Patents Examined by Hope A. Robinson
  • cAMP receptor protein variant, coding sequence and method of producing L-amino acid using the same
    Patent number: 11473113
    Abstract: Provided are a cAMP receptor protein variant and coding sequence, a microorganism including the same, and a method of producing a L-amino acid using the same.
    Type: Grant
    Filed: July 25, 2019
    Date of Patent: October 18, 2022
    Assignee: CJ CHEILJEDANG CORPORATION
    Inventors: Seok Myung Lee, Ki Yong Cheong, Chang Il Seo, Ji Sun Lee
  • Method of producing collagenase
    Patent number: 11473074
    Abstract: The present invention relates to the fields of collagenase production and collagenase products, and particularly to improving the reproducibility, purity, and stability of collagenase I and collagenase II compositions, where the compositions are pure to at least 95% by area as measured by reverse phase high pressure liquid chromatography (RP-HPLC) and essentially free of neutral protease.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: October 18, 2022
    Assignee: Endo Global Aesthetics Limited
    Inventors: Christine A. Sheaffer, Michael Berbaum, John Hanna, Jason Dziadosz, Daniel Shanafelt
  • Production of steviol glycosides in recombinant hosts
    Patent number: 11466302
    Abstract: The invention relates to recombinant microorganisms and methods for producing steviol glycosides and steviol glycoside precursors.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: October 11, 2022
    Assignee: EVOLVA SA
    Inventors: Helene Lunde Robertsen, Iben Nordmark Andersen, Adam Matthew Takos, Swee Chuang Lim Hallwyl, Francesca Ambri, Manuel Quiros Asensio, Michael Dalgaard Mikkelsen, Jens Houghton-Larsen, Veronique Douchin, Jane Dannow Dyekjaer, Simon Carlsen, Nina Nicoline Rasmussen, Esben Halkjaer Hansen
  • Cannabinoid and terpene preservation in biomass using whole fermentation broth
    Patent number: 11453894
    Abstract: The present invention includes a method of preserving cannabinoid concentration in a biomass comprising: providing a hemp biomass in an aqueous solution; adding a culture of a cannabinoid preserving Bacillus bacteria to the hemp biomass solution; and culturing the hemp biomass with the Bacillus bacteria under conditions in which the cannabinoid concentration is maintained.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: September 27, 2022
    Assignee: Van Grow, LLC
    Inventor: Robert Tengler
  • Variants and compositions comprising variants with high stability in presence of a chelating agent
    Patent number: 11453868
    Abstract: The present invention relates to variants of an alpha-amylase having improved stability to chelating agents relative to its parent enzyme, compositions comprising the variants, nucleic acids encoding the variants, methods of producing the variants, and methods for using the variants.
    Type: Grant
    Filed: March 17, 2021
    Date of Patent: September 27, 2022
    Assignee: NOVOZYMES A/S
    Inventors: Allan Svendsen, Annette Helle Johansen, Mads Bjoernvad, Frank W. Rasmussen, Michael Skjoet, Signe Eskildsen Larsen, Jens Oebro, Svend Kaasgaard, Lars Beier
  • Engineered tyrosine ammonia lyase
    Patent number: 11421253
    Abstract: The present invention provides engineered tyrosine ammonia-lyase (TAL) polypeptides and compositions thereof. In some embodiments, the engineered TAL polypeptides have been optimized to provide enhanced catalytic activity and enhanced acid stability, while reducing sensitivity to proteolysis and increasing tolerance to acidic pH levels. The invention also provides methods for utilization of the compositions comprising the engineered TAL polypeptides for therapeutic and industrial purposes.
    Type: Grant
    Filed: January 14, 2021
    Date of Patent: August 23, 2022
    Assignee: Codexis, Inc.
    Inventors: Gjalt W. Huisman, Joyce Liu, Nikki Dellas, Chinping Chng, William Casey Hallows
  • Factor VIII sequences
    Patent number: 11419920
    Abstract: There is provided a nucleic acid molecule comprising a nucleotide sequence encoding a Factor VIII protein, wherein a B domain portion of the Factor VIII protein is encoded by a nucleotide sequence between 90 and 111 nucleotides in length and has an amino acid sequence that is at least 85% identical to SEQ ID NO: 4 which comprises six asparagine residues. Also provided is a Factor VIII protein, a vector comprising the above nucleic acid molecule, a host cell, a transgenic animal, a method of treating Haemophilia for example, Haemophilia A, and a method for the preparation of a parvoviral gene delivery vector.
