 1982
    Date of Patent: October 1, 1985
    Inventors: Roland K. Robins, Ganapathi R. Revankar
  • Process for preparing aryl acetic acid derivatives
    Patent number: 4544766
    Abstract: This invention relates to a process for preparing an aryl acetic acid derivative represented by the formulaAr--CH.sub.2 COY).sub.ncomprising hydrolyzing in an alkaline substance a dichloroethenyl compound represented by the formulaAr--CH.dbd.CCl.sub.2).sub.n.
    Type: Grant
    Filed: February 26, 1982
    Date of Patent: October 1, 1985
    Assignee: Otsuka Kagaku Yakuhin Kabushiki Kaisha
    Inventor: Tatsuya Shono
  • Stable S-adenosylmethionine salts, the process for their preparation, and therapeutic compositions which contain them as active principle
    Patent number: 4543408
    Abstract: S-adenosylmethionine salts have been prepared which are stable even at elevated temperatures for practically indefinite time periods, and which correspond to the formula ##STR1## in which X is the acid equivalent of a strong mineral acid of pK less than 2.5, and n is 4, 5 or 6.The new salts are practically free from toxicity, and find application in numerous fields of human therapy.
    Type: Grant
    Filed: August 16, 1982
    Date of Patent: September 24, 1985
    Assignee: Bioresearch S.p.A.
    Inventor: Federico Gennari
  • .omega.,.omega.-Diacyloxy-2,6-dimethyl-octatrienoates and -octatrienals, their preparation and their use for the synthesis of terpene compounds
    Patent number: 4543417
    Abstract: .omega.,.omega.-Diacyloxy-2,6-dimethyl-octatrienoates and -octatrienals, as novel bifunctional asymmetric C.sub.10 building blocks for terpene syntheses, which possess a formyl or alkoxycarbonyl group at one chain end and 2 geminal acyloxy groups at the other, and a process for their preparation from readily obtainable industrial C.sub.5 building blocks and their use for the synthesis of terpene compounds by carbonyl olefination under conventional conditions.
    Type: Grant
    Filed: November 28, 1983
    Date of Patent: September 24, 1985
    Assignee: BASF Aktiengesellschaft
    Inventors: Klaus Schmieder, Joachim Paust, Rolf Fischer, Hans-Martin Weitz
  • 1-.beta.-D-Arabinofuranosyl-(E)-5-(2-halogenovinyl)-uracil-5'-phosphate, preparation thereof and use thereof
    Patent number: 4542210
    Abstract: 1-.beta.-D-arabinofuranosyl-(E)-5-(2-halogenovinyl)uracil-5'-phosphates of the formula (I): ##STR1## and wherein X is halogen, pharmaceutically acceptable salts thereof, are produced by phosphorylation of the non-phosphorylated precursors of the compounds (I), and are useful as anti-viral agents.
    Type: Grant
    Filed: September 3, 1982
    Date of Patent: September 17, 1985
    Assignee: Yamasa Shoyu Kabushiki Kaisha
    Inventors: Shinji Sakata, Haruhiko Machida
  • Processes for the preparation of spectinomycin analogs, novel products and intermediates therein
    Patent number: 4542227
    Abstract: The present invention relates to novel methods of preparing a wide variety of spectinomycin analogs and biologically acceptable salts thereof. Further, the invention relates both to novel intermediates and novel products therein. The novel products are spectinomycin analogs which can be used for the same biological purposes as spectinomycin. The processes of the invention provide for novel intermediates that are versatile and highly reactive exocyclic enones.
    Type: Grant
    Filed: March 12, 1984
    Date of Patent: September 17, 1985
    Assignee: The Upjohn Company
    Inventors: David R. White, Clarence J. Maring
  • Methods for changing calcium metabolism within the cells of a mammal
    Patent number: 4542153
    Abstract: 2-alkyl-5,6 alkylenedioxyindenes and indane-1-di- or tri- alkylammonium salts are useful as calcium antagonists, for example in arrhythmia. The compounds are prepared from the known corresponding 2,5,6-substituted indene-1-1dimethylammonium salts by alkylation and/or hydrogenation.
    Type: Grant
    Filed: May 11, 1983
    Date of Patent: September 17, 1985
    Assignee: The Ohio State University Research Foundation
    Inventors: Donald T. Witiak, Ralf G. Rahwan
  • Anti-juvenile hormones
    Patent number: 4540830
    Abstract: This invention relates to substituted isopentenyl phenyl compounds and their use as anti-juvenile hormones. The compounds have been found effective in the control of insects by inhibiting the actions of juvenile hormones. Such compounds act to induce precocious maturation of immature insects resulting in a reduction in the ecological impact of the insect. Additional effects which have been obtained include sterilization of mature insects. Based on previous research it is also believed these compounds will cause interruption of embryogenesis in insect eggs, the induction of diapause in insects and the prevention of sex pheromone secretion in insects.
