Patents Examined by Glennon H. Hollrah
  • Patent number: 5444086
    Abstract: This invention relates to benzyl and naphthalenylmethyl thiophenones and cyclopentenones, some of which are novel, which have oral antihyperglycemic activity in diabetic mice, a genetic animal model of non-insulin dependent diabetes mellitus. These compounds are represented by the formula ##STR1## wherein: R.sup.2 and R.sup.3 are independently selected from hydrogen, C.sub.1-6 alkyl, halogen, C.sub.1-6 alkoxy, thio-C.sub.1-6 alkyl, or trifluoromethyl or R.sup.2 together with R.sup.3 forms a benzo ring fused to the phenyl ring and optionally substituted with one or two substituents independently selected from C.sub.1-6 alkyl, halogen, C.sub.1-6 alkoxy, thio-C.sub.1-6 alkyl, or trifiuoromethyl;R.sup.1 is selected from hydrogen, C.sub.1-6 alkyl, halogen, C.sub.1-6 alkoxy, thio-C.sub.1-6 alkyl, or trifluoromethyl;andR.sup.4 is selected from the group consisting of: ##STR2## wherein R.sup.5 is H or C.sub.1-6 alkyl or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 31, 1994
    Date of Patent: August 22, 1995
    Assignee: American Home Products Corporation
    Inventor: Michael S. Malamas
  • Patent number: 5441664
    Abstract: A cleaning composition which comprises approximately by weight 2 to 35% of at least one unsaturated fatty acid having about 8 to 24 carbon atoms; 0.01 to 1.5% of a trialkanolamine; 0.01 to 1.5% of an alkanol having about 1 to about 5 carbon atoms; 1 to 5.0% of an alkali metal hydroxide; 0.02 to 2.0% of an amine oxide; 0.02 to 2.0% of a sultaine; 0.05 to 3.0% of an acidic gelling agent; and the balance being water.
    Type: Grant
    Filed: November 15, 1993
    Date of Patent: August 15, 1995
    Assignee: Colgate Palmolive Co.
    Inventors: Claude Blanvalet, Mary C. Brauchli, Jolanta Dautas, Constance A. Marchese
  • Patent number: 5439671
    Abstract: Process for the production of a neutral-tasting paste of an alkyl ether sulfate in glycerol, comprising the steps of:A) forming an aqueous paste of at least one alkyl ether sulfate wherein the aqueous paste contains from about 25 to about 75% by weight of alkyl ether sulfate;B) adding glycerol to the aqueous paste from step A) in from about 1 to about 4 times the quantity by weight of the aqueous paste;C) distilling off substantially all of the water present in the mixture resulting from step B) to produce a substantially ambydrous paste; andD) passing steam heated to a temperature above C. through skid paste with intensive whirling of the paste and steam phases.
    Type: Grant
    Filed: March 28, 1994
    Date of Patent: August 8, 1995
    Assignee: Henkel Kommanditgesellschaft auf Aktien
    Inventors: Achim Ansmann, Willi Breitzke, Karl-Heinz Gantke
  • Patent number: 5439826
    Abstract: A method of distinguishing between strips for different assays in an automated instrument, wherein characteristics to which the instrument is sensitive are selectively introduced in microwells of individual microstrips which are pretreated with a specific antigen or antibody for a particular test. On each microstrip, the wells having the characteristic collectively define a multi-bit code which corresponds to a particular condition or disease to be tested for. The automated instrument reads the characteristic from the selected wells and thus determines what test is to be conducted. The marks may have optical, radioactive, luminescent, fluorescent, or magnetic characteristics, in accordance with the test to be conducted.
    Type: Grant
    Filed: December 2, 1988
    Date of Patent: August 8, 1995
    Assignees: Bio-Tek Instruments, Inc., Syva Company
    Inventor: Michael Kontorovich
  • Patent number: 5434309
    Abstract: A process for preparing a controlled functional density poly(secondary amine) comprising:(a) contacting a polymer containing olefinic unsaturation with carbon monoxide in hydrogen under hydroformylation conditions in the presence of a hydroformylation catalyst to produce a controlled functional density polyaldehyde containing reactive carbon-carbon double bonds, and (b) contacting the polyaldehyde with hydrogen and a primary amine under reductive amination conditions in the presence of a ruthenium-containing imine hydrogenation catalyst or (b.sup.1) contacting the polyaldehyde with a sterically hindered aliphatic or cycloaliphatic primary amine or an aromatic primary amine under reductive amination conditions in the presence of an alkali metal borohydride to produce poly(secondary amine) having a substantially equivalent ratio of secondary amine groups to reactive carbon-carbon double bonds as the ratio of aldehyde groups to reactive carbon-carbon double bonds in the polyaldehyde.