    Type: Grant
    Filed: September 2, 2020
    Date of Patent: August 23, 2022
    Assignees: UCL BUSINESS LTD, ST. JUDE CHILDREN'S RESEARCH HOSPITAL
    Inventors: Amit Nathwani, Jenny McIntosh, Edward Tuddenham, Andrew Davidoff
  • Mannanase PMAN5A mutant having improved heat resistance, gene thereof, and application
    Patent number: 11407987
    Abstract: The present invention relates to a mannanase PMan5A mutant having improved heat resistance, a gene encoding the mutant and application thereof. The mutant is obtained by a substitution of histidine with tyrosine at amino acid residue 93, phenylalanine with tyrosine at amino acid residue 94, leucine with histidine at amino acid residue 356, and/or alanine with proline at amino acid residue 389. The thermal tolerance of the single site mutation mutant H93Y, L356H and A389P are greatly improved over that of the wild-type mannanase PMan5A, and the thermal tolerance of the combination mutants shows the stack effect of the single site mutation, demonstrating the amino acids at the sites of 93, 94, 356, and 389 play an important role for the thermal stability of the mannanase of GH5 family.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: August 9, 2022
    Inventors: Huiying Luo, Bin Yao, Weina Liu, Yuan Gu, Tao Tu, Yuan Wang, Yaru Wang, Huoqing Huang, Yingguo Bai, Xiaoyun Su, Kun Meng
  • Recombinant yeast strains
    Patent number: 11384135
    Abstract: This invention relates to genetically engineered strains of yeast and methods, for producing recombinant protein (e.g., collagen). Recombinant protein of the present invention is used to produce biofabricated leather or a material having leather-like properties containing recombinant or engineered collagen. The yeast strains are engineered to produce ascorbate and/or increased production of ? ketoglutarate.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: July 12, 2022
    Assignee: MODERN MEADOW, INC.
    Inventors: Lixin Dai, Poonam Srivastava
  • Extracellular heme production method using metabolically engineered microorganism
    Patent number: 11371068
    Abstract: The present invention relates to a microorganism variant having the ability to extracellularly produce heme, and more particularly to a metabolically engineered microorganism variant having the ability to extracellularly produce heme and a method of producing heme using the same. According to the present invention, heme, an organometallic compound which is increasingly used as a health food or food supplement for the treatment of porphyria, can be extracellularly secreted and produced in high yield using the microorganism variant, but not conventional chemical synthesis or enzymatic synthesis.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: June 28, 2022
    Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Sang Yup Lee, Xin Rui Zhao, Kyeong Rok Choi
  • Transformant of coryneform bacterium and production method for useful compound using same
    Patent number: 11359217
    Abstract: Provided is a transformant of a microorganism that has improved catechol productivity.
    Type: Grant
    Filed: February 18, 2019
    Date of Patent: June 14, 2022
    Assignee: RESEARCH INSTITUTE OF INNOVATIVE TECHNOLOGY FOR THE EARTH
    Inventors: Masayuki Inui, Kazumi Hiraga, Masako Suda, Takeshi Kubota
  • Inks for 3D printing, methods of production and uses thereof
    Patent number: 11351289
    Abstract: The present disclosure relates to a silk-fibroin ink suitable for 3D printing. The ink for 3D printing now disclosed may be used in chemical and pharma industries, medicine, engineering, manufacturing namely for the production of capsules, fibres, membranes, particles, scaffolds, medical devices, microfluidic devices and patient-specific implants.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: June 7, 2022
    Assignee: ASSOCIATION FOR THE ADVANCEMENT OF TISSUE ENGINEERING CELL BASED TECHNOLOGIES & THERAPIES (A4TEC)—ASSOCIAÇÃO
    Inventors: João Pedro Bebiano e Costa, Joana Catarina Da Silva Correia de Oliveira, Joaquim Miguel Antunes Correia de Oliveira, Rui Luís Gonçalves Dos Reis
  • Microorganism of genus producing L-arginine and method for producing L-arginine using the same
    Patent number: 11345940
    Abstract: A microorganism of the genus Corynebacterium producing L-arginine, and a method for producing L-arginine using the same.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: May 31, 2022
    Assignee: CJ CHEILJEDANG CORPORATION
    Inventors: Seon Hye Kim, Hyung Joon Kim, Haena Oh, Byoung Hoon Yoon, Min Gyeong Kang
  • Construction of cell factory for producing stearidonic acid and fermentation technology thereof
    Patent number: 11345937
    Abstract: Provided is construction of Mucor circinelloides cell factory for producing stearidonic acid (SDA) and fermentation technology. ?15 Desaturase gene is obtained by cloning from Mortierella alpina, the gene is ligated to an integrative plasmid pMAT1552, and transformed into a Mucor circinelloides defective strain Mu402, and ?15 Desaturase gene is integrated on Mucor circinelloides genome through homologous recombination, to obtain the recombinant strain Mc-?15, finally, the expression of the ?15 Desaturase gene in Mucor circinelloides is realized. The recombinant new strain is accession number CGMCC No. 15888, and the classification name is Mucor circinelloides-D15D.