    Type: Grant
    Filed: June 16, 1982
    Date of Patent: September 10, 1985
    Assignee: Cornell Research Foundation, Inc.
    Inventor: William S. Bowers
  • Oligomers of prefluoro(2,2-dimethyl-1,3-dioxole) and their fluorination products
    Patent number: 4540799
    Abstract: Perfluoro(2,2-dimethyl-1,3-dioxole) forms oligomers on standing in the presence of an ether. The preferred ethers are aliphatic and cycloaliphatic, especially tetrahydrofuran. Free radical generators, especially peroxydicarbonates, may be added to the reaction medium. The oligomers have a degree of polymerization of about 2-8. They are useful as lubricants, hydraulic fluids, heat transfer agents, and plasticizers, and as intermediates to oligomeric acid fluorides and acids, which acids are useful surfactants.
    Type: Grant
    Filed: June 11, 1984
    Date of Patent: September 10, 1985
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Edward N. Squire
  • Preparation of 3-amino-1-[(1,4-benzodioxan)-2-yl-methoxy]-2-propanols
    Patent number: 4539413
    Abstract: The present invention concerns a novel process for the production of new chemical compounds of the general formula: ##STR1## in which: R.sub.1 and R.sub.2 may be identical or different and represent a hydrogen or halogen atom or else a lower alkyl, lower alkoxy, nitro or acetyl group andR represents a lower alkyl or lower aralkyl group, such as benzyl.These compounds are useful in therapy for the treatment of hypertension and cardiac arrhythmia.The novel process involves reaction of a 2-hydroxymethyl-1,4-benzodioxan with epichlorohydrin to produce an intermediate glycidyl ether, which is then reacted with a primary amine to produce the final 3-amino-1-[(1,4-benzodioxan)-2-yl-methoxy]-2-propanol or an acid addition salt thereof.
    Type: Grant
    Filed: January 3, 1983
    Date of Patent: September 3, 1985
    Assignee: Pierre Fabre S.A.
    Inventors: Gilbert Mouzin, Henri Cousse, Pol Vilain
  • (2'-5')-Oligo (3'-deoxyandenylate) and derivatives thereof
    Patent number: 4539313
    Abstract: 3'-deoxyadenosine 5'-triphosphate is oligomerized to form (2'-5')-oligo (3'-deoxyadenylate) by incubation with adenosine triphosphate: (2'-5')-oligo adenosine adenyl transferase, in the presence of an inert support carrying a double stranded polynucleotide. The (2'-5')-oligo (3'-deoxyadenylate) is digested with a suitable phosphatase to remove the terminal phosphate groups. The thus produced corresponding 3'-deoxyadenosine compound is an anti-viral material effective against Herpes simplex infection and effective in inhibiting the transformation of cells infected with Epstein Barr virus.
    Type: Grant
    Filed: April 27, 1984
    Date of Patent: September 3, 1985
    Assignee: Research Corporation
    Inventors: Robert J. Suhadolnik, Joseph M. Wu, Paul Doetsch, Earl E. Henderson
  • Acetals
    Patent number: 4537980
    Abstract: A new method for the preparation of acetals of long chain fatty aliphatic aldehydes and polyols containing four or more hydroxyl groups which produces the acetals in a relatively pure form by reaction in a mutual solvent, preferably a C.sub.1 to C.sub.4 fatty carboxylic acid. The `clean` acetals are useful emulsifying agents and their esters and polyalkoxy substituents are useful dispersants and surfactants for aqueous compositions.
    Type: Grant
    Filed: December 23, 1983
    Date of Patent: August 27, 1985
    Assignee: Imperial Chemical Industries Limited
    Inventor: James N. Greenshields
  • Alpha-substituted-alkylarylketals particularly useful for preparing alpha-arylalkanoic acids
    Patent number: 4537979
    Abstract: Alpha substituted alkylarylketals of formula: ##STR1## wherein Ar is an aromatic radical having from 3 to 20 C atoms,X is halogen, OR.sub.3 (wherein R.sub.3 is H, acyl or aroyl), OSO.sub.2 CH.sub.3 or OSO.sub.2 C.sub.6 H.sub.4 --CH.sub.3,R is H or alkyl having from 1 to 3 C atoms,Y is --CH.sub.2 --C(R.sub.1).dbd.C(R.sub.2)--CH.sub.2 --(wherein, in turn, R.sub.1 and R.sub.2 are H or methyl).The products of formula I are useful for preparing alpha-aryl-alkanoic acids.
    Type: Grant
    Filed: August 3, 1983
    Date of Patent: August 27, 1985
    Assignee: Zambon S.p.A.