    Type: Grant
    Filed: April 28, 1994
    Date of Patent: July 18, 1995
    Assignee: Monsanto Company
    Inventors: Martin P. McGrath, Samuel J. Tremont
  • Patent number: 5434173
    Abstract: Compounds of the formula ##STR1## where R.sub.1, R.sub.2, R.sub.3 and R.sub.4 independently are hydrogen, lower alkyl of 1 to 6 carbons, halogen or lower alkoxy of 1 to 6 carbons; R.sub.5 and R.sub.5 ' independently are hydrogen or lower alkyl of 1 to 6 carbons; Y is oxygen or sulfur; Z is n-alkyl having 1 to 10 carbons, cyclo or branch-chained alkyl of 3 to 10 carbons, and straight chain alkenyl having 2 to 10 carbons, or cyclo or branched chained alkenyl of 3 to 10 carbons; X is a heteroaryl group selected from a group consisting of thienyl, pyridyl, furyl, pyridazinyl, pyrimidinyl, pyrazinyl, thiazolyl and oxazolyl; A is (CH.sub.2).sub.n where n is 0-5, lower branched chain alkyl having 3 to 6 carbons, cycloalkyl having 3 to 6 carbons, alkenyl having 2 to 6 carbons and 1 or 2 double bonds, alkynyl having 2 to 6 carbons and 1 or 2 triple bonds; B is hydrogen, COOH or a pharmaceutically acceptable salt thereof, COOR.sub.8, CONR.sub.9 R.sub.10, --CH.sub.2 OH, CH.sub.2 OR.sub.11, CH.sub.2 OCOR.sub.
    Type: Grant
    Filed: September 24, 1993
    Date of Patent: July 18, 1995
    Assignee: Allergan, Inc.
    Inventor: Roshantha A. S. Chandraratna
  • Patent number: 5432202
    Abstract: Methods for regulating cation transport across cellular membranes possessing cation channels are provided. The cell membrane possessing a specific ion channel is exposed to a non-aromatic polyamine compound having a lysine- or arginine-based moiety (or a guanidine moiety) coupled to a straight chain polyamine.These polyamines as well as a method for regulating NMDA through a spermidine-like effect on NMDA receptors by exposing a cell membrane to selected polyamines are also provided.
    Type: Grant
    Filed: June 9, 1993
    Date of Patent: July 11, 1995
    Assignee: New York University
    Inventors: Bruce D. Cherksey, Rodolfo R. Llinas, Mutsuyuki Sugimori
  • Patent number: 5430190
    Abstract: A one-pot reaction process for the coproduction of two polyurethane catalysts which comprises reacting excess diethylenetriamine (DETA) in a reaction vessel with propylene oxide in the presence of a hydrogenation catalyst under conditions and for a period of time to essentially completely react the propylene oxide to give a mixture of DETA and N-2-hydroxypropyldiethylenetriamine (HPDETA), adding formaldehyde and hydrogen to the reaction vessel, reacting the DETA and HPDETA with the formaldehyde and hydrogen under conditions to effect permethylation of the DETA and HPDETA to afford N,N,N',N',N"-pentamethyldiethylenetriamine (PMDETA), a polyurethane catalyst, and N-2-hydroxypropyl-N,N',N',N"-tetramethyldiethylenetriamine (HPTMDETA) a nonfugitive polyurethane catalyst.
    Type: Grant
    Filed: June 14, 1994
    Date of Patent: July 4, 1995
    Assignee: Air Products and Chemicals, Inc.
    Inventors: Richard V. C. Carr, Craig R. Williams
  • Patent number: 5428048
    Abstract: This invention relates to compounds which inhibit lipoxygenase in the metabolism of arachidonic acid and thus inhibits formation of leukotrienes which are implicated in inflammatory processes and bronchoconstriction and inhibits the oxidation of LDL which is implicated in formation of atherosclerotic plaque.The compounds useful in this invention are represented by the formula: ##STR1## wherein: R.sup.2 is hydrogen, halogen or C.sub.1 -C.sub.6 alkyl; Y of O or S; R.sup.5 is hydrogen or methyl R.sup.6 is --NH.sub.2, --CH.sub.3 or --OCH.sub.3 ;and R.sup.1 is ##STR2## wherein R.sup.7, R.sup.8 and R.sup.10 are independently halogen, trifluoromethyl, alkyl, alkoxy, methanesulfonyl or trifiuoromethanesulfonyl; R.sup.9 is hydrogen or methyl; and Z is O or S,or a pharmaceutically acceptable salt thereof.Compounds of the above formula where R.sup.1 is not ##STR3## when R.sup.3 is H and R.sup.6 is --NH.sub.2 are novel.
