Abstract: Devices for the controlled release of an active agent to the skin or mucosa of a host are disclosed, which devices are laminates of a backing layer, a monolithic carrier layer of an active ingredient selected from active agent, active agent enhancers and mixtures thereof, melt-blended with a thermoplastic matrix polymer capable of controllably releasing the active ingredient, wherein the active ingredient is heat stable at the melt temperature of the matrix polymer, together with means for affixing the laminate to the skin or mucosa of the host so that the active ingredient is continuously released from the carrier layer thereto.

Abstract: A transdermal therapeutic system is described, which is characterized in that it contains a crystallization inhibitor and optionally penetration enhancer in an active ingredient-containing adhesive matrix.

Abstract: A method and device for implanting large diameter objects subcutaneously or into the peritoneal cavity of bovines employs a beveled, puncturing, but substantially non-incising trocar.

Abstract: A method of pigmenting certain parts and products of poultry, fish and crustacea by including in the feed of the pertinent animal one or more of the carotenoids 2'-dehydroplectaniaxanthin, desmethylspheroidenone, spheroidenone, 1-hydroxy-3,4-didehydro-1,2-dihydro-.psi.,.psi.-caroten-2-one, 5'-hydroxy-5',6'-dihydro-4'-apo-.beta.-caroten-6'-one, 1'-hydroxy-3',4'-didehydro-1',2'-dihydro-.beta.,.psi.-carotene-4,2'-dione and 5'-hydroxy-5',6'-dihydro-4'-apo-.beta.-carotene-4,6'-dione, poultry, fish and crustacea feeds for pigmenting certains parts and products of these animals, beadlets and premixes for adding to poultry, fish and crustacea feeds, and the carotenoids 1-hydroxy-3,4-didehydro-1,2-dihydro-.psi.,.psi.-caroten-2-one, 5'-hydroxy-5',6'-dihydro-4'-apo-.beta.-caroten-6'-one, 1'-hydroxy-3',4'-didehydro-1',2'-dihydro-.beta.,.psi.-carotene-4,2'-dione and 5'-hydroxy-5',6'-dihydro-4'-apo-.beta.-carotene-4,6'-dione.

Abstract: Disclosed is a liquid-suspension controlled-release enteric-coated pharmaceutical formulation for the administration of naproxen, comprising (a) microgranules of naproxen and an excipient; (b) four successive coats of polymeric hydrophilic and hydrophobic materials, at least the innermost of said coats imparting controlled-release properties to said naproxen according to a predetermined release profile, and at least the outermost of said coats imparting resistance to dissolution in gastric fluids; and (c) a liquid administration vehicle. This composition enables the oral administration of naproxen as a single daily dose the adjustment of the dosage to a patient's requirements, and avoids detrimental effects of prolonged contact of naproxen with the gastric mucosa thus aiding oral intake and minimizing the drug's typical side effects.

Abstract: A method and device for implanting large diameter objects subcutaneously or into the peritoneal cavity of bovines employs a beveled, puncturing, but substantially non-incising trocar.

Abstract: An active substance-containing patch for the controlled release of nitroglycerin to the skin, consisting of an impermeable backing layer, a reservoir attached thereto and comprising pressure-sensitive hot melt adhesive and active substance, and a removable protective layer, in which patch the reservoir comprises in homogeneous mixture:a) tackifying soft and/or hard resins,b) plasticizers,c) nitroglycerin preparation.

Abstract: In a transdermal drug delivery system, encapsulation material used to coat drug granules controls the release of an active ingredient. The active ingredient is released into a water retaining matrix, which acts as a reservoir, and transdermal drug penetration is driven by the resulting concentration gradient. The delivery system is enclosed in a patch comprising a composite shell, which acts as an occlusive covering when attached to skin, thus enhancing the hydration of the skin area and fostering absorption of the drug. Visible change indicators incorporated into the system provide indicators at significant "landmarks" in the lifetime of the patch. Microcapsules used for the indicator may be formulated so that the penetration of moisture effects a color change at a time when the active ingredient is almost exhausted. This feature alerts to the user to the need for application of a replacement patch.

Abstract: The present invention relates to a transdermal therapeutic formulation comprising capsaicin, a nonsteroidal anti-inflammatant and pamabrom. The formulation is used to alleviate pain or discomfort in a mammal by being applied to the skin of the mammal thereby causing the active ingredients in the formulation to pass into and/or through the skin of the mammal. In a preferred embodiment of the present invention, the formulation is used in patch form for the treatment of the pain and discomfort associated with menstrual cramps, water retention (e.g., "bloating") and/or muscular pain (e.g., muscular back pain).

Abstract: A wound dressing containing a water-insoluble, water swellable cross-linked cellulose derivative, water and a polyol component wherein the dressing comprises a gel and the cellulose derivative comprises less than 10% by weight of the gel. The dressing is easy to apply and is believed to enhance moisture penetration of necrotic tissue and thus speed up debriding action in facilitating wound healing.

Abstract: Devices for the controlled release of an active agent to the skin or mucosa of a host are disclosed, which devices are laminates of a backing layer, a monolithic carrier layer of an active ingredient selected from active agent, active agent enhancers and mixtures thereof, melt-blended with a thermoplastic matrix polymer capable of controllably releasing the active ingredient, wherein the active ingredient is heat stable at the melt temperature of the matrix polymer, together with means for affixing the laminate to the skin or mucosa of the host so that the active ingredient is continuously released from the carrier layer thereto.

