Patents Examined by Ivan Greene
  • Patent number: 11135174
    Abstract: Provided are methods for producing mesoporous nanoparticles that can, once loaded, retain small or large molecules (e.g., molecules having a molecular weight that is less or greater than about 900 Da) until release is desired, upon which time the mesoporous nanoparticles can release the loaded molecule in a controlled manner for a desired period of time, including an extended period of time. Also disclosed are methods for treating a subject comprising administering to the subject a mesoporous nanoparticle according to the present disclosure.
    Type: Grant
    Filed: April 12, 2012
    Date of Patent: October 5, 2021
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Paul Ducheyne, Sanjib Bhattacharyya
  • Patent number: 11096934
    Abstract: The present invention includes methods of treating patients with acute myeloid leukemia across a range of genetic subtypes with DHODH inhibitors, such as 6-fluoro-2-(2?-fluoro-[1,1?-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid).
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: August 24, 2021
    Assignees: THE BROAD INSTITUTE, INC., THE GENERAL HOSPITAL CORPORATION, PRESIDENT AND FELLOWS OF HARVARD COLLEGE, BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: David B. Sykes, David Scadden, Timothy A. Lewis, Andreas Janzer, Hanna Meyer, Detlef Stöckigt
  • Patent number: 11083820
    Abstract: The present invention discloses elastic macro porous scaffold and a process for the preparation thereof. The present invention also provides a process for the preparation of macroporous, elastic nano particulate scaffolds comprising of coated or grafted cross linkable nanoparticles, and a crosslinker prepared by crosslinking during ice templating, wherein the modulus increases linearly with temperature.
    Type: Grant
    Filed: January 21, 2014
    Date of Patent: August 10, 2021
    Assignee: Council of Scientific & Industrial Research
    Inventors: Guruswamy Kumaraswamy, Raja Rajamanickam, Sayam Sengupta
  • Patent number: 11052029
    Abstract: A cationic compatible metal oxide and oral care compositions containing the metal oxide are disclosed. Preferably, the oral care compositions contain a cationic compatible metal oxide and a cationic ingredient, such as for example, a cationic antibacterial agent such as cetyl pyridinium chloride (“CPC”). The cationic compatible metal oxide, e.g. silica, comprise metal oxide particles having a substantially negative surface charge and a vitamin deposited onto or reacted with the surface of the metal oxide particles in an amount sufficient to provide a substantially positive surface charge on the metal oxide particle. Processes for making and using the vitamin modified metal oxide in oral care compositions are also disclosed.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: July 6, 2021
    Assignee: W. R. Grace & Co.-Conn.
    Inventor: James George Miller
  • Patent number: 11013715
    Abstract: Disclosed herein are compositions, having nanosized droplets, wherein the nanosized droplets may contain a cannabinoid oil, a dietically acceptable carrier oil, a surfactant, and water. Also disclosed herein are methods of making and using the same.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: May 25, 2021
    Assignee: Vertosa, Inc.
    Inventor: Chunxiao Han
  • Patent number: 10864302
    Abstract: The present invention provides a method for preparing an injectable thermosensitive hydrogel for preventing adhesion including mixing methyl cellulose, polyethylene glycol, oxidized cellulose nanofibers and carboxymethyl cellulose. The injectable thermosensitive hydrogel for preventing adhesion is a sol at a low temperature and induces rapid gelation upon in vivo implantation due to thermosensitivity. In addition, the hydrogel can be rapidly changed into physical hydrogel without separate additives or chemical reaction during in vivo condition. In addition, the injectable thermosensitive hydrogel for preventing adhesion exhibits excellent biodegradability and biocompatibility, has no cytotoxicity, inhibits in vitro migration of rat bone marrow mesenchymal stem cells (rBMSCs), and exhibits anti-adhesion efficacy in a rat model of sidewall defect-cecum abrasion in vivo, thus being useful as an effective anti-adhesive agent.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: December 15, 2020
    Assignees: SOONCHUNHYANG UNIVERSITY INDUSTRY ACADEMY COOPERATION FOUNDATION, NATIONAL INSTITUTE OF FOREST SCIENCE
    Inventors: Byong Taek Lee, Sun-Young Lee, Tamanna Sultana, Celine Abueva
  • Patent number: 10842810
    Abstract: The present invention concerns polymer particles made from poly(lactic-co-glycolic acid) (PLGA) polymer, poly(lactic-co-glycolic acid)-polyethylene glycol-poly(lactic-co-glycolic acid) (PLGA-PEG-PLGA) copolymer, or the mixture of same, combined with hyaluronic acid molecules or hyaluronic acid salts, and the method for preparing same. The present invention also concerns injectable pharmaceutical or cosmetic compositions comprising such polymer particles, the method for preparing such compositions, and the use thereof for medical purposes, in particular for the prevention and/or treatment of musculoskeletal diseases, diseases and traumatic conditions of the skin, oral disorders, vaginal mucosa dryness and urinary infections or cystitis, dryness of the eye membrane and eye infections, obesity, and the use of same to combat ageing of the skin and/or for repairing the dermal tissue (mesotherapy).
