Patents Examined by G. S. Kishore
  • Patent number: 5268180
    Abstract: This composition consists in an aqueous dispersion D, lamellar structure lipid vesicles encapsulating an aqueous phase E; it is characterised by the fact that the lipid phase forming the layers of the said vesicles is at least partly made up of a compound as formula (I): ##STR1## wherein R represents a linear saturated on unsaturated hydrocarbonated chain containing 9 to 17 carbon atoms. The compounds (I) have the advantage that they are easily biodegradable and of very low cytotoxicity.
    Type: Grant
    Filed: November 8, 1991
    Date of Patent: December 7, 1993
    Assignee: L'Oreal
    Inventors: Jean-Luc Morancais, Michel Philippe
  • Patent number: 5266303
    Abstract: This invention relates to aerosol hair spray formulations based on (1) a sulfonate-containing, water-dispersible or water-dissipatible, linear polyester having a glass transition temperature of about C. to about C. and (2) a water-soluble, polyvinyl lactam polymer. In addition, the formulations contain water as the liquid vehicle and a propellant. Such aerosol hair spray formulations do not contain any volatile organic compounds other than propellant yet exhibit fast drying times and excellent performance characteristics.
    Type: Grant
    Filed: November 30, 1992
    Date of Patent: November 30, 1993
    Assignee: Eastman Kodak Company
    Inventors: Garry L. Myers, John J. Hiller, Robin L. Minga, Suzanne W. Dobbs, Andy H. Singleton
  • Patent number: 5266322
    Abstract: This invention relates to a cosmetic film forming composition which is especially useful as a nail coating composition which upon drying forms a film which will adhere to keratin of a nail. More particularly, the present invention relates to cosmetic film forming compositions which consist of aqueous emulsion (A) which comprises a sulfopolyester and a copolymer of vinyl acetate and dialkyl maleate, and aqueous emulsion (B) which comprises an aqueous emulsion of acetoacetoxyethyl alkylacrylate or the reaction product of acetoacetoxyethyl alkylacrylate with a vinylfunctional monomer. These cosmetic film forming compositions are fast drying, have good adhesive properties and are environmentally compatible.
    Type: Grant
    Filed: May 29, 1992
    Date of Patent: November 30, 1993
    Assignee: Eastman Kodak Company
    Inventors: Garry L. Myers, John J. Hiller, Waylon L. Jenkins, Robin L. Minga, W. D. Nottingham, Suzanne W. Dobbs, Stacey J. Marsh, Keith M. Moody
  • Patent number: 5264220
    Abstract: The present invention relates to a composition for increasing the vascular dwell-time of a particulate therapeutic or diagnostic agent in a mammal through the adjunct administration of an effective amount of the particulate therapeutic or diagnostic agent and an effective amount of a vascular dwell-time enhancing agent. Suitable therapeutic and diagnostic agents include those whose efficacy within the body is predicated on their ability to remain within or to be carried within the vascular compartment. Accordingly this method can be readily adapted for treating several diseases and disorders, including hypoxia, hypoxemia, anemia and cancer and for imaging selected regions of a mammal by various imaging techniques, including ultrasound imaging, X-ray imaging and MRI imaging.
    Type: Grant
    Filed: November 12, 1991
    Date of Patent: November 23, 1993
    Inventors: David M. Long, Jr., Raymond A. Long
  • Patent number: 5264221
    Abstract: A drug-containing protein-bonded liposome comprising a liposome containing a drug and having maleimide residues on its surface, and a protein and residues of a compound having a polyalkylene glycol moiety, bonded via respective thiol groups to the maleimide residues.
    Type: Grant
    Filed: May 22, 1992
    Date of Patent: November 23, 1993
    Assignee: Mitsubishi Kasei Corporation
    Inventors: Toshiaki Tagawa, Saiko Hosokawa, Kazuhiro Nagaike
  • Patent number: 5260292
    Abstract: A method and composition for topically treating acne and acneiform dermal disorders includes applying an amount of an antibiotic selected from the group consisting of ampicillin, amoxicillin, other aminopenicillins, and cephalosporin, and derivatives and analogs thereof, effective to treat the acne and acneiform dermal disorders. The antibiotic is blended with a carrier suitable for topical application to dermal tissues. The carrier is selected from the group consisting of an aqueous liquid, an alcohol base, a water soluble gel, a lotion, an ointment base, petrolatum, a nonaqueous liquid base, a mineral oil base, a blend of mineral oil and petrolatum, a suspension of solid particles in a liquid, and a suspension of an ion-exchange resin in water.