    Inventors: Graziano Castaldi, Claudio Giordano
  • Method of making acetals by catalytic reaction of aldehydes with hydroxyalkanes
    Patent number: 4536585
    Abstract: It is disclosed that a Pd-Tl alloy catalyst is used in making acetals and acetalic ethers from alcohols and saturated or unsaturated aldehydes, and to make cyclic acetals and cyclic acetalic ethers when reacting with diols.
    Type: Grant
    Filed: December 5, 1983
    Date of Patent: August 20, 1985
    Assignee: The Standard Oil Company
    Inventors: Christos Paparizos, Robert S. Shout, Wilfrid G. Shaw
  • Combating pests with substituted benzoyl-(thio)ureas
    Patent number: 4536587
    Abstract: A compound of the formula ##STR1## in which R.sup.1 represents a hydrogen or halogen atom or an alkyl radical,R.sup.2 represents a hydrogen or halogen atom,X represents an oxygen or sulphur atom,Y represents a hydrogen or halogen atom or an alkyl or halogenoalkyl radical andA represents an alkylene radical which is substituted by fluorine and optionally additionally substituted by chlorine,which possesses insecticidal activity.
    Type: Grant
    Filed: May 12, 1983
    Date of Patent: August 20, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wilhelm Sirrenberg, Albrecht Marhold, Ingeborg Hammann, Ingomar Krehan, Wilhelm Stendel
  • Acetal glycol diacrylates and process for producing them
    Patent number: 4536588
    Abstract: Acetal glycol diacrylates of the formula: ##STR1## wherein R.sub.1 represents H or CH.sub.3 and R.sub.2 represents CH.sub.3, C.sub.2 H.sub.5 or C.sub.3 H.sub.7,and a process for producing them are provided.
    Type: Grant
    Filed: June 13, 1983
    Date of Patent: August 20, 1985
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Minoru Yokoshima, Kazuyoshi Nawata, Tetsuo Ohkubo, Hideaki Hattori
  • Optically active N-substituted phenylalaninols and use thereof
    Patent number: 4536601
    Abstract: Optically active N-substituted phenylalaninols of the formula (I): ##STR1## wherein R is isopropyl, 1-ethylpropyl, cyclopentyl, cyclohexyl, cycloheptyl, 4-methylbenzyl, 4-methoxybenzyl, or 3,4-methylenedioxybenzyl; and acid addition salts thereof which are useful as a resolving agent, and a process for preparing D-3-acetylthio-2-methylpropionic acid which comprises reacting DL-3-acetylthio-2-methylpropionic acid with an optically active N-substituted phenylalaninol of the formula (I) to form diastereomeric salts, subjecting the formed diastereomeric salts to a fractional crystallization from a solvent to separate the D-acid salt from the L-acid salt, and then decomposing the D-acid salt with a mineral acid to give D-3-acetylthio-2-methylpropionic acid.
    Type: Grant
    Filed: September 23, 1983
    Date of Patent: August 20, 1985
    Assignee: Dainippon Pharmaceutical Co., Ltd.
    Inventors: Masatoshi Tukamoto, Tadahiro Sawayama
  • Saturated aminocyclitol derivatives, their preparation and medicaments containing these compounds
    Patent number: 4536493
    Abstract: The invention relates to saturated aminocyclitol derivatives, as defined herein in Formula (F). Also included in the invention are methods for preparing said saturated aminocyclitol derivatives, compositions containing said saturated aminocyclitol derivatives and methods for the use of said compounds and compositions to provide inhibition of .alpha.-glycoside hydrolases.
    Type: Grant
    Filed: June 4, 1982
    Date of Patent: August 20, 1985
    Assignee: Baker Aktiengesellschaft
    Inventors: Bodo Junge, Lutz Muller
  • Fluorodioxoles
    Patent number: 4535175
    Abstract: Novel fluorodioxoles which may have Cl or F substituents in the 4 or 5 positions and have two F or CF.sub.3 substituents in the 2 position are useful monomers for the preparation of homopolymers and copolymers with tetrafluoroethylene and terpolymers with tetrafluoroethylene and vinylidene fluoride. The homopolymers are suitable for glazing materials, while copolymers are useful, among others, for corrosion-resistant seals, gaskets, and linings.
    Type: Grant
    Filed: April 18, 1984
    Date of Patent: August 13, 1985
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Edward N. Squire
  • Dibenzo[b,f]thiepin-3-carboxaldehydes as prostaglandin antagonists
    Patent number: 4535171
    Abstract: Novel dibenzo[b,f]thiepin-3-carboxaldehydes and derivatives are prepared and employed in the treatment and control of allergic conditions such as allergic asthma.
    Type: Grant
    Filed: October 11, 1983
    Date of Patent: August 13, 1985
    Assignee: Merck Frosst Canada, Inc.
    Inventor: Joshua Rokach