Patents Examined by Gary L. Geist
  • Patent number: 5484584
    Abstract: The present invention relates to a highly efficient method of preparing modified microcapsules exhibiting selective targeting. These microcapsules are suitable for encapsulation surface attachment of therapeutic and diagnostic agents. In one aspect of the invention, surface charge of the polymeric material is altered by conjugation of an amino acid ester to the providing improved targeting of encapsulated agents to specific tissue cells. Examples include encapsulation of radiodiagnostic agents in 1 .mu.m capsules to provide improved opacification and encapsulation of cytotoxic agents in 100 .mu.m capsules for chemoembolization procedures. The microcapsules are suitable for attachment of a wide range of targeting agents, including antibodies, steroids and drugs, which may be attached to the microcapsule polymer before or after formation of suitably sized microcapsules. The invention also includes microcapsules surface modified with hydroxyl groups.
    Type: Grant
    Filed: July 17, 1992
    Date of Patent: January 16, 1996
    Assignee: Board of Regents, The University of Texas System
    Inventors: Sidney Wallace, David Yang, Michael Wallace, Chun Li, Li-Ren Kuang
  • Patent number: 5480631
    Abstract: Novel, substituted benzamides in radioiodinated form are useful in radiopharmaceutical compositions in nuclear medicine as imaging agents to detect, visualize, and analyze the distribution and function of the dopamine D2 receptor in the mammalian brain. These compounds have a specific combination of lipophilicity and dopamine D2 receptor affinity required to attain a required image contrast. The iodinated benzamides identified by the above discovery can be made by reacting a trialkyltin substituted benzamide with an acid in the presence of radioactive iodine which, in turn, is generated by in situ oxidation of an appropriate iodide nuclide salt.
    Type: Grant
    Filed: May 28, 1992
    Date of Patent: January 2, 1996
    Assignee: Vanderbilt University
    Inventors: Tomas De Paulis, Robert M. Kessler, Howard E. Smith, Aaron Janowski, Jeffrey A. Clanton
  • Patent number: 5480581
    Abstract: The invention relates to a liquid-crystalline medium based on a mixture of polar compounds having positive dielectric anisotropy, characterized in that it contains one or more compounds of the general formula I ##STR1## in which X is fluorine, chlorine, CF.sub.3, OCF.sub.3 or OCHF.sub.2, ring A is trans-1,4-cyclohexylene or 1,4-phenylene, and R is alkyl, oxaalkyl, fluoroalkyl or alkenyl, in each case having up to 7 carbon atoms.
    Type: Grant
    Filed: April 7, 1994
    Date of Patent: January 2, 1996
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Herbert Plach, Ulrich Finkenzeller, Volker Reiffenrath, Eike Poetsch, Bernhard Rieger, Hiroshi Numata
  • Patent number: 5478802
    Abstract: A gelling composition and a process for wellbore treatment comprising injecting the composition into reservoirs are disclosed wherein the composition comprise a produced brine; a water-soluble polymer such as, for example, polyacrylamide; a crosslinker such as, for example, a complexed zirconium compound; and optionally a complexing ligand such as, for example, lactic acid.
    Type: Grant
    Filed: December 29, 1992
    Date of Patent: December 26, 1995
    Assignee: Phillips Petroleum Company
    Inventor: Ahmad Moradi-Araghi
  • Patent number: 5476976
    Abstract: Fluoronitrobenzenes are prepared in an advantageous way from the corresponding chloronitrobenzenes and an alkali metal fluoride by means of a chlorine-fluorine exchange reaction with replacement of a chlorine atom by a fluorine atom, by catalyzing the reaction with a quaternaryammonium compound which comprises at least one alkoxypolyoxyalkyl radical.
    Type: Grant
    Filed: July 19, 1994
    Date of Patent: December 19, 1995
    Assignee: Hoechst AG
    Inventors: Thomas Schach, Theodor Papenfuhs
  • Patent number: 5472633
    Abstract: A stable, salt-free iron chelate for use in aqueous alkaline systems is prepared by contacting iron oxide with an aqueous mixture of from 30 to 45 mole percent trisodium HEDTA and from 55 to 70 mole percent EDTA, heating the mixture to dissolve the iron, and adjusting the pH to from 7 to 10 with base.
    Type: Grant
    Filed: October 6, 1992
    Date of Patent: December 5, 1995
    Assignee: The Dow Chemical Company
    Inventors: Freddie Griffin, Jr., David A. Wilson, Steven H. Christiansen
  • Patent number: 5472638
    Abstract: A corrosion inhibitor is disclosed which is produced by reacting an aqueous alkanolamine solution with an acid gas to form an amide and an alkanolamine salt, mixing aqueous alkanolamine with said amide and said alkanolamine salt in the absence of added inorganic base, and reacting the mixture at elevated temperature.