    Type: Grant
    Filed: May 12, 1992
    Date of Patent: November 9, 1993
    Assignees: Marvin S. Towsend, Leonard Bloom
    Inventors: Howard N. Robinson, Neil F. Martin
  • Patent number: 5256422
    Abstract: The present invention features water-in-oil emulsions having intact lipid vesicles dispersed in the water or aqueous phase. Methods of making the emulsions are also disclosed. The preferred vesicles for use in the emulsions are paucilamellar lipid vesicles, most preferably those having nonionic amphiphiles as their major structural component. The water-in-oil emulsions are useful in cosmetics, pharmaceuticals, and foods such as margarine.
    Type: Grant
    Filed: July 8, 1992
    Date of Patent: October 26, 1993
    Assignee: Micro Vesicular Systems, Inc.
    Inventors: Elizabeth C. Albert, Donald F. H. Wallach, Rajiv Mathur
  • Patent number: 5254330
    Abstract: Pharmaceutical excipients useful in dry powder inhalents comprise particles having a rugosity (measured by air permeametry) of less than 1.75. The use of these carriers increases the amount of drug injested by the patient using a dry powder inhaler. The preferred excipients are crystalline sugars such as lactose which may conveniently be prepared by controlled crystallisation from an aqueous medium.
    Type: Grant
    Filed: September 20, 1991
    Date of Patent: October 19, 1993
    Assignee: British Technology Group Ltd.
    Inventors: David Ganderton, Nuha M. Kassem
  • Patent number: 5252336
    Abstract: A liposome composition is obtained by using as constituent components of the liposome membrane a polyoxyethylene derivative represented by the general formula:X--O--(CH.sub.2 CH.sub.2 O).sub.n --Y (I)wherein X represents an alkanoyl group or an alkyl group, Y represents a residue of a compound having a negative charge, and n is an integer of 2 to 50, and a phospholipid. The liposome composition has good dispersibility, high drug-encapsulation property and high stability.
    Type: Grant
    Filed: June 5, 1991
    Date of Patent: October 12, 1993
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Katsumi Iga, Kazuhiro Ohkouchi, Yasuaki Ogawa
  • Patent number: 5252339
    Abstract: Pharmaceutical compositions for oral use, preferably selected from capsules, tablets or sugar coated tablets, coated by an enterosoluble gastroresistant film, containing a lyophilizate consisting of therapeutically effective amounts of a glycosaminoglycan, a thickening substance and surfactants, and process for obtaining them. The compositions make possible the absorption of the orally administered glycosaminoglycans in the duodenum and in the intestine and the consequent performance of their anticoagulant, fibrinolytic, antithrombotic, antiatherosclerotic and antihyperlipoproteinemic properties.
    Type: Grant
    Filed: January 15, 1992
    Date of Patent: October 12, 1993
    Assignee: Alfa Wasserman S.p.A.
    Inventors: Manlio Cristofori, Egidio Marchi, Leone G. Rotini
  • Patent number: 5252348
    Abstract: The production of artificial viral envelopes by a novel double-detergent dialysis technique is disclosed. Specifically exemplified is the production of HIV-1 and RSV viral envelopes. The resulting artificial viral envelopes are essentially identical to the natural virus with regard to characteristics which are relevant to immunogenicity.
    Type: Grant
    Filed: July 30, 1992
    Date of Patent: October 12, 1993
    Assignee: Univ. of Florida Research Foundation, Inc.
    Inventors: Hans Schreier, Ramesh Chander, Arlene A. Stecenko
  • Patent number: 5246707
    Abstract: The novel uses of the phospholipid-coated microcrystal in the delivery of water-soluble biomolecules such as polypeptides and proteins. The proteins are rendered insoluble by complexation and the resulting material forms the solid core of the phospholipid-coated particle. Alternatively, the proteins, bio-molecules or drugs can be entrapped in water-soluble form between the membranous layers of the coated microcrystal. All types of phospholipid microcrystals can incorporate 5 nm to 10 um diameter iron oxide particles to allow for manipulation by magnetic fields. Water-soluble bio-molecules including proteins, peptides, and drugs can be entrapped and retained with long shelf life in liposomes at high concentrations, provided that the phospholipid concentration is greater than 10% (w/v) such that greater than 50% of the system volume is enclosed within phospholipid membranes. Both the phospholipid-coated microcrystal and the phospholipid-coated microdroplet can be used as vaccine adjuvants.
    Type: Grant
    Filed: December 3, 1991
    Date of Patent: September 21, 1993
    Inventor: Duncan H. Haynes
  • Patent number: 5246698
    Abstract: Disclosed are biocompatible viscoelastic gel slurries formed from a polymeric gel, preferably a hyaluronan or a derivative thereof such as hylan swollen in an aqueous medium and a fluid phase which is an aqueous solution of a polymer which may also but not necessarily be a hyaluronan or derivative thereof. Also disclosed are methods of making such slurries, controlling their rheological properties and the uses thereof.
