Patents Examined by G. S. Kishore
  • Patent number: 5389366
    Abstract: A composition for oral administration to cancer patients includes a neocarzinostatin derivative and from 0.1 and 100 ml per mg of the neocarzinostatin derivative of at least one fatty acid glyceride which has from 6 to 20 carbon atoms and which is noniodized. The composition is effective in the treatment of cancer by oral administration, including a solid cancerous tumor.
    Type: Grant
    Filed: May 17, 1993
    Date of Patent: February 14, 1995
    Assignees: Yamanouchi Pharmaceutical Co., Ltd., Hiroshi Maeda, Kuraray Co., Ltd., Kayaku Antibiotics Research Co., Ltd.
    Inventors: Hiroshi Maeda, Fujio Suzuki, Kiichiro Oka, Shohei Tanaka
  • Patent number: 5387421
    Abstract: A drug delivery system includes a first capsule half having an inner chamber for containing a drug therein. A plug is disposed in a passageway of the capsule half for plugging the opening thereof. The plug is releasable from the passageway opening upon the application of pressure from within the inner chamber. A pump mechanism causes an increase in pressure within the inner chamber and forces the plug out of the passageway to release the drug from the inner chamber and out of the passageway thereby providing a second pulse of drug release at a predetermined time after initial ingestion of the capsule. The invention further provides a method of manufacturing the drug delivery system and method by which the drug delivery system provides the drug to the body.
    Type: Grant
    Filed: May 31, 1994
    Date of Patent: February 7, 1995
    Assignee: TSRL, Inc.
    Inventors: Gordon L. Amidon, Glen D. Leesman, Lizbeth B. Sherman
  • Patent number: 5385738
    Abstract: The present invention relates to a sustained-release injection, which comprises a suspension of a powder comprising an active ingredient and a pharmaceutically acceptable biodegradable carrier (e.g. proteins, polysaccharides and synthetic high molecular compounds, preferably collagen, atelocollagen, gelatin, and a mixture thereof) in a viscous solvent for injection (e.g. vegetable oils, polyethylene glycol, propylene glycol, silicone oil, and medium-chain fatty acid triglycerides). The sustained-release injection can release the active ingredient at an effective level for a long period of time when injected.
    Type: Grant
    Filed: March 4, 1992
    Date of Patent: January 31, 1995
    Assignee: Sumitomo Pharmaceuticals Company, Ltd.
    Inventors: Yoshiya Yamahira, Keiji Fujioka, Shigeji Sato, Yoshihiro Takada
  • Patent number: 5385739
    Abstract: The present invention relates to a stable formulation of omeprazole microgranules containing a neutral core consisting of sugar and starch, characterized in that it contains an active layer consisting of a dilution of omeprazole in mannitol in substantially equal amounts. It also relates to a process for producing such formulations.
    Type: Grant
    Filed: June 16, 1993
    Date of Patent: January 31, 1995
    Assignee: Ethypharm
    Inventors: Patrice Debregeas, Gerard Leduc
  • Patent number: 5384126
    Abstract: The present invention relates to a novel composition based on hydrated lipidic lamelar phases or on liposomes and to a cosmetic or pharmaceutical, particularly dermatological composition incorporating it.According to the invention, the hydrated lipidic lamelar phases or the liposomes contain at least in part a derivative of labdane, or a plant extract containing it.The invention makes it possible to reduce hair drop and to promote regrowth of hair and also makes it possible to prevent gray hair from appearing or to treat gray hair.
    Type: Grant
    Filed: December 12, 1991
    Date of Patent: January 24, 1995
    Assignee: LVMH Recherche
    Inventors: Frederic Bonte, Alain Meybeck, Christian Marechal
  • Patent number: 5384132
    Abstract: Disclosed are lyophilized gonadotropin containing preparations containing a dicarboxylic acid salt stabilizer. The particular proteins (e.g. LH, TSH, FSH, or HCG) are in admixture with, and at least partially capable of stabilization by, the particular stabilizer in lyophilized form. The preparations contain a sufficient amount of dicarboxylic acid salt to stabilize the protein in freeze-dried form for a desired time at a desired temperature. Typical dicarboxylic acid salts disclosed are the salts of citric, tartaric, and aspartic acids. The preparations preferably include a non-reducing disaccharide to increase the collapse temperature of the solution to be lyophilized. Methods of making the preparations in lyophilized form and the resulting injectable preparations are also disclosed.