    Type: Grant
    Filed: April 28, 1994
    Date of Patent: December 5, 1995
    Assignee: Mobil Oil Corp.
    Inventors: Bruce D. McLaughlin, Tsoung Y. Yan
  • Patent number: 5473075
    Abstract: A diastereomer salt of optically active quinolinemevalonic acid of the formula ((-)I.
    Type: Grant
    Filed: September 20, 1993
    Date of Patent: December 5, 1995
    Assignee: Nissan Chemical Industries Ltd.
    Inventors: Yoshio Ohara, Mikio Suzuki, Yoshinobu Yanagawa, Hiroshi Iwasaki, Nobuhide Miyachi
  • Patent number: 5472635
    Abstract: Provided is a phase plate comprising a light transmitting base, an alignment layer formed on said base, and a film formed on said alignment layer by a liquid crystalline polymer which exhibits a nematic orientation in the state of liquid crystal and assumes a glassy state at a temperature below the liquid crystal transition point of the polymer.
    Type: Grant
    Filed: March 28, 1994
    Date of Patent: December 5, 1995
    Assignees: Nippon Oil Company, Ltd., Ricoh Company, Ltd.
    Inventors: Shigeki Iida, Takehiro Toyooka, Hiroyuki Itoh, Yasuyuki Takiguchi, Akihiko Kanemoto, Haruo Iimura
  • Patent number: 5470844
    Abstract: The present invention is directed to a class of 3-phosphono-pyrrolidine derivatives as described by Formula I and their use as NMDA antagonists.
    Type: Grant
    Filed: November 30, 1993
    Date of Patent: November 28, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventor: Jeffrey P. Whitten
  • Patent number: 5468756
    Abstract: Disclosed are imidazonaphthyridine derivatives represented by formula (I) ##STR1## wherein: R.sup.1 represents lower alkyl or substituted or unsubstituted aryl; andX--Y--Z represents ##STR2## wherein R.sup.2 represents hydrogen, lower alkyl, alkenyl, aralkenyl, or --C (R.sup.5)H--(CH.sub.2).sub.n --R.sup.4 (wherein R.sup.4 represents substituted or unsubstituted aryl, substituted or unsubstituted pyridyl, substituted or unsubstituted furyl, hydroxy-substituted lower alkyl, lower alkanoyloxy, morpholino, lower alkanoyl, carboxy, lower alkoxycarbonyl, cycloalkyl, hydroxy, lower alkoxy, halogen or NR.sup.6 R.sup.7 wherein R.sup.6 and R.sup.7 independently represents hydrogen or lower alkyl; R.sup.5 represents hydrogen, lower alkyl, or phenyl; and n represents an integer of 0 to 3); and R.sup.3 represents hydrogen, mercapto, hydroxy, lower alkyl, or aryland pharmaceutically acceptable salts thereof.The compounds show a potent anti-inflammatory, anti-allergic and broncho-dilative activity.
    Type: Grant
    Filed: May 12, 1994
    Date of Patent: November 21, 1995
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Fumio Suzuki, Takeshi Kuroda, Shigeto Kitamura, Kenji Ohmori
  • Patent number: 5468717
    Abstract: Oxime ether derivatives of the formula I ##STR1## where R.sup.1 and R.sup.2 are each hydrogen or alkyl, Het is quinolyl, unsubstituted or substituted, and X is oxygen or sulfur, their plant-tolerated acid addition salts, metal complexes and N-oxides, and fungicides containing these compounds.
    Type: Grant
    Filed: May 4, 1994
    Date of Patent: November 21, 1995
    Assignee: BASF Aktiengesellschaft
    Inventors: Bernd Wenderoth, Siegbert Brand, Franz Schuetz, Thomas Kuekenhoehner, Franz Roehl, Eberhard Ammermann, Gisela Lorenz
  • Patent number: 5468303
    Abstract: A rust, corrosion, and scale removing composition is provided. It comprises an additive concentrate and water. The additive concentrate preferably consists of, on a parts by weight basis, 1.5 to 5 parts glycolic acid, 0.2 to 1 parts tetrasodium salt of ethylenediaminetetraacetic acid, 2 to 6 parts citric acid, and 1 to 3 parts trisodium citrate dihydrate.
    Type: Grant
    Filed: February 25, 1994
    Date of Patent: November 21, 1995
    Assignee: ZT Corporation
    Inventor: Glenn C. Thomas, Sr.