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: November 24, 2020
    Assignee: GENBIOTECH
    Inventors: Yannis Guillemin, Dominique Vacher, Thomas Perrier, Maud Gonnet, Jean-Noël Gouze
  • Patent number: 10806753
    Abstract: A core-shell gel particle of the invention contains a crosslinked hyaluronic acid, has a higher equilibrium swelling capacity at the surface than at the center, the equilibrium swelling capacity showing a change curve with an inflection point from the center to the surface, and has a probe pushing force of 20 nN or less from the surface to a depth of 800 nm.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: October 20, 2020
    Assignee: Denka Company Limited
    Inventors: Akio Ohno, Masamichi Hashimoto, Harei Nemoto, Takafumi Harada, Kenji Fujii
  • Patent number: 10780053
    Abstract: This invention provides methods for producing a polymer particle which contains unusually high negative charges on the surface of the particle. Preferably, the polymer is pharmaceutically acceptable. The negative charges can be conferred by chemical groups such as carboxyl, sulfonate, nitrate, fluorate, chloride, iodide, persulfate, and many others, with carboxyl group being preferred. The invention also provides polymer particle produced by the methods of the invention.
    Type: Grant
    Filed: November 6, 2019
    Date of Patent: September 22, 2020
    Assignee: Phosphorex, Inc.
    Inventor: Bin Wu
  • Patent number: 10597544
    Abstract: The present invention relates to pigments based on multicoated flake-form substrates which are distinguished by the fact that at least 8 layers [layers (A)-(H)] are on the substrate, where an SiO2 layer (=layer A) is located directly on the surface of the substrate, and to the use thereof, inter alia, in paints, surface coatings, automobile paints, powder coatings, printing inks, security printing inks, plastics, ceramic materials, glasses, paper, in toners for electrophotographic printing processes, in seed, in greenhouse sheeting and tarpaulins, as absorbers in the laser marking of paper and plastics, and in cosmetic formulations, for the preparation of pigment pastes with water, organic and/or aqueous solvents, for the preparation of pigment compositions and dry preparations.
    Type: Grant
    Filed: October 20, 2011
    Date of Patent: March 24, 2020
    Assignee: MERCK PATENT GMBH
    Inventors: Marcus Mathias, Meike Saatze
  • Patent number: 10589134
    Abstract: The present disclosure is directed to a system and methods for maintaining or improving hand health and hygiene. More particularly, the system and methods prevent or overcome skin damage caused by frequent hand washing and use of hand sanitizers and/or cleansers. The hand care system comprises an article, such as an elastomeric glove, that has a moisturizing liquid liner composition on the skin-contacting surface of the article that delivers a skin health benefit to the skin, a non-irritating hand cleanser capable of moisturizing the skin, and a moisturizing hand sanitizer.
    Type: Grant
    Filed: January 30, 2008
    Date of Patent: March 17, 2020
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Douglas Robert Hoffman, Scott W. Wenzel, David William Koenig, Lisa Flugge-Berendes
  • Patent number: 10568860
    Abstract: The present invention provides a novel nanotechnology-based strategy for therapeutic neovascularization. Said statin-loaded nanoparticle allows local delivery of statin and thus improves therapeutic efficacy of several kind of diseases which may treated by statin such as ischemic neovascularization.
    Type: Grant
    Filed: August 30, 2007
    Date of Patent: February 25, 2020
    Assignees: KOWA CO., LTD., SENTANIRYOUKAIHATSU CO., LTD.
    Inventor: Kensuke Egashira
  • Patent number: 10543207
    Abstract: The present disclosure is directed to compounds and methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic kidney disease, end-stage renal disease, liver disease, and peroxisome proliferator-activated receptor (PPAR) gamma agonist-induced fluid retention. The present disclosure is also directed to compounds and methods for the treatment of hypertension. The present disclosure is also directed to compounds and methods for the treatment of gastrointestinal tract disorders, including the treatment or reduction of pain associated with gastrointestinal tract disorders. The methods generally comprise administering to a mammal in need thereof a pharmaceutically effective amount of a compound, or a pharmaceutical composition comprising such a compound, that is designed to be substantially active in the gastrointestinal (GI) tract to inhibit NHE-mediated antiport of sodium ions and hydrogen ions therein.
    Type: Grant
    Filed: January 9, 2017
    Date of Patent: January 28, 2020
    Assignee: ARDELYX, INC.
    Inventors: Dominique Charmot, Marc Navre, Christopher Carreras, Noah Bell, Michael Robert Leadbetter, Jeffrey W. Jacobs
  • Patent number: 10543153
    Abstract: The present invention relates to a cosmetic product having a visible pattern consisting of one or more colours, comprising a cosmetic composition including one or more dyes and/or pigments which contain magnetic or magnetisable particles, characterised in that said cosmetic composition is housed in a container enclosing a magnet capable of generating a magnetic field, whereby said dyes and/or pigments are positioned and/or oriented in the container by said magnetic field, thereby creating the visible pattern.
    Type: Grant
    Filed: April 8, 2015
    Date of Patent: January 28, 2020
    Assignee: ART COSMETICS S.R.L.