    Type: Grant
    Filed: September 3, 1993
    Date of Patent: January 24, 1995
    Assignee: Akzo N.V.
    Inventors: Andreas L. J. De Meere, Marinus A. De Ruiter
  • Patent number: 5380531
    Abstract: The present invention relates to liposomal compositions having a concentration gradient which load amino acids and peptides exhibiting weak acid or base characteristics into liposomes. Specifically loaded into liposomes by the methods of the present invention are C-terminal substituted amino acids or peptides. The liposomes are preferably large unilamellar vesicles. The concentration gradient is formed by encapsulating a first medium in the liposomes, said medium having a first concentration of the one or more charged species, and suspending the liposomes in a second medium having a second concentration of the one or more charged species, such as for example a pH gradient. Also disclosed are pharmaceutical preparations comprising such C-terminal substituted amino acids or peptides which have been loaded into the liposomes by the method of the invention.
    Type: Grant
    Filed: June 2, 1992
    Date of Patent: January 10, 1995
    Assignee: The Liposome Company, Inc.
    Inventors: Ajoy Chakrabarti, Ian Clark-Lewis, Pieter R. Cullis
  • Patent number: 5380530
    Abstract: Disclosed are several oral hygiene preparations including plaque disrupting and gingivitis control preparations in the form of chewing gums, wherein a chewing gum is coated with a plaque disrupting emulsion containing an ingestible surfactant and a polydimethyl siloxane emulsified therein, and wherein the emulsion coating can further contain a therapeutic substance such as the gingivitis control substance stannous fluoride.
    Type: Grant
    Filed: December 29, 1992
    Date of Patent: January 10, 1995
    Assignee: WhiteHill Oral Technologies
    Inventor: Ira D. Hill
  • Patent number: 5378474
    Abstract: The present invention relates to a pharmaceutical pellet composition having a core element including at least one highly soluble active ingredient and a core coating which is partially soluble at a highly acidic pH. The pharmaceutical composition provides a slow release of active ingredient at a highly acidic pH and provides a constant, relatively faster rate of release at a more alkaline pH such as that of the intestine. Oral administration of the pharmaceutical pellet composition of the present invention to a patient is effective to deliver to the blood levels of active ingredient within the therapeutic range and to maintain such levels over an extended period of time.
    Type: Grant
    Filed: February 22, 1993
    Date of Patent: January 3, 1995
    Assignee: F. H. Faulding & Co. Limited
    Inventors: Angelo M. Morella, Mark C. Fisher
  • Patent number: 5378475
    Abstract: A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained release drug delivery system to a mammalian organism in need of such treatment at an area wherein release of an effective agent is desired and allowing the effective agent to pass through the device in a controlled manner. The device includes an inner core or reservoir comprising the effective agent; a first coating layer, which is essentially impermeable to the passage of the effective agent; and a second coating layer, which is permeable to the passage of the effective agent. The first coating layer covers at least a portion of the inner core; however, at least a small portion of the inner core is not coated with the first coating layer. The second coating layer essentially completely covers the first coating layer and the uncoated portion of the inner core.
    Type: Grant
    Filed: February 21, 1991
    Date of Patent: January 3, 1995
    Assignee: University of Kentucky Research Foundation
    Inventors: Thomas J. Smith, Paul Ashton, Paul A. Pearson
  • Patent number: 5378469
    Abstract: The present invention provides improved collagen threads and methods of making and using such threads, including the production of yarn, as well as braided, knitted, and woven articles of manufacture, comprising such threads.
    Type: Grant
    Filed: October 7, 1991
    Date of Patent: January 3, 1995
    Assignee: Organogenesis, Inc.
    Inventors: Paul D. Kemp, Robert M. Carr, Jr., John G. Maresh, John Cavallaro, Jerome Gross
  • Patent number: 5376382
    Abstract: A solid medicinal form having an active substance content of over 45 weight % and processes for its preparation by granulating with large amounts of water, drying and optionally conventional tableting and/or pelleting.
    Type: Grant
    Filed: March 2, 1993
    Date of Patent: December 27, 1994
    Assignee: Asta Medica Aktiengesellschaft
    Inventors: Joachim Goede, Jurgen Engel, Helmut Hettche
  • Patent number: 5376379
    Abstract: The present invention relates to compositions based on thermal water containing liposomes of thermal water stabilized in a deoxyribonucleic acid (DNA) gel and a process for preparing thereof. The composition is useful in dermatology and cosmetology.