    Type: Grant
    Filed: December 12, 2020
    Date of Patent: May 31, 2022
    Assignee: SHANDONG UNIVERSITY OF TECHNOLOGY
    Inventors: Yuanda Song, Md. Ahsanul Kabir Khan, Junhuan Yang, Yao Zhang, Wu Yang, Shaoqi Li
  • Heterologous expression of taurine in microorganisms
    Patent number: 11326171
    Abstract: Non-naturally occurring microorganisms are provided that produce taurine and/or taurine precursors, e.g., hypotaurine, sulfoacetaldehyde, or cysteate, utilizing exogenously added enzyme activities. Methods of producing taurine and/or taurine precursors in microbial cultures, and feed and nutritional supplement compositions that include taurine and/or taurine precursors produced in the microbial cultures, such as taurine- and/or taurine precursor-containing biomass, are also provided.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: May 10, 2022
    Assignee: KnipBio, Inc.
    Inventors: Lawrence F. Feinberg, Christopher J. Marx, Max A. Wall, Daniel R. Smith, Catherine J. Pujol-Baxley, Bonnie D. McAvoy
  • Process for enzymatic hydrolysis of lignocellulosic material and fermentation of sugars
    Patent number: 11319559
    Abstract: The invention relates to a process for the preparation of a sugar and/or fermentation product from lignocellulosic material.
    Type: Grant
    Filed: October 8, 2018
    Date of Patent: May 3, 2022
    Assignee: DSM IP ASSETS B.V.
    Inventors: Johannes Augustinus Kroon, Pierre Louis Woestenborghs
  • Engineered heme-binding compositions and uses thereof
    Patent number: 11312949
    Abstract: Described herein are heme-binding compositions and methods relating to their use, for example methods of treatment of sepsis and rhabdomyolysis.
    Type: Grant
    Filed: October 23, 2019
    Date of Patent: April 26, 2022
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Michael Super, Alexander L. Watters, Philip T. Snell, Donald E. Ingber
  • Glycosylated beta-galactosidase compositions having improved transgalactosylating activity
    Patent number: 11304425
    Abstract: The present invention relates to compositions, particularly liquid compositions, comprising polypeptides having beta-galactosidase activity, methods of making said compositions, and uses of the compositions for making e.g. dairy products. The polypeptides having beta-galactosidase activity are modified by glycation of lysine and/or arginine residues by incubating the enzyme in the presence of reducing sugars, optionally combined with a heat treatment. Thereby, transgalactosylating activity is increased.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: April 19, 2022
    Assignee: Novozymes A/S
    Inventor: Jeppe Wegener Tams
  • Process for modifying human cell lines to produce factor VII
    Patent number: 11286503
    Abstract: A process for producing blood coagulation Factor VII in large scale in 3 human cell lines (HepG2, Sk-Hep, and HKB-11) and to select the best recombinant protein producer is described. The murine line BHK-21 was used as control. The data allowed for the assertion that the system used to modify cell lines was efficient, so that all the cells were satisfactorily modified, and produced the protein of interest in a stable form. In addition, when comparing the murine line BHK-21 with the human cells (HepG2, Sk-Hep-1 and HKB-11), the latter proved to be able to produce rFVII more efficiently, which allows us to conclude that human cell lines are a great alternative to produce recombinant blood coagulation factors in large scale.
    Type: Grant
    Filed: February 10, 2020
    Date of Patent: March 29, 2022
    Inventors: Dimas Tadeu Covas, Marcela Cristina Corrêa de Freitas, Virginia Picanço e Castro, Kamilla Swiech
  • Schizochytrium limacinum strain, building method therefor and application thereof
    Patent number: 11248244
    Abstract: Provided is a Schizochytrium limacinum strain, a building method therefor and an application thereof. The strain disclosed is classified and named as Schizochytrium sp. HX-RS, and the preservation number is CCTCC NO: M2017046. An acyltransferase functional domain originating from Shewanella PKS enzyme is adopted instead of an acyltransferase functional domain originating from Schizochytrium sp. PKS enzyme, and the strain is obtained by performing flat panel screening and acclimation screening with a high rotation seed and a low temperature.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: February 15, 2022
    Assignee: Nanjing University of Technology
    Inventors: He Huang, Lujing Ren, Shenglan Chen, Lingjun Geng, Xiaojun Ji, Xuechao Hu