    Inventor: Piero Origo
  • Patent number: 10478398
    Abstract: Discrete microstructures of predefined size and shape are prepared using sol-gel phase-reversible hydrogel templates. An aqueous solution of hydrogel-forming material is covered onto a microfabricated silicon wafer master template having predefined microfeatures, such as pillars. A hydrogel template is formed, usually by lowering the temperature, and the formed hydrogel template is peeled away from the silicon master template. The wells of predefined size and shape on the hydrogel template are filled with a solution or a paste of a water-insoluble polymer, and the solvent is removed to form solid structures. The formed microstructures are released from the hydrogel template by simply melting the hydrogel template in water. The microstructures are collected by centrifugation. The microstructures fabricated by this method exhibit pre-defined size and shape that exactly correspond to the microwells of the hydrogel template.
    Type: Grant
    Filed: January 16, 2018
    Date of Patent: November 19, 2019
    Assignee: Akina, Inc.
    Inventors: Kinam Park, Ghanashyam S. Acharya, Haesun Park
  • Patent number: 10434060
    Abstract: A solid dose for insertion into the skin of a patient wherein the solid dose has a hollow core. There is also provided a solid dose carrier, a device, a method of manufacturing the solid dose and a method of delivering a solid dose transdermally to a human or animal.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: October 8, 2019
    Assignee: NDM TECHNOLOGIES LIMITED
    Inventor: Dewan Fazlul Hoque Chowdhury
  • Patent number: 10428186
    Abstract: Multi-component particles comprising inorganic nanoparticles distributed in an organic matrix and processes for making and using same. A flowing aerosol is generated that includes droplets of a precursor medium dispersed in a gas phase. The precursor medium contains a liquid vehicle and at least one precursor. At least a portion of the liquid vehicle is removed from the droplets of precursor medium under conditions effective to convert the precursor to the nanoparticles or the matrix and form the multi-component particles.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: October 1, 2019
    Assignee: SICPA HOLDING SA
    Inventors: Toivo T. Kodas, Mark J Hampden-Smith, Scott T. Haubrich, Heng Yu, Ned J. Hardman, Ralph E. Kornbrekke, Aaron Stump, Klaus Kunze, David Dericotte, Karel Vanheusden
  • Patent number: 10407572
    Abstract: The invention relates to aluminum pigments which are at least partially coated with lubricant, wherein the aluminum pigments have a relative breadth of thickness distribution ?h of from 30% to less than 70%, as determined by a scanning electron microscope thickness count and as calculated on the basis of the corresponding cumulative breakthrough curve of the relative frequencies of occurrence, according to the formula ?h=100×(h90?h10)/h50, and an X-ray diffractogram, measured on pigments in substantially plane-parallel orientation, having one or two main peaks which do not correspond to the [111] reflexes. The invention further relates to a method for the production of said aluminum pigments and to uses thereof and also to nail varnishes and printing inks containing said aluminum pigments of the invention.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: September 10, 2019
    Assignee: ECKART GMBH
    Inventors: Stefan Trummer, Michael Becker, Thomas Schlegl
  • Patent number: 10272044
    Abstract: The apparatus and methods of the present invention are of use for the production of emulsion-based microparticles containing a biological or chemical agent. In particular, the apparatus provides a vessel; packing material situated inside such vessel and may further provide material capable of insertion into both ends of said vessel for enclosure of the packing material. In a particular embodiment, the apparatus is a packed bed apparatus. The methods include production of emulsion based microparticles containing a biological or chemical agent. The usefulness of the present invention is that the apparatus and methods of the present invention provide for a low-shear, non-turbulent, production of emulsion-based microparticles that provides a narrow, reproducible, particle size distribution, capable of use with both large and small volumes that is capable of being conveniently scaled up while providing predictable emulsion properties.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: April 30, 2019
    Assignee: Evonik Corporation
    Inventor: Ehud Zeigerson
  • Patent number: 10201501
    Abstract: There is provided use of a mixed metal compound in the manufacture of medicament for neutralizing or buffering stomach acid, wherein the mixed metal compound contains at least one trivalent metal selected from iron (III) and aluminum and at least one divalent metal selected from of magnesium, iron, zinc, calcium, lanthanum and cerium, wherein (A) the mixed metal compound is of formula (I): MII1-aMIIIaObAn?c.zH2O (I) where MII is the at least one bivalent metal; MIII is the at least one trivalent metal; An? at least one n-valent anion; 2+a=2b+?cn and ?cn<0.9a, and z is 2 or less, and/or (B) the mixed metal compound is provided in the form of a granular material comprising (i) at least 50% by weight, based on the weight of the granular material, of the mixed metal compound (ii) from 3 to 12% by weight, based on the weight of the granular material, of non-chemically bound water, and (iii) no greater than 47% by weight based on the weight of the granular material of excipient.
    Type: Grant
    Filed: July 24, 2008
    Date of Patent: February 12, 2019
    Assignee: OPKO IRELAND GLOBAL HOLDINGS, LTD.
    Inventors: Maurice Sydney Newton, James David Morrison, Ruth Diane Pennel, Nigel Peter Rhodes, Alexis John Toft