Abstract: Self-adhesive plaster for the transdermal application of systemically active steroid hormones, comprising an active substance-impermeable backing layer, an active substance-containing pressure-sensitive adhesive layer and a detachable protective layer which, prior to application to the skin, covers said pressure-sensitive adhesive layer, characterized in that the active substance-containing pressure-sensitive adhesive layer comprises a pressure-sensitive hot melt adhesive having a processing temperature of between 60.degree. an 100.degree. C., and dexpanthenol in a concentration of 15 to 25%-wt.

Abstract: A method for hormonal contraception having a first hormonal component and a second hormonal component packaged separately in a packing unit and intended for short-term sequential administration, each of the hormonal components being composed of a plurality of daily hormone units separately packaged and individually removable in the packing unit. The first hormonal component contains almost exclusively an estrogen preparation as an active hormonal ingredient, effecting a disturbance of the follicle stimulation. The second hormonal component contains, in combination, an estrogen preparation and a progestogen preparation in a therapeutic amount sufficient for ovulation inhibition. The total number of daily hormone units is equal to the total number of days of the desired cycle, with the first hormonal component including 5 or 14 daily units and the second hormonal component including 23 or 14 daily units.

Abstract: An apparatus, product formulation, and method for improved dermal permeation of pharmaceuticals wherein the apparatus includes a thin drug formulation reservoir and a heat-generating chamber separated by a first non-permeable wall, wherein the reservoir and chamber are formed in or supported by a housing. The drug formulation reservoir houses or is capable of housing a predetermined amount of a formulation containing pharmaceutically-active agent(s). The heat-generating/temperature-regulating chamber includes a medium for generating controlled heat, preferably a chemical composition made of carbon, iron, water and/or salt which is activated upon contact with air (oxygen).

Abstract: The present invention relates to the transdermal administration of alpha-adrenoceptor blocking compounds. The invention provides methods of administering these compounds to a patient in therapeutically effective amounts.

Abstract: A pouch package, containing a volatile solution-impregnated patch, is made of a peelable barrier film. The pouch envelops an absorbent substrate saturated preferably with bug repellent fluid. A PSA (pressure sensitive adhesive) coated backing film is laminated to the absorbent substrate. The backing film has a connecting portion which is peelably sealed to the inside of the pouch. When the pouch is peeled open, the PSA coated backing film is exposed and placed against a target surface, such as a patch wearer's clothing. Finally, the side of the pouch facing the absorbent substrate is peeled off the backing film connecting portion to expose the absorbent substrate. A key to functionality of the pouch package is differential adhesion. First, the pouch barrier film must be peelable from itself, yet it must not adhere to the pressure sensitive adhesive on the backing film. A release paper may be used to cover the PSA when peeling the pouch open.

Abstract: The present invention pertains to a dual control sustained release drug delivery system which comprises a core and a porous coating layer over the core, wherein the coated core comprises (A) a core comprising in percentages by weight of the core composition (a) a medicament present in an amount from about 60% to about 90%; (b) an edible material having a melting point from about 25.degree. C. to about 100.degree. C. selected from the group consisting of (i) fatty acids having an iodine value from about 1 to about 10, (ii) natural waxes, (iii) synthetic waxes, and (iv) mixtures thereof, present in an amount from about 5% to about 40%; and (B) a porous coating layer over the core comprising in percentages by weight of the coating layer composition (a) a pH-independent water-insoluble polymer present in an amount from about 40% to about 80%; and (b) a water-soluble film forming polymer present in an amount from about 20% to about 60%.

Abstract: The present invention discloses the method of isolation and purification of the bioactive constituents cinnamophilin from Cinnamomum philippinense (Merr.), the same as Machilus acuminatissima (Hayata). Pharmacological evaluation showed that these compounds possess the activity to inhibit platelet aggregation and to produce relaxing effects of aortic vascular constriction.

Abstract: Disclosed is a method and apparatus for forming a transdermal drug delivery device from a multilayer web comprised of a backing layer, a drug-containing pressure sensitive adhesive layer, and a release layer or liner in which cutting is progressively achieved along a line coplanar with the axes of a cutting roller and anvil roller counter-rotating in proximity to each other. In one embodiment, cutting is achieved completely through the web about the periphery of the transdermal drug delivery device, while simultaneously achieving a scoring only of the release liner without penetration of the pressure sensitive adhesive layer or backing layer. In an alternate embodiment there are two arrangements of rollers. A first arrangement has a cutting edge for scoring the web. After scoring, the web is passed to a second arrangement for cutting through the web to result in the transdermal drug delivery device.

Abstract: A method and composition is provided for treating burns, allergies, trauma or disease of the dermis, epidermis, mucous membranes and subcutaneous tissue, in particular the trauma caused by burns. The method includes applying an aqueous solution of Hydrogen Peroxide (H.sub.2 O.sub.2) and certain Aluminum salts of carboxylic acids to the trauma, assuring sufficient time of contact of the solution to the affected area of the skin to greatly enhance the healing process. Sufficient contact has been achieved by applying a bandage moistened with the solution to the area of the skin requiring treatment and keeping the bandage moistened for the term of the treatment. An adequate term of treatment has been measured in as little a time as repeated periods of minutes for a period of one day. Success has also been achieved by immersing the treatment area in the aqueous solution.