    Type: Grant
    Filed: November 8, 1993
    Date of Patent: June 27, 1995
    Assignee: American Home Products Corporation
    Inventors: Michael S. Malamas, Iwan Gunawan
  • Patent number: 5426115
    Abstract: A method of treatment for improving encephalic function which comprises administering, to a subject in need of such treatment, a 15-keto-prostaglandin compound in an amount effective for improvement of encephalic function.
    Type: Grant
    Filed: October 29, 1993
    Date of Patent: June 20, 1995
    Assignee: Kabushikikaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuji Ueno, Hiroyoshi Osama, Tomio Oda
  • Patent number: 5426231
    Abstract: This invention relates to an improved process for the preparation of 3-aminopropanol and a primary amine by reacting a cyanoethyl ketoxime with hydrogen in the presence of a hydrogenation catalyst to generate the primary amine and aminopropanol. The sequence of reactions to form the aminopropanol and primary amine involves the reaction of hydroxylamine with a ketone to generate a ketoxime followed by reaction of acrylonitrile with the ketoxime to generate a cyanoethyl ketoxime followed by complete hydrogenation of the cyanoethyl ketoxime in the presence of a hydrogenation catalyst to generate the primary amine and aminopropanol. The significant advantage associated with this process is the high degree of selectivity to 3-aminopropanol and the primary amine.
    Type: Grant
    Filed: January 5, 1994
    Date of Patent: June 20, 1995
    Assignee: Air Products and Chemicals, Inc.
    Inventors: Richard V. C. Carr, Barry J. Koehler
  • Patent number: 5426225
    Abstract: There are provided perfluoroalkanoyl aminonitrile intermediates and their use in a facile and efficient synthesis of 2-perfluoroalkyl-3-oxazolin-5-one. Said oxazolinone is a key intermediate in the preparation of insecticidal, acaricidal and nematocidal pyrrole compounds.
    Type: Grant
    Filed: December 30, 1993
    Date of Patent: June 20, 1995
    Assignee: American Cyanamid Company
    Inventor: Venkataraman Kameswaran
  • Patent number: 5424447
    Abstract: Inhibitors of nitric oxide formation from arginine useful for treating hypotension, inflammation, stroke and to restore vascular contractile sensitivity to the effects of .alpha..sub.1 adrenergic agonists are physiologically active compounds including -substituted ornithine or N.sup..epsilon. -substituted lysine moieties or monoalkyl carbon-substituted -substituted ornithine or N.sup..epsilon. -substituted lysine moieties, having the formula ##STR1## wherein R is (CH.sub.2).sub.y CH.sub.3 or H, R' is CH.sub.2 or C(H) (CH.sub.2).sub.y CH.sub.3, and R" is CH.sub.2 or C(H) (CH.sub.2).sub.y CH.sub.3, with y ranging from 0 to 5, and x is 0 or 1 and wherein none or only one of R, R' and R" provides an alkyl substituent on ornithine or lysine moiety, and wherein Q is a heme binding moiety and/or a sulfur-containing binding moiety and Q' is --NH.sub.2 when there is a double bond between the omega carbon and Q and Q' is .dbd.
    Type: Grant
    Filed: July 7, 1993
    Date of Patent: June 13, 1995
    Assignee: The Medical College of Wisconsin Research Foundation, Inc.
    Inventors: Owen W. Griffith, Krishnaswamy Narayanan
  • Patent number: 5424280
    Abstract: There are provided aryloxybenzene compounds of formula I ##STR1## Further provided are compositions and methods comprising those compounds for the control of undesirable plant species.
    Type: Grant
    Filed: October 7, 1993
    Date of Patent: June 13, 1995
    Assignee: American Cyanamid Company
    Inventors: Michael E. Condon, Alvin D. Crews, Jr.
  • Patent number: 5422196
    Abstract: A pressure vessel for pressurized secondary cells is disclosed. The vessel includes a generally cylindrical container having both ends closed by substantially flat circular discs. The container has a diameter dimension substantially greater than its axial dimension. A mechanism is provided for supporting a plurality of substantially rectangular stacked electrode plates within the container. A pair of sealed terminal connectors pass through the container, and a terminal assembly mechanism is disposed within the container for directly interconnecting the stacked plates to each terminal connector.
