Abstract: A stabilized patch device for transdermal drug delivery of steroid drugs containing a 3-keto-4-en functional group is described, wherein the patch comprises an effective amount of the steroid drug and a carrier that is free of acid functional groups. The device can further contain additives such as a penetration enhancer or excipient, so long as such additives are also free of acid functional groups. The device can be either a matrix patch or a liquid reservoir patch. In a matrix patch, the carrier is a biocompatible polymeric adhesive with which the steroid drug is intimately admixed. The adhesive is preferably an acrylic polymer or copolymer. In a liquid reservoir patch, the carrier is a controlled-viscosity composition containing a thinner or thickener. Preferred steroid drugs include certain corticosteroids and sex hormones, such as progestins and androgens. A method of stabilizing such steroid drugs during storage in transdermal patches is also disclosed.

Abstract: An active substance-containing patch for the controlled release of active substances, comprising a backing layer, an adjoining active substance-containing reservoir layer softening at body temperature, a membrane controlling the active substance release, a pressure-sensitive adhesive device permitting fixation of the patch to the skin, and a removable protective layer, is characterized by the fact that the reservoir layer which softens at body temperature is spaced away from the controlling membrane by means of a device made of a material impermeable to the active substance which extends all over the mutually facing surfaces of the reservoir and the membrane and which has at least one passage for the reservoir layer which softens at body temperature.

Abstract: A matrix for containing drugs for transdermal delivery systems is disclosed. The matrix, formed of a skin-adhesive acrylate copolymer, attains high rates of drug delivery without the addition of drug delivery rate enhancers. In preferred embodiments the matrix is used to administer steroids, in particular estradiol. Water-soluble polymers may be added as well.

Abstract: The present invention provides an ISDN-containing patch that causes minimal occurrence of skin rash and has excellent percutaneous absorption and adhesive strength. The present invention discloses an isorbide dinitrate-containing patch comprising: an adhesive layer formed on a flexible support, wherein said layer comprises an adhesive composition containing adhesive and isosorbide dinitrate, the adhesive being composed of silicone-based adhesive (A) and polyvinyl acetate-based adhesive (B), their weight ratio being A:B=85:15 to 15:85, and the weight ratio of isosorbide dinitrate (C) to the adhesives (A+B) being (A+B):C=90:10 to 60:40.

Abstract: Patients suffering from Alzheimer's disease are treated by transdermally administering an effective amount of propentofylline in the form of an occulsive device containing a delivery composition comprising a carrier vehicle having uniformly distributed therein effective amounts of propentofylline and, optionally, a penetration enhancer. The occulsive device may be a matrix type patch in which the carrier vehicle is a pressure sensitive adhesive or a reservoir type patch in which the carrier vehicle is a liquid of controlled viscosity, i.e. a gel, wherein the reservoir system contains means for maintaining it in a propentofylline transferring relationship with the derma when applied. Daily dosages of between about 5 and 49 mg/day are sufficient to maintain adequate plasma propentofylline levels.

Abstract: A transdermal contraceptive delivery system (TCDS) for fertility control in women is described comprising a backing layer, an adjoining layer of a solid absorption adhesive polymer matrix in which minimum effective daily doses of an estrogen and a progestin are dispersed and released for transdermal absorption. Presently preferred is use of the natural estrogen, 17-beta-estradiol, and the synthetic progestin, levonorgestrel. Along with these two steroidal contraceptive agents, a combination of several chemical skin permeation enhancing agents, blended at specific weight ratios, are homogeneously dispersed in the adhesive polymer matrix. The invention also provides a process of fertility control utilizing the transdermal contraceptive delivery system.

Abstract: A transdermal delivery system is described, including a backing layer having coated thereon an active drug-containing adhesive layer which includes (a) an acrylic-based adhesive which is self-crosslinking at a temperature of from about 20.degree. C. to about 65.degree. C. and (b) an active drug. A method for manufacturing a transdermal delivery system is also described, including (A) mixing an active drug with an acrylic-based adhesive solution which is self-crosslinking at a temperature of from about 20.degree. C. to about 65.degree. C. to form an active drug-adhesive mixture, (B) forming a coating of the active drug-adhesive mixture on a backing layer, and (C) drying the coating to form an active drug-containing adhesive layer. Examples of the active drug include nitroglycerin and estradiol.

Abstract: The invention provides wound dressings comprising a molecular filtration membrane having a maximum pore size in the range of from 0.001 .mu.m to 0.5 .mu.m, and preferably in the range of from 0.01 .mu.m to 0.25 .mu.m. The wound dressings may also comprise an absorbent layer atop the molecular filtration membrane and/or a wound contact layer of wound-friendly bioabsorbable material for contacting the wound. In use, the molecular filtration membrane retains high molecular weight biopolymers and wound healing factors at the wound surface while excluding bacteria and allowing rapid egress of wound exudate through the membrane into the absorbent layer.

Abstract: A multidose transdermal drug delivery system comprises a laminate composite with a plurality of compartments. Each compartment is a reservoir for a unit dose of a drug active to be transdermally administered. The assembly is adhesively secured to the skin of a patient. Individual seals are provided for resealably enclosing the drug active in each of the reservoirs. The individual enclosing seals are removable to release the unit dose into contact with the skin of the patient and are actuable to control the transdermal absorption of the drug actives. Provisions are also made to automatically indicate the activation of the drug and to prevent an accidental release of medicament.

