Patents Examined by J. R. Brown
  • Patent number: 4749572
    Abstract: A pharmaceutical preparation for the treatment of, e.g. ulcers, burns and skin diseases contains, as essential ingredients, from 5 to 25% by weight of Peru Balsam and from 0.01 to 0.20% by weight of silver nitrate. The preparation may be administered enterally or topically.
    Type: Grant
    Filed: August 21, 1985
    Date of Patent: June 7, 1988
    Assignee: Pharmaceutical Holdings Limited
    Inventor: Mahmoud Ahari
  • Patent number: 4749695
    Abstract: A water-soluble iron dextran having a high iron content is prepared by adding to an aqueous solution containing more than 200 mmol D-glucose per 1000 U.alpha.(1.fwdarw.6)-D- glucosyltansferase, at 265 to 310K and a pH value of 4.5 to 8, an aqueous sucrose solution in a mole ratio of sucrose to glucose of from 2.0 to 5.0; separating, after the consumption of the sucrose, glucose, liberated fructose and undesired oligosaccharides; reacting the so-purified dextran, having an average molar mass of from 2000 to 4000, with freshly precipitated iron (III) hydroxide and, if desired, further purifying the same.Iron dextrans having an iron content of from 27 to 33 percent by weight and an average molar mass of the dextran component of from 2000 to 4000, may be prepared according to the process of the invention which can be used in the treatment of iron deficiency.
    Type: Grant
    Filed: June 5, 1985
    Date of Patent: June 7, 1988
    Assignee: Pfeifer & Langen
    Inventor: Dieter Schwengers
  • Patent number: 4749693
    Abstract: Anthracycline glycosides of the general formula (A'): ##STR1## wherein R.sub.1 represents a hydrogen atom, a hydroxy group or a methoxy group; one of R.sub.2 and R.sub.3 represents a hydroxy group and the other of R.sub.2 and R.sub.3 represents a nitro group; and R.sub.4 represents a hydrogen atom or a hydroxy group; and their pharmaceutically acceptable salts; have anti-tumor activity.
    Type: Grant
    Filed: September 26, 1986
    Date of Patent: June 7, 1988
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Francesco Angelucci, Mauro Gigli, Sergio Penco, Fernando Giuliani
  • Patent number: 4749690
    Abstract: A method for treating allergy by administration of the peptide thymopentin.
    Type: Grant
    Filed: January 27, 1986
    Date of Patent: June 7, 1988
    Assignee: Ortho Pharmaceutical Corporation
    Inventor: Gideon Goldstein
  • Patent number: 4749683
    Abstract: Secretion of gastric acid in the stomach of mammals is inhibited by parenteral administration of alpha-transforming growth factor.
    Type: Grant
    Filed: October 3, 1986
    Date of Patent: June 7, 1988
    Assignee: President and Fellows of Harvard College
    Inventors: Richard A. Murphy, James A. Rhodes
  • Patent number: 4749564
    Abstract: Nail polish compositions comprising pigment material, and film forming material, wherein the pigment material is present in amounts not less than about 2.0% by weight and said nail polish composition has a Newtonian viscosity not greater than about 600 cps.
    Type: Grant
    Filed: February 21, 1986
    Date of Patent: June 7, 1988
    Assignee: Chesebrough-Pond's, Inc.
    Inventors: Joseph R. Faryniarz, John S. Wooster
  • Patent number: 4748157
    Abstract: Fab or Fc fragment of human IgG which is obtainable by enzymatic digestion of the human IgG is reduced by a reducing agent to sever an interchain of disulfide bonds therein and then blocked the SH radicals formed with alkyl group which may contain other group. The resulting alkylated Fab and Fc fragments display therapeutic and prophylactic action for gastrointestinal ulcers by the oral or parenteral administration.
    Type: Grant
    Filed: February 4, 1986
    Date of Patent: May 31, 1988
    Assignee: The Green Cross Corporation
    Inventors: Masakazu Iwai, Kazumasa Yokoyama, Tsunekazu Fukushima
  • Patent number: 4748153
    Abstract: Compounds having somatostatin-like activity have been found to be useful as local anti-inflammatory agents in the treatment of such conditions as, for example, psoriasis, eczema, seborrhea, and other localized inflammatory and allergic conditions. Particularly useful are cyclic and bridged somatostatin analogs.
    Type: Grant
    Filed: September 2, 1987
    Date of Patent: May 31, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Evan R. Morgan, Daniel F. Veber, Sanford L. Steelman
  • Patent number: 4748022
    Abstract: A composition and method of use for the treatment of pain and inflammation associated with lesions of the skin or mucus membrane, such as herpes simplex, herpes labialis, herpes progenitalis, chickenpox lesions, herpes genitalis, sensitivity of gingival tissue due to procedures for etching teeth with HCl, swollen gums, cheilosis, oral traumatic injuries, aphthous ulcer, by applying to the lesion an effective amount of a topical composition comprising diphenhydramine HCl, lidocaine HCl, aloe vera gel, propolis and sufficient base to raise the pH to 8-9.