    Type: Grant
    Filed: August 5, 1992
    Date of Patent: June 6, 1995
    Assignee: Saft America, Inc.
    Inventor: Glenn C. Klein
  • Patent number: 5415877
    Abstract: The present invention provides a fungicide composition which contains ingredients which are biocompatible for purposes of agricultural applications, and which are harmless to animals and humans. An invention fungicide composition in the form of a dry blend formulation remains non-caking and free-flowing under storage conditions. Illustrative of an invention fungicide composition is a formulation which has a content of sodium bicarbonate, potassium bicarbonate, xanthan gum, dialkylsulfosuccinate salt and alkyl sulfate salt surfactants, and magnesium silicate anti-caking ingredient. The xanthan gum and surfactants function as an effective spreader-sticker and film-forming medium when the composition is diluted with water for agricultural applications.
    Type: Grant
    Filed: December 22, 1993
    Date of Patent: May 16, 1995
    Assignee: Church & Dwight Co., Inc.
    Inventor: Anthony E. Winston
  • Patent number: 5414130
    Abstract: A method of producing 4,6-diaminoresorcinol comprisinga) reducing a dinitroarylether of the formula: ##STR1## wherein R is hydrogen, C.sub.1 -C.sub.6 alkyl, cycloalkyl or CH.dbd.CH.sub.2, R' is hydrogen or CH.sub.2 --R, each A is independently Cl, Br, or I, and n is 0, 1 or 2; to form a diaminoarylether, andb) cleaving the ether group(s) from the diaminoarylether under conditions such that 4,6-diaminoresorcinol is formed as a salt or other stabilized form thereof.
    Type: Grant
    Filed: December 23, 1993
    Date of Patent: May 9, 1995
    Assignee: The Dow Chemical Company
    Inventors: Zenon Lysenko, Richard G. Pews, Paul Vosejpka
  • Patent number: 5414128
    Abstract: The present invention relates to a process for the preparation of compounds of the general formula I ##STR1## by reaction of compounds of the general formula II ##STR2## with amines of the general formula III ##STR3## wherein R.sup.1 and R.sup.2 independently of one another denote hydrogen, (C.sub.1 -C.sub.4)-alkyl, C.sub.1 -C.sub.4)-hydroxyalkyl or (C.sub.5 -C.sub.6)-cycloalkyl, or, together with the nitrogen atom carrying them, form (C.sub.4 -C.sub.6)-heterocyclyl and R.sup.3 and R.sup.4 independently of one another denote hydrogen, (C.sub.1 -C.sub.4)-alkyl, (C.sub.1 -C.sub.4)-hydroxyalkyl, (C.sub.1 -C.sub.2)-alkylcarbonyl or tosyl.
    Type: Grant
    Filed: December 3, 1992
    Date of Patent: May 9, 1995
    Assignee: Cassella AG
    Inventors: Willi Steckelberg, Rolf Muller, Peter Koch
  • Patent number: 5414129
    Abstract: A process for the improved purification and separation of trans 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride from a reaction mixture containing the trans isomer, the cis isomer and Grignard reaction side products, comprising combining the mixture with a solution of hydrochloric acid in a low molecular weight alcohol or with gaseous hydrogen chloride in the presence of an organic solvent selected from medium molecular weight alcohols, ketones, esters and ethers or aromatic ethers, to effect the selective precipitation of trans 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride.
    Type: Grant
    Filed: September 8, 1993
    Date of Patent: May 9, 1995
    Assignee: Chemagis, Ltd.
    Inventors: Stephen Cherkez, Ori Lerman, Michael Tennenbaum, Hasalia Avner, Tamar Kunyevski
  • Patent number: 5412105
    Abstract: A thiophene-silole copolymer represented by the formula below and its method of manufacture are disclosed; ##STR1## wherein, R is a monofunctional hydrocarbon group having 1 to 20 carbon atoms or hydrogen, A and B are alkyl groups, aromatic groups, alkenyl groups, or represent an aliphatic group forming a ring wherein A is bonded to B, m and p are integers no less than 1, n is a natural number which can be 0, X is a hydrogen or halogen atom, and Y is a hydrogen atom, halogen atom or thiophene.
    Type: Grant
    Filed: March 16, 1993
    Date of Patent: May 2, 1995
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Yoshihiko Ito, Kohei Tamao, Shigehiro Yamaguchi, Yoshiki Nakagawa