Abstract: A burn dressing in the form of a non-irritating, non-woven synthetic fabric containing a therapeutic, nontoxic, water-soluble and biodegradable gel. The primary ingredients of the gel are water and Tea Tree Oil and/or Tea Tree Blend. A gum material or thickening agent is used to maintain the water and Tea Tree Oil and/or Blend in a thickened or gel state. Other ingredients are also provided for increasing shelf life and for imparting bacteriostatic and penetrating properties.

Abstract: An adhesive patch for delayed onset transdermal drug delivery, comprising a reservoir or matrix containing the drug. An impervious membrane is arranged on said reservoir or matrix and designed to become pervious after a given delay period by receiving an external stimulus that alters its physical/chemical structure.

Abstract: Sufficiently high blood benzopyrone levels cannot be achieved on oral administration of benzopyrone. From the point of view of pharmacokinetics and chronic application, the use of benzopyrone as an ointment is not optimal because the blood levels thus achievable cannot be controlled. It has now surprisingly been found that benzopyrone in a particular formulation as part of a transdermal dermal therapeutic system (TDS), after application to the skin, is released to the skin in a constant manner as a function of time and over a longer period owing to the absorption of perspiration, and that constant therapeutically effective blood and tissue levels of benzopyrone are achieved in humans, which levels are a factor of 50 higher than those following the oral administration of the same doses of benzopyrone.

Abstract: A composition of matter for application to a body surface or membrane to administer a drug by permeation through the body surface or membrane, the composition comprising, in combination the drug to be administered, in a therapeutically effective amount; and a permeation enhancing mixture comprising a monoglyceride or a mixture of monoglycerides, and a lactic ester or a mixture of lactate esters, present in specific concentrations.

Abstract: A vaso-active agent is administered in combination with a therapeutic agent which is useful in treatment of tissue of the body which is located below the stratum corneum or the outermost layer of the epidermis, wherein the vaso-active agent may be administered by a local, topical or transdermal route to a particular site and the therapeutic agent may be administered in a similar manner in combination with the vaso-active agent or may be administered separately, wherein the vaso-active agent and the therapeutic agent for topical and/or transdermal administration may be provided in the form of a composition so as to increase local perfusion and/or concentration of the therapeutic agent at or adjacent an administration site of the vaso-active agent.

Abstract: The therapeutic elements for oral administration of medication to animals comprise an active principle contained in a craved for envelope. The envelope (1) comprises, in admixture, one or more craved for materials and one or more substances agglomerating the craved for materials, the envelope possessing a high mechanical and thermal resistance, and being previously formed into a hollow shape appropriate for consumption by the animal, and defining an internal volume, such internal volume being filled by a craved for binder (3) and comprising the active principle (2), the binder closely conforming the internal shape of the envelope (1) in order to provide a continuity between the envelope (1) and the active principle (2).

Abstract: A composition of matter for application to a body surface or membrane to administer oxybutynin by permeation through the body surface or membrane, the composition comprising, in combination the oxybutynin to be administered, in a therapeutically effective amount; and a permeation enhancing mixture comprising a monoglyceride or a mixture of monoglycerides, and a lactic ester or a mixture of lactate esters, present in specific concentrations.

Abstract: A transdermal therapeutic formulation is made of a composition comprising a polymer and ingredients mixed with the polymer which are a pharmacologically active substance, an alcohol, a percutaneous absorption promoter utilized according to necessity and water utilized according to necessity. The polymer comprises lipophilic monomer units and hydrophilic monomer units in a specific ratio. The alcohol, the percutaneous absorption promoter and water are mixed with the polymer in specific amounts. The transdermal therapeutic formulation has excellent percutaneous absorption, has many kinds of applicable pharmacologically active substances, shows good stability of percutaneous absorption with time because of absence of crystallization of the pharmacologically active substance, has good adhesive strength and thus favorably utilized as transdermal therapeutic plaster.

Abstract: The present invention relates to dual textured treatment pads comprising at least one paper pad layer laminated to at least one nonwoven, synthetic fiber pad layer. The invention also encompases treatment pads impregnated with a suitable medicated, cleansing, or cosmetic composition. The invention further encompasses a method of treating ache and skin wrinkling and/or atrophy with these medicated pads.

Abstract: A medication patch to be applied to the skin includes a self-supporting backing layer to give the patch the required integrity and strength by acting as a supporting framework for other components, and a flexible hydrophilic pressure-sensitive adhesive reservoir comprising a natural or synthetic polymer for the sustained release of medication to be absorbed topically through the skin into the body of a patient. The reservoir has two portions: first, an external coating layer with an exposed lower skin-contacting surface that forms a pressure-sensitive bond with the skin, and second, an upper internal portion which infiltrates the porous backing and becomes solidified therein after being applied so that the reservoir and the backing are unified, enabling the backing itself to act as a storage location for the medication-containing reservoir.

Abstract: The present invention is to provide a method and a transdermal drug delivery device for treating erectile dysfunction which comprises a patch containing pharmaceutically active ingredient and being directly apply to the male glans penis and its support and the rings for constricting the base part of the penis to aid the erection. The patch according to the present invention may be divided into two types, i.e. a cylinder type patch and a multi-reservoir type patch. The transdermal drug delivery patch device of the present invention is painless and safely to use and may be effectively produced and maintained erection of the penis without the adverse side effects and with a high degree of patient acceptability in the case of male impotence.