    Type: Grant
    Filed: June 4, 1993
    Date of Patent: December 27, 1994
    Assignee: Pierre Fabre Cosmetique
    Inventors: Pierre Fabre, Henri Cousse, Gilbert Mouzin, Marie-Therese Trebosc
  • Patent number: 5376385
    Abstract: A process for binding water-sensitive active materials in essentially non-aqueous systems.
    Type: Grant
    Filed: December 18, 1992
    Date of Patent: December 27, 1994
    Inventors: Derek J. Barton, Malcolm G. J. Macduff, John M. Newton
  • Patent number: 5374429
    Abstract: A medical adhesive sheet comprising a support comprising a laminate of a polyester film having a thickness of from 0.5 to 6 .mu.m and a polyester nonwoven fabric having a basis weight of from 5 to 20 g/m.sup.2, and a pressure-sensitive adhesive layer laminated on the surface of the nonwoven fabric.
    Type: Grant
    Filed: April 16, 1993
    Date of Patent: December 20, 1994
    Assignee: Nitto Denko Corporation
    Inventors: Takashi Kinoshita, Saburo Otsuka, Hitoshi Akemi, Kazuhiro Higashio
  • Patent number: 5370877
    Abstract: .alpha.-Aminocarboxylic acid derivatives of the formula: ##STR1## where n, X, Y and Z have the meanings stated in the description, and their preparation are described. The compounds are used in a method for improving delivery and reducing toxicity of biologically active substances by encapsulation of the biologically active substance with the above compounds.
    Type: Grant
    Filed: March 31, 1993
    Date of Patent: December 6, 1994
    Assignee: Knoll AG
    Inventors: Joerg Rosenberg, Hans-Heinrich Gruenhagen, Dieter Lenke
  • Patent number: 5369119
    Abstract: The subject of the present invention is the use of imexon for the production of pharmaceutical compositions with an immunosuppressive action. The present invention also provides pharmaceutical compositions containing imexon and further active materials.
    Type: Grant
    Filed: March 2, 1993
    Date of Patent: November 29, 1994
    Assignee: Boehringer Mannheim GmbH
    Inventors: Dieter Herrmann, Rainer Haag, Elmar Bosies, Uwe Bicker, Wolfgang Kampe
  • Patent number: 5369130
    Abstract: Skin barrier paste compositions free from organic solvents comprised of at least a rubber component and a filler component wherein the rubber component includes a liquid rubber having an average molecular weight of about 1,000 to about 80,000 and a viscosity of about 200 poise to about 6,000 poise at 40.degree. C., the rubber component being present in the paste composition in the range of about thirty percent to about seventy percent by weight. The present inventive paste compositions can be freely formed with the fingertips or a spatula; they are less irritating to the skin, mucosa and/or the injured area; and they are less susceptible to a viscosity change when exposed to the atmosphere, thus assuring an ease of application and a stable paste formulation when stored in a container.
    Type: Grant
    Filed: January 25, 1993
    Date of Patent: November 29, 1994
    Assignee: Alcare Co., Ltd.
    Inventor: Satoru Numata
  • Patent number: 5366733
    Abstract: Oral compositions for the local administration of a therapeutic agent to a periodontal pocket of a patient for alleviating dental disease comprise a plurality of dry, discrete microparticles each of which comprise an effective amount of at least one therapeutic agent dispersed in a matrix comprising a biocompatible and biodegradable polymer. Apparatus and methods are also provided for the dispensing of the dry microparticles to the periodontal pocket whereby they become tacky and adhere to the involved tissue so as to induce long term therapeutic benefits.
    Type: Grant
    Filed: May 28, 1991
    Date of Patent: November 22, 1994
    Assignee: American Cyanamid Company
    Inventors: Nancy S. Brizzolara, Michael G. Lanzilotti, James R. Lawter
  • Patent number: 5366732
    Abstract: A method of preparing, treating and then milking cows includes the use of a flexible wipe (A) constructed of hydrophilic material containing a moisture-activated antimicrobial composition. The process includes washing teats and udder of a milk-bearing cow with water or an aqueous soap solution; simultaneously drying, sanitizing and conditioning the thus-washed teats and udder with the moisture-activated antimicrobial wipe comprising a hydrophilic substrate impregnated with an antimicrobial agent, effective to sanitize the teats and udder; and then milking the thus-prepared cow.
    Type: Grant
    Filed: April 18, 1994
    Date of Patent: November 22, 1994
    Inventor: Jaime Zighelboim R