    Type: Grant
    Filed: December 20, 1991
    Date of Patent: September 21, 1993
    Assignee: Biomatrix, Inc.
    Inventors: Edward Leshchiner, Endre A. Balazs, Nancy E. Larsen, Adelya Leshchiner
  • Patent number: 5244672
    Abstract: The invention relates to a composition containing liposomes, stabilized by a stabilizing support comprising a mixture of atelocollagen and glycosaminoglycans in a relative proportion preferably ranging between 18 and 25% by weight of the atelocollagen. The preferred use of this composition is in pharmacy or beauty care.
    Type: Grant
    Filed: November 6, 1991
    Date of Patent: September 14, 1993
    Assignee: Coletica
    Inventors: Alain Huc, Chantal Buffevant, Daniel Herbage
  • Patent number: 5242690
    Abstract: A granular substrate, and method for preparation thereof, is provided for use with herbicide, fungicide, and/or insecticide formulations, the substrate comprising an agglomerated grain dust and/or hulls in combination with a binder, particularly a lignosulfonate binder. The granular substrate can readily disintegrate when wetted or maintain its integrity under wetting conditions.
    Type: Grant
    Filed: February 18, 1992
    Date of Patent: September 7, 1993
    Assignee: Cargill, Incorporated
    Inventor: Bruce W. Moechnig
  • Patent number: 5238683
    Abstract: An aerosol preparation of reduced glutathione (GSH) is provided to augment the level of GSH in the lungs. Treatment of pulmonary conditions, where reduced level of GSH is found, by the aerosol preparation of the present invention is taught.
    Type: Grant
    Filed: November 24, 1989
    Date of Patent: August 24, 1993
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventor: Ronald G. Crystal
  • Patent number: 5229506
    Abstract: An improvement to the process for synthesizing cellulose aminomethanate is disclosed which comprises slurring cellulose in low concentrations of aqueous caustic solutions, in the presence of urea, and steeping the slurried mixture, at from about C. to about C., for a time sufficient to permit swelling of the cellulose and uniform distribution of the urea. Cellulose aminomethanate manufactured from product prepared in accord with this process, has a uniform distribution of aminomethanate throughout the cellulose at the molecular level and comprises a suitable product for manufacturing sausage casing.
    Type: Grant
    Filed: June 12, 1989
    Date of Patent: July 20, 1993
    Assignee: Teepak, Inc.
    Inventors: Matiur Rahman, Douglas J. Bridgeford
  • Patent number: 5227165
    Abstract: A local anesthetic microsuspension system is disclosed that includes lipospheres, that are solid, water-insoluble microparticles that have a layer of a phospholipid embedded on their surface. The core of the liposphere is a solid anesthetic such as lidocaine or marcaine, or an anesthetic dispersed in an inert solid vehicle, such as a wax. Anesthetic lipospheres provide a controlled delivery of local anesthetics to achieve extended, effective relief from pain by slowly releasing the anesthetic from the solid hydrophobic core. This is highly preferred over the situation in which an aqueous solution of local anesthetic must be frequently administered because it is quickly systemically absorbed.
    Type: Grant
    Filed: January 22, 1992
    Date of Patent: July 13, 1993
    Assignee: Nova Pharmaceutical Corporation
    Inventors: Abraham J. Domb, Manoj Maniar
  • Patent number: 5221535
    Abstract: A microsuspension system containing insect repellent is disclosed that includes lipospheres, that are solid, water-insoluble microparticles that have a layer of a phospholipid embedded on their surface. The core of the liposphere is a solid insect repellent, or an insect repellent dispersed in an solid vehicle, such as a wax. Insect repellents include compounds that repel insects, are insecticidal, or regulate or inhibit insect growth on humans and other animals and plants. Insect repellent lipospheres provide controlled release of insect repellents while minimizing absorption through the skin.
    Type: Grant
    Filed: January 23, 1992
    Date of Patent: June 22, 1993
    Assignee: Nova Pharmaceutical Corporation
    Inventor: Abraham J. Domb
  • Patent number: 5219576
    Abstract: Collagen implants that are useful as wound healing matrices are characterized by being formed of collagen fibrils that are not chemically cross-linked, and having a bulk density of 0.01 to 0.3 g/cm.sup.3 and a pore population in which at least about 80% of the pores have an average pore size of 35 to 250 microns. The implants are capable of promoting connective tissue deposition, angiogenesis, reepithelialization, and fibroplasia. The wound healing matrix also serves as an effective sustained delivery system for bioactive agents.
    Type: Grant
    Filed: December 3, 1991
    Date of Patent: June 15, 1993
    Assignee: Collagen Corporation
    Inventors: George H. Chu, Yasushi Ogawa, John M. McPherson, George Ksander, Bruce Pratt, Diana Hendricks, Hugh McMullin