  • Patent number: 5466807
    Abstract: Novel perylene compounds based on perylene-3,4,9,10-tetracarboxylic acid monoanhydride monoimides which are substituted by alkylene- or arylenesulfonic acid groups on one or both imide nitrogen atoms, or on corresponding tetracarboxylic acid diimides, or on a halogenation product thereof, have properties which render them accessible, in addition to their use as dispersing agent for pigments of the same class of compound or other categories, also for direct use as pigments and fluorescent dyestuffs as well as polymer-soluble dyestuffs.
    Type: Grant
    Filed: March 9, 1992
    Date of Patent: November 14, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Erwin Dietz, Manfred Urban
  • Patent number: 5464842
    Abstract: Pharmaceutically useful nitrogen containing cyclic oxime and amine substituted compounds of the formulas I to XVI are disclosed (See specification for definitions of the substituents). Specifically, the compounds are 1-azabicyclo [3.2.1]oximes, 1-azabicyclo[3.3.1]oximes, 1-aza-4-oxobicyclo[3.3.1]oximes, 1-aza-4-oxobicyclo[3.2.
    Type: Grant
    Filed: March 3, 1994
    Date of Patent: November 7, 1995
    Assignee: Warner-Lambert Company
    Inventors: David J. Lauffer, Haile Tecle
  • Patent number: 5464563
    Abstract: A bleaching composition for cellulosic materials such as paper pulp, cotton and cotton blends. The chemical system of the present invention includes a mixture of sodium hydroxide, optical brighteners and an enhanced hydrogen peroxide including a silicate-free stabilizer. In the preferred embodiment, the silicate-free stabilizer includes; magnesium acetate; phosphonic acid derivative or substituted phosphonic acids; dipicolinic acid; and the balance water. The resulting textile goods are soft, absorbent, silicate-free with a Hunter Scale whiteness of greater than about 85. Because a silicate-free stabilizer is used, low levels of extractable solids are obtained.
    Type: Grant
    Filed: August 25, 1993
    Date of Patent: November 7, 1995
    Assignee: Burlington Chemical Co., Inc.
    Inventors: Samuel B. Moore, James F. Leuck, Edwin T. Turner
  • Patent number: 5462693
    Abstract: An air purifying agent comprising a carrier which contains short pulp fiber, on which one or more chemical components selected from the group consisting of acids, alkalis, oxidizing agents, reducing agents and antimicrobial components are supported. According to the present invention, an air purifying agent which is low in weight, is safe to handle and exhibits excellent effect in removing contaminated gases containing low concentrations of contaminants.
    Type: Grant
    Filed: May 25, 1993
    Date of Patent: October 31, 1995
    Assignee: Nippon Chemical Industrial Co., Ltd.
    Inventors: Shozo Ichimura, Seikichi Tabei, Michinori Hashimoto
  • Patent number: 5463030
    Abstract: The present invention relates to a new group of compounds (e.g., N,N"-bis(2,6-dimethylcarbaniloylmethylene diethylene triamino triacetic acid, N,N"-bis(pyridoxylamine)diethylene triamino triacetic acid) which can be used as metal chelating agents and can be complexed with paramagnetic metal atoms form new complexes with improved and unexpected stability which make them extremely useful as contrast agents in magnetic resonance imaging and other types of diagnostic imaging. The chelating agents and corresponding paramagnetic metal complexes are derivatives of diethylene triamino pentaacetic acid and triethylene tetraamino hexaacetic acid.
    Type: Grant
    Filed: May 31, 1994
    Date of Patent: October 31, 1995
    Assignee: Research Foundation of the State of New York
    Inventors: Gopal Subramanian, Richard F. Schneider
  • Patent number: 5463060
    Abstract: Pergolide is produced from 8,9-dihydroelymoclavine by a one-pot process in which it is reacted successively with 1-iodopropane, with a sulfonyl halide, and with an alkali metal thiomethoxide without isolation of intermediate products.
    Type: Grant
    Filed: May 21, 1992
    Date of Patent: October 31, 1995
    Assignee: Eli Lilly and Company
    Inventor: Jerry W. Misner
  • Patent number: 5463112
    Abstract: This invention concerns novel sulphoperoxyacids having the following generic formula ##STR1## wherein the R', R", and M are as defined in the specification. Bleach compositions and methods of bleaching using such novel sulphoperoxyacids are also taught.
    Type: Grant
    Filed: February 2, 1993
    Date of Patent: October 31, 1995
    Assignee: Solvay Interox Limited
    Inventors: John P. Sankey, William Sanderson, Graham R. Horne