    Type: Grant
    Filed: December 9, 1986
    Date of Patent: May 31, 1988
    Inventor: John A. Busciglio
  • Patent number: 4748159
    Abstract: Disclosed is a method for the treatment of hyperglycemia, hyperlipemia, inflammatory diseases, pains due to the accentuation of central nerve, pyrexia due to the accentuation of central nerve or tumor, which comprises administering to a patient suffering therefrom a pharmaceutically effective amount of p-aminobenzoic acid-N-L-rhamnoside or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: November 24, 1986
    Date of Patent: May 31, 1988
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Chikao Yoshikumi, Yoshio Ohmura, Fumio Hirose, Masanori Ikuzawa, Kenichi Matsunaga, Takayoshi Fujii, Minoru Ohhara, Takao Ando
  • Patent number: 4748158
    Abstract: Alkyl glycosides are used to greatly increase the microbicidal activity of biguanide compounds, such as chlorhexidine salts. The alkyl glycoside/biguanide agents have a particular utility in teeth cleaning preparations due to their improved microbicidal activity against gram-positive bacteria.
    Type: Grant
    Filed: December 6, 1985
    Date of Patent: May 31, 1988
    Assignee: Henkel Kommanditgesellschaft auf Aktien
    Inventors: Manfred Biermann, Rudolf Lehmann, Harald Schnegelberger, Walter Ploeger, Hans-Juergen Klueppel, Karl-Heinz Schmid
  • Patent number: 4748152
    Abstract: An improved, viscous, transparent, pyrogen-free, isotonic, succinylated atelocollagen solution provides an effective medium for use in viscosurgery and as a replacement for vitreous.
    Type: Grant
    Filed: July 16, 1986
    Date of Patent: May 31, 1988
    Assignees: Opticol Corp., Koken Co., Ltd.
    Inventors: Teruo Miyata, Michael W. Dunn
  • Patent number: 4746742
    Abstract: Provided herein is a derivative of 2-deoxy-2-amino-4-O-phophono-D-glucopyranose, which is derived from lipid A, of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are a member in a pair selected from the group consisting of those indicated in a following table:______________________________________ Com- pound No. R.sub.1 R.sub.2 ______________________________________ I(R,R) --O--CO--(CH.sub.2).sub.12 --CH.sub.3 --O--CO--(CH.sub.2).sub.12 --CH.sub.3 II --O--CO--(CH.sub.2).sub.12 --CH.sub.3 --OH II(R,R) --O--CO--(CH.sub.2).sub.12 --CH.sub.3 --OH II(S,S) --O--CO--(CH.sub.2).sub.12 --CH.sub.3 --OH III --OH --O--CO--(CH.sub.2).sub.12 --CH.sub.3 III(R,R) --OH --O--CO--(CH.sub.2).sub.12 --CH.sub.3 III(S,S) --OH --O--CO--(CH.sub.2).sub.12 --CH.sub.3 IV(R) --H --O--CO--(CH.sub.2).sub.12 --CH.sub.3 ______________________________________The compounds of this invention include those of rectus and sinister configurations and act as mitogens for polyclonal B cells.
    Type: Grant
    Filed: November 12, 1986
    Date of Patent: May 24, 1988
    Assignee: Toho Yakuhin Kogyo Kabushiki Kaisha
    Inventors: Akira Hasegawa, Makoto Kiso, Kazuyuki Morihara
  • Patent number: 4746650
    Abstract: A new acidic polycyclic ether antibiotic UK-58,852 has the formula: ##STR1## wherein R and R.sup.1 are both hydrogen, and can be prepared by the submerged aerobic propagation in aqueous nutrient media of Actinomadura sp. ATCC 39697. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in controlling coccidiosis, enteritis, swine dysentery and theileriosis as well as being effective in promotion of growth and/or improving efficiency of feed utilization in swine and ruminants. Two minor components, wherein R is H and R.sup.1 is CH.sub.3 and wherein R and R.sup.1 are both CH.sub.3, have also been isolated from the fermentation.
    Type: Grant
    Filed: June 21, 1985
    Date of Patent: May 24, 1988
    Assignee: Pfizer Inc.
    Inventors: Walter P. Cullen, Hiroshi Maeda, John C. Ruddock, Junsuke Tone
  • Patent number: 4746516
    Abstract: A method is disclosed for purifying non-homogeneous systems, known as liposomic suspensions, from non-entrapped drugs wherein said suspensions are treated with liquid or solid polymers of synthetic and organic nature having chemical functionality, which are used as ion-exchangers. The liquid or solid polymers are based on styrene, divinylbenzene, acrylic acid, methacrylic acid, and the like, normally known as ion-exchange resins, and may include carboxylic, phosphonic or sulphonic functions of different matrices. The ion-exchange resins may also include salified quaternary ammonium, primary, secondary and tertiary amminic or phosphinic functions or other functions with different matrices, including phenolformaldehyde, styrene-divinylbenzene, acrylates, methacrylates, hydrocarbons and condensation-resins.
    Type: Grant
    Filed: October 22, 1986
    Date of Patent: May 24, 1988
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Luigi Moro, Guido Neri, Alessandro Rigamonti
  • Patent number: 4745098
    Abstract: The healing of wounds is promoted by contacting the wound surfaces with a suspension of collagen and a glycosaminoglycan that is chemotactic for fibroblasts and/or endothelial cells. Typical glycosaminoglycans that exhibit the desired chemotaxis are heparin, heparan sulfate, and alginate. Two or more glycosaminoglycans can be present in the suspensions. Collagen is present in the suspension in the order of 7-10 mg/ml; while the glycosaminoglycan is present in much lower concentrations, e.g., 250-350 .mu.g/ml. Application of the collagen/glycosaminoglycan suspension to open wounds greatly increases the rate of healing.
    Type: Grant
    Filed: February 24, 1984
    Date of Patent: May 17, 1988
    Assignee: The Regents of the University of California
    Inventor: Dov Michaeli
  • Patent number: 4745102
    Abstract: A novel method of treating prostate adenocarcinoma, prostate benign hypertrophia, endometriosis, dysmenorrhea, hirsuitism, hormono-dependent mammary tumors, treatment and prevention of precocious puberty, induction of a retardation of the appearance of puberty and treatment of acne of mammals comprising administering to warm-blooded animals an effective amount of a peptide of the formulaP Glu-His-Trp-Ser-Tyr-X-Y-Arg-Pro-Z (I)wherein (a) Z is Gly-NH.sub.2, Y is Leu and X is Gly, (b) Z is Gly-NH.sub.2, Y is Leu, X is DN Leu, DN Val, D Abu (.alpha.-aminobutyric acid), D Phe, D Ser, D Thr, D Met, D Pgl, D Lys, Leu, Ile, Nle, Val, N Val, Met, Phe, D Leu, D Arg, D Ser (tbu), D Thr (tbu), D Cys (tbu), D Asp (O tbu), D Glu (Otbu), D Orn (boc), D Lys (boc), D Trp, Trp, 2-methyl Ala, D Tyr, .epsilon.-lauryl-D Lys, .epsilon.
    Type: Grant
    Filed: October 22, 1986
    Date of Patent: May 17, 1988
    Assignee: Roussel Uclaf
    Inventors: Fernand Labrie, Jean-Pierre Raynaud
  • Patent number: 4745104
    Abstract: Methods for treating mammals to reduce pain, reduce cell proliferation and/or reduce inflammation are described based on administering to the mammals compounds having the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are hydrogen or an acyl residue hydrocarbon having from 1 to 6 carbon atoms, R.sub.5 is hydrogen or CH.sub.2 OH and R.sub.6 is a functionalized hydrocarbon having from 1 to 10 carbon atoms. Natural and synthetic 1,12-seco derivatives of pseudopterosin with similar utilities are disclosed. Synthetic compositions having the above general formula which are useful in the method are disclosed.
    Type: Grant
    Filed: April 15, 1985
    Date of Patent: May 17, 1988
    Assignee: The Regents of the University of California
    Inventors: Robert S. Jacobs, William H. Fenical
  • Patent number: 4745100
    Abstract: A method and preparation for the stimulation of tear secretion. The method involves topically applying to the ocular surface gastrointestinal hormones and/or biologically active peptides and their precursors, derivatives, and fragments which activate vasoactive intestinal peptide receptors of lacrimal gland tissue. The preparation contains a peptide of hormone that activates the vasoactive intestinal peptide receptor such as glucagon or vasoactive intestinal peptide, a vehicle and may also contain an ophthalmic preservative.
    Type: Grant
    Filed: February 19, 1986
    Date of Patent: May 17, 1988
    Assignee: Eye Research Institute of Retina Foundation
    Inventors: Jeffrey P. Gilbard, Darlene A. Dartt
  • Patent number: 4745105
    Abstract: Low molecular weight heparin derivatives containing hydrophobic groups and exhibiting improved permeability are disclosed. Said derivatives exhibit anticoagulant activity and improved solubility in organic solvents.
    Type: Grant
    Filed: August 20, 1986
    Date of Patent: May 17, 1988
    Inventors: Charles C. Griffin, Kevin M. Foley, Eduardo Amaya